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Inhibition of botulinum toxin's association with rat brain synaptosomes by toosendanin,an antibotulismic triterpenoid

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Neural Regeneration Research 2006年第6期1卷 489-492页

作者： jianying Zhou Yuliang shi Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

BACKGROUND： Toosendanin （TSN）, a tnterpenoid derivative extracted from the bark of Melia toosendanin Sieb et Zucc, has been demonstrated to be an effective drug for treatment of experimental botulism. OBJECTIVE ： To explore its antibotulismic mechanism by observing the effect of toosendanin on association of botulinum toxin （BoTx） with rat brain synaptosomes under different conditions. DESIGN： A randomized controlled experiment SETTING： Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences MATERIALS： Sprague-Dawiey rats, weighing （220±12） g, were involved. TSN was a sample recrystallized in ethanol with a punty 〉 98%. BoTx/A and BoTx/C of 500 ku （1.8×10^7 mouse LD50/mg） were purchased from Wako （Japan）, Horse antitoxins to BoTx/A and/C （primary antibodies） were purchased from Lanzhou Institute of Biological Products （China）. METHODS ： Major experiments were finished between March 2005 and October 2005 in key laboratory of neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. （1） Preparation of synaptosome of rats： one aliquot of synaptosome was pre-incubated with TSN （17 μmol/L） for 20 minutes at 4 % or 37 % （another aliquot of synaptosome which was untouched was used as control）. Then, BoTx was respectively added for another 20-minute incubation. （2） A homochronous expenment was still performed at 37 %. Differently, high level of K^＋ was used to stimulate synaptosome for 25 minutes. Two aliquots of synaptosomes with or without TSN （17 μmol/L）were preincubated for 15 minutes, Then, 30 mmol/L KCl was separately added in two aliquots, 5 minutes later, 13 nmol/L BoTx/C was separately added followed by 20-minute incubation. （3）The effect of TSN on BoTx binding was observed by Western blot and synchronization method. （4） t test was used for comparing the difference of measurement data. MAIN OUTCOME MEASURES ： The gray value of BoTx bands from western blot was used to estimate the bound amount of BoTx. RES

关键词： antibotulismic mechanism measurement data botulinum toxin Western blot type A

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Surface wettability and flow properties of non-metallic pipes in laminar flow

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Chinese Journal of Chemical Engineering 2020年第3期28卷 636-642页

作者： Hongyuan Qi Aiguo Liang Huayi Jiang jianying shi Nana Sun Yulong Wang College of Petroleum Engineering Xi'an Shiyou UniversityXi'an 710065China Shaanxi Key Laboratory of Advanced Stimulation Technology for Oil&Gas Reservoirs Xi'an Shiyou UniversityXi'an 710065China Karamay Hongshan Oilfield Co.Ltd. Karamay 834000China No.1 Production Plant Xinjiang Oilfield Branch CompanyKaramay 834000China

In this paper,three liquids flowing in five pipes with the same inner diameter of 14 mm were studied to determine the relationship between the surface wettability and flow properties in laminar flow(Re b 2000).This was motivated by oilfield observations of increased pressure drops in non-metallic pipes compared to those in metal pipes,which was contrary to expectations.A new expression for the frictional coefficient that considers the Reynolds number and contact angleθin laminar flow for non-metallic pipes was proposed based on the experimental results of single-phase flow using dimension and regression *** solutions of the anomalous phenomenon were proposed from the perspectives of the pipe diameter,contact-angle difference,and the compatibility between flexible composite pipe and JLHW105 oil according to the new *** surprising finding was that the surface wettability could control the frictional resistance by the critical contact angle(39.9°)obtained at the same Reynolds *** 0°bθ≤39.9°,the frictional coefficient increased as the contact angle *** contrast,if 39.9°bθb 180°,the frictional coefficient decreased with increasing contact *** influences of the pipe diameter and contactangle difference on the pressure drop difference of JLHW105 oil showed an inversely proportional relation.A series of materials and liquids were *** selection of pipe material for transporting a given fluid can be based on the contact angle,surface tension,and critical limit of the contact angle *** research results are expected to provide some guidelines for the selection of the appropriate pipe material for a given set of fluids.

关键词： Wettability Contact angle Frictional coefficient Fluid mechanics Laminar flow Petroleum

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Study on Quantitative Relationship between Surface Wettability and Frictional Coefficient of Liquid Flowing in a Turbulent Horizontal Pipe

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China Petroleum Processing & Petrochemical Technology 2017年第3期19卷 105-114页

作者： Jing Jiaqiang Qi Hongyuan Jiang Huayi Liang Aiguo shi jianying Wang Yulong Sun Nana Zhang Yixiang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Chengdu 610500 Oil&Gas Fire Protection Key Laboratory of Sichuan Province Chengdu 611731 College of Petroleum Engineering Xi’an Shiyou UniversityXi’an 710065 No.1 Production Plant of Xinjiang Oilfield Branch Company Karamay 834000 Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049

This paper had investigated the effects of surface wettability on the frictional resistance of turbulent horizontal flow for tap water in five pipes made of various materials and four kinds of liquids in a polytetrafluoroethylene(PTFE) pipe,with the same inner diameter of 14 mm. Pressure drops were measured under different flow rates through an experimental flow loop. The contact angles and adhesion work of liquids in contact with pipe surfaces were determined using a contact angle meter. Based on the dimension and regression analyses, two kinds of modified relationships between the frictional coefficient and the surface wettability were established according to the measured results corresponding to tap water in five pipes and four liquids in PTFE pipe. The experimental results show that the surface wettability has some influence on frictional coefficient of the studied liquids flowing in macroscale pipes, and the frictional coefficient decreases with the increase of the contact angle at the same Reynolds number. Meanwhile the effect of wettability on the hydrophobic surface is greater than that on the hydrophilic one. The frictional coefficients predicted by the modified formulas have verified to be in good agreement with the experimental values, the relative errors of which are within ±6% and ±3% for the tap water flowing in five different pipes and four kinds of liquids flowing in PTFE pipe, respectively.

关键词： wettability contact angle frictional coefficient adhesion work fluid mechanics turbulent flow

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Recognition System for Diagnosing Pneumonia and Bronchitis Using Children’s Breathing Sounds Based on Transfer Learning

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Intelligent Automation & Soft Computing 2023年第9期37卷 3235-3258页

作者： jianying shi Shengchao Chen Benguo Yu Yi Ren Guanjun Wang Chenyang Xue School of Information and Communication Engineering Hainan UniversityHaikou570228China School of Biomedical Information and Engineering Hainan Medical CollegeHaikou571199China Department of Pediatrics Haikou Hospital of the Maternal and Child HealthHaikou570203China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China School of Instrument and Electronics North University of ChinaTaiyuan030051China

Respiratory infections in children increase the risk of fatal lung disease,making effective identification and analysis of breath sounds ***,most studies have focused on adults ignoring pediatric patients whose lungs are more vulnerable due to an imperfect immune system,and the scarcity of medical data has limited the development of deep learning methods toward reliability and high classification *** this work,we collected three types of breath sounds from children with normal(120 recordings),bronchitis(120 recordings),and pneumonia(120 recordings)at the posterior chest position using an off-the-shelf 3M electronic *** features were extracted from the wavelet denoised signal:spectrogram,mel-frequency cepstral coefficients(MFCCs),and Delta *** recog-nition model is based on transfer learning techniques and combines fine-tuned MobileNetV2 and modified ResNet50 to classify breath sounds,along with software for displaying analysis *** experiments on a real dataset demonstrate the effectiveness and superior performance of the proposed model,with average accuracy,precision,recall,specificity and F1 scores of 97.96%,97.83%,97.89%,98.89%and 0.98,respectively,achieving superior performance with a small *** proposed detection system,with a high-performance model and software,can help parents perform lung screening at home and also has the potential for a vast screening of children for lung disease.

关键词： Deep learning breath sounds transfer learning signal denoising

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Bi掺杂NaTaO_3中Bi的化学价态对其光催化性能的影响（英文）

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催化学报 2015年第7期36卷 969-974页

作者：崔华楠石建英刘鸿中山大学化学与化学工程学院环境与能源化学广东普通高校重点实验室广东广州510275

分别采用Na Bi O3和Bi(NO3)3为Bi源制备了Bi掺杂Na Ta O3光催化剂,研究了Bi离子的价态对Na Ta O3光催化分解水制氢性能的影响.采用X射线衍射(XRD)、拉曼光谱、X射线光电子能谱(XPS)和紫外-可见吸收光谱研究了催化剂的晶体结构、Bi离子... 详细信息

分别采用Na Bi O3和Bi(NO3)3为Bi源制备了Bi掺杂Na Ta O3光催化剂,研究了Bi离子的价态对Na Ta O3光催化分解水制氢性能的影响.采用X射线衍射(XRD)、拉曼光谱、X射线光电子能谱(XPS)和紫外-可见吸收光谱研究了催化剂的晶体结构、Bi离子的化学状态和催化剂的光学吸收性能.以光催化分解水制氢反应研究了Bi离子掺杂Na Ta O3的催化性能.XRD结果表明,对于两个不同Bi源掺杂的Na Ta O3样品,Bi离子的掺杂没有改变催化剂的单斜相结构,但拉曼光谱证实Bi离子的掺杂致使Ta–O–Ta键角偏离了***结果表明,以Bi(NO3)3为Bi源时,Bi离子以Bi3+掺杂于Na Ta O3的A位;当以Na Bi O3为原料时,Bi3+和Bi5+共掺杂于Na Ta O3的A位.两种不同Bi源掺杂得到的样品在紫外-可见吸收光谱中给出了相似的光学吸收,但Bi3+的掺杂对Na Ta O3光催化性能影响不大,而Bi3+和Bi5+共掺杂大大提高了Na Ta O3的光解水制氢性能.Bi离子取代Na离子在A位的掺杂,在Na Ta O3结构中引入了能够促进载流子分离的空位和缺陷;与此同时,Bi的掺杂导致Ta–O–Ta键角偏离180o而不利于载流子迁移.对于Bi3+掺杂的Na Ta O3样品,这两种作用相互抵消,使得其催化性能与Na Ta O3相比没有变化;而Bi3+和Bi5+的共掺杂和高价态Bi5+的掺杂引入了更多的空位和缺陷,提高了光生电子-空穴的分离效率,从而提高了光催化产氢性能.研究表明,光催化过程中载流子的迁移是影响催化性能的重要因素,而在ABO3钙钛矿结构的A位引入高价态离子是促进光生载流子分离的有效途径.

关键词：光催化剂钽酸钠 Bi掺杂化学价态水分解

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Immobilization of metal-organic molecular cage on g-C3N4 semiconductor for enhancement of photocatalytic H2 generation

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Chinese Journal of Catalysis 2019年第8期40卷 1198-1204页

作者： Yuanpu Wang Liang Liu DongJun Wu Jing Guo jianying shi Junmin Liu Chengyong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of Chemistryand School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275GuangdongChina State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A new compound based on immobilizing of Pd6(RuL3)8(BF4)28 (L=2-(pyridin-3-yl)-1H-imidazo [4,5-f][1,10]-phenanthroline) cage (MOC-16) on g-C3N4 was synthesized. Infrared spectrum and powder X-ray diffraction were used to characterize structure of hybrid MOC-16/g-C3N4, as well as UV-vis absorption spectrum and X-ray photoelectron spectroscopy were carried out to unveil photocatalytic mechanism. With the introduction of MOC-16, the absorption edge of MOC-16/g-C3N4 in UV-vis spectrum extended apparently to long-wavelength region compared with pristine g-C3N4. H2 evolution yielded with MOC-16/g-C3N4 in aqueous solution containing TEOA was much higher than that with RuL3/g-C3N4, Pd/RuL3/g-C3N4 and mixture of MOC-16 and g-C3N4, showing that the octahedral cage structure with high-efficient electron transfer and the interface interaction between MOC-16 and g-C3N4 were significant for improvement of H2 evolution.

关键词： g-C3N4 Metal-organic cage Photocatalytic H2 evolution Visible light Stability

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GaN肖特基SIT的Monte Carlo模拟

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固体电子学研究与进展 2007年第1期27卷 13-17页

作者：郭宝增师建英宫娜河北大学电子信息工程学院河北保定071002

用全带多粒子Monte Carlo模拟方法研究了GaN基肖特基势垒静电感应晶体管(SIT)的特性,给出了器件的电势、电场强度和电子浓度分布的Monte Carlo模拟结果。模拟得到的SIT输出特性曲线呈现非饱和特性,即类三极管特性。当VGS=0,VDS=35 V时,... 详细信息

用全带多粒子Monte Carlo模拟方法研究了GaN基肖特基势垒静电感应晶体管(SIT)的特性,给出了器件的电势、电场强度和电子浓度分布的Monte Carlo模拟结果。模拟得到的SIT输出特性曲线呈现非饱和特性,即类三极管特性。当VGS=0,VDS=35 V时,漏源电流为47 A/cm,跨导为300 mS/mm,电流截至频率为150 GHz。结果表明该器件具有大电流、高跨导和高频工作的潜力。

关键词：蒙特卡罗方法静电感应晶体管氮化镓

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我国西部文化创意产业发展对策

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开放导报 2016年第1期 86-88页

作者：石建莹刘琦中共西安市委党校陕西西安710054

文化创意产业已经成为推动全球新兴产业的重要支撑,已成为创新性服务业的有效载体。但是与东部地区的文化创意产业相比,我国西部地区在产业化、集约化和市场化等方面存在较大差距。西部地区要加强产业规划和引导,打造知名品牌,培育龙头... 详细信息

文化创意产业已经成为推动全球新兴产业的重要支撑,已成为创新性服务业的有效载体。但是与东部地区的文化创意产业相比,我国西部地区在产业化、集约化和市场化等方面存在较大差距。西部地区要加强产业规划和引导,打造知名品牌,培育龙头企业,提高文化创意产业市场化程度,加快人才的培养,完善创意产业法规和政策,营造良好的政策环境和创意氛围。

关键词：文化创意产业市场化人才培养对策研究

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Photochemical Hydrogen-Evolving by a Nanoscale Pd6(RuL3)8 Metal-Organic Cage:A Supramolecular Photocatalyst Incorporating Multiply Light Harvest and Catalytic Centers

Photochemical Hydrogen-Evolving by a Nanoscale Pd6(RuL3)8 Me...

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第七届全国物理无机化学学术会议

作者： Sha Chen Kang Li Fang Zhao Lei Zhang jianying shi Cheng-Yong Su State Key Laboratory of Optoelectronic Materials and Technologies School of Chemistry and Chemical Engineering Sun Yat-Sen University

Photocatalytic water splitting into hydrogen is an attractive way harnessing renewable solar energy to generate clean hydrogen *** devices simultaneously incorporating multiple photocenters and multiple catalytic metal centers are somewhat rare in literatures.A self-assembled Pd(RuL) metal-organic cage(MOC)as PMD simultaneously incorporating multiple photocenters and multiple

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垂直电场作用下的钎锌矿相GaN电子输运特性的Monte Carlo研究

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固体电子学研究与进展 2012年第3期32卷 246-251页

作者：郭宝增刘鑫师建英河北大学电子信息工程学院河北保定071002

在GaN NMOSFET中,沟道电子由于受垂直于其运动方向电场的作用而产生界面散射,从而影响MOSFET特性。研究采用Monte Carlo体模拟方法计算钎锌矿相GaN材料在界面散射下的电子输运特性。模拟中在电子漂移方向加一个水平电场,同时在与其垂直... 详细信息

在GaN NMOSFET中,沟道电子由于受垂直于其运动方向电场的作用而产生界面散射,从而影响MOSFET特性。研究采用Monte Carlo体模拟方法计算钎锌矿相GaN材料在界面散射下的电子输运特性。模拟中在电子漂移方向加一个水平电场,同时在与其垂直的方向加另外一个电场,在垂直电场作用下,电子发生界面散射。采用基于指数协方差函数的界面粗超度函数计算界面散射率,计算中给定界面粗糙方均根值和相干长度,通过改变垂直电场强度,计算电子平均漂移速度和迁移率特性.在界面粗糙方均根值为0.65nm,相干长度值为1.5nm情况下,当垂直电场大于1×105V/cm时,电子迁移率由于受界面散射的影响开始下降;当垂直电场大于1×106V/cm时,电子迁移率低于200cm2/(V.s)。与直接采用MOS结构研究电子受界面散射的方法相比,此方法排除了MOS结构沟道电场不均匀、非瞬态输运等非理想因素。

关键词：氮化镓蒙特卡罗模拟界面散射输运特性

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