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Hydrogen storage of multiwalled carbon nanotubes coated with Pd-Ni nanoparticles under moderate conditions

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Chinese Science Bulletin 2006年第24期51卷 2959-2963页

作者： REN jianwei liao Shijun LIU Junmin College of Chemistry South China University of Technology Guangzhou 510641 China

A type of novel material with a high hy-drogen storage capacity was prepared by supporting PdNi18 alloy nanoparticles,which were synthesized by using a new colloid method,on the surface of pretreated multiwalled carbon nanotubes (MWCNTs). The average PdNi18 alloy particle sizes calculated from XRD patterns were ca. 3 nm,and the high dis-persion of these particles on MWCNTs was con-firmed by TEM image. Hydrogen storage perform-ance of the composite was investigated under mod-erate pressure (0.1―1.5 MPa) at room temperature,and a maximum storage capacity of ca. 2.3 wt% was achieved under 1.5 MPa at room temperature,which was much higher than that reported previously under the same conditions.

关键词：多壁碳纳米管纳米颗粒贮氢能力钯镍合金

Resource Search in Unstructured Peer-to-Peer System Based on Multiple-Tree Overlay Structure

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Wuhan University Journal of Natural Sciences 2007年第5期12卷 887-892页

作者： YU Jianqiao liao jianwei College of Computer and Information Science Southwest University Chongqing 400715 China

We propose a multiple-tree overlay structure for resource discovery in unstructured P2P systems. Peers that have similar interests or hold similar type of resources will be grouped into a tree-like cluster. We exploit the heterogeneity of peers in each cluster by connecting peers with more capacities closer to the root of the tree. The capacity of a peer can be defined in different ways （e.g. higher network bandwidth, larger disk space, more data items of a certain type etc.） according to different needs of users or applications.

关键词： unstructured P2P system tree-like cluster similar interest

Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma

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Oncology Research 2024年第4期32卷 691-702页

作者： JIJIE XIAO HONG XIAO YUJUN CAI jianwei liao JUE LIU LIN YAO SHAOLIN LI Department of Radiology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai510900China Department of Ultrasound The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou528405China PCFM Lab of Ministry of Education School of Materials Science and EngineeringGuangzhou510275China

Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient *** has shown great potential in the treatment of ***,the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma *** dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor ***,we prepared a dual pH-sensitive nanocarrier,loaded with the photosensitizer Chlorin e6(Ce6)and CD47 monoclonal antibodies(aCD47),to deliver synergistic photodynamic and immunotherapy of *** laser irradiation,Ce6 can generate reactive oxygen species(ROS)to kill cancer cells directly and induces immunogenic tumor cell death(ICD),which further facilitates the dendritic cell maturation induced by blockade of CD47 by ***,both calreticulin released during ICD and CD47 blockade can accelerate phagocytosis of tumor cells by macrophages,promote antigen presentation,and eventually induce T lymphocyte-mediated antitumor ***,the dual pH-sensitive nanodrug loaded with Ce6 and aCD47 showed excellent immune-activating and anti-tumor effects in osteosarcoma,which may lay the theoretical foundation for a novel combination model of osteosarcoma treatment.

关键词： Immunotherapy Osteosarcoma Nanodrug Photodynamic therapy CD47

TP53-specific mutations serve as a potential biomarker for homologous recombination deficiency in breast cancer:a clinical next-generation sequencing study

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Precision Clinical Medicine 2024年第2期7卷 122-131页

作者： Yongsheng Huang Shuwei Ren Linxiaoxiao Ding Yuanling jiang Jiahuan Luo Jinghua Huang Xinke Yin Jianli Zhao Sha Fu jianwei liao Cellular&Molecular Diagnostics Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Laboratory The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510655China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangzhou Regenerative Medicine and Health Guangdong LaboratorySun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Background:TP53 mutations and homologous recombination deficiency(HRD)occur frequently in breast ***,the characteristics of TP53 pathogenic mutations in breast cancer patients with/without HRD are not ***:Clinical next-generation sequencing(NGS)of both tumor and paired blood DNA from 119 breast cancer patients(BRCA-119 cohort)was performed with a 520-gene ***,tumor mutation burden(TMB),and genomic HRD scores were assessed from NGS *** data from 47 breast cancer patients in the HRD test cohort were analyzed for further ***:All TP53 pathogenic mutations in patients had somatic origin,which was associated with the protein expression of estrogen receptor and progestogen *** to patients without TP53 pathologic mutations,patients with TP53 pathologic mutations had higher levels of HRD scores and different genomic *** frequency of TP53 pathologic mutation was higher in the HRDhigh group(HRD score≥42)relative to that in the HRD-low group(HRD score<42).TP53 has different mutational characteristics between the HRD-low and HRD-high ***53-specific mutation subgroups had diverse genomic features and ***,TP53 pathogenic mutations predicted the HRD status of breast cancer patients with an area under the curve(AUC)of ***53-specific mutations,namely HRD-low mutation,HRD-high mutation,and HRD common mutation,predicted the HRD status of breast cancer patients with AUC values of 0.32,0.72,and 0.58,***,TP53 HRD-high mutation and HRD common mutation combinations showed the highest AUC values(0.80)in predicting HRD ***:TP53-specific mutation combinations predict the HRD status of patients,indicating that TP53 pathogenic mutations could serve as a potential biomarker for poly-ADP-ribose polymerase(PARP)inhibitors in breast cancer patients.

关键词： next-generation sequencing homologous recombination deficiency TP53 breast cancer

小空间推动大馆藏——高职院校图书馆诚信书吧服务案例

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图书馆杂志 2016年第12期35卷 41-47页

作者：廖建威广西经贸职业技术学院

诚信是一面镜子,馆藏服务是一扇窗口,小空间大利用是我馆推动读者服务创新的一次尝试。随着近年来读者到馆率下降,馆藏流通量降低。馆藏如何走出去,读者如何请进来,资源服务如何嵌入校园文化,成为我馆面临的现实问题。诚信书吧案例是嵌... 详细信息

诚信是一面镜子,馆藏服务是一扇窗口,小空间大利用是我馆推动读者服务创新的一次尝试。随着近年来读者到馆率下降,馆藏流通量降低。馆藏如何走出去,读者如何请进来,资源服务如何嵌入校园文化,成为我馆面临的现实问题。诚信书吧案例是嵌入教学主体单元的一次实践,通过主动走出去的服务战略,将高职院校图书馆纸本资源服务、数字资源服务、读者需求服务通过小而精、精而美的空间融入读者日常生活之中,提高读者需求粘度,实现馆藏资源共建共享。

关键词：馆藏服务数字资源读者服务

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心理测试技术在火灾调查中的应用

中国人民警察大学学报 2023年第2期39卷 18-21页

作者：廖建伟重庆市涪陵区消防救援支队重庆408000

简介心理测试技术的概念和基本原理,探讨将心理测试技术引入疑难火灾调查工作中的必要性。结合有关火灾案例着重论述了在进行心理测试时如何确定、编制适合火灾调查工作特点的测试主题和测试题目,并根据具体案情选择有针对性的测试方法... 详细信息

简介心理测试技术的概念和基本原理,探讨将心理测试技术引入疑难火灾调查工作中的必要性。结合有关火灾案例着重论述了在进行心理测试时如何确定、编制适合火灾调查工作特点的测试主题和测试题目,并根据具体案情选择有针对性的测试方法。阐明心理测试技术在筛查调查线索、突破嫌疑人心理防线和提供调查方向等火灾调查工作中发挥的作用。

关键词：心理测试题目编制测试方法火灾调查