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Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer

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Cancer Communications 2022年第1期42卷 17-36页

作者： Bo Cheng Kaikai Ding Pengxiang Chen jianxiong ji Tao Luo Xiaofan Guo Wei Qiu Chunhong Ma Xue Meng jian Wang jinming Yu Yuan Liu Department of Radiation Oncology Shandong Cancer Hospital and InstituteCheeloo College of MedicineShandong UniversityJinanShandong 250012P.R.China Department of Radiation Oncology Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinanShandong 250012P.R.China Department of Neurosurgery Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinanShandong 250012P.R.China Department of Neurology Loma Linda University HealthLoma LindaCA 92354USA Shandong Key Laboratory of Brain Functional Remodeling JinanShandong 250012P.R.China Department of Biomedicine University of BergenBergen 5009Norway Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology Shandong University School of MedicineJinanShandong 250012P.R.China Department of Neurosurgery the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310000P.R.China

Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 and transforming growth factor-beta/transforming growth factor-beta receptor(TGF-P/TGF-βR).Consequently,it is necessary to identify predictive factors of lung cancer patients who are not only resistant to PD-1/PD-LI inhibitors but also sensitive to bifunctional *** purpose of this study was to search for such ***:Multivariable Cox regression was used to study the association between the clinical outcome of treatment with PD-1/PD-L1 inhibitors and lym-phocyte recovery after lymphopenia in lung cancer *** CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic *** imag-ing,flow cytometry,and immunohistochemistry were employed to detrmine response to immunotherapy and function of tumor-infiltrating immune ***:For lung cancer patients treated with anti-PD-1/PD-LI antibodies,poor lymphocyte recovery was associated with a shorter progression-free survival(PFS;P<0.001),an accumulation of regulatory T cells(Tregs),and an elimi-nation of CD8+T cells in the peripheral *** of CD8+T cells and Treg cells were also imbalanced in the tumors and peripheral immune organs of mice with poor lymphocyte recovery after ***,these mice failed to respond to anti-PD-1 antibodies but remained sensitive to the anti-PD-LI/TGF-βR fusion protein(SHR-1701).Consistently,SHR-1701 but not anti-PD-1 antibod-ies,markedly enhanced IFN-γproduction and Ki-67 expression in peripheral CD8+T cells from patients with impaired lymphocyte ***:Lung cancer patients with poor lymphocyte recovery and suffer-ing from persistent lymphopenia after previous chemotherapy are resistant to anti-PD-1/PD-L1 antibodies but might be sen

关键词： SHR impaired markedly

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多尺度视域下的大遗址治理模式研究——基于汉长安城遗址的实证分析

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城市规划 2021年第4期45卷 48-56,105页

作者：陈稳亮冀剑雄宋孟霖长安大学建筑学院城乡规划系太原市城乡规划设计研究院长安大学

快速城镇化背景下,地处城市边缘区的大遗址的治理问题已成为我国空间治理的一大难题。面对汉长安城遗址管理的尺度失配问题,在对国外多尺度研究进行理论总结的基础上,针对汉长安城未央宫遗址"申遗"前后的两个不同时段,分别以遗址区和典... 详细信息

快速城镇化背景下,地处城市边缘区的大遗址的治理问题已成为我国空间治理的一大难题。面对汉长安城遗址管理的尺度失配问题,在对国外多尺度研究进行理论总结的基础上,针对汉长安城未央宫遗址"申遗"前后的两个不同时段,分别以遗址区和典型村落作为焦点对遗址区系统进行了多尺度分析;基于遗址区系统的结构特征、驱动要素和演化趋势,对汉长安城遗址适应性治理的模式进行了探索与研究。

关键词：大遗址多尺度分析适应性治理汉长安城

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从衰变到延续：韩城古城渐进式保护与发展模式初探

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城市发展研究 2020年第2期27卷 7-12页

作者：陈稳亮冀剑雄宋孟霖长安大学建筑学院

快速城镇化背景下,我国的许多历史城市及历史街区在保护和更新中面临衰退与异化的二元困境,历史城市保护与其"真实性、完整性和生活延续性的愿景"渐行渐远,其可持续的保护与发展面临巨大挑战。为此,以韩城古城为例,在对古城衰退与异化... 详细信息

快速城镇化背景下,我国的许多历史城市及历史街区在保护和更新中面临衰退与异化的二元困境,历史城市保护与其"真实性、完整性和生活延续性的愿景"渐行渐远,其可持续的保护与发展面临巨大挑战。为此,以韩城古城为例,在对古城衰退与异化这一衰变现象进行现状分析与问题诊断的基础上,遵循"特色延续—生活延续—系统延续—价值延续"的思路,对韩城古城渐进式保护与发展的模式进行了探索与研究。

关键词：衰变延续古城保护与发展渐进式韩城古城

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Mechanical reliable,NIR light-induced rapid self-healing hydrogel electrolyte towards flexible zinc-ion hybrid supercapacitors with low-temperature adaptability and long service life

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Journal of Energy Chemistry 2024年第5期92卷 63-73页

作者： Tengjia Gao Na Li Yang Yang jing Li Peng ji Yunlong Zhou jianxiong Xu School of Materials and Advanced Manufacturing Hunan Key Laboratory of Electrochemical Green Metallurgy TechnologyHunan University of TechnologyZhuzhou 412007HunanChina School of Life Sciences and Chemistry Hunan Key Laboratory of Biomedical Nanomaterials and DevicesHunan University of TechnologyZhuzhou 412007HunanChina

Hydrogel electrolytes hold great potential in flexible zinc ion supercapacitors(ZICs)due to their high conductivity,good safety,and ***,freezing of electrolytes at low temperature(subzero)leads to drastic reduction in ionic conductivity and mechanical properties that deteriorates the performance of flexible ***,the mechanical fracture during arbitrary deformations significantly prunes out the lifespan of the flexible ***,a Zn^(2+)and Li^(+)co-doped,polypyrrole-dopamine decorated Sb_(2)S_(3)incorporated,and polyvinyl alcohol/poly(N-(2-hydroxyethyl)acrylamide)double-network hydrogel electrolyte is constructed with favorable mechanical reliability,anti-freezing,and self-healing *** addition,it delivers ultra-high ionic conductivity of 8.6 and 3.7 S m^(-1)at 20 and−30°C,respectively,and displays excellent mechanical properties to withstand tensile stress of 1.85 MPa with tensile elongation of 760%,together with fracture energy of 5.14 MJ m^(-3).Notably,the fractured hydrogel electrolyte can recover itself after only 90 s of infrared illumination,while regaining 83%of its tensile strain and almost 100%of its ionic conductivity during−30–60°***,ZICs coupled with this hydrogel electrolyte not only show a wide voltage window(up to 2 V),but also provide high energy density of 230 Wh kg^(-1)at power density of 500 W kg^(-1)with a capacity retention of 86.7%after 20,000 cycles under 20°***,the ZICs are able to retain excellent capacity even under various mechanical deformation at−30°*** contribution will open up new insights into design of advanced wearable flexible electronics with environmental adaptability and long-life span.

关键词： Flexible zinc ion supercapacitor Hydrogel electrolyte Self-healing Anti-freezing

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Deep learning enhanced lithium-ion battery nonlinear fading prognosis

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Journal of Energy Chemistry 2023年第3期78卷 565-573,I0015页

作者： Shanling ji jianxiong Zhu Zhiyang Lyu Heze You Yifan Zhou Liudong Gu jinqing Qu Zhijie Xia Zhisheng Zhang Haifeng Dai School of Mechanical Engineering Southeast UniversityNanjing 211189JiangsuChina Guangdong Provincial Key Lab of Green Chemical Product Technology South China University of TechnologyGuangzhou 510006GuangdongChina Engineering Research Center of New Light Sources Technology and Equipment Ministry of EducationNanjing 211189JiangsuChina Clean Energy Automotive Engineering Center School of Automotive EngineeringTongji UniversityShanghai 201804China School of Mathematics Southeast UniversityNanjing 211189JiangsuChina

With the assistance of artificial intelligence,advanced health prognosis technique plays a critical role in the lithium-ion(Li-ion) batteries management ***,conventional data-driven early aging prediction exhibited dramatic drawbacks,i.e.,volatile capacity nonlinear fading trajectories create obstacles to the accurate multistep ahead prediction due to the complex working conditions of ***,a novel deep learning model is proposed to achieve a universal and accurate Li-ion battery aging *** battery datasets with various electrode types and cycling conditions are developed to validate the proposed ***-point probability(KPP),extracted from the capacity loss curve,is first proposed to detect knee points and improve state-of-health(SOH) predictive accuracy,especially during periods of rapid capacity *** one-cycle data of partial raw voltage as the model input,the SOH and KPP can be simultaneously predicted at multistep ahead,whereas the conventional method showed worse ***,to explore the underlying characteristics among various degradation tendencies,an online model update strategy is developed by leveraging the adversarial adaptationinduced transfer learning *** work gains new sights into the comprehensive Li-ion battery management and prognosis framework through decomposing capacity degradation trajectories and adversarial learning on the unlabeled samples.

关键词： Battery aging prognosis Deep learning Knee-point probability Sate-of-health

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Effectiveness of COVID-19 Vaccination Against SARS-CoV-2 Omicron Variant Infection and Symptoms—China,December 2022–February 2023

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China CDC weekly 2023年第17期5卷 369-373,I0001-I0005页

作者： Di Fu Guanhao He Huanlong Li Haomin Tan Xiaohui ji Ziqiang Lin jianxiong Hu Tao Liu jianpeng Xiao Xiaofeng Liang Wenjun Ma Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhou CityGuangdong ProvinceChina Disease Control and Prevention Institute Jinan UniversityGuangzhou CityGuangdong ProvinceChina Key Laboratory of Ministry of Education for Viral Pathogenesis&Infection Prevention and Control Jinan UniversityGuangzhou CityGuangdong ProvinceChina Fuyang District Center for Disease Control and Prevention Hangzhou CityZhejiang Province Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina

Summary What is already known about this topic?A considerable percentage of the population has received both primary and booster vaccinations,which could potentially provide protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron infections and related *** is added by this report?The self-reported infection rate,as determined from an online survey,reached its peak(15.5%)between December 19 and 21,2022,with an estimated 82.4%of individuals in China being infected as of February 7,*** the epidemic,the effectiveness of booster vaccinations against SARS-CoV-2 Omicron infection was found to be 49.0%within three months of vaccination and 37.9%between 3 and 6 months following ***,the vaccine effectiveness of the booster vaccination in relation to symptom prevention varied from 48.7%to 83.2%within three months and from 25.9%to 69.0%between 3 and 6 months post-booster vaccination.

关键词： vaccination prevention acute

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Current Status and Application of Ceramic Foam Filter for Aluminum Melt

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China's Refractories 2010年第2期19卷 30-37页

作者： ji Shujun GUO Xueyi DONG jianxiong SU Peng School of Metallurgical Science and Engineering Central South University Changsha 410083 China Baotou Aluminum Co. Ltd. Baotou 014046 China

The importance of purification for aluminum and aluminum alloy casting was outlined. By comparing ceramic foam filters （CFF） in China and overseas, the existing problems and challenges of China＇ s CFF for aluminum were given. Measures to improve the performance of CFF were put forward based on material, preparation process, utility evaluation, etc.

关键词： Aluminum melt Inclusion Purification Ceramic foam filter

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肝细胞癌肝移植供肝选择策略

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中华消化外科杂志 2020年第8期19卷 135-138页

作者：霍枫季茹陈建雄中国人民解放军南部战区总医院肝胆外科肝移植中心广州510010

供肝数量不足是制约肝移植发展的主要因素,更是制约肝细胞癌肝移植治疗的突出因素。既往对肝细胞癌肝移植的研究多集中在受者选择标准、降期治疗、免疫抑制方案等方面,近年来研究发现供肝的选择对肝细胞癌肝移植术后肿瘤复发也有显著影... 详细信息

供肝数量不足是制约肝移植发展的主要因素,更是制约肝细胞癌肝移植治疗的突出因素。既往对肝细胞癌肝移植的研究多集中在受者选择标准、降期治疗、免疫抑制方案等方面,近年来研究发现供肝的选择对肝细胞癌肝移植术后肿瘤复发也有显著影响。笔者从临床供肝的主要类型、肝细胞癌肝移植适应证的把握、适应证内肝细胞癌肝移植和超适应证肝细胞癌肝移植的供肝选择以及供肝选择对肝细胞癌肝移植预后的影响进行深入探讨。

关键词：肝肿瘤肝移植供肝选择标准肿瘤复发

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三维散射中心模型辅助的一维距离像要害部位选择

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信号处理 2021年第9期37卷 1709-1718页

作者：陈冀吴宏铭朱永锋周剑雄国防科技大学电子科学学院湖南长沙410073 火箭军61基地96813部队安徽黄山242700

不同于传统爆炸杀伤型武器,碰撞杀伤以其毁伤集中的优势正逐渐被应用于拦截、破甲等多个领域,而准确判定要害部位实现对于目标的有效毁伤打击有重要的意义。由于一维距离像具有姿态、强度及平移敏感性,仅基于距离像进行要害部位选择难... 详细信息

不同于传统爆炸杀伤型武器,碰撞杀伤以其毁伤集中的优势正逐渐被应用于拦截、破甲等多个领域,而准确判定要害部位实现对于目标的有效毁伤打击有重要的意义。由于一维距离像具有姿态、强度及平移敏感性,仅基于距离像进行要害部位选择难以实现。本文提出一种三维散射中心模型辅助的一维距离像要害部位选择方法。通过获取目标三维散射中心的先验模型,结合要害部位三维位置实现三维向二维、二维向一维的图像投影,得到一维散射点序列模板。按照滑动最大匹配原则将目标散射点序列模板与待识别距离像匹配,此时一维散射点序列模板中要害部位所对应的距离像位置视为要害部位所在的实际位置。该方法运算复杂性小,便于实现,具有较强的实用意义,基于地面目标的电磁计算仿真数据说明算法有较好的要害部位选择性能且对角度偏移有适应性。

关键词：合成孔径雷达高分辨一维距离像三维散射中心要害部位选择

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大横路钴铜矿电气石及方解石稀土元素、同位素组成及其对成矿过程的指示

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岩石学报 2024年第10期40卷 3010-3027页

作者：朱志勇佘宇伟马健雄潘辰旭姜杭云冀磊自然资源部同位素地质重点实验室中国地质科学院地质研究所北京100037 自然资源部深地科学与探测技术实验室中国地质科学院地质研究所北京100037 中国地质科学院北京100037

大横路钴铜矿钴的储量为2.7万t,它是我国大型的钴矿床,其经历了复杂的沉积-变质作用,长期以来被认为是典型的沉积-变质型矿床。其热液期成矿作用可能被低估,本研究通过详细的岩相-矿相学观察,证实了除变质流体外,确实有岩浆热液作用参... 详细信息

大横路钴铜矿钴的储量为2.7万t,它是我国大型的钴矿床,其经历了复杂的沉积-变质作用,长期以来被认为是典型的沉积-变质型矿床。其热液期成矿作用可能被低估,本研究通过详细的岩相-矿相学观察,证实了除变质流体外,确实有岩浆热液作用参与了成矿过程。本研究对方解石锶同位素,电气石硼同位素进行了激光微区分析。电气石硼同位素在空间上有显著变化,自热液脉至基质由-4‰降低至-14‰左右;电气石与方解石锶同位素(^(87)Sr/^(86)Sr)并无显著差异,其平均值分别为1.0896和1.0948,略低于全岩的平均值1.1063。尽管目前还无法定量估算岩浆热液对成矿物质的贡献,但是本研究表明岩浆热源所驱动的热液促进了成矿元素的氧化、活化和迁移;然后热液在赋矿层位的碳质千枚岩中还原沉淀,这是岩浆热液期最主要的成矿方式。但是岩浆热液在成矿物质上并无显著贡献,且本次研究暂未发现海相蒸发岩参与成矿的证据。因而,方解石与电气石单矿物微量元素和同位素组成是重建热液成矿作用过程的重要指示矿物。

关键词：成矿过程硼同位素锶同位素电气石方解石稀土元素

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