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A Modified Crank-Nicolson Numerical Scheme for the Flory-Huggins Cahn-Hilliard Model

Communications in Computational Physics 2022年第1期31卷 60-93页

作者： Wenbin Chen jianyu jing Cheng Wang Xiaoming Wang Steven M.Wise Shanghai Key Laboratory for Contemporary Applied Mathematics Fudan UniversityShanghai 200433P.R.China School of Mathematical Sciences Fudan UniversityShanghai 200433P.R.China Mathematics Department University of MassachusettsNorth DartmouthMA 02747USA International Center for Mathematics and Department of Mathematics and Guangdong Provincial Key Laboratory of Computational Science and Material Designand National Center for Applied Mathematics ShenzhenSouthern University of Science and TechnologyShenzhen 518055P.R.China Mathematics Department University of TennesseeKnoxvilleTN 37996USA

In this paper we propose and analyze a second order accurate numericalscheme for the Cahn-Hilliard equation with logarithmic Flory Huggins energy potential. A modified Crank-Nicolson approximation is applied to the logarithmic nonlinear term, while the expansive term is updated by an explicit second order AdamsBashforth extrapolation, and an alternate temporal stencil is used for the surface diffusion term. A nonlinear artificial regularization term is added in the numerical scheme,which ensures the positivity-preserving property, i.e., the numerical value of the phasevariable is always between -1 and 1 at a point-wise level. Furthermore, an unconditional energy stability of the numerical scheme is derived, leveraging the special formof the logarithmic approximation term. In addition, an optimal rate convergence estimate is provided for the proposed numerical scheme, with the help of linearizedstability analysis. A few numerical results, including both the constant-mobility andsolution-dependent mobility flows, are presented to validate the robustness of the proposed numerical scheme.

关键词： Cahn-Hilliard equation Flory Huggins energy potential positivity preserving energy stability second order accuracy optimal rate convergence estimate

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三江平原地下水补给影响因素及补给量估算方法分析

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云南水力发电 2024年第5期40卷 39-43页

作者：杨枭戴长雷荆建宇黑龙江大学水利电力学院黑龙江哈尔滨150080 黑龙江大学寒区地下水研究所黑龙江哈尔滨150080 黑龙江省寒区水文与水利工程联合实验室(国际合作) 黑龙江哈尔滨150080

黑龙江省是以农业生产为主的粮食大省,地下水又是农业灌溉的主要取水源,因此了解影响地下水补给因素和补给量估算对于维持该地区农田的灌溉,生态环境健康稳定和可持续发展具有重要意义。通过三江平原多年地区降雨量、蒸发量、径流量和... 详细信息

黑龙江省是以农业生产为主的粮食大省,地下水又是农业灌溉的主要取水源,因此了解影响地下水补给因素和补给量估算对于维持该地区农田的灌溉,生态环境健康稳定和可持续发展具有重要意义。通过三江平原多年地区降雨量、蒸发量、径流量和地下水转化量数据分析总结出具体影响因素并对现有补给量估算方法进行分析。显示出未来三江平原地下水补给量将会受到许多的因素影响,包括气候因素和人为因素。并总结对于该地区的影响程度。阐述了传统估算法作用于三江平原地理特征时出现的缺点与不足。研究了MOD16遥感技术与SWATMOD耦合模型用于估算的新尝试。

关键词：三江平原地下水补给因素影响因素估算方法

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松花江干流佳木斯-同江段地表水与地下水转化关系分析

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云南水力发电 2024年第10期40卷 208-211页

作者：杨枭于淼荆建宇戴长雷黑龙江大学水利电力学院黑龙江哈尔滨150080 黑龙江大学寒区地下水研究所黑龙江哈尔滨150080 黑龙江省寒区水文和水利工程联合实验室黑龙江哈尔滨150080

地下水与地表水相互作用是水文循环过程中的重要环节,且松花江流域转化复杂,理解该流域地表水地下水之间的转化过程非常重要。文中利用针对流域水循环的,累计转化量法与地表水水量平衡,对松花江佳木斯同江段进行研究,分析了2020年两者... 详细信息

地下水与地表水相互作用是水文循环过程中的重要环节,且松花江流域转化复杂,理解该流域地表水地下水之间的转化过程非常重要。文中利用针对流域水循环的,累计转化量法与地表水水量平衡,对松花江佳木斯同江段进行研究,分析了2020年两者之间的转化关系,即2020年9月末—12月末,1月—3月,5月—6月为地表水补给地下水。4月—5月,7月—9月为地表水补给地下水。并且用两种方法进行对比,分析了实验的可行性,是开展松花江流域水资源调查评价的基础性研究。

关键词：松花江流域地表水地下水转化关系地表水量平衡累计转化法

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三江平原地下水研究综述

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吉林水利 2024年第5期 73-78页

作者：王新宇贾青尉意茹荆建宇黑龙江大学水利电力学院黑龙江哈尔滨150080 黑龙江大学寒区地下水研究所黑龙江哈尔滨150080 东北联邦大学地质勘探学院雅库茨克67700

结合近几十年的文献研究及数据,对三江平原地下水的水文特征进行研究。通过分析地下水分布特征、数值计算与开发利用的研究进程,总结归纳了地下水开发利用现状及存在的问题:在水文地质方面,通过地球物理勘探、地下水化学分析等手段,对... 详细信息

结合近几十年的文献研究及数据,对三江平原地下水的水文特征进行研究。通过分析地下水分布特征、数值计算与开发利用的研究进程,总结归纳了地下水开发利用现状及存在的问题:在水文地质方面,通过地球物理勘探、地下水化学分析等手段,对地下水的分布、流动方向、水质特征进行了系统梳理;在水质研究方面,大量的水质监测数据积累为分析水质时空变化提供了坚实的数据基础;同时,地下水模型的建立与优化也为进一步认识地下水系统提供了工具支持。

关键词：三江平原地下水水资源开发利用

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Remarkably Enhanced Hydrogen Oxidation Reaction Activity of Carbon-supported Pt by Facile Nickel Modification

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Chemical Research in Chinese Universities 2020年第1期36卷 105-109页

作者： HUANG Xuewei LONG Chang HAN jianyu ZHANG jing QIU Xueying TANG Zhiyong College of Chemistry Zhengzhou UniversityZhengzhou 450001P.R.China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190P.R.China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150080P.R.China Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006P.R.China

Developing high activity catalysts for hydrogen oxidation reaction(HOR)under alkaline condition remains a challenge in the exchange membrane fuel cell(AEMFC).Herein,we report that the activity of carbon-supported platinum(Pt/C)towards the hydrogen oxidation reaction(HOR)in alkaline media can be remarkably enhanced by simple immersion of Pt/C in nickel chloride *** adsorption of hydrogen on the catalyst surface is weakened by modification of *** HOR activity on the Pt/C after immersion possesses an excellent mass current density of 33.4 A/gmetal,which is 18%higher than that(28.3 A/gmetal)on Pt/C.

关键词： Electrocatalyst Hydrogen oxidation Pt/C Modified nickel

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Expression of Bcl-2 in cells with different telomerase activities

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Chinese Science Bulletin 2001年第23期46卷 1980-1984页

作者： CHEN jing REN Jianguo ZHENG jianyu CAI Guoping DAI Yaoren Department of Biological Sciences and Biotechnology Tsinghua UniversityNational Key Laboratory of Biomembrance and Membrance BiotechnologyBeijing 100084China Institute for Molecular Biology Nankai UniversityTianjin 300071China

Both tclomerase and Bcl-2 are important genes in controlling apoptosis. The activation of telomerase and the abnormal regulation of Bcl-2 are also closely related to carcinogenesis. However, little is known about the linkage between telomerase and Bcl-2. The effect of activated telomerase on the expression of Bcl-2 has been investigated. It is demonstrated that in tumor and transformed cells with higher telomerase activity, Bcl-2 expression is significantly lower than that in telomerase negative or less telomerose activity cells. Further study showed that in the telomerase gene-transformed 2BS-fibroblasts, Bcl-2 expression is inhibited significantly while the exogenous telomerase catalyticsubunit gene is re-expressed in flbroblasts. Results indicated that there might be a certain linkage between the expression of telomerase and Bcl-2, and overexpression of exogenous telomerase gene might down regulate the expression of Bcl-2.

关键词： telomere telomerase Bcl-2.

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Methylation profile of the promoter CpG islands of 14 “drug-resistance”genes in hepatocellular carcinoma

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World Journal of Gastroenterology 2004年第23期10卷 3433-3440页

作者： ShengDing Bang-DongGong jianyu JunGu Hong-YuZhang Zu-BinShang QiFei PengWang jing-DeZhu TheState-KeyLaboratoryforOncogenesandRelatedGenes ShanghaiCancerInstituteShanghaiJiaotongUniversityShanghai200032China

AIM: To establish the DNA methylation patterns of the promoter CpG islands of 14 'drug-resistance' genes in hepatocellular carcinoma (HCC).METHODS: The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC ***: While 11 genes (ATP-binding cassette, sub-family G (WHITE), member 2(ABCG2), activating transcription factor (ATF2), beta-2-microglobulin (B2M), deoxycytidine kinase(DCK, occludin (OCLN, v-raf-1 murine leukemia viral oncogene homolog (RAF/), ralA binding protein 1 (RALBP1),splicing factor (45 kD) (SPF45), S-phase kinase-associated protein 2 (p45) (SKP2), tumor protein p53 (Li-Fraumeni syndrome) (TP53) and topoisomerase (DNA) II beta (TOP2B) maintained the unmethylated patterns, three genes displayed to various extents the hypermethylation state in tumor tissues in comparison with the normal counterparts. The catalase (CAT) was hypermethylated in tumor and the neighboring non-cancerous tissue of one case (3.3%). Both glutathione S-transferase pi (GSTp/) (80%, 24/30 in tumor and 56.7%,17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) (CF-FR) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. No significant difference in the hypermethylation occurrence was observed between the HCC and its neighboring non-cancerous ***: Hypermethylation of promoter CpG islands of both CF-FR and GSTpigenes occurs prevalently in HCC,which may correlate with the low expression of these two genes at the mRNA level and has the profound etiological and clinical implications. It is likely to be specific to the early phase of HCC carcino

关键词：甲基化促进剂 CpG 岛状物 14基因麻药抵抗作用肝细胞癌肿瘤消化系统 HCC

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The superiority of nonconjugated structures in fluorescence:through-space ***-bond charge transfer

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Science China Chemistry 2024年第9期67卷 3121-3130页

作者： Weihao Tu Zuping Xiong Lei Wang jianyu Zhang jing Zhi Sun Haoke Zhang Ben Zhong Tang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215China Centre of Healthcare Materials Shaoxing InstituteZhejiang UniversityShaoxing 312000China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172China

Constructing charge transfer(CT)state by introducing donor(D)and acceptor(A)is an efficient strategy to regulate the photophysical properties of luminescent *** CT-type luminophores are built onπ-conjugated fused-ring structures,which always show hybrid CT/locally excited(LE)states and luminescence quenching effect in the aggregate *** this work,eight conjugated biphenyl(BP)and nonconjugated diphenylmethane(DPM)derivatives with different donors and acceptors are synthesized to investigate the CT *** photophysical characterization and theoretical calculation demonstrate that the through-space CT(TSCT)in nonconjugated DA-DPM exhibit superior photophysical performance than the conjugated DA-BP with through-bond CT(TBCT),the main manifestations are as follows:(1)TSCT luminophores produce longer maximum emission wavelength(λ_(em))than the corresponding TBCT *** example,the longest λ_(em)of DMA-CN-DPM(DMA,dimethylamino)is 621 nm but the corresponding λ_(em)of DMA-CN-BP is only 480 nm.(2)TSCT-based DA-DPM demonstrates more sensitive responsiveness to environmental stimuli such as temperature and polarity.(3)Complete separation of the the highest occupied molecular orbital(HOMO)and the lowest unoccupied molecular orbital(LUMO)distribution exists in all kinds of conformation of DA-DPM,which was hard to realize in conjugated DA-BP.

关键词： through-space charge transfer through-space conjugation clusteroluminescence diphenylmethane

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Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis

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World Journal of Gastroenterology 2004年第23期10卷 3441-3454页

作者： Xiao-UXu jianyu Hong-YuZhang Meng-HongSun JunGu XiangDu Da-RenShi PengWang Zhen-HuaYang jing-DeZhu DepartmentofPathology.CancerHospital FudanUniversityShanghai200032China TheState-KeyLaboratoryforOncogenesandRelatedGenes cancerInstituteofShanghaiJiaotongUniversityShanghai200032China InstituteofRespiratoryDisease ZhongShanHospitalFudanUniversityShanghai200032China

AIM: To establish the methylation profile of the promoter CpG islands of 31 genes that might play etiological roles in colon ***: The methylation specific PCR in conjunction of sequendng verification was used to establish the methylationprofile of the promoter CpG islands of 31 genes in colorectal cancer (n = 65), the neighboring non-cancerous tissues (n = 5), colorectal adenoma (n = 8), and normal mucosa (n = 1). Immunohistochemically, expression of 10 genes was assessed on the home-made tissue microarrays of tissues from 58 patients. The correlation of tumor specific changes with each of clinical-pathologic features was scrutinized with relevant statistic ***: In comparison with the normal mucosa of the non-cancer patients, the following 14 genes displayed no tumor associated changes: breast cancer 1, early onset (BRCA1), cadherin 1, type 1, E-cadherin (epithelial) (CDH1),death-associated protein kinase 1 (DAPK1), DNA (cytosine-5-)-methyltransferase 1 (DNMT1), melanoma antigen, family A, 1 (directs expression of antigen MZ2-E) (MAGEA1), tumor suppressor candidate 3 (N33), cyclin-dependent kinase inhibitor 1A (p21, Cipl) (p21^WAF1), cyclin-dependent kinase inhibitor 1B (p27, 10pl) (p27^WAF1), phosphatase and tensin hornolog (mutated in multiple advanced cancers 1) (PTEN), retinoic acid receptor, beta (RAR-, Ras association (RaIGDS/AF-6) domain family 1 C (RASSFIC), secreted frizzled-related protein 1 (SFRP1), tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinfiammatory) (TIMP3),and von HippeI-Lindau syndrome (VHL). The rest 17 targets exhibited to various extents the tumor associated *** changes in methylation of the following genes occurred marginally, their impact on the formation of colorectal cancer were trivial: adenomatous polyposis coli (APC) (8%, 5165),Ras association (RaIGDS/AF-6) domain family 1A (RASSFIA) (3%, 2/65) and cyclin-dependent kinase inhibitor 2A,alternated reading frame Co14~) (6%, 4/

关键词：甲基化作用 CpG 31基因致癌作用结直肠癌肿瘤消化系统

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Optimization of Agrobacterium tumefaciens-Mediated Genetic Transformation of Maize

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Phyton-International Journal of Experimental Botany 2022年第2期91卷 363-374页

作者： Mengtong Liu Yangyang Zhou Tongyu Liu jianyu Lu jing Qu Shuyan Guan Yiyong Ma College of Life Sciences Jilin Agricultural UniversityChangchun130118China College of Agronomy Jilin Agricultural UniversityChangchun130118China

Immature embryos of inbred maize(Zea mays)lines(H8183,H8184,and H8185)were used for Agrobacterium *** used theβ-glucuronidase gene(GUS)as the target gene and the glufosinate resistance gene(bar)as the selection *** conducted research on several aspects,such as different genotypes,coculture conditions,screening agent concentrations,and concentrations of indole-3-butytric acid(IBA),6-benzylaminopurine(6-BA),and ascorbic acid(Vc)in the differentiation *** optimized the genetic transformation system,and the obtained results indicated that among the three lines studied,the induction rate of H8185 was the highest at 93.2%,followed by H8184,with H8183 having the lowest induction rate(80.1%).The best coculture method was that using the N6 coculture medium layered with a sterile filter *** orthogonal analysis,we found that the optimal combination of the three factors in the differentiation medium was A_(3)(1 mg mL^(−1)IBA),B_(3)C_(1)(1.6 mg mL^(−1)6-BA),and D_(3)(1.5 mg mL^(−1)Vc).Through GUS staining analysis,Bar test-strip analysis,and polymerase chain reaction,five transgenic plants were finally *** study established the optimal conditions for genetic transformation in maize.

关键词： Maize optimization genetic regeneration immature embryos Agrobacterium-mediated transformation

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