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Structural design of the fluted shaped charge liner using multi-section optimization method

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Defence Technology（防务技术） 2023年第7期25卷 249-262页

作者： Shengjie Sun jianwei jiang Shuyou Wang Jianbing Men Mei Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081PR China Tangshan Research Institute Beijing Institute of TechnologyTangshan 063000HebeiPR China

Spin effect of the small diameter shaped charge results in the centrifugal stress during the jet stretching process. Consequently, the jet scatters, which deceases the jet penetration capability. In the present study, a multi-section method was proposed to design the spin-compensation liner. The spincompensation rate(SCR) of the liner was defined as the specific angular velocity that a fluted liner can offset. Based on the plain stress theory, SPH numerical method was applied to study the converging process of the 2D fluted structure. The spin-compensation mechanism of the fluted structure was illustrated. Then, nine cross sections were chosen along the liner axis equidistantly. On each of the section, a 2D fluted structure was designed to offset a given initial angular velocity. After, the optimized fluted structures were integrated into a 3D fluted liner. Jet appearances of the normal liner and the fluted liners under different initial angular velocities were compared, which verifies the practicality of the multi-sectional method. The multi-section optimization method provides a new efficient method of designing the shaped charge liner for a specific usage.

关键词： Fluted liner Spin-compensation SPH Structural optimization

Investigation on the spatial distribution characteristics of behind-armor debris formed by the perforation of EFP through steel target

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Defence Technology（防务技术） 2020年第1期16卷 119-135页

作者： Xin Wang jianwei jiang Shengjie Sun Jianbing Men Shuyou Wang State Key Laboratory of Explosion Science and Technology Beijing Institution of TechnologyChina

The behind-armor debris(BAD) formed by the perforation of an EFP is the main damage factor for the secondary destruction to the behind-armor *** at investigating the BAD caused by EFP,flash X-ray radiography combined with an experimental witness plate test method was used,and the FEM-SPH adaptive conversion algorithm in LS-DYNA software was erployed to model the perforation *** simulation results of the debris cloud shape and number of debris were in good agreement with the flash X-ray radiographs and perforated holes on the witness plate,*** numerical simulations of EFP's penetration under various impact conditions were *** results show that,an ellipsoidal debris cloud,with the major-to-minor axis radio(a/b)smaller than that caused by shaped charge jets,was formed behind the *** the increase of target thickness(h) and decrease of impact velocity(v_0) and obliquity(θ),the value of a/b *** number of debris ejected from target is significantly higher than that from *** on the statistical analysis of the spatial distribution of the BAD,An engineering calculation model was established considering the influence of h,v_0 and θ.The model can with reasonable accuracy predict the quantity and velocity distribution characteristics of BAD formed by EFP.

关键词： Behind-armor debris EFP FEM-SPH adaptive conversion algorithm Spatial distribution

Targeting ferroptosis opens new avenues for the development of novel therapeutics

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4716-4745页

作者： Shumin Sun Jie Shen jianwei jiang Fudi Wang Junxia Min The First Affiliated Hospital Institute of Translational MedicineThe Second Affiliated HospitalSchoolof Public HealthCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,including altered iron homeostasis,reduced defense against oxidative stress,and abnormal lipid *** studies have provided compelling evidence supporting the notion that ferroptosis plays a key pathogenic role in many diseases such as various cancer types,neurodegenerative disease,diseases involving tissue and/or organ injury,and inflammatory and infectious diseases.

关键词： peroxidation diseases homeostasis

Novel phenanthrene/bibenzyl trimers from the tubers of Bletilla striata attenuate neuroinﬂammation via inhibition of NF-κB signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期22卷 441-454页

作者： SHAO Siyuan SUN Mohan MA Xianjie jiang jianwei TIAN Jinying ZHANG Jianjun YE Fei LI Shuai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Five novel(9,10-dihydro)phenanthrene and bibenzyl trimers,as well as two previously identified biphenanthrenes and bibenzyls,were isolated from the tubers of Bletilla *** structures were elucidated through comprehensive analyses of NMR and HRESIMS spectroscopic *** absolute configurations of these compounds were determined by calculating rotational energy barriers and comparison of experimental and calculated ECD *** 5b and 6 exhibited inhibitory effects on LPS-induced NO production in BV-2 cells,with IC_(50) values of 12.59±0.40 and 15.59±0.83μmol·L^(-1),respectively.A mechanistic study suggested that these compounds may attenuate neuroinflammation by reducing the activation of the AKT/IκB/NF-κB signaling ***,compounds 3a,6,and 7 demonstrated significant PTP1B inhibitory activities,with IC_(50) values of 1.52±0.34,1.39±0.11,and 1.78±0.01μmol·L^(-1),*** investigation revealed that compound 3a might inhibit LPS-induced PTP1B overexpression and NF-κB activation,thereby mitigating the neuroinflammatory response in BV-2 cells.

关键词： Bletilla striata Phenanthrene/bibenzyl trimer NO inhibition AKT/IκB/NF-κB signaling pathway PTP1B inhibitory effect

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

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Frontiers of Medicine 2012年第3期6卷 317-321页

作者： Qinggang Hu Shanglong Liu jianwei jiang Chen Zhang Xiaowei Liu Qichang Zheng Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

In order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromal tumors(GISTs)after surgical resection,we collected clinical records of 80 patients with malignant *** location,size,mitotic index,necrosis were compared with the prognosis of malignant GISTs by Kaplan-Meier method and log-rank *** a median follow-up of 844 days(52–2145),we found that as National Institutes of Health suggested,tumors with intermediate risk had more favorable prognosis than that with high *** 3-year survival rate were 65.3% and 41.3%,respectively(P10 cm were 62.3% and 41.8%,respectively(P=0.002),Tumors with mitotic index≤5/50 HPF had a higher 3-year survival rate than tumors with mitotic index>5/50 HPF(67.1% versus 40.7%,P=0.005).The presence of necrosis was directly related to the malignant *** 3-year survival rate for presence and absence necrosis were 50.8% and 64.8%(P=0.008).From the present study,we can conclude that besides tumors size and mitotic index,tumor location and necrosis also influence on the long-term survival of patient with malignant GISTs after surgical resection.

关键词： gastrointestinal stromal tumors surgery survival

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基于正交约束的分块不完整多视角聚类

模式识别与人工智能 2020年第1期33卷 41-49页

作者：姜健伟殷俊上海海事大学信息工程学院

在处理数据特征提取问题时,已有的基于非负矩阵分解的不完整多视角聚类算法对局部特征的提取不够准确.针对此问题,文中提出基于正交约束的分块不完整多视角聚类(CIMVCO).利用非负矩阵分解获得所有视角的潜在特征矩阵,通过加入正交约束... 详细信息

在处理数据特征提取问题时,已有的基于非负矩阵分解的不完整多视角聚类算法对局部特征的提取不够准确.针对此问题,文中提出基于正交约束的分块不完整多视角聚类(CIMVCO).利用非负矩阵分解获得所有视角的潜在特征矩阵,通过加入正交约束得到更好的局部特征.对于各个视角的缺失样本,CIMVCO给予较小的权重以减小缺失数据的影响.为了解决大规模数据的聚类问题,CIMVCO逐块处理数据以减少内存需求和处理时间.在Reuters和Digit数据集上的实验验证CIMVCO的有效性.

关键词：分块多视角聚类非负矩阵分解(NMF) 正交约束

Animal Experiment Study on Antitumor Effect of Matrine Liposome

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Journal of Pharmacy and Pharmacology 2017年第4期5卷 227-229页

作者： jiang jianwei WANG Chunlei ZHANG Hongyan Zhejiang Cancer Hospital Zhejiang 310022 China

Objective： To study the antitumor effect of matrine liposome in mice. Methods： The mice were selected as the research object, and SPSS （statistic package for social science）, matrine and matrine liposome were used for grouping. The antitumor effects of EAC, S 180 and H22 were evaluated by tumor weight, thymus weight and spleen weight. Results： The inhibitory effect of matrine liposome on EAC, S180 and H22 in mice was significantly higher than matrine, P 〈 0.05, which had statistical significance. Conclusion： Matrine liposome can effectively enhance the anti-tumor effect and improve the immunity of animals, which is worthy of clinical promotion.

关键词： Matrine liposome antitumor.

ELECTROACUPUNCTURE ANALGESIA POTENTIATED BY INTRAVENOUS INJECTION OF L-TETRAHYDROPALMATINE AND ITS ANALOGUES IN RABBITS

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针刺研究 1989年第Z1期 161-162页

作者： Wu Gang jiang jianwei Wu Gencheng Cao Xiaoding Department of Neurobiology, Institute of Acuputncure Research, Shanghai Medical University, Shanghai

L-Tetrahydropalmatine (L-THP) is a non-narcotic analgesic which possessesmanifold pharmacologic effects such as analgesia, tranquitizing, antiarrhythmiaand so on. Tetrahydroberberine (THB) and L-stephotidine (L-SPD) are two ana-logues of L-THP which have been used in ctinics. In present paper, the effectsof L-THP, THB or L-SPD on electroacupuncture (EA) analgesia were observedand compared in rabbits so as to provide the laboratory information about see-king certain synergists of acupuncture anethesia.

关键词： THP EA SPD ELECTROACUPUNCTURE ANALGESIA POTENTIATED BY INTRAVENOUS INJECTION OF L-TETRAHYDROPALMATINE AND ITS ANALOGUES IN RABBITS

EFFECT OF L-THP ON SUPPRESSION OF EVOKED CORTICAL POTENTIALS TO STIMULATION OF TOOTH PUIP BYELECTROACUPUNCTURE IN RABBITS

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针刺研究 1989年第Z1期 22-23页

作者： Wu Gang jiang jianwei Wu Gencheng Cao Xiaoding Department of Neurobiology, Institute of Acupuncture Research, Shanghai Medical University, Shanghai

Previously we found that L-tetrahydropalmatine (L-THP) could enhancethe inhibitory effect of electroacupuncture (EA) on the defense behaviourresponse to the noxious stimulation of the rabbit's ear skin by potassium ionto-phoretic dolorimetry. In this paper, the effects of L-THP and EA on evokedcortical potentials to stimulation of tooth pulp were observed to study thesynergism botween L-THP and EA analgesia at sense level.

关键词： THP EA EFFECT OF L-THP ON SUPPRESSION OF EVOKED CORTICAL POTENTIALS TO STIMULATION OF TOOTH PUIP BYELECTROACUPUNCTURE IN RABBITS