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2012中国器官移植大会

作者： jianwen jiang,zhigang ren,xinhua chen,yong he,haiyang xie,lin zhou,shusen zheng key laboratory of combined multi-organ transplantation,ministry of public health Department of hepatobiliary and Pancreatic Surgery,First Affiliated Hospital,School of Medicine,Zhejiang University

【Background】Chronic graft dysfunction has become the biggest obstacle for long-term function of allograft and better life quality of patients following liver transplantation(LT).It is essential to emphasis graft function after *** observed the effect of Glycyl-glutamine(Gly-Gln) by enteral feeding on graft structure and function in rats following allogenetic LT.【Methods】Twelve inbred Lewis rats were selected as donors,and 24 inbred BN rats as *** recipients were divided into control group(Ala,n=12) and experimental group(Gly-Gln,n=12).In each group,6 normal BN rats were sampled

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Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic liver transplantation

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Frontiers of Medicine 2019年第4期13卷 451-460页

作者： Junjun Jia Xinyao Tian jianwen jiang zhigang ren Haifeng Lu Ning he haiyang xie lin zhou shusen zheng Department of hepatobiliary and Pancreatic Surgery the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China key laboratory of combined multi-organ transplantation Ministry of Public Health Collaborative Innovation Center for Diagnosis and Treatment ofInfectious Diseases the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China State key laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

Understanding the effect of immunosuppressive agents on intestinal microbiota is important to reduce the mortality and morbidity from orthotopic liver transplantation (OLT). We investigated the relationship between the commonly used immunosuppressive agent cyclosporine A (CSA) and the intestinal microbial variation in an OLT model. The rat samples were divided as follows:(1) N group (normal control);(2) I group (isograft LT, Brown Norway [BN] rat to BN);(3) R group (allograft LT, Lewis to BN rat);and (4) CSA group (R group treated with CSA). The intestinal microbiota was assayed by denaturing gradient gel electrophoresis profiles and by using real-time polymerase chain reaction. The liver histopathology and the alanine/aspartate aminotransferase ratio after LT were both ameliorated by CSA. In the CSA group, the numbers of rDNA gene copies of Clostridium cluster I, Clostridium cluster XIV, and Enterobacteriaceae decreased, whereas those of Faecalibacterium prausnitzii increased compared with the R group. Cluster analysis indicated that the samples from the N, I, and CSA groups were clustered, whereas the other clusters contained the samples from the R group. hence, CSA ameliorates hepatic graft injury and partially restores gut microbiota following LT, and these may benefit hepatic graft rejection.

关键词： microbial community liver transplantation immunosuppressive agents cyclosporine A

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Dynamic Metabonomic Analysis of Liver transplantation on Rat Host Metabolism with Ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Dynamic Metabonomic Analysis of Liver Transplantation on Rat...

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2013年浙江省肠外肠内营养学学术年会

作者： jianwen jiang Deying chen zhigang ren xinhua chen lin zhou Lanjuan Li shusen zheng Department of hepatobiliary Pancreatic Surgery FKey Lab of Combined Multi-organ TransplantationMinistry of Public Health State key laboratory for Diagnosis and Treatment of Infectious Diseases Ph.D. M.D.1.1Department of Hepatobiliary Pancreatic SurgeryFKey Lab of Combined Multi-organ TransplantationMinistry of Public Health

Body:Objective:This study was designed to explore the dynamic impact of liver transplantation on host metabolomic changes by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC/QTOF-MS). Methods:Stable syngeneic Brown Norway(BN) rat liver transplantation(LT) model was set *** rats were sampled from tail vein on the pre-transplantation,on the 1st,2nd and 4th week after LT;The UPLC/QTOF-

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Liver ischemic preconditioning(IPC)improves intestinal microbiota following liver transplantation in rats through 16s rDNA-based analysis of microbial structure shift

Liver ischemic preconditioning(IPC)improves intestinal micro...

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2013中国器官移植大会

作者： zhigang ren Guangying Cui Haifeng Lu jianwen jiang lin zhou Weilin Wang shusen zheng key laboratory of combined multi-organ transplantation Ministry of Public Health State key laboratory for Diagnosis and Treatment of Infectious Disease First Affiliated HospitalSchool of MedicineZhejiang University

Background Ischemia-reperfusion(I/R)injury is associated with intestinal microbial ***"gut-liver axis"closely links gut function and liver function in health and *** preconditioning(IPC)has been proven to reduce I/R injury in the *** study aims to explore the effect of IPC on intestinal microbiota and to analyze characteristics of microbial structure shift following liver transplantation(LT). Methods The LT animal models of liver and gut IPC were *** graft function was assessed by histology and serum ALT/*** barrier function was evaluated by mucosal ultrastructure,serum endotoxin,bacterial translocation,fecal sIgA content and serum *** bacterial populations were determined by quantitative *** composition was characterized by DGGE and specific bacterial species were determined by sequence analysis.

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