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Artificial periosteum in bone defect repair--A review

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Chinese Chemical Letters 2017年第9期28卷 1801-1807页

作者： Quan Wang jianxiang xu Haiming Jin Wenhao Zheng Xiaolei Zhang Yixing Huang Zhiyong Qian Department of Orthopaedics The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027 China Department of Oncology and Cancer Center West China Hospital Sichuan University Chengdu 610041 China Zhejiang Provincial Key Laboratory of Orthopaedics Wenzhou 325027 China

Periosteum is a thin membrane that encases the surfaces of most *** is composed of an outer fibrous layer contains longitudinally oriented cells and collagen fibers and an inner cambial layer that consists of multipotent mesenchymal stem cells（MSCs）and osteogenic progenitor *** has a function of regulating cell and collagen arrangement,which is important to the integrity,modelling and remodelling of bone,particularly during bone defect *** from autograft and allograft,artificial periosteum,or tissue-engineered periosteum mimicking native periosteum in structure or function,made up of small intestinal submucosa,acellular dermis,induced membrane,cell sheets,and polymeric scaffolds,and so on,has been developed to be used in bone defect *** this review,we classify the artificial periosteum into three approaches based on the material source,that is,native tissues,scaffoldfree cell sheets and scaffold-cell ***,methods and efficacy of each approach are *** obstacles and enabling technologies for future directions are also discussed.

关键词： Artificial periosteum Bone defect Tissue engineering Extracellular matrix Biomimetic

Research fronts of agriculture in 2023

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 347-354页

作者： jianxiang xu Yunzhou LI Jie ZHAO Liang SHI Yinkun YAO Jingyue TANG Science and Technology Journal Center Higher Education PressBeijing 100029China FASE Editorial Office of Institute for Science and Technology Development China Agricultural UniversityBeijing 100193China

At the end of 2023, Chinese Academy of Sciences(CAS) and Chinese Academy of Engineering(CAE) successively announced “2023 Research Fronts”^[1] and “2023 Engineering Fronts”^([2,3]), respectively. Among them, agric... 详细信息

关键词： occupy successively agriculture

GENOME EDITING:A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 309-311页

作者： jianxiang xu Yunzhou LI Yinkun YAO Jie ZHAO Jingyue TANG Zixuan FENG Sci-Tech Journal Centre Higher Education PressBeijing 100029China Editorial Office of Frontiers of Agricultural Science&Engineering China Agricultural UniversityBeijing 100193China

‘Global Engineering Fronts’ is a report released by the Chinese Academy of Engineering(CAE) every year since 2017, which aims to assemble talents in the field of engineering science and technology to represent the global engineering research and development fronts by reviewing global papers, patents, and other data. The results are also expected to provide a reference for people on responding to global challenges and achieving sustainable development.

关键词： EDIT ING sustainable

Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

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Frontiers of Agricultural Science and Engineering 2015年第1期2卷 90-99页

作者： jianxiang xu Dengke PAN Jie ZHAO Jianwu WANG Xiaohong HE Yuehui MA Ning LI State Key Laboratory for Agrobiotechnology China Agricultural University Institute of Animal Sciences Chinese Academy of Agricultural Sciences

Myostatin is a transforming growth factor-beta family member that normally acts to limit skeletal muscle growth. Myostatin gene (MSTN) knockout (KO) mice show possible effects for the prevention or treatment of metabolic disorders such as obesity and type 2 diabetes. We applied chromatography and mass spectrometry based metabonomics to assess system-wide metabolic response of heterozygous MSTN KO (MSTN+/-) swine. Most of the metabolic data for MSTN+/- swine were similar to the data for wild type (WT) control swine. There were, however, metabolic changes related to fatty acid metabolism, glucose utilization, lipid metabolism, as well as BCAA catabolism caused by monoallelic MSTN depletion. The statistical analyses suggested that: (1) most metabolic changes were not significant in MSTN+/- swine compared to WT swine; (2) only a few metabolic properties were significantly different between KO and WT swine, especially for lipid metabolism. Significantly, these minor changes were most evident in female KO swine and suggested differences in gender sensitivity to myostatin.

关键词： myostatin transforming growth factor-beta family skeletal muscle metabolic disorders chromatography mass spectrometry metabonomics

Animal stem cells: the engineering development front of 2018

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Frontiers of Agricultural Science and Engineering 2019年第1期6卷 93-95页

作者： Wenye YUAN jianxiang xu Chenying LI Lijuan SHI Aidong YANG Yan WANG Lu XING Shaozhong KANG Division of Scientific R&D China Agricultural University Division of Natural Science Academic Publishing Higher Education Press Library China Agricultural University Center for Agricultural Water Research in China China Agricultural University

The Engineering Fronts reports are important guidelines for the future development directions of engineering science and technology. The Chinese Academy of Engineering (CAE) has been conducting studies relevant to Eng... 详细信息

关键词： MA the engineering development front of 2018 Animal stem cells

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转基因动物生物安全研究与评价

生物工程学报 2012年第3期28卷 267-281页

作者：许建香李宁中国农业大学农业生物技术国家重点实验室北京100193

随着转基因动物在新品种培育、异种器官移植、生物反应器和疾病模型等方面的研究与发展,转基因动物的生物安全性引起了人们的广泛关注。目前,各国政府与机构已制定了相应的法律法规来规范转基因动物的研究与应用。文中介绍了转基因动物... 详细信息

随着转基因动物在新品种培育、异种器官移植、生物反应器和疾病模型等方面的研究与发展,转基因动物的生物安全性引起了人们的广泛关注。目前,各国政府与机构已制定了相应的法律法规来规范转基因动物的研究与应用。文中介绍了转基因动物生物安全研究的内容、评价原则、评价政策与程序、上市或有望上市的转基因动物产品。最后,对转基因动物及其产品的研究与应用进行了展望。

关键词：转基因动物生物安全异种器官移植生物反应器基因水平转移木马基因效应非预期性效应

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非定常尾迹宽度对动叶传热影响的数值研究

中国电机工程学报 2014年第35期34卷 6338-6345页

作者：张玲汪山入祝健徐健翔东北电力大学能源与动力工程学院吉林省吉林市132012 沈阳市热力工程设计研究院辽宁省沈阳市110000

应用Standard k-=紊流模型并结合SIMPLE算法,近壁区流动的处理采用壁面函数法,对燃气轮机首级静叶产生的非定常尾迹及动叶流场进行数值模拟。通过在动叶前放置直径为d=2、4、6 mm的圆柱来模拟静叶尾迹的宽度,研究不同时刻尾迹宽度对下... 详细信息

应用Standard k-=紊流模型并结合SIMPLE算法,近壁区流动的处理采用壁面函数法,对燃气轮机首级静叶产生的非定常尾迹及动叶流场进行数值模拟。通过在动叶前放置直径为d=2、4、6 mm的圆柱来模拟静叶尾迹的宽度,研究不同时刻尾迹宽度对下游动叶传热特性的影响。结果表明:静叶产生的尾迹对下游动叶压力面与吸力面的速度影响呈现周期性变化,圆柱尾迹产生的速度亏损,使主流的流速降低,压力面低速回流区在1/4T时刻达到最大。低吹风比M=0.5时,尾迹宽度增大(d=4 mm)能使压力面传热增强,而吸力面的传热变化很小,但过高的尾迹宽度(d=6 mm)将会同时降低压力面和吸力面的努赛尔数。高吹风比M=1.5时,随着尾迹宽度增大,压力面和吸力面的传热均增强,在d=6 mm时努赛尔数达到最大。

关键词：非定常尾迹尾迹宽度传热努赛尔数动叶数值模拟

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数值模拟方法在农业气象学实验教学中的应用

实验技术与管理 2023年第10期40卷 193-198页

作者：李成钟磊徐建祥扬州大学植物保护学院江苏扬州225009

该文以潜在蒸散实验为例,将目前国际上主流的15种潜在蒸散估算模型进行集成,形成了可视化估算软件(MEPET),实现了对潜在蒸散量的多模型集成模拟。教学效果表明,MEPET模拟软件凭借其可视化的结果输出,能够用于比较不同数值模型对潜在蒸... 详细信息

该文以潜在蒸散实验为例,将目前国际上主流的15种潜在蒸散估算模型进行集成,形成了可视化估算软件(MEPET),实现了对潜在蒸散量的多模型集成模拟。教学效果表明,MEPET模拟软件凭借其可视化的结果输出,能够用于比较不同数值模型对潜在蒸散量的模拟效果,并揭示潜在蒸散量对气象要素变化的响应特征,弥补了传统实验教学的不足,有利于培养学生的自主探究能力,有利于提高农业气象学实验教学的质量与效率。

关键词：农业气象学潜在蒸散数值模拟实验教学

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杠杆率对区域性金融风险的影响研究——基于中国省级数据的分析

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新金融 2021年第8期 11-19页

作者：贾松波周兵徐健翔河南财经政法大学金融学院交通银行私人银行部中南财经政法大学金融学院

为应对2008年次贷危机,我国采用宽松政策刺激经济。在经济复苏的同时,各部门杠杆率的较大攀升和整体杠杆率水平的上升,极大地影响了我国系统性区域性金融风险,结构性去杠杆成为国家应对金融风险的重要手段。通常认为,快速上升的区域杠... 详细信息

为应对2008年次贷危机,我国采用宽松政策刺激经济。在经济复苏的同时,各部门杠杆率的较大攀升和整体杠杆率水平的上升,极大地影响了我国系统性区域性金融风险,结构性去杠杆成为国家应对金融风险的重要手段。通常认为,快速上升的区域杠杆率往往会带来较大的区域性金融风险,但通过选取我国2006-2018年31个省市数据,研究发现:区域杠杆率的上升会显著增大区域性金融风险,然而这一影响作用受制于区域经济增长水平的高低,当区域经济增长水平较低时,区域杠杆率的增加会提升区域性金融风险,而当区域经济增长水平较高时,区域杠杆率的增加反而可以对区域性金融风险起到一定的缓释作用;进一步研究发现,区域实体经济部门杠杆率对区域性金融风险的影响能够通过区域金融部门杠杆率进行传导。因此,应结合不同地区的经济增长水平,建立差异化的区域杠杆率预警体系,并加强对区域金融部门的重点监管,从而有效防范化解区域性金融风险。

关键词：杠杆率经济增长区域性金融风险杠杆率传导机制