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Food Science and Human Wellness 2024年第2期13卷 791-800页

作者： Guohui Nan Haixia Zhao Qiong Wu Lisong liu Zichao Guan Chenglei Li Huala Wu Dabing Xiang Qi Wu College of Life Science Sichuan Agricultural UniversityYa'an 625014China Faculty of Quality Management and Inspection&Quarantine Yibin UniversityYibin 644000China College of Pharmacy and Biological Engineering Chengdu UniversityChengdu 610106China

Tartary buckwheat(Fagopyrum tataricum)is a well-known pseudocereal for its health and economic ***,abundant antinutritional factors(ANFs)reduces its health *** reported,germination can improve the nutritional profile of *** this study,we systematically evaluate the safety of Tartary buckwheat seeds(TB)and Tartary buckwheat sprouts(TBS)used as high active *** evaluating nutrition levels,bioactive compounds and ANFs in TBS during germinating,5^(th)-day TBS were selected as the raw material.C57BL/6J mice were gavaged daily with distilled water,TB,or TBS for 6 *** physiological indices related to ANFs were *** showed that the TB intake tends to generate negative effects on the gut microbiota,and ***,upon TB intake,the Fe^(3+)content in serum,trypsin activity in pancreas and jejunum decreased,while the cytokine,IgE,and histamine levels in serum,water content in faeces,cytokine levels in liver and jejunum ***,TBS did not induce any obvious negative effects on the above relevant indices and showed better lipid-lowering ***,TBS are safer and more effective as a raw material to produce the functional food for long-term consumption with the intention of preventing and treating hyperlipidaemia.

关键词： Tartary buckwheat Tartary buckwheat sprouts Antinutritional factors Gut microbiota Health effect

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Mapping the knowledge domain of crash risk in older drivers studies: A scientometric analysis

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Bingshuo Chen Xiaohua Zhao Yang Li Xiaoming liu Beijing Key Laboratory of Traffic Engineering， College of Metropolitan Transportation， Beijing University of Technology Department of Road Traffic Management， Beijing Police College

With the rapid global progression of population aging， the traffic safety of older drivers has emerged as a worldwide concern， resulting in a significant surge in the number of manuscripts on this subject. This study employed scientometric analysis to scrutinize 1652 original manuscripts concerning research on older drivers. To visually depict the current state of knowledge in the field， Mapping Knowledge Domain (MKD) was employed for scientometric analysis， shedding light on the evolution of this research area. Firstly， a statistical analysis was conducted to scrutinize the development of research on older drivers. Secondly， VOSviewer was utilized for manuscript co-citation analysis， revealing five primary research topics: cognitive function and crash risk， visual processing impairment and crash risk， potential consequences of changes in driving patterns， involvement of older drivers in crashes， as well as identifying and enhancing factors contributing to unsafe driving. Thirdly， CitNetExplorer was applied to identify core publications and their reference relationships. Research predominantly focused on visual function， cognitive function， and physical health. Fourthly， VOSviewer’s keyword co-citation analysis pinpointed research hotspots in the last five years concerning older drivers: driving risk factors， driving fitness evaluation， impact of distraction on driving， and impact of visual impairment on driving. Finally， based on the aforementioned discussions and the situation in China， some feasible research directions are proposed. This paper summarizes the overall trends in the study of older drivers and the risk factors for traffic accidents. These findings can serve as a reference for improving the driving and road traffic safety of older drivers.

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Analysis of the Application Value of Virtual Reality Combined with Flipped Classroom Teaching Mode in Cardiopulmonary Resuscitation Teaching

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Journal of Contemporary Educational Research 2024年第5期8卷 154-159页

作者： Hua liu Yantai Affiliated Hospital of Binzhou Medical College Yantai 26400Shandong ProvinceChina

Objective:To analyze the value of using virtual reality combined with the flipped classroom teaching model in teaching cardiopulmonary resuscitation(CPR).Methods:Two classes of our nursing program were randomly selected for the study from September 2022 to September 2023,Class A(52 students,conventional teaching method)and Class B(52 students,virtual reality combined with flipped classroom teaching mode).The assessment scores and independent learning ability scores of the students in the two classes were ***:CPR theory and operation scores,passing rate,and independent learning ability scores of Class B were higher than those of Class A(P<0.05).Conclusion:the use of virtual reality combined with the flipped classroom teaching mode in CPR teaching is conducive to the improvement of students’assessment scores and independent learning ability.

关键词： Virtual reality Flipped classroom teaching mode Cardiopulmonary resuscitation Assessment performance Independent learning ability

Generative Models for the Evolution of Transportation Systems

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Yixu He Hongyi Lin Lan Yang Yang liu School of Information Engineering， Chang'an University School of Vehicle and Mobility， Tsinghua University Department of Architecture and Civil Engineering， Chalmers University of Technology

As the development of big data and artificial intelligence accelerates， many studies have begun to incorporate methods of machine learning and deep learning to address multifaceted challenges within the field of transportation. Generative models， garnering increasing attention in recent years， are gradually bolstering the progression of intelligent transportation systems. This paper conducts an extensive investigation into the applications and potential of generative models in the evolution of transportation systems. It specifically delves into three primary areas: trajectory generation， traffic flow prediction， and autonomous driving. While generative models have already made significant contributions， their full capabilities remain underexplored. Consequently， this paper introduces promising avenues for future exploration， such as the potential integration of diffusion models in autonomous driving， harnessing generative models for infrastructure planning， and leveraging generative models to enhance traffic safety. It is anticipated that this paper will serve as a comprehensive and insightful reference for researchers and scholars engaged in generative models and their applications in the transportation domain.

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Plants affect the horizontal transmission of a new densovirus infecting the green peach aphid Myzus persicae by modulating honeydew production

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Insect Science 2024年第1期31卷 236-254页

作者： Ya Guo Yani Zhao Yang Yang Yahong Zhang Yuying Li Honggang Tian Tong-Xian liu Zhaofei Li State Key Laboratory of Crop Stress Biology for Arid Areas Key Laboratory of Northwest Loess Plateau Crop Pest Management of Ministry of AgricultureCollege of Plant ProtectionNorthwest A&F UniversityYanglingChina Institute of Entomology and Institute of Plant Health&Medicine Guizhou UniversityGuiyangChina

In a tritrophic context of plant-insect-entomopathogen,plants play important roles in modulating the interaction of insects and their pathogenic ***,the influence of plants on the transmission of insect viruses has been mainly studied on baculoviruses and some RNA viruses,whereas the impact of plants on other insect viruses is largely ***,we identified a new densovirus infecting the green peach aphid Myzus persicae and tested whether and how host plants influence the transmission of the aphid *** complete single-stranded DNA genome of the virus,*** densovirus 2,is 5727 nt and contains inverted terminal *** and phylogenetic analysis indicated that the virus was distinct from other a few identified aphid *** virus abundance was detected highly in the intestinal tract of aphids,compared with the lower level of it in other tissues including head,embryo,and *** and pepper plants had no obvious effect on the vertical transmission and saliva-mediated horizontal transmission of the ***,the honeydew-mediated horizontal transmission among aphids highly depended on host plants(65%on cabbages versus 17%on peppers).Although the virus concentration in the honeydew produced by aphids between 2 plants was similar,the honeydew production of the infected aphids reared on peppers was dramatically *** together,our results provide evidence that plants influence the horizontal transmission of a new densovirus in an aphid population by modulating honeydew secretion of aphids,suggesting plants may manipulate the spread of an aphid-pathogenic densovirus in nature.

关键词： aphids densovirus host plants MpDV2 Myzus persicae transmission

Non-weight modules over the algebra SW(b)

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Science China Mathematics 2024年

作者： Yan liu Xinyue Wang Yao Ma Liangyun Chen School of Mathematics and Statistics Northeast Normal University

In this paper, we denote the semi-direct product of the Witt algebra and the loop Schr?dinger algebra by SW(b), where b belongs to C. Our primary focus is on classifying U(Cd0 ⊕ Ch0)-free modules of rank1 over SW(b). We characterize both the irreducibility and isomorphism classes of these modules. Furthermore,we construct new non-weight modules over SW(0) by taking the tensor product of U(Cd0 ⊕ Ch0)-free modules with irreducible highest weight modules. We also consider the irreducibility and isomorphism classes for the tensor product modules. Finally, we reformulate some tensor product modules over SW(0) as induced modules derived from modules over certain subalgebras.

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Hierarchically Distributed Optimization with a Flexible and Complexity-Reducing Algorithm

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Journal of Systems Science & Complexity 2024年

作者： LIANG Shu ZHANG Lei WEI Yiheng liu Yemo Department of Control Science and Engineering Tongji University Shanghai Research Institute for Intelligent Autonomous Systems School of Mathematics Southeast University Beijing Aerospace Automatic Control Institute

In this paper, the authors consider distributed convex optimization over hierarchical networks. The authors exploit the hierarchical architecture to design specialized distributed algorithms so that the complexity can be reduced compared with that of non-hierarchically distributed *** this end, the authors use local agents to process local functions in the same manner as other distributed algorithms that take advantage of multiple agents' computing resources. Moreover, the authors use pseudocenters to directly integrate lower-level agents' computation results in each iteration step and then share the outcomes through the higher-level network formed by pseudocenters. The authors prove that the complexity of the proposed algorithm exponentially decreases with respect to the total number of pseudocenters. To support the proposed decomposition-composition method for agents and pseudocenters, the authors develop a class of operators. These operators are generalizations of the widely-used subgradient based operator and the proximal operator and can be used in distributed convex optimization. Additionally, these operators are closed with respect to the addition and composition operations; thus, they are suitable to guide hierarchically distributed design and analysis. Furthermore,these operators make the algorithm flexible since agents with different local functions can adopt suitable operators to simplify their calculations. Finally, numerical examples also illustrate the effectiveness of the method.

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SFNet:Stellar Feature Network with CWT for Stellar Spectra Recognition

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Research in Astronomy and Astrophysics 2024年第9期 262-272页

作者： Hao Fu Peng liu Xuan Qi Xue Mei College of Electrical Engineering and Control Science Nanjing Tech University

Stellar spectral classification is crucial in astronomical data analysis. However, existing studies are often limited by the uneven distribution of stellar samples, posing challenges in practical applications. Even when balancing stellar categories and their numbers, there is room for improvement in classification accuracy. This study introduces a Continuous Wavelet Transform using the Super Morlet wavelet to convert stellar spectra into wavelet images. A novel neural network, the Stellar Feature Network, is proposed for classifying these images. Stellar spectra from Large Sky Area Multi-Object Fiber Spectroscopic Telescope DR9, encompassing five equal categories (B, A, F, G,K), were used. Comparative experiments validate the effectiveness of the proposed methods and network,achieving significant improvements in classification accuracy.

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Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1742-1758页

作者： Renming Fan Ruizhuo Lin Shuo Zhang Aohua Deng Yongrui Hai Junyan Zhuang Yang liu Maosheng Cheng Gaofei Wei Institute of Medical Research Northwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationSchool of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China

Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to the activation of cellular oxidative stress and immune responses. While the role of mitochondrial membrane remodeling in promoting inflammation in hepatocytes is well-established, its effects on tumors have remained unclear. In this study, we designed a novel Pt(IV) complex, OAP2, which is composed of oxaliplatin (Oxa) and acetaminophen (APAP), to enhance its anti-tumor effects and amplify the immune response. Our findings demonstrate that OAP2 induces nuclear DNA damage, resulting in the production of nuclear DNA. Additionally, OAP2 downregulates the expression of mitochondrial Sam50, to promote mitochondrial membrane remodeling and trigger mtDNA secretion, leading to double-stranded DNA accumulation and ultimately synergistically activating the intracellular cGAS-STING pathway. The mitochondrial membrane remodeling induced by OAP2 overcomes the limitations of Oxa in activating the STING pathway and simultaneously promotes gasdermin-D-mediated cell pyroptosis. OAP2 also promotes dendritic cell maturation and enhances the quantity and efficacy of cytotoxic T cells, thereby inhibiting cancer cell proliferation and metastasis. Briefly, our study introduces the first novel small-molecule inhibitor that regulates mitochondrial membrane remodeling for active immunotherapy in anti-tumor research, which may provide a creative idea for targeting organelle in anti-tumor therapy.

关键词： Anti-tumor drug Prodrug Platinum Chemo-immunotherapy Mitochondrial membrane modeling STING Pyroptosis mtDNA

Mitochondrial genomes of Tapes dorsatus and Cardita variegata:insights into Heteroconchia phylogeny

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Journal of Oceanology and Limnology 2024年第3期42卷 943-959页

作者： Xumin WANG Hua ZHANG Xindong TENG Wenhui SUN Zhikai XING Shuang WANG Xiumei liu Jiangyong QU Lijun WANG College of Life Science Yantai UniversityYantai 264005China Qingdao International Travel Healthcare Center Qingdao 266071China

Heteroconchia,a widespread and abundant aquatic invertebrate,is an important clade of bivalve *** relationship between the three branches of Heteroconchia,Palaeoheterodonta,Archiheterodonta,and Euheterodonta has become a main controversy in molecular studies of the relationships between *** the present study,we assembled the complete mitochondrial genomes of Tapes dorsatus(Veneridae)and Cardita variegata(Carditidae)using high-throughput *** is the first mitochondrial genome belonging to the family Carditidae to be *** used 12 protein coding genes(excluding atp8)from the complete mitochondrial genomes of 146 species to recover the internal relationships of *** results support the traditional view of early branching of Palaeoheterodonta and the recovery of the monophyly of Palaeoheterodonta,Anomalodesmata,*** analysis show that gene arrangement within Venerida was highly ***-calibrated phylogenetic studies based on a relaxed molecular clock model suggested that Veneridae originated approximately 337.62 million years ago(Ma)and split into two major clades,whereas Carditidae originated approximately 510.09 *** results provide evidence of the internal relationships of Heteroconchia.

关键词： Tapes dorsatus Cardita variegata mitochondrial genome phylogeny

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