检索结果-南通市图书馆

Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第2期18卷 258-284页

作者： Tianjing Sun Mo Li Qi liu Anyong Yu Kun Cheng jianxing Ma Sean Murphy Patrick Michael McNutt Yuanyuan Zhang Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Department of Nephrology Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Division of Pharmacology and Pharmaceutical Sciences School of PharmacyUniversity of Missouri-Kansas CityKansas CityMO64108USA Department of Biochemistry Wake Forest University School of MedicineWinston-SalemNC27157USA Wake Forest Institute of Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC27109USA

Exosome therapy holds great promise as a novel approach to improve acute skin wound healing.This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond.Exosomes,small extracellular vesicles secreted by various stem cells,have emerged as potent mediators of intercellular communication and tissue repair.One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy,such as immune rejection or stem cells differentiating into unwanted cell types.However,further research is necessary to optimize exosome therapy,not only in the areas of exosome isolation,characterization,and engineering,but also in determining the optimal dose,timing,administration,and frequency of exosome therapy.Thus,optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer,ischemia,or inflammation.This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

关键词： exosomes stem cells therapeutic impact skin wound healing

Sliding Mode Control in Power Converters and Drives: A Review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2022年第3期9卷 392-406页

作者： Ligang Wu jianxing liu Sergio Vazquez Sudip K.Mazumder IEEE Department of Control Science and Engineering Harbin Institute of TechnologyHarbin 150001China Electronic Engineering Department Universidad de Sevilla41092 SevillaSpain Electrical and Computer Engineering Department University of Illinois ChicagoChicagoIL 60607 USA

Sliding mode control(SMC)has been studied since the 1950s and widely used in practical applications due to its insensitivity to matched disturbances.The aim of this paper is to present a review of SMC describing the key developments and examining the new trends and challenges for its application to power electronic systems.The fundamental theory of SMC is briefly reviewed and the key technical problems associated with the implementation of SMC to power converters and drives,such chattering phenomenon and variable switching frequency,are discussed and analyzed.The recent developments in SMC systems,future challenges and perspectives of SMC for power converters are discussed.

关键词： Motor drive power electronics systems sliding mode control

Effectiveness and safety of acupuncture in treatment of pregnancyrelated symptoms:a systematic review and Meta-analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第1期44卷 16-26页

作者： liu Tingting liu Tongou liu Mingfu School of Traditional Chinese Medicine Clinical Medicine Hubei University of Traditional Chinese MedicineWuhan 430000China First Clinical College of Hubei University of Traditional Chinese Medicine Wuhan 430000China Department of Acupuncture and Tuina Affiliated Hospital of Hubei University of Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430000China

OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during pregnancy.METHODS:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during pregnancy.RESULTS:Sixteen RCTs with a cumulative sample size of 1178 cases were included.Of these,964 patients were included in the Meta-analysis.The Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low incidence.CONCLUSIONS:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively safe.However,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.

关键词： acupuncture pregnancy nausea vomiting sleep initiation and maintenance disorders low back pain pelvic pain mood abnormalities Meta-analysis systematic review

在线全文

学校读者我要写书评

暂无评论

常德高铁站房结构设计

建筑钢结构进展 2024年第2期26卷 104-112页

作者：刘康包联进陈建兴华东建筑设计研究院有限公司上海200002

常德高铁站是常益长正线线路上的重要站点,站房分为下部混凝土结构和上部钢屋盖。屋盖采用Γ形刚架作为主要支撑结构,一方面斜柱有效地增加了结构的抗侧刚度,另一方面也与桃花盛开的建筑意象相契合,其结构形式经历了立体三角形桁架、箱... 详细信息

常德高铁站是常益长正线线路上的重要站点,站房分为下部混凝土结构和上部钢屋盖。屋盖采用Γ形刚架作为主要支撑结构,一方面斜柱有效地增加了结构的抗侧刚度,另一方面也与桃花盛开的建筑意象相契合,其结构形式经历了立体三角形桁架、箱桁结合实腹梁、箱形实腹梁3轮方案的推敲演变。针对天窗区域连系桁架拱形下弦的矢高取值,采用Grasshopper+SAP2000联动程序进行自动化参数找形,得到结构受力性能和建筑空间效果均优的平衡点。通过ABAQUS壳单元模型与SAP2000杆单元模型的对比分析,验证了利用SAP2000截面设计器对变截面的异形截面构件分析的准确性,同时对Γ形刚架进行了弹塑性极限承载力分析,结果满足要求。Γ形刚架形态舒张有力,结构受力合理,实现了建筑与结构的完美结合。

关键词：高铁站房 Γ形刚架斜柱结构结构参数化找形

Integral sliding mode control design for nonlinear stochastic systems under imperfect quantization

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2017年第12期60卷 71-81页

作者： Yabin GAO Wensheng LUO jianxing liu Ligang WU Research Institute of Intelligent Control and Systems Harbin Institute of Technology

This paper presents a sliding mode control(SMC) scheme via output-feedback approach for It?o stochastic systems under a quantization mechanism. The quantization process is formulated with the imperfection that random packet loss occurs at the logarithmic quantizer. A Luenberger observer is designed, based on the packet loss rate and the imperfect quantized measurement. A novel SMC law is synthesized by utilization of an integral sliding surface. The stochastic stability of the resulting closed-loop system is analyzed in terms of Lyapunov stability, and a set of solvable matrix inequalities are established for practical application requirements. Finally, a simulation example is employed for the illustration of the effectiveness of the presented control scheme.

关键词： stochastic systems quantized control sliding mode control observer design packet loss

Removal of Cr(Ⅵ)by glutaraldehyde-crosslinked chitosan encapsulating microscale zero-valent iron:Synthesis,mechanism,and longevity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第8期142卷 115-128页

作者： Yijun Duan Fang liu Xiang liu Miao Li School of Environment Tsinghua UniversityBeijing 100084China Transportation Institute of Inner Mongolia University Hohhot 010070China

Microscale zero-valent iron(mZVI)has shown great potential for groundwater Cr(Ⅵ)remediation.However,low Cr(Ⅵ)removal capacity caused by passivation restricted the wide use of mZVI.We prepared mZVI/GCS by encapsulating mZVI in a porous glutaraldehydecrosslinked chitosan matrix,and the formation of the passivation layer was alleviated by reducing the contact between zero-valent iron particles.The average pore diameter of mZVI/GCS was 8.775 nm,which confirmed the mesoporous characteristic of this material.Results of batch experiments demonstrated that mZVI/GCS exhibited high Cr(Ⅵ)removal efficiency in a wide range of pH(2-10)and temperature(5-35℃).Common groundwater coexisting ions slightly affected m ZVI/GCS.The material showed great reusability,and the average Cr(Ⅵ)removal efficiency was 90.41%during eight cycles.In this study,we also conducted kinetics and isotherms analysis.Pseudo-second-order model was the most matched kinetics model.The Cr(Ⅵ)adsorption process was fitted by both Langmuir and Freundlich isotherms models,and the maximum Langmuir adsorption capacity of m ZVI/GCS reached243.63 mg/g,which is higher than the adsorption capacities of materials reported in most of the previous studies.Notably,the column capacity for Cr(Ⅵ)removal of a mZVI/GCS-packed column was 6.4 times higher than that of a mZVI-packed column in a 50-day experiment.Therefore,mZVI/GCS with a porous structure effectively relieved passivation problems of mZVI and showed practical application prospects as groundwater Cr(Ⅵ)remediation material with practical application prospects.

关键词： Chitosan Glutaraldehyde mZVI Cr(Ⅵ) Groundwater

Imperfection sensitivity of mechanical properties in soft network materials with horseshoe microstructures

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2021年第7期37卷 1050-1062,I0001页

作者： jianxing liu Xinyuan Zhu Zhangming Shen Yihui Zhang AML Department of Engineering MechanicsCenter for Flexible Electronics TechnologyTsinghua UniversityBeijing 100084China

Developments of soft network materials with rationally distributed wavy microstructures have enabled many promising applications in bio-integrated electronic devices,due to their abilities to reproduce precisely nonlinear mechanical properties of human tissues/organs.In practical applications,the soft network materials usually serve as the encapsulation layer and/or substrate of bio-integrated electronic devices,where deterministic holes can be utilized to accommodate hard chips,thereby increasing the filling ratio of the device system.Therefore,it is essential to understand how the hole-type imperfection affects the stretchability of soft network materialswith various geometric constructions.Thiswork presents a systematic investigation of the imperfection sensitivity of mechanical properties in soft network materials consisting of horseshoe microstructures,through combined computational and experimental studies.A factor of imperfection insensitivity of stretchability is introduced to quantify the influence of hole imperfections,as compared to the case of perfect soft network materials.Such factor is shown to have different dependences on the arc angle and normalized width of horseshoe microstructures for triangular network materials.The soft triangular and Kagome network materials,especially with the arc angle in the range of(30?,60?),are found to be much more imperfection insensitive than corresponding traditional lattice materials with straight microstructures.Differently,the soft honeycomb network materials are not as imperfection insensitive as traditional honeycomb lattice materials.

关键词： Imperfect network material Imperfection insensitivity Microstructure shape Lattice topology Stretchability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

岩石磁学方法在海洋样品研究中的多解性讨论

地球物理学报 2024年第5期67卷 1891-1912页

作者：张强刘双迟刘建兴刘传周李金华刘青松中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029 自然资源部第一海洋研究所海洋地质与成矿作用重点实验室青岛266061 中国科学院地质与地球物理研究所地球与行星物理院重点实验室北京100029 南方科技大学海洋科学与工程系深圳518055

岩石磁学是研究自然以及人工合成磁性矿物性质变化的应用型学科.海底岩石和海洋沉积物等海洋样品中含有不同成因及来源的磁性矿物.这些磁性矿物蕴含了全球气候变化、微生物矿化、地球动力学演化等关键地质信息.岩石磁学可以快速解析这... 详细信息

岩石磁学是研究自然以及人工合成磁性矿物性质变化的应用型学科.海底岩石和海洋沉积物等海洋样品中含有不同成因及来源的磁性矿物.这些磁性矿物蕴含了全球气候变化、微生物矿化、地球动力学演化等关键地质信息.岩石磁学可以快速解析这些海洋样品中磁性矿物种类、含量、磁畴等特征的变化,为提取相关地质演化信息提供丰富的指标记录.然而,由于磁性矿物循环和海洋内部过程的固有复杂性,岩石磁学参数解译在海洋样品研究中存在多解性,在一定程度上制约了相关地质信息的深入解读.解决这一问题的关键在于对样品中载磁矿物的准确识别和量化.为此,本文首先简述了海洋样品中主要的磁性矿物类型,随后系统论述了应用岩石磁学方法评估海洋样品磁性矿物种类、含量以及磁畴状态等方面的多解性和注意事项.本文同时对岩石磁学的局限性、新兴技术和未来研究思路进行了展望.

关键词：岩石磁学磁性矿物海洋地质海洋科学参数多解性

维普期刊数据库博看期刊

Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC system.However,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC system.Moreover,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is high.Thus,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind farms.The simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed