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BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules

Cancer Biology & Medicine 2019年第1期16卷 131-138页

作者： Ya Wu Ting Xu Xingyue cao Xin Zhao Hongyan Deng jianxiang Wang Xiao Li Qing Yao Xinhua Ye Meiping Shen Xiaohong Wu Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University Department of Endocrinology Jiangsu Province Official Hospital Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University Department of Pathology The First Affiliated Hospital of Nanjing Medical University Department of General Surgery The First Affiliated Hospital of Nanjing Medical University

Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V ***: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound ***: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules.

关键词： Papillary thyroid carcinoma fine-needle aspiration cytology(FNAC) BRAFV600E thyroid imaging reporting and data system(TIRADS) Bethesda classification

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Blood pressure,body mass index lowering and ketogenesis in Qigong Bigu

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Acta Epileptologica 2021年第1期3卷 172-178页

作者： Bin Hong Runqi Luo Dezhi cao Man Zhang Kewei Fang Jianhong Guo jianxiang Liao Bijie Second People’s Hospital Bijie 551700Guizhou ProvinceChina Shenzhen Children’s Hospital Shenzhen 518038Guangdong ProvinceChina School of Traditional Chinese Medicine Ningxia Medical UniversityYinchuan 750021Ningxia Hui Autonomous RegionChina

Background:Hypertension is one of the most common comorbid conditions of *** and epilepsy may be related to each *** Bigu practice induces a similar effect as fasting in the first *** ketogenesis is induced during ketogenic diet therapy,we hypothesize that ketogenesis is detectable and related body weight loss would occur during the first week of Qigong Bigu ***:During the prospective observational study,34 healthy adult participants attended the Qigong Bigu practice for one *** blood pressure,body weight,calorie consumption,blood glucose and beta-hydroxybutyrate level were ***:The body weight and body mass index decreased by 2.39±1.34 kg(95%CI 1.92–2.85)and 0.94±0.57(95%CI 0.73–1.15),respectively,after five days of practice(P<0.001).The systolic and diastolic blood pressure decreased by 17.86±14.17 mmHg(95%CI 12.36–23.35)and 9.75±7.45 mmHg(95%CI 6.86–12.64),respectively(P<0.001).The average five-day calorie consumption was 1197.47±569.97 kcal(95%CI 998.60–1396.35).Meanwhile,no symptomatic hypoglycemia or other significant side effects were *** blood beta-hydroxybutyrate level increased to a nutritional level of 1.15±1.12 mmol/L(95%CI 0.76–1.62).The calorie consumption negatively correlated to the beta-hydroxybutyrate level in the *** loss of body weight and the decrease of body mass index were positively correlated to the blood beta-hydroxybutyrate ***:Qigong Bigu can decrease the blood pressure,the body weight and the body mass index in healthy adult *** fasting stage of Qigong Bigu is accompanied by *** trial of Qigong Bigu in hypertension and epilepsy patients might be *** blood beta-hydroxybutyrate might be used as a biomarker to evaluate the effect of Qigong Bigu practice during fasting.

关键词： Blood pressure Body weight Body mass index Epilepsy Ketogenic diet Qigong Bigu Fasting Comorbidity Hypertension Pigu

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Anti-NMDAR encephalitis with seizure-like activity and hemiplegia-a case report and literature review

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Acta Epileptologica 2022年第4期5卷 263-267页

作者： Junjie Hu Cailei Zhao Xia Zhao Yu Fang Huiting Zhang Dezhi cao jianxiang Liao Shenzhen Children’s Hospital Medical College of Shantou UniversityShenzhenChina Imaging department Shenzhen Children’s HospitalShenzhenChina Neurology department Shenzhen Children’s HospitalShenzhenChina Shenzhen Children’s Hospital China Medical UniversityShenzhenChina

Background Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis accounts for the vast majority of cases of autoimmune *** common clinical symptoms are psychiatric symptoms,behavioral dysfunction,seizures,speech impairment,cognitive impairment,movement disorders,decreased consciousness,and autonomic *** report was aimed to provide evidence for anti-NMDAR encephalitis with seizure-like activity,based on the clinical presentations,brain magnetic resonance imaging(MRI),and electroencephalogram(EEG)*** presentation We report a 11-year-old girl who suffered epigastric pain after vigorous physical *** felt weakness of the *** had syncope only once and urinary incontinence on the way to the hospital and vomited at the *** entire procedure lasted approximately 15 *** next night she had recurrent headache attacks along with irritability,like someone“tapping”to the right occipital *** experienced numbness in the left upper limbs and shallowing of the frontal lines on the left *** monitoring showed normal findings,but brain MRI,EEG recording,and cerebrospinal fluid(CSF)antibody testing showed abnormal *** patient was finally diagnosed with anti-NMDAR *** treatment with glucocorticoids and acyclovir,she fully recovered and was discharged from the *** Although the patient presented with pain and impaired limb movements,she did not have respiratory or(and)circulatory failure,and the symptoms entirely *** accurate diagnosis and timely treatment are essential for patients with anti-NMDAR encephalitis.

关键词： Autoimmune encephalitis Anti-N-methyl-D aspartate receptor encephalitis Syncope Hemiplegia

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Successful medical treatment of west syndrome with a KCNA2 variant: a case report

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Acta Epileptologica 2022年第1期5卷 62-70页

作者： Han Wang Yanwei Zhu Dezhi cao Hong Chen Xin Ding Qi Zeng Huafang Zou jianxiang Liao Neurology Department Shenzhen Children’s Hospital affiliated to China Medical UniversityShenzhen 518038China

Background:West syndrome is a devastating disorder characterized by a triad of epileptic spasms,abnormal electroencephalography(EEG),and developmental arrest or psychomotor *** addition to early diagnosis,knowing the etiology of the condition is also important for its *** various etiologies,the genetic factors,especially mutations of ion channel genes,are very common and strongly linked to West *** presentation:A boy who had epileptic spasms from the age of 4 months was diagnosed with West syndrome based on the clinical manifestation and EEG results in Shenzhen Children's Hospital in June *** whole-exome sequencing(WES)test and protein structural model prediction were *** also reviewed the clinical and genetic features of this syndrome and the mechanisms of action of topiramate(TPM)by literature search in databases of Online Mendelian Inheritance in Man,Clinical Genome Resource,PubMed,Chinese National Knowledge Infrastructure and Wanfang database using keywords"KCNA2""West syndrome"and"Topiramate"by December *** relationship between the effect of TPM and the pathogenesis of the KCNA2 variant was also *** WES test revealed c.244C>T/***82Cys varaint of KCNA2(NM_004974.3)in this patient,and Sanger sequencing identified this was a de novo *** far as we know,this is the first report of the C.244C>T/***82Cys variant in KCNA2,which was likely a pathogenic *** seizures were successfully controlled for 10 months by TPM after failure of sodium valproate,large doses of vitamin B6,and adrenocorticotropic *** speculate that the therapeutic effect of TPM in this patient is partially due to the inhibition of carbonic ***:Mutations in the KCNA2 gene should be considered for patients with West *** TPM treatment is probably effective for KCNA2-associated disorders.

关键词： Epilepsy Gene variation KCNA2 West syndrome Topiramate

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Chinese expert recommendations on ketogenic diet therapy for super-refractory status epilepticus

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Acta Epileptologica 2022年第1期5卷 5-15页

作者： Xin Tong Qianyun Cai Dezhi cao Lifei Yu Dan Sun Guang Yang Jiwen Wang Hua Li Zengning Li Juan Wang Shaoping Huang Meiping Ding Fang Fang Qun Wang Rong Luo jianxiang Liao Jiong Qin Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Neurology Shenzhen Children's HospitalShenzhen 518035China Department of Neurology Children’s Hospital of Fudan UniversityShanghai 200032China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100036China Department of Neurology Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghai 200127China Epilepsy Center Guangdong 999 Brain HospitalGuangzhou 510510China Department of Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Neurology Children's Hospital of Chongqing Medical UniversityChongqing 401122China Department of Pediatrics The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004China Department of Neurology Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Depart-ment of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Pediatrics Peking University People's HospitalBeijing 100044China

Super-refractory status epilepticus(SRSE)is a serious and life-threatening neurological *** diet(KD)is a diet characterized by high fat,low carbohydrate,and moderate *** KD shows effectiveness in controlling seizures in more than half of SRSE patients,it can be a treatment option for ***,KD treatment for SRSE is based on personal experience and observational evidence has been *** the context of a lack of a validated guideline,we convened a multicenter expert panel within the China Association Against Epilepsy(CAAE)Ketogenic Diet Commission to work out the Chinese expert recommendations on KD for *** summarize and discuss the latest clinical practice of KD for SRSE in critical care *** are given on patient selection,the timing of KD,diet implementation,and *** research data are needed in this area to support better clinical practice.

关键词： Super-refractory status epilepticus Ketogenic diet Intensive care units Consensus China

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头皮高频脑电图的临床应用

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中华实用儿科临床杂志 2015年第12期30卷 892-894页

作者：操德智廖建湘深圳市儿童医院神经内科 518038

随着癫癎手术的不断普及,脑电图记录技术的不断改进,高频振荡越来越被人重视,特别是在致癎灶的定位、术后疗效评估方面的研究越来越深入.虽然绝大多数研究均采用颅内电极记录,但近几年,有学者发现头皮脑电图也可以清楚地记录高频振荡.... 详细信息

随着癫癎手术的不断普及,脑电图记录技术的不断改进,高频振荡越来越被人重视,特别是在致癎灶的定位、术后疗效评估方面的研究越来越深入.虽然绝大多数研究均采用颅内电极记录,但近几年,有学者发现头皮脑电图也可以清楚地记录高频振荡.头皮高频脑电图无疑给研究这种特殊的脑电活动提供了一种更加安全、无创而简便的方法.现就头皮高频脑电图在临床上的应用以及目前所存在的问题进行阐述.

关键词：头皮高频脑电图高频振荡临床应用

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杨梅侧生器官边界域基因组鉴定及进化分析

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森林与环境学报 2021年第2期41卷 172-179页

作者：梁健翔吴进樟张尧曹世江福建农林大学林学院福建福州350002

为探究杨梅侧生器官边界域基因(LBD)在杨梅全基因组中的数量和结构,利用杨梅最新基因组的数据,结合生物信息学的方法对基因蛋白进行结构、系统进化和共线性分析,对杨梅LBD基因家族进行了鉴定,并分析其分子质量和等电点,为今后研究LBD基... 详细信息

为探究杨梅侧生器官边界域基因(LBD)在杨梅全基因组中的数量和结构,利用杨梅最新基因组的数据,结合生物信息学的方法对基因蛋白进行结构、系统进化和共线性分析,对杨梅LBD基因家族进行了鉴定,并分析其分子质量和等电点,为今后研究LBD基因家族在杨梅成长过程和逆境调节中的详细功能奠定基础。结果表明,从杨梅基因组中共鉴定出33个杨梅LBD(MrLBD)基因,根据染色体分布对其进行重命名。根据其LBD结构域和系统进化树分析的特征,杨梅LBD家族基因分为ClassⅠ和ClassⅡ两类,各有28个和5个LBD基因。杨梅LBD家族基因的结构并不复杂,其中内含子总数不超过2。在对保守域的研究中,通过对LBD基因进行亚细胞定位、三级结构的同源建模和种内与种间共线性分析,发现同一组的基因往往具有相似的外显子-内含子、基序和蛋白质结构。

关键词：杨梅侧生器官边界域基因组系统进化分析转录因子生物信息学

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基于FDS的变压器油浸纸老化程度与水分含量评估方法

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电力自动化设备 2017年第1期37卷 217-223页

作者：黎成林曹保江孙健翔雷帆吴广宁高波西南交通大学电气工程学院四川成都610031

搭建了频域介电谱(FDS)技术测试试验平台,测试了不同老化程度和不同水分含量油浸纸样品的复介电常数,并对测试结果进行对比分析。分析结果表明:绝缘纸聚合度的降低使油浸纸样品的复介电常数实部和虚部在低频段增大,而在高频段基本不变;... 详细信息

搭建了频域介电谱(FDS)技术测试试验平台,测试了不同老化程度和不同水分含量油浸纸样品的复介电常数,并对测试结果进行对比分析。分析结果表明:绝缘纸聚合度的降低使油浸纸样品的复介电常数实部和虚部在低频段增大,而在高频段基本不变;绝缘纸水分含量的增加使油浸纸样品的复介电常数实部在10~2 Hz以下的频域范围内增大,虚部在整个测试频域范围内增大,且虚部曲线随水分含量的增大呈现向右平移趋势。提出利用复介电常数虚部的等效下降幅度作为绝缘纸聚合度映射特征量,以此评估油浸纸的老化状态。拟合出特征频率10^(-4) Hz处复介电常数实部与水分含量的关系式,以此提出一种适用于不同老化程度和油浸纸水分含量的频域介电特征量评估方法。

关键词：变压器油纸绝缘材料老化 FDS 聚合度水分等效下降幅度

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工业加氢裂化反应器模型的建立

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石油学报（石油加工） 2010年第6期26卷 966-971页

作者：卢建翔周华师佳江青茵曹志凯厦门大学化学化工学院福建厦门361005

以某工业加氢裂化反应器装置为研究对象,根据物料平衡、能量平衡和反应动力学方程,建立了加氢裂化反应器的数学模型,并根据工业数据,采用遗传算法对模型中的参数进行了拟合,还以不同的工业数据对模型进行了验证。结果表明,所建立的模型... 详细信息

以某工业加氢裂化反应器装置为研究对象,根据物料平衡、能量平衡和反应动力学方程,建立了加氢裂化反应器的数学模型,并根据工业数据,采用遗传算法对模型中的参数进行了拟合,还以不同的工业数据对模型进行了验证。结果表明,所建立的模型能够较好反映加氢裂化装置性能,且能较好地预测加氢裂化主要产品的收率分布及反应器的温度分布。

关键词：加氢裂化参数估计遗传算法建模

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高通量测序技术诊断婴幼儿广州管圆线虫嗜酸性脑膜脑炎2例

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中华实用儿科临床杂志 2021年第10期36卷 781-783页

作者：陈鸿丁鑫代渝曹雪艳邹华芳廖建湘操德智汕头大学医学院附属深圳市儿童医院神经内科广东深圳518038

婴幼儿患广州管圆线虫嗜酸性脑膜脑炎(AEM)虽然罕见,但能造成严重后果,通过对2019年深圳市儿童医院神经内科收治的2例AEM患儿(<2岁)进行病例分析,探讨高通量测序对AEM的诊断价值。例1主要表现为间断发热、呕吐、精神差、前囟隆起。例2... 详细信息

婴幼儿患广州管圆线虫嗜酸性脑膜脑炎(AEM)虽然罕见,但能造成严重后果,通过对2019年深圳市儿童医院神经内科收治的2例AEM患儿(<2岁)进行病例分析,探讨高通量测序对AEM的诊断价值。例1主要表现为间断发热、呕吐、精神差、前囟隆起。例2主要表现为间断发热、咳嗽、呕吐、抽搐。结合患儿外周血及脑脊液嗜酸性粒细胞增多,以及广州管圆线虫高通量测序及抗体检测阳性,最终确诊AEM。予阿苯达唑驱虫、小剂量泼尼松预防炎症反应后病情好转。婴幼儿AEM的临床特征不典型,高通量测序技术可协助诊断AEM。

关键词：广州管圆线虫嗜酸性脑膜脑炎高通量测序技术诊断儿童

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