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Evaluation of the Shallow Gas Hydrate Production Based on the Radial Drilling-Heat Injection-Back Fill Method

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Journal of Ocean University of China 2024年第1期23卷 119-128页

作者： CHEN Qiang WAN Yizhao WU Nengyou SUN jianye WANG Jian liU Changling li Yanlong li Chengfeng HU Gaowei Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao 266071China Laboratory for Marine Mineral Resources Laoshan LaboratoryQingdao 266071China CNPC Offshore Engineering Company limited Beijing 100028China Technology Innovation Center for Marine Methane Monitoring Ministry of Natural ResourcesQingdao 266071China

It has been evidenced that shallow gas hydrate resources are abundant in deep oceans worldwide.Their geological back-ground,occurrence,and other characteristics differ significantly from deep-seated hydrates.Because of the high risk of well construction and low production efficiency,they are difficult to be recovered by using conventional oil production methods.As a result,this paper proposes an alternative design based on a combination of radial drilling,heat injection,and backfilling methods.Multi-branch holes are used to penetrate shallow gas hydrate reservoirs to expand the depressurization area,and heat injection is utilized as a supplement to improve gas production.Geotechnical information collected from an investigation site close to the offshore production well in the South China Sea is used to assess the essential components of this plan,including well construction stability and gas production behavior.It demonstrates that the hydraulic fracturing of the 60mbsf overburden layer can be prevented by regulating the drilling fluid densities.However,the traditional well structure is unstable,and the suction anchor is advised for better mechanical performance.The gas produc-tion rate can be significantly increased by combining hot water injection and depressurization methods.Additionally,the suitable produc-tion equipment already in use is discussed.

关键词： shallow gas hydrate trail production radial drilling-heat injection-back fill method experimental and numerical simulation

Functionalized Hydrogel-Based Wearable Gas and Humidity Sensors

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Nano-Micro Letters 2023年第9期15卷 103-147页

作者： Yibing Luo jianye li Qiongling Ding Hao Wang Chuan liu Jin Wu State Key Laboratory of Optoelectronic Materials and Technologies and the Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China

Breathing is an inherent human activity;however,the composition of the air we inhale and gas exhale remains unknown to us.To address this,wearable vapor sensors can help people monitor air composition in real time to avoid underlying risks,and for the early detection and treatment of diseases for home healthcare.Hydrogels with three-dimensional polymer networks and large amounts of water molecules are naturally flexible and stretchable.Functionalized hydrogels are intrinsically conductive,self-healing,self-adhesive,biocompatible,and room-temperature sensitive.Compared with traditional rigid vapor sensors,hydrogel-based gas and humidity sensors can directly fit human skin or clothing,and are more suitable for real-time monitoring of personal health and safety.In this review,current studies on hydrogel-based vapor sensors are investigated.The required properties and optimization methods of wearable hydrogel-based sensors are introduced.Subsequently,existing reports on the response mechanisms of hydrogel-based gas and humidity sensors are summarized.Related works on hydrogel-based vapor sensors for their application in personal health and safety monitoring are presented.Moreover,the potential of hydrogels in the field of vapor sensing is elucidated.Finally,the current research status,challenges,and future trends of hydrogel gas/humidity sensing are discussed.

关键词： Health and safety monitoring Gas and humidity sensor Functionalized hydrogel Wearable sensor Flexible and stretchable sensor

Discontinuous mechanical behaviors of existing shield tunnel with stiffness reduction at longitudinal joints

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Frontiers of Structural and Civil Engineering 2023年第1期17卷 37-52页

作者： Xiang liU Qian FANG Annan JIANG Dingli ZHANG jianye li liaoning Key Laboratory of Marine Environmental Bridge and Tunnel Engineering Dalian Maritime UniversityDalian 116026China Key Laboratory for Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China

An analytical model is proposed to estimate the discontinuous mechanical behavior of an existing shield tunnel above a new tunnel. The existing shield tunnel is regarded as a Timoshenko beam with longitudinal joints. The opening and relative dislocation of the longitudinal joints can be calculated using Dirac delta functions. Compared with other approaches, our method yields results that are consistent with centrifugation test data. The effects of the stiffness reduction at the longitudinal joints (α and β), the shearing stiffness of the Timoshenko beam GA, and different additional pressure profiles on the responses of the shield tunnel are investigated. The results indicate that our proposed method is suitable for simulating the discontinuous mechanical behaviors of existing shield tunnels with longitudinal joints. The deformation and internal forces decrease as α, β, and GA increase. The bending moment and shear force are discontinuous despite slight discontinuities in the deflection, opening, and dislocation. The deflection curve is consistent with the additional pressure profile. Extensive opening, dislocation, and internal forces are induced at the location of mutation pressures. In addition, the joints allow rigid structures to behave flexibly in general, as well as allow flexible structures to exhibit locally rigid characteristics. Owing to the discontinuous characteristics, the internal forces and their abrupt changes at vulnerable sections must be monitored to ensure the structural safety of existing shield tunnels.

关键词： tunnel–soil interaction discontinuous analysis longitudinal joints existing shield tunnel Timoshenko beam Dirac delta function

Humidity Sensing of Stretchable and Transparent Hydrogel Films for Wireless Respiration Monitoring

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Nano-Micro Letters 2022年第11期14卷 218-236页

作者： Yuning liang Qiongling Ding Hao Wang Zixuan Wu jianye li Zhenyi li Kai Tao Xuchun Gui Jin Wu State Key Laboratory of Optoelectronic Materials and Technologies and the Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Respiratory monitoring plays a pivotal role in health assessment and provides an important application prospect for flexible humidity sensors.However,traditional humidity sensors suffer from a trade-off between deformability,sensitivity,and transparency,and thus the development of high-performance,stretchable,and low-cost humidity sensors is urgently needed as wearable electronics.Here,ultrasensitive,highly deformable,and transparent humidity sensors are fabricated based on cost-effective polyacrylamide-based double network hydrogels.Concomitantly,a general method for preparing hydrogel films with controllable thickness is proposed to boost the sensitivity of hydrogel-based sensors due to the extensively increased specific surface area,which can be applied to different polymer networks and facilitate the development of flexible integrated electronics.In addition,sustainable tapioca rich in hydrophilic polar groups is introduced for the first time as a second cross-linked network,exhibiting excellent water adsorption capacity.Through the synergistic optimization of structure and composition,the obtained hydrogel film exhibits an ultrahigh sensitivity of 13,462.1%/%RH,which is unprecedented.Moreover,the hydrogel film-based sensor exhibits excellent repeatability and the ability to work normally under stretching with even enhanced sensitivity.As a proof of concept,we integrate the stretchable sensor with a specially designed wireless circuit and mask to fabricate a wireless respiratory interruption detection system with Bluetooth transmission,enabling real-time monitoring of human health status.This work provides a general strategy to construct high-performance,stretchable,and miniaturized hydrogel-based sensors as next-generation wearable devices for real-time monitoring of various physiological signals.

关键词： Stretchable and transparent humidity sensors Hydrogel film Wireless and wearable sensor Respiration monitoring Ultrasensitive

Adsorption Properties and Cost of Dicarboxylic Nanocellulose on Copper Ions for Wastewater Treatment

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Journal of Renewable Materials 2022年第3期10卷 751-766页

作者： Xiaozheng Sun Yu Yang Qiang He jianye li Rui li Haitao Chen College of Engineering Northeast Agricultural UniversityHarbin150030China College of Mechanical Engineering Jiamusi UniversityJiamusi154007China

The accumulation of Cu^(2+)in water is a potential threat to human health and environment.Dicarboxylic nano-cellulose(DNC)with rich carboxyl groups was prepared through the NaIO_(4)–NaClO_(2) sequential oxidation meth-od to efficiently remove copper ions,and the Cu 2+adsorption properties and cost were studied.The maximum adsorption capacity reached 184.2 mg/g at pH 6 and an adsorbent dose of 5 g/L.Theoretically,the maximum adsorption capacities of monocarboxylic nanocellulose(MNC),DNC,and tricarboxylic nanocellulose(TNC)with carboxyl groups as the main adsorption sites were calculated to be 228.7,261.3,and 148.1 mg/g,respectively.The Cu^(2+)adsorption costs of MNC,DNC,and TNC were calculated and compared with those of powdered activated carbon(PAC).The Cu^(2+)adsorption capacity of DNC is higher than that of PAC,and the adsorption cost is close to or lower than that of PAC,demonstrating that the DNC prepared by sequential oxidation of NaIO_(4)–NaClO_(2) has competitive adsorption capacity and cost in the treatment of wastewater containing Cu^(2+).

关键词： Nanocellulose heavy metal ions maximum adsorption capacity adsorption cost

18F-prostate specific membrane antigen positron emission tomography/computerized tomography for lymph node staging in medium/high risk prostate cancer: A systematic review and meta-analysis

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中华医学杂志(英文版) 2024年第8期137卷 2023 Sep 8页

作者： Lv Zhengtong Song liuqi Wang Miao Hou Huimin li Haodong Wang Xuan Wang jianye Wang Jianlong liu Ming Beijing 100029 Department of Urology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing 100730 China Peking University Fifth School of Clinical Medicine Peking University China-Japan Friendship School of Clinical Medicine

Background: Lymph node staging of prostate cancer (PCa) is important for planning and monitoring of treatment.18F-prostate specific membrane antigen positron emission tomography/computerized tomography (18F-PSMA PET/CT) has several advantages over68Ga-PSMA PET/CT, but its diagnostic value requires further investigation. This meta-analysis focused on establishing the diagnostic utility of18F-PSMA PET/CT for lymph node staging in medium/high-risk PCa.Methods: We searched the EMBASE, PubMed, Cochrane library, and Web of Science databases from inception to October 1, 2022. Prostate cancer,18F, lymph node, PSMA, and PET/CT were used as search terms and the language was limited to English. We additionally performed a manual search using the reference lists of key articles. Patients and study characteristics were extracted and the QUADAS-2 tool was employed to evaluate the quality of included studies. Sensitivity, specificity, the positive and negative likelihood ratio (PLR and NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and 95% confidence interval (CI) were used to evaluate the diagnostic value of18F-PSMA PET/CT. Stata 17 software was employed for calculation and statistical analyses.Results: A total of eight diagnostic tests including 734 individual samples and 6346 lymph nodes were included in this meta-analysis. At the patient level, the results of each consolidated summary were as follows: sensitivity of 0.57 (95% CI 0.39-0.73), specificity of 0.95 (95% CI 0.92-0.97), PLR of 11.2 (95% CI 6.6-19.0), NLR of 0.46 (95% CI 0.31-0.68), DOR of 25 (95% CI 11-54), and AUC of 0.94 (95% CI 0.92-0.96). At the lesion level, the results of each consolidated summary were as follows: sensitivity of 0.40 (95% CI 0.21-0.62), specificity of 0.99 (95% CI 0.95-1.00), PLR of 40.0 (95% CI 9.1-176.3), NLR of 0.61 (95% CI 0.42-0.87), DOR of 66 (95% CI 14-311), and AUC of 0.86 (95% CI 0.83-0.89).Conclusions: 18F-PSMA PET/CT showed moderate sensitivity but high specificity in lymph node staging of medium/high-risk PCa. The

关键词： 18F-PSMA PET/CT Diagnostic test Lymph node Meta-analysis Prostate cancer

Azetidine synthesis enabled by photo-induced copper catalysis via [3+1] radical cascade cyclization

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The Innovation 2022年第3期3卷 106-114页

作者： jianye li Lu Yu Yun Peng Bin Chen Rui Guo Xiaodong Ma Xiao-Song Xue Yunkui liu Guozhu Zhang CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal University(CCNU)152 Luoyu RoadWuhanHubei 430079China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryCenter for Excellence in Molecular SynthesisUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RoadShanghai 200032China

Azetidines are an important type of saturated,highly strained,fourmembered,nitrogen-containing heterocyclic compound.These compounds serve as important raw materials,intermediates,and catalysts in organic synthesis,as well as important active units in amino acids,alkaloids,and pharmaceutically active compounds.Thus,the development of an efficient and concise method to construct azetidines is of great significance in multiple disciplines.In this work,we reported on the photo-induced copper-catalyzed radical annulation of aliphatic amines with alkynes to produce azetidines.

关键词： synthesis copper radical

Small-molecule agents for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 905-952页

作者： Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu liu Chuan Yang Ying Zheng Xiaopeng li Yu Lu Kenneth Kin Wah To Chenglai Xia jianye Zhang Zhi Shi Zeping Hu Min Huang liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare Hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regression and overall survival benefit in many types of cancer.With the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for immunotherapy.Small molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively investigated.Monotherapy of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor resistance.Here,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

Micro/nano flow chemistry by Beyond limits Manufacturing

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Chinese Chemical Letters 2024年第5期35卷 3-12页

作者： Peiwen liu Fang Zhao Jing Zhang Yunpeng Bai Jinxing Ye Bo Bao Xinggui Zhou li Zhang Changlu Zhou Xinhai Yu Peng Zuo jianye Xia lian Cen Yangyang Yang Guoyue Shi lin Xu Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

In September 2018,we proposed the cutting-edge concept of“Beyond limits Manufacturing”(BLM).BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser,to invent micro/nano scale flow chips or devices,which makes it possible for the microform,integration,economy,safety,high efficiency,green and intelligence of research,development and manufacturing process,so as to realize transformational manufacturing in the era of Industry 4.0.In this paper,we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project(December 2019 to August 2023),and discussed its application prospects in micro/nano flow chemistry.

关键词： Beyond limits Manufacturing Flow chemistry Pharmaceutical manufacturing Microreactor