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Journal of Genetics and Genomics 2021年第8期48卷 727-736页

作者： Yu Sun Xiujuan Wei Fang Fang Yiping Shen Haiyan Wei Jiuwei Li Xianglai Ye Yongkun Zhan Xiantao Ye Xiaomin Liu Wei Yang Yuhua Li Xiangju Geng Xuelin Huang Yiyan Ruan Zailong Qin Shang Yi jianxin lyu Hezhi Fang Yongguo Yu Department of Pediatric Endocrinology and Genetics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai Institute for Pediatric ResearchShanghai 200092China Key Laboratory of Laboratory Medicine Ministry of EducationZhejiang Provincial Key Laboratory of Medical GeneticsSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325035China Department of Neurology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China The Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region Guangxi Birth Defects Prevention and Control InstituteNanning 530000China Shanghai Children's Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200127China Boston Children's Hospital Harvard Medical SchoolBostonMA 02115USA Department of Endocrinologic and Inherited Metabolic Henan Childen's HospitalZhengzhou Children's HospitalZhengzhou 450078China Department of Radiology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Rehabilitation Henan Children's HospitalZhengzhou Children's HospitalZhengzhou 450018China Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical CollegeHangzhou 310014China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai 200092China

Mitochondrial diseases are caused by variants in both mitochondrial and nuclear genomes.A nuclear gene HPDL(4-hydroxyphenylpyruvate dioxygenase-like),which encodes an intermembrane mitochondrial protein,has been recently implicated in causing a neurodegenerative disease characterized by pediatric-onset spastic movement ***,we report six Chinese patients with bi-allelic HPDL pathogenic variants from four unrelated families showing neuropathic symptoms of variable severity,including developmental delay/intellectual disability,spasm,and *** different pathogenic variants are identified,of which five are *** fibroblasts and immortalized lymphocytes derived from patients show impaired mitochondrial respiratory function,which is also observed in HPDL-knockdown(KD)He La *** these He La cells,overexpression of a wild-type HPDL gene can rescue the respiratory phenotype of oxygen consumption *** addition,a decreased activity of the oxidative phosphorylation(OXPHOS)complex II is observed in patient-derived lymphocytes and HPDL-KD He La cells,further supporting an essential role of HPDL in the mitochondrial respiratory ***,our data expand the clinical and mutational spectra of this mitochondrial neuropathy and further delineate the possible disease mechanism involving the impairment of the OXPHOS complex II activity due to the bi-allelic inactivations of HPDL.

关键词： HPDL gene Mitochondrial disease Respiration impairment OXPHOS Respiration chain complexⅡ

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行业期刊的全媒体融合营销

编辑学报 2020年第2期32卷 209-211页

作者：周晟宇吕建新机械工业信息研究院北京100037

在当今全媒体时代,随着信息网络技术的飞速发展和新媒体的崛起,各种新兴媒体形式和传播手段不断涌现,给面向市场的传统行业期刊带来了严峻的考验,同时也为其发展提供了更多的可能。本文重点阐述在全媒体的大背景下,行业期刊如何打造自... 详细信息

在当今全媒体时代,随着信息网络技术的飞速发展和新媒体的崛起,各种新兴媒体形式和传播手段不断涌现,给面向市场的传统行业期刊带来了严峻的考验,同时也为其发展提供了更多的可能。本文重点阐述在全媒体的大背景下,行业期刊如何打造自己的全媒体平台,利用新的媒体形式和传播手段,做好融合营销。

关键词：行业期刊全媒体融合营销

Lightweight Underwater Target Detection Using YOLOv8 with Multi-Scale Cross-Channel Attention

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Computers, Materials & Continua 2025年第1期82卷 713-727页

作者： Xueyan Ding Xiyu Chen Jiaxin Wang jianxin Zhang School of Computer Science and Engineering Dalian Minzu UniversityDalian116600China Research Center of Multimodal Information Perception and Intelligent Processing Dalian Minzu UniversityDalian116600China

Underwater target detection is extensively applied in domains such as underwater search and rescue,environmental monitoring,and marine resource *** is crucial in enabling autonomous underwater robot operations and promoting ocean ***,low imaging quality,harsh underwater environments,and obscured objects considerably increase the difficulty of detecting underwater targets,making it difficult for current detection methods to achieve optimal *** order to enhance underwater object perception and improve target detection precision,we propose a lightweight underwater target detection method using You Only Look Once(YOLO)v8 with multi-scale cross-channel attention(MSCCA),named *** the proposed multiscale cross-channel attention module,multi-scale attention(MSA)augments the variety of attentional perception by extracting information from innately diverse sensory *** cross-channel strategy utilizes RepVGGbased channel shuffling(RCS)and one-shot aggregation(OSA)to rearrange feature map channels according to specific *** aggregates all features only once in the final feature mapping,resulting in the extraction of more comprehensive and valuable feature *** experimental results show that the proposed YOLOv8-UOD achieves a mAP50 of 95.67%and FLOPs of 23.8 G on the Underwater Robot Picking Contest 2017(URPC2017)dataset,outperforming other methods in terms of detection precision and computational cost-efficiency.

关键词： Deep learning underwater target detection attention mechanism

DecMamba:Mamba Utilizing Series Decomposition for Multivariate Time Series Forecasting

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Computers, Materials & Continua 2025年第1期82卷 1049-1068页

作者： jianxin Feng Jianhao Zhang Ge Cao Zhiguo Liu Yuanming Ding Communication and Network Key Laboratory Dalian UniversityDalian116622China

Multivariate time series forecasting iswidely used in traffic planning,weather forecasting,and energy *** decomposition algorithms can help models better understand the underlying patterns of the original series to improve the forecasting accuracy of multivariate time ***,the decomposition kernel of previous decomposition-based models is fixed,and these models have not considered the differences in frequency fluctuations between *** problems make it difficult to analyze the intricate temporal variations of real-world time *** this paper,we propose a series decomposition-based Mamba model,DecMamba,to obtain the intricate temporal dependencies and the dependencies among different variables of multivariate time series.A variable-level adaptive kernel combination search module is designed to interact with information on different trends and periods between *** backbone structures are proposed to emphasize the differences in frequency fluctuations of seasonal and trend *** with superior performance is used instead of a Transformer in backbone structures to capture the dependencies among different variables.A new embedding block is designed to capture the temporal features better,especially for the high-frequency seasonal component whose semantic information is difficult to acquire.A gating mechanism is introduced to the decoder in the seasonal backbone to improve the prediction accuracy.A comparison with ten state-of-the-art models on seven real-world datasets demonstrates that DecMamba can better model the temporal dependencies and the dependencies among different variables,guaranteeing better prediction performance for multivariate time series.

关键词： Data prediction time series Mamba series decomposition

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媒体融合环境下高校图书馆阅读推广探索

现代情报 2019年第5期39卷 104-108页

作者：吕建新孙嫄媛李晋瑞河北北方学院图书馆河北张家口075000 辽宁工程技术大学图书馆辽宁阜新123000 大连理工大学图书馆辽宁大连116024

[目的/意义]本文以媒介融合为视角,结合新媒体环境下读者阅读需求与高校图书馆阅读推广工作的实践,梳理了当前高校图书馆阅读推广工作现状,以期为高校图书馆基于媒体融合进行阅读推广提供了新的思路。[方法/过程]分析了现有高校图书馆... 详细信息

[目的/意义]本文以媒介融合为视角,结合新媒体环境下读者阅读需求与高校图书馆阅读推广工作的实践,梳理了当前高校图书馆阅读推广工作现状,以期为高校图书馆基于媒体融合进行阅读推广提供了新的思路。[方法/过程]分析了现有高校图书馆阅读推广工作的不足,探究媒体融合环境下高校图书馆阅读推广发展趋势并提出相关措施。[结果/结论]高校图书馆可通过变革资源组织模式、加强数字多媒体宣传推广、投身数字资源的组织利用等措施,拓展阅读推广渠道,创新阅读推广方式,为我国高校图书馆的阅读推广工作提供借鉴。

关键词：高校图书馆阅读推广数字资源APP 媒体融合

多个血液学指标联合对于甲胎蛋白阴性肝癌患者的诊断效能分析

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中华医学杂志 2022年第17期102卷 1303-1310页

作者：王鹤董矜鲍金凤王成彬吕建新温州医科大学检验医学院生命科学学院温州325000 解放军总医院第一医学中心检验科北京100853

目的建立联合多个实验室血液学指标诊断甲胎蛋白(AFP)阴性肝细胞癌(AFP-NHCC)的模型,探讨其临床诊断效能。方法纳入2011年12月到2017年6月在解放军总医院首次确诊为AFP-NHCC的住院患者124例,男110例,女14例,年龄[M(Q1,Q3)]为57(51,66)岁... 详细信息

目的建立联合多个实验室血液学指标诊断甲胎蛋白(AFP)阴性肝细胞癌(AFP-NHCC)的模型,探讨其临床诊断效能。方法纳入2011年12月到2017年6月在解放军总医院首次确诊为AFP-NHCC的住院患者124例,男110例,女14例,年龄[M(Q1,Q3)]为57(51,66)岁;以同期331例非癌人群作为对照组,男279例,女52例,年龄为58(51,63)岁,包括47例乙型肝炎、40例肝硬化、64例肝血管瘤或囊肿、7例肝结节、8例脂肪肝、146例非肝病患者以及19名健康体检者。将AFP-NHCC组和对照组人群分为训练组与验证组:训练组共纳入196例受试者,包括103例AFP-NHCC患者和93例非癌人群(包括19名健康体检者、25例乙型肝炎患者、22例肝硬化患者、23例肝血管瘤和囊肿患者以及4例肝结节患者),用来分析实验室指标的差异和建立不同AFP水平下AFP-NHCC的诊断模型;验证组共纳入259例受试者,其中包括113例肝病患者,用来验证诊断模型对AFP-NHCC的诊断效能。采用受试者工作特征(ROC)曲线对不同模型的诊断效能进行灵敏度及特异度分析,采用曲线下面积(AUC)评估不同模型的诊断效能。结果在训练组中,AFP≤5μg/L时所建立的AFP-NHCC诊断模型包括血小板(PLT)、凝血酶原活动度(PTA)、血清白蛋白(ALB)、凝血酶原时间(PT)和糖类抗原19-9(CA19-9),AUC为0.848(95%CI:0.786~0.911);AFP≤10μg/L时所建立的AFP-NHCC诊断模型包括PLT、PTA、ALB、PT和红细胞压积(HCT),AUC为0.839(95%CI:0.780~0.897);AFP≤20μg/L时所建立的AFP-NHCC诊断模型包括PLT、PTA、ALB、PT、HCT和AFP,AUC为0.866(95%CI:0.815~0.917);这3种模型的AUC值均高于AFP和CA19-9单项诊断AFP-NHCC时的AUC值[0.634(95%CI:0.560~0.709)、0.691(95%CI:0.620~0.761),均P<0.05]。将这3种模型筛选出的指标联合,建立最终诊断模型,包括PLT、PTA、ALB、PT、HCT、CA19-9和AFP,其AUC为0.873(95%CI:0.824~0.923),灵敏度为78.6%(81/103),特异度为81.7%(76/93)。在验证组中,最终诊断模型在肝病患者中的预测AUC为0.892(95%CI:0.832~0.951),灵敏度为100%(21/21),特异度为71.7%(66/92);在全部验证人群中的预测AUC为0.931(95%CI:0.890~0.972),灵敏度为100.0%(21/21),特异度为75.6%(180/238)。结论建立的最终诊断模型包括PLT、PTA、ALB、PT、HCT、CA19-9和AFP,其灵敏度和特异度均较高,对于临床诊断AFP-NHCC具有较好的诊断效能。

关键词：甲胎蛋白类肝肿瘤诊断模型诊断试验

An Eight-year Epidemiologic Study of Head and Neck Tuberculosis in Texas,USA

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线粒体DNA5178位点C／A多态性对于2型糖尿病发生和发展的影响

2018年浙江省检验医学学术年会

作者： XU QIAN Duc T.Nguyen Andreas E.Albers Yue Dong jianxin lyu Qing H.Meng Xiaohong Bi Edward A.Graviss Department of Laboratory Medicine Zhejiang Cancer Hospital Center for Precision Biomedicine Institute of Molecular MedicineMcGovern Medical Schoolthe University of Texas Health Science Center at Houston Key Laboratory of Laboratory Medicine Ministry of EducationZhejiang Provincial Key Laboratory of Medical GeneticsWenzhou Medical University Houston Methodist Research Institute Department of Otorhinolaryngology Head and Neck SurgeryBerlin Institute of HealthCharit éUniversit?tsmedizin Berlincorporate member of Freie Universit?t BerlinHumboldt-Universit?t zu BerlinCampus Benjamin Franklin People's Hospital of Hangzhou Medical College Department of Laboratory Medicine The University of Texas MD Anderson Cancer Center

Background:Head and neck tuberculosis (HNTB) especially cervical lymphadenopathy are the most common extrapulmonary indications of TB,but remain a diagnostic *** this study,we describe and analyze the epidemiologic ch...

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中华医学遗传学杂志 2015年第6期32卷 855-860页

作者：杨训俊张宇宁马胤赵琼雅吕建新温州医科大学浙江省遗传学重点实验室浙江325000

目的探讨线粒体DNANADH脱氢酶2亚基（NADH dehydrogenase subunit2，ND2）基因5178位点的C／A多态性与中国汉族人群2型糖尿病（type 2 diabetes mellitus，T2DM）的相关性。方法收集1103例T2DM患者和791名正常对照的血液样本，通过聚合... 详细信息

目的探讨线粒体DNANADH脱氢酶2亚基（NADH dehydrogenase subunit2，ND2）基因5178位点的C／A多态性与中国汉族人群2型糖尿病（type 2 diabetes mellitus，T2DM）的相关性。方法收集1103例T2DM患者和791名正常对照的血液样本，通过聚合酶链反应结合测序的方法确定Mt5178C／A的多态性。采用Logistics回归分析计算患病风险比（oddsratio，OR）和95％可信区间（95％ confidenceinterval，95％CI）。汇总研究Mt5178突变与T2DM相关性的文献，提取数据，进行荟萃分析。结果病例对照研究未发现Mt5178多态性与T2DM发生的相关性。Meta分析共纳入8篇已发表的研究，分析结果同样未发现Mt5178多态性与T2DM发生的相关性。但结果提示T2DM患者携带5178C基因型合并肾病并发症的风险更高（OR=1．49，95％CI：1．005-2．197，P〈0．05），而该基因型的患者并发高血压的风险则有所降低（OR=0．744，95％CI：0．556～0．996，P〈0．05）。结论线粒体ND2基因Mt5178c／A多态性与T2DM发生无关，但可能与T2DM的并发症如肾病和高血压的发展相关。

关键词：荟萃分析线粒体ND2基因多态性 2型糖尿病并发症

Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU Rongqi MI jianxin WANG Shulin XU Man ZHU Li BAI Lei TANG Dandan LEI Yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment