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Jitter analysis with concentric needle electrodes in the extensor digitorum communis for the diagnosis of myasthenia gravis：a pilot study

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Chinese Medical Journal 2014年第18期127卷 3209-3212页

作者： wang jianwen Ji Fang Luo Benyan Department of Neurology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

Background Single-fiber electromyography is the most sensitive neurophysiological test for the diagnosis of myasthenia gravis （MG）,but its use is limited by the potential risk of transmission of *** analysis with disposable concentric needle electrodes （CNEs） is therefore being *** pilot study aimed to evaluate jitter analysis with CNEs for the diagnosis of *** Forty-two healthy Chinese volunteers and 44 MG patients were prospectively *** patients were classified according to the Osserman classification,and acetylcholine receptor antibody titer was *** analysis with CNEs in the extensor digitorum communis and repetitive nerve stimulation （RNS） testing were *** was expressed as the mean consecutive difference （MCD）,and 20 action potential pairs were analyzed in each *** mean MCD in each subject and the mean individual MCD of all action potential pairs were compared between *** The mean MCD and mean individual MCD were higher in MG patients （（42.3±20.0） μs and （42.2±26.0） μs） than in healthy volunteers （（23.0±3.1） μs and （22.8±7.5） μs）.The area under the receiver operating characteristic curve for the mean MCD of MG patients and healthy volunteers combined was *** mean MCD and mean individual MCDwere higher in generalized MG patients （（64.1±18.5） μs and （63.6±30.0） μs） than in ocular MG patients （（33.1±12.0） μs and （33.2±17.6） μs）,and were higher in MG patients with abnormal RNS results （（57.2±18.3） μs and （57.3±29.2） μs） than in MG patients with normal RNS results （（32.9±14.8） μs and （32.7±18.3） μs）.Abnormal RNS results were observed in 38.60% （17/44） of MG patients and abnormal jitter were observed in 72.70% （32/44） of MG *** Jitter analysis with CNEs is feasible for the diagnosis of MG.

关键词： myasthenia gravis single fiber electromyography,'jitter concentric needle electrode

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甲下恶性黑色素瘤28例临床病理分析

中国麻风皮肤病杂志 2024年第3期40卷 182-185页

作者：王建文陈学超周桂芝陈声利卢宪梅张雪燕张帆刘永霞山东第一医科大学附属皮肤病医院山东济南250022 山东省皮肤病性病防治研究所山东济南250022

目的:探讨原发甲下恶性黑色素瘤的临床病理特征。方法:回顾性分析2013年1月至2022年06月山东第一医科大学附属皮肤病医院病理科28例甲下恶性黑色素瘤的临床病理资料。结果:28例甲下恶性黑色素瘤中,男12例、女16例,平均年龄50岁,好发于拇... 详细信息

目的:探讨原发甲下恶性黑色素瘤的临床病理特征。方法:回顾性分析2013年1月至2022年06月山东第一医科大学附属皮肤病医院病理科28例甲下恶性黑色素瘤的临床病理资料。结果:28例甲下恶性黑色素瘤中,男12例、女16例,平均年龄50岁,好发于拇指,临床表现为甲黑线、甲破坏等,黑线宽度均>3 mm,哈钦森征阳性9例;组织学类型主要为肢端雀斑样痣型,细胞组成主要为上皮样细胞,免疫组化SOX10比S100表达阳性率高;28例中随访16例7例扩大切除8例局部截肢治疗1例化疗后死亡。12例失访。结论:甲下恶性黑色素瘤有不同于其他部位恶性黑色素瘤的临床病理学特点,临床与病理均易误诊。对于年龄大于50岁,临床表现为甲黑线,宽度>3 mm,哈钦森阳性的患者均应警惕甲下恶性黑色素瘤,应及时做病理检查。

关键词：甲恶性黑色素瘤临床病理分析

Mo_(2)B_(2)O_(2)MBene for Efficient Electrochemical CO Reduction to C_(2)Chemicals:Computational Exploration

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Energy & Environmental Materials 2024年第6期7卷 342-350页

作者： Bikun Zhang jianwen Jiang Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117576Singapore

Emerging as a new class of two-dimensional materials with atomically thin layers,MBenes have great potential for many important applications such as energy storage and *** mitigating carbon footprint,there has been increasing interest in CO_(2)/CO conversion on MBenes,but mostly focused on C_(1)products.C^(2+)chemicals generally possess higher energy densities and wider applications than C_(1)***,C–C coupling is technically challenging because of high energy requirement and currently few catalysts are suited for this ***,we explore electrochemical CO reduction reaction to C_(2)chemicals on Mo_(2)B_(2)O_(2)MBene via density-functional theory ***,the most favorable CO–COH coupling is revealed to be a spontaneous and barrierless process,making Mo_(2)B_(2)O_(2)an efficient catalyst for C–C *** C_(1)and C_(2)chemicals,ethanol is predicted to be the primary ***,by charge and bond analysis,it is unraveled that there exist significantly more unbonded electrons in the C atom of intermediate*COH than other C_(1)intermediates,which is responsible for the facile C–C *** an atomic scale,this work provides microscopic insight into C–C coupling process and suggests Mo_(2)B_(2)O_(2)a promising catalyst for electrochemical CO reduction to C_(2)chemicals.

关键词： C_(2)chemicals C-C coupling density-functional theory MBene Mo2B2O2

基于大数据的萧山区智慧农业水利系统设计与应用

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浙江水利科技 2024年第3期52卷 8-12页

作者：胡建杰俞学军王建文姚嘉誉徐建军杭州市萧山区林业水利局浙江杭州311200 浙江贵仁信息科技股份有限公司浙江杭州311200

推进智慧水利建设是推动新阶段水利高质量发展的实施路径之一,构建基于大数据的系统平台是智慧水利建设的重要举措。如何高效管理并利用农业资源、提升水利部门之间的业务协作性、解决好防汛排涝、促进农业高效发展是当前杭州市萧山区... 详细信息

推进智慧水利建设是推动新阶段水利高质量发展的实施路径之一,构建基于大数据的系统平台是智慧水利建设的重要举措。如何高效管理并利用农业资源、提升水利部门之间的业务协作性、解决好防汛排涝、促进农业高效发展是当前杭州市萧山区水利信息化建设过程中亟待解决的关键问题。分析智慧农业水利系统的总体架构,研究基于自主研发模型云平台的萧山区智慧农业水利系统主要功能及应用成效,结果表明,系统运行成效显著。

关键词：杭州市萧山区水利信息化大数据智慧农业

血管瘤样纤维组织细胞瘤14例临床病理学观察

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临床与实验病理学杂志 2024年第8期40卷 818-823页

作者：杨宝凤伏利兵张楠姚兴凤徐佳童管晓星王建文何乐健首都医科大学附属北京儿童医院病理科北京100045

目的探讨血管瘤样纤维组织细胞瘤(angiomatoid fibrous histiocytoma,AFH)的临床病理特征及分子学改变,分析其诊断、鉴别诊断及预后。方法收集14例AFH的临床、病理及随访资料,并文献复习。结果14例AFH患儿中,男童11例,女童3例;年龄11个... 详细信息

目的探讨血管瘤样纤维组织细胞瘤(angiomatoid fibrous histiocytoma,AFH)的临床病理特征及分子学改变,分析其诊断、鉴别诊断及预后。方法收集14例AFH的临床、病理及随访资料,并文献复习。结果14例AFH患儿中,男童11例,女童3例;年龄11个月~12岁11个月,平均5.9岁。肿瘤位于四肢3例,躯干5例,头颈部5例,颅内1例。镜下肿瘤细胞核呈空泡状,合体样、漩涡状排列,可见纤维性假包膜及淋巴细胞鞘。9例可见假血管腔隙,2例可见钙化,2例核分裂活跃(活跃处11个/10 HPF)。3例镜下见硬化、黏液样间质。免疫表型:desmin(10/14)、EMA(12/14)、CD99(12/14)、SMA(9/12)、ALK(7/8)阳性,Ki67平均增殖指数16%。分子检测EWSR1基因断裂7例、EWSR1-ATF1融合2例、EWSR1-CREB1融合2例。14例患儿平均随访46个月,均无复发、转移。结论AFH是一种交界性或低度恶性肿瘤,儿童患者预后良好,很少复发或转移。诊断及鉴别诊断需要结合临床特点、组织形态、免疫组化及EWSR1、FUS基因检测综合分析。

关键词：软组织肿瘤血管瘤样纤维组织细胞瘤诊断

Enhanced structural damage behavior of liquid-filled tank by reactive material projectile impact

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Defence Technology（防务技术） 2024年第1期31卷 211-229页

作者： jianwen Xie Yuanfeng Zheng Zhenyang Liu Chengzhe Liu Aoxin Liu Pengwan Chen Haifu wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

A series of ballistic experiments were performed to investigate the damage behavior of high velocity reactive material projectiles(RMPs) impacting liquid-filled tanks,and the corresponding hydrodynamic ram(HRAM) was studied in ***/Al/W RMPs with steel-like and aluminum-like densities were prepared by a pressing/sintering *** projectiles impacted a liquid-filled steel tank with front aluminum panel at approximately 1250 m/*** corresponding cavity evolution characteristics and HRAM pressure were recorded by high-speed camera and pressure acquisition system,and further compared to those of steel and aluminum *** different from the conical cavity formed by the inert metal projectile,the cavity formed by the RMP appeared as an ellipsoid with a conical *** RMPs were demonstrated to enhance the radial growth velocity of cavity,the global HRAM pressure amplitude and the front panel damage,indicating the enhanced HRAM and structural damage ***,combining the impact-induced fragmentation and deflagration characteristics,the cavity evolution of RMPs under the combined effect of kinetic energy impact and chemical energy release was *** mechanism of enhanced HRAM pressure induced by the RMPs was further revealed based on the theoretical model of the initial impact wave and the impulse ***,the linear correlation between the deformation-thickness ratio and the non-dimensional impulse for the front panel was obtained and *** was determined that the enhanced near-field impulse induced by the RMPs was the dominant reason for the enhanced structural damage behavior.

关键词： Reactive material projectile Hydrodynamic ram Enhanced structural damage Liquid-filled tank Impact

调教训练不同阶段对伊犁马粪便代谢组学的影响

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中国畜牧兽医 2024年第2期51卷 568-580页

作者：韩紫祥姚新奎臧长江孟军曾亚琦王川坤杨利平薛宇恒李鹏程王建文新疆农业大学动物科学学院乌鲁木齐830052 新疆马繁育与运动生理重点实验室乌鲁木齐830052

[目的]研究调教训练不同阶段伊犁马粪便代谢物变化特征,初步筛选受影响伊犁马调教训练的差异代谢物。[方法]于新疆伊犁昭苏马场选取饲养管理一致、未经调教训练的10匹速步型伊犁马,分为两组,一组开展专项训练,另一组为未训练组。采集训... 详细信息

[目的]研究调教训练不同阶段伊犁马粪便代谢物变化特征,初步筛选受影响伊犁马调教训练的差异代谢物。[方法]于新疆伊犁昭苏马场选取饲养管理一致、未经调教训练的10匹速步型伊犁马,分为两组,一组开展专项训练,另一组为未训练组。采集训练第30、60天的马匹粪便样本,采用液相色谱-质谱联用(LC-MS)技术进行非靶向代谢组检测,并对检测结果进行分析。[结果]训练第30天组(QY)和未训练第30天组(QB)比较结果中有27个正离子模式代谢物和20个负离子模式代谢物差异显著,2-花生酰基甘油、丙酰左旋肉碱和肌酸等代谢物显著上调,代谢物主要聚集在β-丙氨酸代谢、精氨酸与脯氨酸代谢、戊糖磷酸途径、花生四烯酸代谢、5-羟色胺能突触等代谢途径中。训练第60天组(HY)和未训练第60天组(HB)比较结果中有57个正离子模式代谢物和33个负离子模式代谢物差异显著,棕榈油酸、棕榈酸、甲睾酮和褪黑素等代谢物显著上调,皮质醇和叶酸等代谢物显著下调,代谢物主要聚集在类固醇激素生物合成、库欣综合征、皮质醇的合成和分泌、神经活性配体-受体相互作用、脂肪酸生物合成、不饱和脂肪酸生物合成等代谢途径中。[结论]调教训练不同阶段伊犁马粪便代谢物之间存在差异,为改善马匹的整体健康水平和促进运动表现提供了基础理论依据。

关键词：伊犁马调教训练代谢物代谢途径

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基于Paddle OCR识别水准标尺检定证书的方法研究

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测绘与空间地理信息 2024年第9期47卷 188-191,196页

作者：齐文刘晓云王建文马润霞刘和平自然资源部大地测量数据处理中心陕西西安710054

传统水准测量数据处理作业中,采用人工方式读取标尺检定证书信息,一定程度制约了水准测量数据处理实现全流程自动化。本文基于Paddle OCR模型识别标尺检定证书图片中的文字信息,对块状识别结果进行分行整理,经过数据清洗、联系上下文、... 详细信息

传统水准测量数据处理作业中,采用人工方式读取标尺检定证书信息,一定程度制约了水准测量数据处理实现全流程自动化。本文基于Paddle OCR模型识别标尺检定证书图片中的文字信息,对块状识别结果进行分行整理,经过数据清洗、联系上下文、信息互补校验等操作后获取关键信息,实现了水准标尺检定信息的自动化提取。经验证,该识别方法精度达到98.7%,可以承担工程应用中对算者的角色,为实现人工智能技术与测绘地理信息专业的交叉融合提供技术参考,也为未来开发智能化无人水准测量数据处理软件提供技术储备。

关键词：水准标尺检定证书 Paddle OCR 图片文字识别人工智能

PbGIF1 promoting cell-proliferation in pear fruit is transcriptionally activated by Pb RR1

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Horticultural Plant Journal 2024年第3期10卷 689-697页

作者： Huibin wang Guangya Sha Rui Gao jianwen Pang Rui Zhai Chengquan Yang Zhigang wang Lingfei Xu College of Horticulture Northwest A&F UniversityYanglingShaanxi 712100China College of Life Science Hebei Agricultural UniversityBaodingHebei 071000China

As a cell proliferation regulator involved in wide biological processes in plants,GRF-INTERACTING FACTOR(GIF)controls different tissues ***,whether GIF participates in fruit development remains *** to transcriptome data,we identified PbGIF1was highly expressed during fruit development in cytokinins induced parthenocarpy *** the present study,the biofunction of PbGIF1 was initially *** of PbGIF1 promoted fruit size of transgenic *** size of flesh fruit was not affected by cell expansion but the cell proliferation was promoted by overexpressing Pb *** accelerated cell proliferation process was also observed in PbGIF1-overexpressed transgenic pear fruit *** transcriptional regulation of cytokinins on PbGIF1 was further confirmed by exogenous CPPU treatments in pear *** investigate the underlying mechanism,the cytokinins-responded factor,PbRR1,was further focused *** results of Yeast-one-hybrid assay suggested that PbRR1 can bind to the promoter sequence of *** transcriptional activation of PbRR1 on PbGIF1 was also confirmed by Dual-Luciferase *** together,the results showed that cytokinins control pear fruit development via the transcriptional activation of PbGIF1 by PbRR1.

关键词： PbGIF1 Cell proliferation Pear Fruit development Cytokinins PbRR1