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Aggregate 2024年第1期5卷 436-450页

作者： Lianxue Zhang jianxiang huang Damiano Buratto Panli Han Zaixing Yang Ruhong Zhou Institute of Quantitative Biology Shanghai Institute for Advanced StudyCollege of Life SciencesZhejiang UniversityHangzhouChina State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversitySuzhouChina Cancer Center Zhejiang UniversityHangzhouChina Department of Chemistry Columbia UniversityNew YorkNew YorkUSA

The efficacy of nanoparticle(NP)-based drug delivery technology is hampered by aberrant tumor stromal microenvironments(TSMs)that hinder NP transportation.Therefore,the promotion of NP permeation into deep tumor sites via the regulation of tumor microenvironments is of critical importance.Herein,we propose a potential solution using a dihydralazine(HDZ)-loaded nanoparticle drug delivery system containing a pH-responsive,cyclic RGD peptide-modified prodrug based on doxorubicin(cRGD-Dex-DOX).With a combined experimental and theoretical approach,we find that the designed NP system can recognize the acid tumor environments and precisely release the encapsulated HDZ into tumor tissues.HDZ can notably downregulate the expression levels of hypoxia-inducible factor 1α(HIF1α),α-smooth muscle actin,and fibronectin through the dilation of tumor blood vessels.These changes in the TSMs enhance the enrichment and penetration of NPs and also unexpectedly promote the infiltration of activated T cells into tumors,suggesting that such a system may offer an effective“multifunctional therapy”through both improving the chemotherapeutic effect and enhancing the immune response to tumors.In vivo experiments on 4T1 breast cancer bearing mice indeed validate that this therapy has the most outstanding antitumor effects over all the other tested control regimens,with the lowest side effects as well.

关键词： antitumor dihydralazine drug delivery system tumor stromal microenvironment vasculature

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Recent Advances in Fault Diagnosis Techniques for Photovoltaic Systems:a Critical Review

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Protection and Control of Modern Power Systems 2024年第3期9卷 36-59页

作者： Bo Yang Ruyi Zheng Yiming Han jianxiang huang Miwei Li Hongchun Shu Shi Su Zhengxun Guo the School of Electrical Engineering Kunming University of Science and TechnologyKunmingChina Kunming University of Science and Technology KunmingChina the School of Faculty of Electric Power Engineering Kunming University of Science and TechnologyKunming 650500China the Kunming Bureau of CSG EHV Transmission Company KunmingChina the Power Science Research Institute of Yunnan Power Grid Co. LtdKunmingChina

If a failure in the components of a photovoltaic(PV)system,such as PV module,controller,inverter,load,cable,etc.goes undetected and uncorrected,it can seriously affect the efficiency,safety,and reliability of the entire PV power plant.In addition,fires can occur if specific faults,such as arc,ground,and line-to-line faults remain unresolved.Therefore,PV system(PVS)fault diagnoses are crucial for PV power plant reliability,efficiency,and safety.Many fault diagnosis methods and techniques for PVS components have been developed.In addition,with the development of PV devices,more advanced and intelligent diagnostic technologies are continuously being researched and developed.However,a systematic and thorough analysis,summary,and conclusion are still urgently required.Thus,this paper introduces the types,causes,and impacts of PVS faults,and reviews and discusses the methods proposed in the literature for PVS fault diagnosis,and in particular,failures in PV arrays.Special attention is paid to the optimization direction of various fault diagnosis methods under different priorities,and their limitations,feasibility,complexity,and cost-effectiveness.Finally,challenges and suggestions are put forward for future research.

关键词： PVS monitoring system PV fault types PV diagnosis review.

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Probing the electrostatic aggregation of nanoparticles with oppositely charged molecular ions

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聚集体(英文) 2023年第4期4卷 185-194页

作者： jianxiang huang Damiano Buratto Ruhong Zhou Institute of Quantitative Biology College of Life SciencesHangzhouChina Department of Chemistry Columbia UniversityNew YorkNew YorkUSA

The co-assembly of charged nanoparticles with oppositely charged molecular ions has emerged as a promising technique in the fabrication of nanoparticle superstructures.However,the underlying mechanism behind these molecular ions in mediating the repulsion between these charged nanoparticles remains elusive.Herein,coarsegrained molecular dynamics simulations are used to elucidate the effects of valency,shape,and size of molecular anions on their co-assembly with gold nanoparticles coated with positively charged ligands.The findings suggest that the valency,shape,and size of molecular anions significantly influence the repulsion and aggregating dynamics among these positively charged nanoparticles.Moreover,the free energy calculations reveal that ring-shaped molecular anions with higher valences and larger sizes are more effective at reducing the repulsion between these gold nanoparticles and thus enhance the stability of the aggregate.This study contributes to a better understanding of the critical roles of valence,shape,and size of ions in mediating the electrostatic co-assembly of nanoparticles with oppositely charged ions,and it also guides the future design of DNA templates and DNA origami in co-assembly with oppositely charged nanoparticles.

关键词： aggregation coarse-grained molecular dynamics simulation co-assembly electrostatic interaction nanoparticle

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Temporal-spatial analysis of cyromazine in cowpea using liquid chromatography–mass spectrometry coupled with mass spectrometry imaging

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Food Quality and Safety 2023年第3期7卷 466-473页

作者： Xuemei Tang Congling huang jianxiang huang Jiale Wang Zhiting Chen Yan Chen Zemiao Xiao Kai Wan Institute of Quality Standard and Monitoring Technology for Agro-Products of Guangdong Academy of Agricultural Sciences Key Laboratory of Testing and Evaluation for Agro-Product Safety and Quality(Guangzhou)Ministry of Agriculture and Rural AffairsNational Reference Laboratory for Agricultural Testing(Pesticide Residues)GuangzhouChina

Background:Cowpea(Vigna unguiculata L.Walp.)is an economically important crop.It is nutritious and popular with consumers.However,it has been listed as one of the agricultural products of critical concern about safety in China and cyromazine is the major risk factor.Objectives:This study analyzed the dissipation and permeation kinetics of cyromazine residue in cowpea,to offer a scientific basis for the rational use of pesticide and ensure the safety of agricultural products.Materials and methods:The dissipation and residue level of the systemic insecticide cyromazine on cowpea under field and stored conditions were investigated.Subsequently,the spatial distribution of cyromazine was studied using mass spectrometry imaging to visualize the dynamic processes of permeation and migration in the tissues post pesticide application.Results:The dissipation processing of cyromazine in cowpea was shown to follow the first-order kinetics and half-life was 7.76 d in the field.In cowpea,the permeation and migration rate of cyromazine was faster than that in kidney beans and accumulation was mainly in the pulp.It is not safe to apply cyromazine to cowpeas with reference to the application method on kidney beans.Conclusions:These findings present vital data for the determination of risks linked with cowpea consumption and pesticide intake.

关键词： Cyromazine cowpea mass spectrometry imaging pesticide residue

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Experimental Synthesis of Polyacrylic-Type Superabsorbent Polymer and Analysis of Its Internal Curing Performances

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Fluid Dynamics & Materials Processing 2022年第1期18卷 15-27页

作者： Jin Yang Wen Liang Xingyang He Ying Su Fulong Wang Tie Wang jianxiang huang School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China Building Waterproof Engineering and Technology Research Center of Hubei Province Hubei University of TechnologyWuhan430068China

A solution polymerization method has been used to synthesize a polyacrylic-type superabsorbent polymer(SAP).The influence of various influential factors,such as the temperature,neutralization degree,cross-linking agent,and initiator,on the water absorption capacity of SAP has been investigated.The results show that the absorption can display a non-monotonic behavior depending on the synthesis conditions.The absorption can also change according to the pH,ion types and ion concentration.As the pH value increases,the water absorption capacity decreases significantly.It also decreases if the N^(a+)concentration becomes higher and becomes particularly low in solutions containing Mg^(2+).With the addition of SAP,the compressive strength of cement mortar decreases;the internal relative humidity can be maintained at 96%within 200 hours;and autogenous shrinkage can be reduced by nearly 69%.

关键词： Superabsorbent polymer synthesis internal relative humidity internal curing

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Ultralong excimer phosphorescence by the self-assembly and confinement of terpyridine derivatives in polymeric matrices

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聚集体(英文) 2023年第4期4卷 230-238页

作者： Guangqiang Yin Wei Lu jianxiang huang Rui Li Depeng Liu Longqiang Li Ruhong Zhou Guifei Huo Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina School of Chemical Sciences University of Chinese Academy of SciencesBeijingChina Institute of Quantitative Biology College of Life SciencesZhejiang UniversityHangzhouChina Department of Chemistry National University of SingaporeSingaporeSingapore

Ultralong organic room temperature phosphorescence(RTP)is attracting increas-ing attention due to its fascinating optical phenomena and wide applications.Among various RTP,excimer phosphorescence is of fundamental significance,but it remains a considerable challenge to achieveflexible,multicolor and large-area excimer RTP materials,which should greatly advance the understanding and devel-opment of organic light-emitting devices.Herein,we present ultralong excimer RTPfilms by the self-assembly and confinement of terpyridine(Tpy)derivatives in polymeric matrices.Strikingly,the self-assembly of Tpy derivatives induces the formation of excimer complexes,thus immensely minimizing singlet-triplet split-ting energy(ΔEST)to promote the intersystem crossing process.Furthermore,the confinement by multiple hydrogen bonding interactions as well as the compact aggregation of phosphors jointly suppresses the nonradiative transitions,leading to long-lived excimer RTP(τ543.9 ms,19,000-fold improvements over the pow-=der).On account of the outstanding afterglow performance and color-tunability of RTP materials,flexible and large-areafilms were fabricated for intelligent display,anticounterfeiting,and time-resolved information encryption.

关键词： aggregation excimer information encryption room temperature phosphorescence terpyridine

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Mechanochemical transformation of fluorescent hydrogel based on dynamic lanthanide-terpyridine coordination

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Chinese Chemical Letters 2023年第3期34卷 430-433页

作者： Guangqiang Yin jianxiang huang Depeng Liu Rui Li Shuxin Wei Muqing Si Feng Ni Yinfei Zheng Qiu Yang Ruhong Zhou Xiaoxia Le Wei Lu Tao Chen Key Laboratory for Biomedical Engineering of Ministry of Education Ministry of China College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou 310027China Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Quantitative Biology Zhejiang UniversityHangzhou 310027China Research Center for Intelligent Sensing Zhejiang LabHangzhou 311100China Ningbo New Material Testing and Evaluation Center Co. Ltd.Ningbo 315000China

As a burgeoning research field, ultrasound-responsive materials have attracted intense interest in healthcare research. However, the basic mechanism of sonochemical effect in the quasi-solid state is far from being well understood than those in the solution. Herein, we showcase mechanochemical transformations of europium(Ⅲ) complexes in a supramolecular hydrogel matrix. With the combination of labile terpyridine-europium complexes(TPY-Eu^(3+)) as mechanochromic moieties and an ultrasound-responsive fluorogen(URF) as a molecular tweezer, the hydrogel produces a notable fluorescence change in response to ultrasound. The mechanochemical transformation was elucidated by molecular dynamics(MD) simulations, and fully probed and evidenced by electrochemical experiments, X-ray photoelectron spectroscopy(XPS), and attenuated total reflectance-Fourier transform infrared(ATR-FTIR) spectroscopy.

关键词： Supramolecular hydrogel Ultrasound-responsive Mechanochemical transformation Terpyridine-europium coordination Dynamic interaction

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冠心病合并高血压患者降脂治疗现状及LDL-C达标的关联因素分析

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中华全科医师杂志 2024年第6期23卷 625-632页

作者：冯泽锟汪驰田露李雁洁兰丽花黄健翔葛振薛浩辛倩解放军总医院第六医学中心心血管病医学部北京100037 南开大学医学院天津300071

目的:调查冠心病合并高血压患者降脂治疗现状,并探讨低密度脂蛋白胆固醇(LDL-C)达标的关联因素。方法:该研究为横断面研究。纳入2008年8月5日至2018年7月22日解放军总医院心内科住院的冠心病合并高血压患者,根据LDL-C是否达标,分为达标... 详细信息

目的:调查冠心病合并高血压患者降脂治疗现状,并探讨低密度脂蛋白胆固醇(LDL-C)达标的关联因素。方法:该研究为横断面研究。纳入2008年8月5日至2018年7月22日解放军总医院心内科住院的冠心病合并高血压患者,根据LDL-C是否达标,分为达标组和未达标组。研究数据来自解放军总医院心内科住院患者冠状动脉造影记录和电子病历数据库,多次住院的患者使用首次诊断为冠心病时的数据。收集入选患者的临床资料。采用多因素logistic回归模型分析冠心病合并高血压患者LDL-C达标的关联因素。结果:共入选患者18800例,来自我国31个省/自治区/直辖市,其中北京占比最高[5692例(30.28%)],其次为河北[3621例(19.26%)]、河南[1837例(9.77%)]、山东[1618(8.61%)]等。入选患者中,LDL-C<1.4 mmol/L者1493例(达标组),LDL-C≥1.4 mmol/L者17307例(未达标组)。入选患者中仅1493例(7.94%)LDL-C达标。LDL-C为1.4~<2.0、2.0~<2.5、2.5~<3.8和≥3.8 mmol/L的患者分别4518例(24.03%)、4366例(23.22%)、6924例(36.83%)和1499例(7.97%)。17885例(95.13%)患者已使用他汀类药物进行治疗,但联合应用他汀类药物和依折麦布降脂治疗者仅1334例(7.10%)。入选患者中心血管事件低危者4986例(26.52%)、中危者6515例(34.65%)、高危者7299例(38.82%)。中、高危患者中应用他汀类药物联合依折麦布进行降脂治疗者分别占7.43%(484/6515)、7.48%(546/7299)。多因素logistic回归分析结果显示年龄增大、男性、合并糖尿病、合并卒中、经皮冠状动脉介入治疗史与冠心病合并高血压患者LDL-C达标呈正向关联,而肥胖和急性心肌梗死则呈负向关联(均P<0.01)。结论:我国冠心病合并高血压患者LDL-C达标率较低,尽管大多数患者已接受了他汀类药物治疗,但联合接受依折麦布治疗者比例极低,在我国冠心病合并高血压患者中再发心血管事件中、高危患者的比例较高,而此类患者接受他汀类药物联合依折麦布进行降脂治疗的比例较低。本研究结果还显示年龄增大、男性以及合并糖尿病、卒中、经皮冠状动脉介入治疗史与冠心病合并高血压患者LDL-C达标呈独立正向关联,肥胖和急性心肌梗死则呈独立负向关联。

关键词：冠心病高血压胆固醇 LDL 降脂治疗

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不同无机增稠剂对3D打印水泥基材料性能的影响

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硅酸盐通报 2024年第5期43卷 1642-1650页

作者：马逍遥蹇守卫李宝栋黄健翔高欣薛文浩汪才峰武汉理工大学硅酸盐建筑材料国家重点实验室武汉430070

3D打印水泥基材料的工作性能是影响其最终状态的决定性因素,现有技术多采用有机增稠剂调节其工作性能,但存在强度下降、成本较高等问题。本文选用凹凸棒土、硅藻土和钠基膨润土三种无机增稠剂,研究了在不同增稠剂掺量下3D打印水泥基材... 详细信息

3D打印水泥基材料的工作性能是影响其最终状态的决定性因素,现有技术多采用有机增稠剂调节其工作性能,但存在强度下降、成本较高等问题。本文选用凹凸棒土、硅藻土和钠基膨润土三种无机增稠剂,研究了在不同增稠剂掺量下3D打印水泥基材料的工作性能和力学性能。结果表明,3D打印水泥基材料的工作性能会随着无机增稠剂掺量的增加而改善,凹凸棒土和硅藻土最佳掺量为2.5%(质量分数),钠基膨润土最佳掺量为1.0%(质量分数),其中钠基膨润土的改善效果最好。不同无机增稠剂对3D打印水泥基材料的力学性能会产生不同的影响,高掺量(2.5%)的凹凸棒土对3D打印水泥基材料的强度无不利影响,硅藻土能增强3D打印水泥基材料的后期强度,少量钠基膨润土就能显著提高3D打印水泥基材料的整体强度。掺1.0%钠基膨润土的3D打印水泥基材料具有最优的综合性能。

关键词： 3D打印无机增稠剂硫铝酸盐水泥流变性能可堆叠性力学性能

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凹凸棒土对石膏3D打印材料基本性能和可打印性能的影响

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硅酸盐通报 2024年第5期43卷 1748-1755页

作者：汪才峰蹇守卫李宝栋黄健翔高欣马逍遥薛文浩武汉理工大学硅酸盐建筑材料国家重点实验室武汉430070

增稠剂是3D打印材料的关键组分,但常用的增稠剂以有机物为主,会降低石膏的力学性能。为此,本文选取了凹凸棒土与羟丙基甲基纤维素醚作对比,测试了凹凸棒土对石膏3D打印材料工作性能、力学性能以及实际打印性能的影响。结果表明:与羟丙... 详细信息

增稠剂是3D打印材料的关键组分,但常用的增稠剂以有机物为主,会降低石膏的力学性能。为此,本文选取了凹凸棒土与羟丙基甲基纤维素醚作对比,测试了凹凸棒土对石膏3D打印材料工作性能、力学性能以及实际打印性能的影响。结果表明:与羟丙基甲基纤维素醚相似,凹凸棒土降低了石膏3D打印材料的流动度,增加了动态屈服应力;随凹凸棒土掺量增加,材料抗折抗压强度先降低后增加,而羟丙基甲基纤维素醚组抗折、抗压强度则呈下降趋势;在实际打印中,凹凸棒土组体积稳定性和开放时间结果与羟丙基甲基纤维素醚组相似,实际打印强度高于羟丙基甲基纤维素醚组23%以上。羟丙基甲基纤维素醚通过吸水溶胀、分子缠绕来提高浆体的黏度,而凹凸棒土具有丰富的孔结构,在浆体中以氢键和范德瓦耳斯力吸附水分子和增稠石膏颗粒。

关键词：高强石膏 3D打印无机增稠剂凹凸棒土工作性能可打印性

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