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Antibacterial Nanoparticles with Universal Adhesion Function Based on Dopamine and Eugenol

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Journal of Bioresources and Bioproducts 2019年第3期4卷 43-48页

作者： Huilin XU Dongyue ZHANG jianshu li College of Polymer Science and Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

In this work,dopamine methacrylamide(DMA)and eugenyl methacrylate(EMA)were used to synthesize polymeric particles of Poly(DMA-co-EMA)by free radical precipitation *** two monomers were modified from dopamine(consisting of the catechol moieties adhering to various materials)and eugenol(with antibacterial property),*** proton nuclear magnetic resonance(^(1)H NMR)and Fourier transform infrared(FT-IR)spectroscopy were applied to confirm the successful synthesis of the two monomers and *** scanning electron microscope(SEM)images showed the size and morphology of the polymer *** results indicated that regular particles with uniform size could be obtained with a monomer feeding ratio of 5꞉*** results of antibacterial activity test indicated that the obtained polymer particles have an antibacterial rate over 90%to Eugenia coli.

关键词： antibacterial universal adhesion particle,precipitation polymerization

Advances in biomineralization-inspired materials for hard tissue repair

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International Journal of Oral Science 2021年第4期13卷 345-369页

作者： Shuxian Tang Zhiyun Dong Xiang Ke Jun Luo jianshu li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduChina Med-X Center for Materials Sichuan UniversityChengduChina

Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties,including the bones and teeth in *** underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard *** particular,the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in ***,we review recent advances in biomineralization-inspired materials developed for hard tissue ***-inspired materials are categorized into different types based on their specific applications,which include bone repair,dentin remineralization,and enamel ***,the advantages and limitations of these materials are summarized,and several perspectives on future directions are discussed.

关键词： utilizing limitations summarized

Two-in-one strategy:a remineralizing and anti-adhesive coating against demineralized enamel

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International Journal of Oral Science 2020年第3期12卷 258-268页

作者： Ailin Hou Jun Luo Min Zhang jianshu li Wenlin Chu Kunneng liang Jiaojiao Yang Jiyao li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina College of Polymer Science and Engineering Sichuan UniversityChengduChina College of Polymer Science and Engineering&State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduChina

Tooth enamel is prone to be attacked by injurious factors,leading to a de/remineralization *** repair demineralized enamel and prevent pulp inflammation caused by biofilm accumulation,measures are needed to promote remineralization and inhibit bacterial adhesion on the tooth *** innovative material,poly(aspartic acid)-polyethylene glycol(PASP-PEG),was designed and synthesized to construct a mineralizing and anti-adhesive surface that could be applied to repair demineralized enamel.A cytotoxicity assay revealed the low cytotoxicity of synthesized *** results demonstrated that PASPPEG possesses a high binding affinity to the hydroxyapatite(HA)/tooth *** vitro experiments and scanning electron microscopy(SEM)demonstrated a strong capacity of PASP-PEG to induce in situ remineralization and direct the oriented growth of apatite *** dispersive X-ray spectroscopy(EDS),X-ray diffraction analysis(XRD)and Vickers hardness tests demonstrated that minerals induced by PASP-PEG were consistent with healthy enamel in Ca/P ratio,crystal form and surface *** angle tests and bacterial adhesion experiments demonstrated that PASP-PEG yielded a strong antiadhesive *** summary,PASP-PEG could achieve dual effects for enamel repair and anti-adhesion of bacteria,thereby widening its application in enamel repair.

关键词： coating thereby Adsorption

Ectopic mineralization-inspired cell membrane-based matrix vesicle analogs for in-depth remineralization of dentinal tubules for treating dentin hypersensitivity

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Nano Research 2023年第5期16卷 7269-7279页

作者： Mingjing li Xiaoran Zheng Zhiyun Dong Yuyue Zhang Wei Wu Xingyu Chen Chunmei Ding Jiaojiao Yang Jun Luo jianshu li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing UniversityChongqing 400030China College of Medicine Southwest Jiaotong UniversityChengdu 610003China State Key Laboratory of Oral Diseases West China Hospital of Stomatology and Med-X Center for MaterialSichuan UniversityChengdu 610041China Med-X Center for Material Sichuan UniversityChengdu 610041China

The invasion of etched dentinal tubules(DTs)by external substances induces dentin hypersensitivity(DH).The deep and compact occlusion of DTs is highly desirable for treating DH but still challenging due to the limited penetrability and mineralization capacities of most current *** vesicles(MVs)participate in the regulation of ectopic ***,ectopic MV analogs are prepared by employing natural cell membranes to endow mineral precursors with natural biointerfaces and integrated biofunctions for stimulating dentin *** analogs quickly access DTs(>20μm)in only 5 min and further penetrate deep into the interior of DTs(an extraordinary~200μm)in 7 *** in vitro and in vivo studies confirm that the DTs are efficiently sealed by the newly formed minerals(>50μm)with excellent resistance to wear and acid erosion,which is significantly deeper than most reported *** repair,the microhardness of the damaged dentin can be recovered to those of healthy *** the first time,cell membrane coating nanotechnology is used as a facile and efficient therapy for in-depth remineralization of DTs in treating DH with thorough and long-term effects,which provides insights into their potential for hard tissue repair.

关键词： bioinspiration dentin remineralization cell membrane coating nanotechnology ectopic matrix vesicles mineral precursors

Antibacterial and antioxidant bifunctional hydrogel based on hyaluronic acid complex MoS_(2)-dithiothreitol nanozyme for treatment of infected wounds

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Regenerative Biomaterials 2024年第4期3卷 98-110页

作者： Yongping Lu Weiqi Kang Yue Yu ling liang Jinrong li Haiying Lu Ping Shi Mingfang He Yuemin Wang jianshu li Xingyu Chen Guangyuan Central Hospital Guangyuan 628000P.R.China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065P.R.China Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengdu 610031P.R.China

Wound repair is a complex physiological process that often leads to bacterial infections,which significantly threaten human ***,developing wound-healing materials that promote healing and prevent bacterial infections is *** this study,the coordination interaction between sulfhydryl groups on dithiothreitol(DTT)and MoS_(2)nanosheets is investigated to synthesize a MoS_(2)-DTT nanozyme with photothermal properties and an improved free-radical scavenging ***-bond-modified hyaluronic acid is used as a monomer and is cross-linked with a PF127-DA *** is prepared in coordination with MoS_(2)-DTT as the functional *** hydrogel exhibits antioxidant and antibacterial properties,attributed to the catalytic activity of catalase-like enzymes and photothermal *** the near-infrared(NIR),it exhibits potent antibacterial effects against gram-positive(Staphylococcus aureus)and gram-negative bacteria(Escherichia coli),achieving bactericidal rates of 99.76%and 99.42%,***,the hydrogel exhibits remarkable reactive oxygen species scavenging and antioxidant capabilities,effectively countering oxidative stress in L929 ***,in an animal model,wounds treated with the PHMoD(2.0)and NIR laser heal the fastest,sealing completely within 10 *** results indicate the unique biocompatibility and bifunctionality of the PHMoD,which make it a promising material for wound-healing applications.

关键词： hydrogel wound repair antibacterial antioxidant nanozyme photothermal therapy

Bioinspired mineral-in-shell nanoarchitectonics:Functional empowerment of mineral precursors for guiding intradentinal mineralization

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Nano Research 2024年第5期17卷 4338-4349页

作者： Xiaoran Zheng Yang liu Mingjing li Yuyan li Wanshan Gao Rongmin Qiu Jiaqi Xing Jiaojiao Yang Yantao Chen Xinyuan Xu Mingming Ding Jun Luo jianshu li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China College of Stomatology Hospital of Stomatology Guangxi Medical UniversityGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and ReconstructionGuangxi Clinical Research Center for Craniofacial DeformityGuangxi Key Laboratory of Oral and Maxillofacial Surgery Disease TreatmentGuangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious DiseasesNanning 530021China State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Shenzhen Key Laboratory of Environmental Chemistry and Ecological Remediation College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China Med-X Center for Material Sichuan UniversityChengdu 610041China

Effective mineralization of biological structures poses a significant challenge in hard tissue engineering as it necessitates overcoming geometric complexities and multistep biomineralization *** this regard,we propose“mineral-in-shell nanoarchitectonics”,inspired by the nanostructure of matrix vesicles,which can influence multiple mineralization *** nanostructural design empowers mineral precursors with tailorable properties through encapsulating amorphous calcium phosphate within a multifunctional tannic acid(TA)and silk fibroin(SF)*** bioinspired nanosystem facilitates efficient recruitment of mineral precursors throughout the dentin structures,followed by large-scale intradentinal mineralization both in vitro and in vivo,which provides persistent protection against external *** simulations combined with experimental studies attribute the success of intradentinal mineralization to the TA-SF nanoshell,which exhibits a strong affinity for the dentin structure,stabilizing amorphous precursors and thereby facilitating concomitant mineral ***,this bioinspired mineral-in-shell nanoarchitectonics shows a promising prospect for hard tissue repair and serves as a blueprint for next-generation biomineralization-associated materials.

关键词： mineral-in-shell nanohybrids self-assembly biomineralization dentinal tubule occlusion dental hypersensitivity

New Editorial Team for Journal of Bioresources and Bioproducts (JB&B)

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Journal of Bioresources and Bioproducts 2019年第1期4卷 1-2页

作者： Huining Xiao Yonghao Ni Orlando Rojas Fei Wang Yongcan Jin jianshu li

Greetings on behalf of the new editorial team of Journal of Bioresources and Bioproducts(JB&B).Launched at the University of New Brunswick(UNB)in Fredericton Canada in 2016 with the inaugural volume appearing in February 2016,JB&B has successfully published 95 articles in total,included in 3 volumes(12 issues).In spite of the limited space over the published issues,a broader spectrum of interesting topics has been covered to the best of the editors’*** November 2018,JB&B has been published jointly by Nanjing Forestry University(China)and UNB,and the journal has undergone some minor changes in personnel and *** the present time,the new editorial team is transitioning into its new responsibilities,whereas the scopes of the journal remain similar with very minor *** are very thankful to the authors,reviewers,editorial board members,the publishing staffs,last but not least,our readers for making JB&B a *** ask for your indulgence and encouragement while the transition is *** thanks are also due to the previous editorial board members who have made tremendous contributions to our journal.

关键词： journal behalf jointly

Advances of cyclodextrin polymers for the delivery of biotech drugs

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Journal of Bioresources and Bioproducts 2016年第1期1卷 7-17页

作者： Yanpeng liu jianshu li College of Polymer Science and Engineering Sichuan UniversityChengdu610065China. State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China.

Currently,biological drugs such as gene,protein,and monoclonal antibody are widely applied in the clinic due to their excellent ***,they still have some problems,including poor solubility,instability,toxicity,and weak capability to cross cell *** to the specific structure of cyclodextrins(CDs)and the advantage of polymeric backbones,various cyclodextrin polymers(CDPs)have been designed as delivery systems for biotech *** this review,after a brief introduction on CDPs and discussion of their physicochemical and biological properties,we will focus on recent advances in the use of CDPs for the delivery of biotech *** review highlights the structure-function relationship of CDPs to their performance in biotech drug ***,an outlook will be proposed on the developing trends and challenge in this field.

关键词： Cyclodextrin polymers Drug Delivery System Biotech Drugs Gene Protein

Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy

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Bioactive Materials 2023年第4期22卷 239-253页

作者： Yuemin Wang Duan Wang Yuyue Zhang Hong Xu Luxuan Shen Jing Cheng Xinyuan Xu Hong Tan Xingyu Chen jianshu li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China Orthopedic Research Institution Department of OrthopedicsWest China HospitalSichuan UniversityChengdu610041China College of Medicine Southwest Jiaotong UniversityChengdu610003China State Key Laboratory of Oral Diseases West China Hospital of StomatologyMed-X Center for MaterialsSichuan UniversityChengdu610041China

Chemodynamic therapy(CDT),a noninvasive strategy,has emerged as a promising alternative to conventional chemotherapy for treating ***,its therapeutic effect is limited by the amount of H_(2)O_(2),pH value,the hypoxic environment of tumors,and it has suboptimal tumor-targeting *** this study,tumor cell membrane-camouflaged mesoporous Fe_(3)O_(4) nanoparticles loaded with perfluoropentane(PFP)and glucose oxidase(GOx)are used as a tumor microenvironment-adaptive nanoplatform(M-mFeP@O_(2)-G),which synergistically enhances the antitumor effect of *** Fe_(3)O_(4) nanoparticles are selected as inducers for photothermal and Fenton reactions and as *** depletes glucose within tumor cells for starving the cells,while producing H2O2 for subsequent⋅OH ***,PFP,which can carry O_(2),relieves hypoxia in tumor cells and provides O_(2) for the cascade ***,the nanoparticles are camouflaged with osteosarcoma cell membranes,endowing the nanoparticles with homologous targeting and immune escape *** in vivo and in vitro evaluations reveal high synergistic therapeutic efficacy of M-mFeP@O_(2)-G,with a desirable tumor-inhibition rate(90.50%),which indicates the great potential of this platform for clinical treating cancer.

关键词： Chemodynamic therapy Tumor microenvironment Cell membranes Homologous targeting Perfluoropentane Glucose oxidase