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Overexpression of c-Myc-dependent heterogeneous nuclear ribonucleoprotein A1 promotes proliferation and inhibits apoptosis in NOTCH1-mutated chronic lymphocytic leukemia cells

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Chinese Medical Journal 2022年第8期135卷 920-929页

作者： Yixin Zou Hanning Tang Yi Miao Huayuan Zhu Li Wang Lei Fan jianxin fu Wei Xu Jianyong Li Yi Xia department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China Pukou CLL Center NanjingJiangsu 210000China

Background: NOTCH1 mutation is an essential molecular biologic aberration in chronic lymphocytic leukemia (CLL). CLL patients withNOTCH1 mutation have shown an unfavorable survival and a poor response to chemoimmunotherapy. This study aims to present the mechanisms of adverse prognosis caused byNOTCH1 mutation from the perspective of the splicing factor heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1).Methods: The microarray data in Gene Expression Omnibus datasets were analyzed by bioinformatics and the function of hnRNPA1 was checked by testing the proliferation and apoptosis of CLL-like cell lines. Afterward, quantitative reverse transcription-polymerase chain reaction and Western blotting were applied to explore the relationship among NOTCH1, c-Myc, and hnRNPA1.Results: RNA splicing was found to play a vital part inNOTCH1-mutated CLL cells;hence, hnRNPA1 was selected as the focus of this study. Higher expression of hnRNPA1 validated in primaryNOTCH1-mutated CLL samples could promote proliferation and inhibit apoptosis in CLL. The expression of hnRNPA1 increased when NOTCH1 signaling was activated by transfection with NOTCH1 intracellular domain (NICD)-overexpressed adenovirus vector and declined after NOTCH1 signaling was inhibited by NOTCH1-shRNA. Higher expression of c-Myc was observed in NICD-overexpressed cells and hnRNPA1 expression was downregulated after applying c-Myc inhibitor 10058-F4. Moreover, in NICD-overexpressed cells, hnRNPA1 expression decreased through c-Myc inhibition.Conclusion: Overexpression of c-Myc-dependent hnRNPA1 could promote proliferation and inhibit apoptosis inNOTCH1- mutated CLL cells, which might partly account for the poor prognosis of patients withNOTCH1 mutation.

关键词： Chronic lymphocytic leukemia NOTCH1 mutation c-Myc Heterogeneous nuclear ribonucleoprotein A1

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应力–渗流耦合下深部花岗岩力学行为及破坏特征

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工程科学学报 2024年第4期46卷 600-613页

作者：张超杜翠凤宋卫东付建新北京科技大学土木与资源工程学院北京100083 金属矿山高效开采与安全教育部重点实验室北京100083

在矿山深部开采过程中,高应力与高水压耦合作用导致岩石的力学特性演化机理更加复杂.为分析深部复杂条件下花岗岩的力学行为及破坏特征,利用低场核磁共振核技术(NMR)进行花岗岩初始孔隙率测量,借助岩石高温三轴流变系统开展应力–渗流... 详细信息

在矿山深部开采过程中,高应力与高水压耦合作用导致岩石的力学特性演化机理更加复杂.为分析深部复杂条件下花岗岩的力学行为及破坏特征,利用低场核磁共振核技术(NMR)进行花岗岩初始孔隙率测量,借助岩石高温三轴流变系统开展应力–渗流耦合试验,引入耗能比实现花岗岩破坏过程的能量演化分析.研究结果表明:岩石的峰值强度、峰值应变随孔隙水压的增大呈线性减小且减小速率逐渐提升,随围压的增大呈线性增加且增大速率逐渐变缓;峰值渗透率随着孔隙水压的增大呈线性增大,随围压的增大呈线性减小;岩石破坏应变能表现出明显的围压效应和孔隙水压效应,峰值应力点为弹性能极值点,峰值点之后弹性能迅速转化为岩石损伤的耗散能,岩石耗能比整体呈现增大→减小→增加的“S”型变化规律;引入花岗岩初始孔隙率,将岩石视为固体骨架和孔隙两部分组成,综合考虑变形特征并构建应力–渗流耦合本构模型,与试验对比后认为该模型具有较高普适性.

关键词：应力–渗流耦合低场核磁共振本构模型破裂特征能量耗散

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低场核磁共振技术在充填体材料的应用优势

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当代化工研究 2024年第2期 73-75页

作者：臧春龙王坤付建新巴州敦德矿业有限责任公司新疆841599 北京科技大学土木与资源学院北京100083 北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083

低场核磁共振技术近年来应用发展迅速,具有精准高效低价无损的特点,通过检测多孔结构中氢质子的核磁共振弛豫信号,来反映孔隙及其内部流体信息。研究矿山充填体材料的孔隙结构、水化进程和水分迁移,对于维护矿山与工程稳定具有重大意义... 详细信息

低场核磁共振技术近年来应用发展迅速,具有精准高效低价无损的特点,通过检测多孔结构中氢质子的核磁共振弛豫信号,来反映孔隙及其内部流体信息。研究矿山充填体材料的孔隙结构、水化进程和水分迁移,对于维护矿山与工程稳定具有重大意义。本文主要介绍了近年来低场核磁共振技术在矿山充填材料中的应用,如孔隙度、孔径分布、水化进程、水分迁移等;阐述了低场核磁相应设备的发展,对其前景的展望。

关键词：低场核磁共振孔隙结构水化过程水分迁移充填体

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基于GIS的孝义市地名文化景观研究

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云南地理环境研究 2024年第2期36卷 32-40页

作者：穆志腾付建新郭文炯太原师范学院地理科学学院山西晋中030619 太原师范学院城镇与区域发展研究所山西晋中030619

以孝义市305个地理名称为研究对象,采用数理统计方法对这些地名进行了分类统计,并将形成的核密度图和数字高程数据图进行叠加分析,以此来提供直观的地名文化景观空间分布状况。研究结果表明,孝义市自然景观地名主要分布在中西部山区和... 详细信息

以孝义市305个地理名称为研究对象,采用数理统计方法对这些地名进行了分类统计,并将形成的核密度图和数字高程数据图进行叠加分析,以此来提供直观的地名文化景观空间分布状况。研究结果表明,孝义市自然景观地名主要分布在中西部山区和丘陵地带,水文和地形因素对地名形成的影响最为显著;而东北部城区的地名主要受到交通和经济等因素的影响,人文类地名文化景观也呈现出集中的趋势。自然类地名文化景观与人文类地名文化景观共同构成了孝义市丰富的地名文化景观,其中人文类占比更多,这表明当地地名受人文因素影响更显著。

关键词：地名文化景观空间分布孝义市

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Effect of Ti and Ta content on the oxidation resistance of Co-Ni-based superalloys

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 351-361页

作者： Yuheng Zhang Zixin Li Yunwei Gui Huadong fu jianxin Xie Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China

Co-Ni-based superalloys are known for their capability to function at elevated temperatures and superior hot corrosion and thermal fatigue resistance.Therefore,these alloys show potential as crucial high-temperature structural materials for aeroengine and gas turbine hot-end components.Our previous work elucidated the influence of Ti and Ta on the high-temperature mechanical properties of alloys.However,the intricate interaction among elements considerably affects the oxidation resistance of alloys.In this paper,Co-35Ni-10Al-2W-5Cr-2Mo-1Nb-xTi-(5−x)Ta alloys(x=1,2,3,4)with varying Ti and Ta contents were designed and compounded,and their oxidation resistance was investigated at the temperature range from 800 to 1000℃.After oxidation at three test conditions,namely,800℃for 200 h,900℃for 200 h,and 1000℃for 50 h,the main structure of the oxide layer of the alloy consisted of spinel,Cr_(2)O_(3),and Al_(2)O_(3)from outside to inside.Oxides consisting of Ta,W,and Mo formed below the Cr_(2)O_(3)layer.The interaction of Ti and Ta imparted the highest oxidation resistance to 3Ti2Ta alloy.Conversely,an excessive amount of Ti or Ta resulted in an adverse effect on the oxidation resistance of the alloys.This study reports the volatilization of W and Mo oxides during the oxidation process of Co-Ni-based cast superalloys with a high Al content for the first time and explains the formation mechanism of holes in the oxide layer.The results provide a basis for gaining insights into the effects of the interaction of alloying elements on the oxidation resistance of the alloys they form.

关键词： Co-Ni-based superalloys high-temperature oxidation Ti and Ta elements formation mechanism of holes

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节段预制拼装混凝土盖梁胶接缝抗剪性能试验

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福建建设科技 2024年第3期 84-87页

作者：傅健鑫李长春李鑫匡鑫徐文琪王文豪卓卫东福州大学土木工程学院福建福州350108

针对采用键齿胶接缝构造的节段预制拼装混凝土盖梁拼接缝抗剪性能研究较为缺乏的现状,设计制作了3组共7个足尺胶接缝键齿试件,考虑键齿倾角、键齿深度和侧向压应力3种影响因素,进行直剪试验研究。试验结果表明:键齿胶接缝在直剪荷载作... 详细信息

针对采用键齿胶接缝构造的节段预制拼装混凝土盖梁拼接缝抗剪性能研究较为缺乏的现状,设计制作了3组共7个足尺胶接缝键齿试件,考虑键齿倾角、键齿深度和侧向压应力3种影响因素,进行直剪试验研究。试验结果表明:键齿胶接缝在直剪荷载作用下的破坏模式均为脆性破坏,主裂缝形态受侧向压应力、键齿深度及键齿倾角的耦合影响;增大侧向压应力或键齿深度均能有效提高键齿胶接缝的抗剪承载力,且破坏相对滑移保持为同量级;键齿倾角为30°时,键齿胶接缝的开裂荷载和抗剪承载力最大;当键齿倾角>45°,抗剪承载力有明显下降,故实际工程中键齿倾角不应超过45°。

关键词：胶接缝侧向压应力键齿倾角键齿深度开裂荷载抗剪承载力

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Criterion of local energy release rate of gob instability in deep mines considering unloading stress path

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International Journal of Mining Science and Technology 2017年第6期27卷 1011-1017页

作者： fu jianxin Song Weidong Tan Yuye Civil and Resources Engineering School University of Science and Technology Beijing Beijing 100083 China State Key Laboratory of High-Efficient Mining and Safety of Metal Mines Ministry of Education Beijing 100083 China

The stress path characteristics of surrounding rock in the formation of gob were analyzed and the unloading was solved. Taking Chengchao Iron Mine as the engineering background, the model for analyzing the instability of deep gob was established based on the mechanism of stress relief in deep mining.The energy evolution law was analyzed by introducing the local energy release rate index(LERR), and the energy criterion of the instability of surrounding rock was established based on the cusp catastrophe theory. The results show that the evolution equation of the local energy release of the surrounding rock is a quartic function with one unknown and the release rate increases gradually during the mining process.The calculation results show that the gob is stable. The LERR per unit volume of the bottom structure is relatively smaller which means that the stability is better. The LERR distribution showed that there was main energy release in the horizontal direction and energy concentration in the vertical direction which meets the characteristics of deep mining. In summary, this model could effectively calculate the stability of surrounding rock in the formation of gob. The LERR could reflect the dynamic process of energy release,transfer and dissipation and that provided an important reference for the study of the stability of deep mined out area.

关键词： Deep mine Gob Unloading Local energy release rate Cusp catastrophe

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Design of low-alloying and high-performance solid solution-strengthened copper alloys with element substitution for sustainable development

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 826-832页

作者： Jiaqiang Li Hongtao Zhang Jingtai Sun Huadong fu jianxin Xie Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Liaoning Academy of Materials Shenyang 110004China

Solid solution-strengthened copper alloys have the advantages of a simple composition and manufacturing process,high mechanical and electrical comprehensive performances,and low cost;thus,they are widely used in high-speed rail contact wires,electronic component connectors,and other devices.Overcoming the contradiction between low alloying and high performance is an important challenge in the development of solid solution-strengthened copper alloys.Taking the typical solid solution-strengthened alloy Cu-4Zn-1Sn as the research object,we proposed using the element In to replace Zn and Sn to achieve low alloying in this work.Two new alloys,Cu-1.5Zn-1Sn-0.4In and Cu-1.5Zn-0.9Sn-0.6In,were designed and prepared.The total weight percentage content of alloying elements decreased by 43%and 41%,respectively,while the product of ultimate tensile strength(UTS)and electrical conductivity(EC)of the annealed state increased by 14%and 15%.After cold rolling with a 90%reduction,the UTS of the two new alloys reached 576 and 627MPa,respectively,the EC was 44.9%IACS and 42.0%IACS,and the product of UTS and EC(UTS×EC)was 97%and 99%higher than that of the annealed state alloy.The dislocations proliferated greatly in cold-rolled alloys,and the strengthening effects of dislocations reached 332 and 356 MPa,respectively,which is the main reason for the considerable improvement in mechanical properties.

关键词： element substitution copper alloy solid solution strengthening microstructure and performance

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Analysis of SF6 decomposed products by fibre-enhanced Raman spectroscopy for gas-insulated switchgear diagnosis

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High Voltage 2024年第1期9卷 206-216页

作者： jianxin Wang Weigen Chen Pinyi Wang fu Wan Zhixian Zhang Shoufei Gao Yingying Wang School of Electrical Engineering Chongqing UniversityChongqingChina State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina Institute of Photonics Technology Jinan UniversityGuangzhouChina

Sulphur hexafluoride(SF6)decomposed products analysis is highly critical in the earlystage fault diagnosis of gas-insulated switchgear(GIS).Spectrum technology outperforms traditional methods on non-invasiveness,no sample preparation,and no consumption.Here,the authors present an improved fibre-enhanced Raman spectroscopy(FERS)as a comprehensive analytical tool to detect a suite of SF_(6)decomposed products(SO_(2)F_(2),SOF_(2),SO_(2),H_(2)S,CF_(4),OCS,CO_(2),and CO).The FERS approach is combined with two iris diaphragms for spatial filtering and a rear-end reflector for additional Raman signal enhancement.Limits of detection down to 1×10^(−6)–8×10^(−6)are achieved for different SF6 decompositions,and quantification of an undefined multigas,sampled from an 800 kV GIS in service,is realised utilising SF6 as the internal standard gas and with a maximum error of 5.5%.The GIS is diagnosed according to the results and confirmed by an on-site check.The authors foresee that this technique will provide a route for trace gas analysis in the power industry.

关键词： SF6 diagnosis fibre

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1980—2020年汾河流域“三生空间”土地利用功能变化及其驱动力

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应用生态学报 2023年第7期34卷 1901-1911页

作者：付建新太原师范学院城镇与区域发展研究所山西晋中030619

分析国土“三生空间”土地利用功能变化及其驱动因素,对实现“三生空间”协调发展具有重要作用。本研究基于1980、1990、2000、2010和2020年土地利用遥感影像数据,利用土地利用动态度、转移矩阵、重心转移和地理探测器等方法,分析汾河... 详细信息

分析国土“三生空间”土地利用功能变化及其驱动因素,对实现“三生空间”协调发展具有重要作用。本研究基于1980、1990、2000、2010和2020年土地利用遥感影像数据,利用土地利用动态度、转移矩阵、重心转移和地理探测器等方法,分析汾河流域“三生空间”变化规律,并探索其影响因素。结果表明:1980—2020年,流域内“三生空间”面积占比分别为生态空间>生产空间>生活空间,其中,生态空间和农业生产用地呈下降态势,分别减少72441.19、105882.96 hm^(2),而生活空间和工业生产用地表现为上升趋势,分别增加119503.02、58821.13 hm^(2)。“三生空间”土地利用变化差异明显,转出面积最大的地类是农业生产用地,占转出总面积的47.9%,2000—2010年工业生产用地最大转入面积是农业生产用地,占工业生产用地转入总面积的61.3%。城镇生活用地占农业生产用地现象主要分布在太原盆地各城区的边缘区,其中,太原市区的城镇生活用地增加表现为逐渐向南扩展态势。城镇生活用地和工业生产用地的重心迁移最明显,其中,城镇生活用地重心迁移表现出先向南再向北迁移的趋势,工业生产用地重心向北迁移显著。社会经济因子对流域“三生空间”土地利用变化影响程度明显强于自然因子,社会经济因子之间的交互作用对“三生空间”土地利用变化的解释力更强。研究结果将为理清“三生空间”土地利用变化关系和优化用地功能提供参考。

关键词：生产⁃生活⁃生态空间土地利用功能变化国土空间优化汾河流域

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