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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 354-364页

作者： Hao Zhang jianwen sun Zhuping Wang Department of Control Science and Engineering Tongji UniversityShanghai 201804China

This paper studies the fully distributed formation control problem of multi-robot systems without global position measurements subject to unknown longitudinal slippage *** is difficult for robots to obtain accurate and stable global position information in many cases,such as when indoors,tunnels and any other environments where GPS(global positioning system)is denied,thus it is meaningful to overcome the dependence on global position ***,unknown slippage,which is hard to avoid for wheeled robots due to the existence of ice,sand,or muddy roads,can not only affect the control performance of wheeled robot,but also limits the application scene of wheeled mobile *** solve both problems,a fully distributed finite time state observer which does not require any global position information is proposed,such that each follower robot can estimate the leader’s states within finite *** distributed adaptive controllers are further designed for each follower robot such that the desired formation can be achieved while overcoming the effect of unknown ***,the effectiveness of the proposed observer and control laws are verified by simulation results.

关键词： Adaptive control distributed formation control finite-time observer multi-robot systems slippage

Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1377-1389页

作者： Fangyu Du Ruolin Cao Lu Chen jianwen sun Yajie Shi Yang Fu Bruce D.Hammock Zhonghui Zheng Zhongbo Liu Guoliang Chen Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center University of California DavisDavisCA 95616USA Shandong Xinhua Pharmaceutical Co. Ltd.Zibo 2550S6China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Soluble epoxide hydrolase(sEH) is related to arachidonic acid cascade and is over-expressed in a variety of diseases, making sEH an attractive target for the treatment of pain as well as inflammatory-related diseases. A new series of memantyl urea derivatives as potent sEH inhibitors was obtained using our previous reported compound 4 as lead compound. A preferential modification of piperidinyl to 3-carbamoyl piperidinyl was identified for this series via structure-based rational drug design. Compound A20 exhibited moderate percentage plasma protein binding(88.6%) and better metabolic stability in vitro. After oral administration, the bioavailability of A20 was 28.6%. Acute toxicity test showed that A20 was well tolerated and there was no adverse event encountered at dose of 6.0 g/kg. Inhibitor A20 also displayed robust analgesic effect in vivo and dose-dependently attenuated neuropathic pain in rat model induced by spared nerve injury, which was better than gabapentin and sEH inhibitor(±)-EC-5026. In one word, the oral administration of A20 significantly alleviated pain and improved the health status of the rats, demonstrating that A20 was a promising candidate to be further evaluated for the treatment of neuropathic pain.

关键词： Soluble epoxide hydrolase Analgesia Synthesis Neuropathic pain Inhibitor

Blind spectral deconvolution algorithm for Raman spectrum with Poisson noise

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Photonics Research 2014年第6期2卷 168-171页

作者： Hai Liu Zhaoli Zhang jianwen sun Sanya Liu National Engineering Research Center for E-Learning Central China Normal UniversityWuhan 430079China

A blind deconvolution algorithm with modified Tikhonov regularization is *** improve the spectral resolution,spectral structure information is incorporated into regularization by using the adaptive term to distinguish the spectral structure from other *** proposed algorithm can effectively suppress Poisson noise as well as preserve the spectral structure and detailed ***,it becomes more robust with the change of the regularization *** results on simulated and real degraded Raman spectra are *** recovered Raman spectra can easily extract the spectral features and interpret the unknown chemical mixture.

关键词： parameter. regularization spectral

COMET ■: “cone of experience” enhanced large multimodal model for mathematical problem generation

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Science China(Information Sciences) 2024年第12期67卷 97-98页

作者： Sannyuya LIU Jintian FENG Zongkai YANG Yawei LUO Qian WAN Xiaoxuan SHEN jianwen sun National Engineering Research Center of Educational Big Data Central China Normal University Faculty of Artificial Intelligence in Education Central China Normal University School of Software Technology Zhejiang University

The impact of generative artificial intelligence on education is unprecedented [1]. Researchers have been exploring possibilities of combining the large multimodal model(LMM)with the teaching process. Specifically, Luo and Yang [2]have explored large model collaborative domain models to support smart education, fostering personalized and adaptive educational experiences. However, existing studies still lack in-depth research on generating educational resources,especially in mathematical problem generation.

关键词： Personnel training

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Decreasing Pin1 suppresses telomerase activity by NF-κB in HCT116 cells colorectal carcinoma

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The Chinese-German Journal of Clinical Oncology 2013年第4期12卷 181-187页

作者： jianwen sun Lijun Fan Meining Li Yuehong Zhang Niuliang Cheng Department of Biochemistry and Molecular Biology Shanxi Medical University

Objective： The aim of our study was to investigate the effect of Pin 1 on the telomerase activity in human colorectal carcinoma HCT116 cells. Methods： Firstly, we transfected plasmid pGenesil-l-Pinl （p-shRNA） using liposome （Lipofectamine 2000） into colorectal cancer HCT-116 cells to down-regulate the expression of Pin1. To detect the apoptotic rate of HCT116 cells was by cytometry （FCM）. The expression of Pin1 and hTERT at RNA levels in human colorectal cancer HCT116 cells were determined by RT-PCR. To evaluate the activity of telomerase was by TRAP-silver staining. The subcellular localization and accumulative level of p-NF-κB/p65 protein at the nuclear was detected by Immunofluorescence and Western blotting. The DNA-binding activity of NF-κB/p65 was detected by electrophoretic mobility shift assay （EMSA）. Results： Using liposome into colorectal cancer HCT-116 cells, and down-regulate the expression of Pin1 （0.392 ± 0.072-fold; P = 0.001）, and the apoptotic rate was increased （11.40% ± 1.54%; P 〈 0.05）. Compared with transfected p-CON cell group, in transfected p-shRNA cell group, the transcription of hTERT was lower （0.171 ±0.060-fold; P = 0.001） by quantitative real-time RT-PCR, and the results of TRAP-silver staining analysis suggested that the telomerase activity was significantly declined （0.384 ± 0.015-fold; P 〈 0.05）. Furthermore, it was demonstrated by Immunofluorescence that p-NF-κB/p65 had a nuclear localization, and the level of p-NF-κB/p65 protein at the nuclear was reduced with silencing the expression of Pin1 by Western blotting. Using EMSA, it was suggested that NF-κB/p65 was able to bind to hTERT promoter, and the direct interaction was declined with silencing the expression of Pin1. Conclusion： Taken together, silencing Pin1 may suppress activity of telomerase and the expression of hTERT by inhibiting NF-κB/p65 activity and reducing the combination of NF-κB/p65 and hTERT gene promoter.

关键词： colonic cancer Pin1 hTERT NF-κB

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公共部门信息再利用中的信息质量问题研究

图书馆 2016年第4期 30-37页

作者：王佩孙建文吴钢武汉大学信息管理学院武汉430072 华中师范大学国家数字化学习工程技术研究中心武汉430079

公共部门信息再利用的成效受到信息质量的直接影响,通过分解公共部门信息再利用的信息增值流程,厘清信息提供方、信息中介和信息用户三类参与者不同的信息质量需求,分析公共部门信息质量的维度,并将公共部门信息再利用过程、再利用参与... 详细信息

公共部门信息再利用的成效受到信息质量的直接影响,通过分解公共部门信息再利用的信息增值流程,厘清信息提供方、信息中介和信息用户三类参与者不同的信息质量需求,分析公共部门信息质量的维度,并将公共部门信息再利用过程、再利用参与者与信息质量维度相结合,提出一套逐级递进的信息质量分级体系,达到对信息再利用各个关键环节中信息质量的控制,实现信息的有效再利用。

关键词：公共部门信息信息质量信息再利用

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基于拓扑优化的电渗流微混合器电极

光学精密工程 2023年第17期31卷 2515-2524页

作者：孙建文张健宇李博文邓永波中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049

电渗是当前芯片实验室设备中微流体常用的驱动方式之一,其中电极版图对控制电渗驱动的外电场起到关键作用。针对电渗流电极版图大多基于尺寸优化和形状优化的方法难以大幅提升微流控器件性能的问题,建立电渗流电极拓扑优化模型,采用滤... 详细信息

电渗是当前芯片实验室设备中微流体常用的驱动方式之一,其中电极版图对控制电渗驱动的外电场起到关键作用。针对电渗流电极版图大多基于尺寸优化和形状优化的方法难以大幅提升微流控器件性能的问题,建立电渗流电极拓扑优化模型,采用滤波方程和阈值投影控制电极结构的特征尺寸,通过连续伴随分析方法获得模型的伴随敏度,进而演化电极版图的结构设计变量,最终实现电渗流电极的拓扑优化。基于上述拓扑优化方法设计电渗流微混合器的电极版图,并对影响微混合器混合效果的因素进行分析。结果表明,电渗流微混合器的混合评价指数达到0.047,能够实现两种不同浓度溶液的完全混合。微混合器良好的混合性能验证了本文提出电渗流电极拓扑优化方法的有效性。

关键词：微流体拓扑优化电渗微混合器电极

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基于LaFeO3/YSZ/Pt结构的混成电势乙醇传感器研究

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传感技术学报 2019年第11期32卷 1608-1612页

作者：洪浩孙剑文吴次南刘泽文贵州大学大数据与信息工程学院贵阳550025 代尔夫特理工大学微电子系北京代尔夫特智能科技研究院北京100083 清华大学微电子研究所北京100084

制备了以掺钇氧化锆(YSZ)为固态电解质,LaFeO3为敏感电极的混成电势乙醇气体传感器。LaFeO3通过溶胶-凝胶法制备并用XRD分析。利用场发射电子扫描显微镜对YSZ基底和敏感电极表面形貌进行了表征。测试结果表明制备的传感器在350℃的工作... 详细信息

制备了以掺钇氧化锆(YSZ)为固态电解质,LaFeO3为敏感电极的混成电势乙醇气体传感器。LaFeO3通过溶胶-凝胶法制备并用XRD分析。利用场发射电子扫描显微镜对YSZ基底和敏感电极表面形貌进行了表征。测试结果表明制备的传感器在350℃的工作条件下对乙醇有良好的响应(400×10^-6乙醇时135 mV)和较快的响应时间(50×10^-6乙醇时14 s)。测试结果还表明此传感器有良好的可重复性和选择性。

关键词：气体传感器混成电势溶胶-凝胶 YSZ LaFeO3

基于双耳麦克风实现机器人骨铣削状态自动控制

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仪器仪表学报 2024年第1期45卷 259-268页

作者：孙健文王瑞夏光明代煜张建勋南开大学机器人与信息系统化研究所天津300350 天津医科大学总医院骨科天津300052

为了提升骨铣削手术机器人的手术质量,要求机器人对于手术中的铣削状态(主要包括铣削深度和铣削角度)能够实时感知并控制。针对此问题,本文提出一种利用双耳麦克风系统来辅助完成铣削状态控制的方法。首先对铣削状态与声信号的关系进行... 详细信息

为了提升骨铣削手术机器人的手术质量,要求机器人对于手术中的铣削状态(主要包括铣削深度和铣削角度)能够实时感知并控制。针对此问题,本文提出一种利用双耳麦克风系统来辅助完成铣削状态控制的方法。首先对铣削状态与声信号的关系进行建模,之后完成铣削深度与铣削角度的标定实验获得所提模型的相关系数,最后利用PD控制器结合所建立的模型函数来实时分析并控制机器人的铣削状态。实验结果表明,铣削期望深度为0.5 mm时,加入角度控制相较于未加角度控制的实验效果在铣削深度与期望值偏差的方面提升了7.0%,铣削稳定性方面提升了34.1%。并且证明在期望深度为0.8 mm的极端情况下引入角度控制同样有着提升铣削效果的积极作用。经过实验验证所提方法能够有效的提升骨铣削手术机器人的工作质量。

关键词：手术机器人骨铣削信号处理深度控制角度控制

应用聚类和证据理论实现变电站保护压板状态校核

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电网技术 2020年第6期44卷 2343-2349页

作者：梁辰孙建文王兰玉黄尊志孙庆森王磊梁伟国网山东省电力公司泰安供电公司山东省泰安市271000

针对目前人工校核保护压板效率低、图像识别易受光照条件影响的问题,提出了一种基于聚类和D-S证据理论的变电站保护压板状态校核方法。首先对压板图像进行聚类分割,按行检查压板图像像素量和边界点,重新分割异常压板。根据压板在投、退... 详细信息

针对目前人工校核保护压板效率低、图像识别易受光照条件影响的问题,提出了一种基于聚类和D-S证据理论的变电站保护压板状态校核方法。首先对压板图像进行聚类分割,按行检查压板图像像素量和边界点,重新分割异常压板。根据压板在投、退状态下的形态特征,构造压板状态指标作为证据,分析了光照、透视变形因素对压板识别的影响。最后,将多个状态指标依据证据理论进行融合,减少个体指标的不确定性影响。结果表明,所提方法在光照条件不良情况下仍能正确识别压板状态,性能优于单一判据及多判据表决方法。

关键词：保护压板形态特征图像识别聚类证据理论

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