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Thermoviscoelastic Modeling Approach for Predicting the Recovery Behaviors of Thermally Activated Amorphous Shape Memory Polymers

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Transactions of Nanjing University of Aeronautics and Astronautics 2019年第5期36卷 798-807页

作者： gu jianping FANG Changqing SUN Huiyu ZHANG Xiaopeng Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of TechnologyNanjing 211167P.R.China Shanghai Space Propulsion Technology Research Institute Shanghai 201109P.R.China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

A thermoviscoelastic modeling approach is developed to predict the recovery behaviors of the thermally activated amorphous shape memory polymers(SMPs)based on the generalized finite deformation viscoelasticity *** this paper,a series of moduli and relaxation times of the generalized Maxwell model is estimated from the stress relaxation master curve by using the nonlinear regression(NLREG)*** that the amorphous SMPs are approximately incompressible isotropic elastomers in the rubbery state,the hyperelastic response of the materials is well modeled with a hyperelastic model in Ogden *** addition,the Williams-Landel-Ferry(WLF)equation is used to describe the horizontal shift factor obtained with time-temperature superposition principle(TTSP).The finite element simulations show good agreement with the experimental thermomechanical ***,the possibility of developing a temperature-responsive intravascular stent with the SMP studied here is investigated in terms of its thermomechanical ***,it can be concluded that the model has good prediction capabilities for the recovery behaviors of amorphous SMPs.

关键词： shape memory polymers(SMPs) thermoviscoelastic modeling approach finite deformation recovery behavior

A hygro-thermo-mechanical constitutive model for shape memory polymers filled with nano-carbon powder

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International Journal of Smart and Nano Materials 2021年第3期12卷 286-306页

作者： jianping gu Xiaopeng Zhang Hao Duan Mengqi Wan Huiyu Sun Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of TechnologyNanjingChina State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjingChina

The nano-carbon powders are often used as fillers to endow the shape memory polymers(SMPs)with *** has been found that the shape memory effects(SMEs)of SMPs filled with nano-carbon powder can be triggered both by temperature and by *** reveal the driving mechanism of SMEs,a constitutive model for describing the thermally activated and moisture activated SMEs of these shape memory polymer composite(SMPCs)is developed *** both of the SMEs share the same driving mechanism,the variable moisture is incorporated into the framework of a thermo-mechanical modeling approach to disclose the effect of moisture on the thermoviscoelastic *** SMPCs are regarded as isotropic materials and the effect of carbon powder on the mechanical properties of the matrix is also considered in the *** the complete recovery may not be reached even they are exposed to the stimulus environment long enough,the blocking mechanism is also considered *** is the mainly new contribution compared to the early *** the method of parameter determination presented here,the effectiveness of the proposed hygro-thermo-mechanical constitutive model is confirmed by comparing the model results with the test data of uniaxial deformation from the literature.

关键词： Shape memory polymer composites nano-carbon powder hygro-thermomechanical constitutive model thermodynamics internal state variables

Manual aspiration thrombectomy for acute and subacute inferior vena cava thrombosis and lower extremity deep venous thrombosis

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Journal of Interventional Medicine 2018年第4期1卷 197-204页

作者： Janesya Sutedjo Yan Li jianping gu Department of Vascular and Interventional Radiology Nanjing First Hospital Nanjing Medical University

Deep vein thrombosis(DVT), which can lead to pulmonary embolism(PE), is a major contributor to the global disease burden and is the third most common cardiovascular pathology after coronary artery disease and stroke. Venous thromboembolic disease, which encompasses the disease entities of DVT and PE, affects up to 10 million cases every year and represents a serious and potentially life-threatening condition. Standard anticoagulation therapy alone is ineffective at promoting deep venous system thrombus removal. Many patients develop postthrombotic syndrome(PTS) despite being on adequate anticoagulation therapy. Aggressive therapy for rapid thrombus removal is important to prevent the development of PTS. Besides impeding the onset of PTS, rapid clearance of the thrombus is also required in the treatment of phlegmasia cerulea dolens, an uncommon but life-threatening complication of acute DVT that can lead to arterial insufficiency, compartment syndrome, venous gangrene, and limb amputation. Manual aspiration thrombectomy(MAT) can provide rapid and effective therapy that could be compared to the open surgical thrombectomy approach with minimal risk of morbidity, mortality, or recurrence after surgery. Though many devices have been developed to date for pharmacomechanical thrombolysis, the cost of the treatment using these devices is very expensive. MAT is simple to perform, easy to learn, inexpensive, and rapid. This review will outline and dissect several studies and case reports, sourced from the Pub Med database, on the subject of the use of MAT in treating inferior vena cava thrombosis and lower extremity DVT, including in patients with compression of the iliac vein and phlegmasia cerulea dolens.

关键词： thrombectomy venous thrombosis lower extremity vena cava inferior

A thermoviscoelastic finite deformation constitutive model based on dual relaxation mechanisms for amorphous shape memory polymers

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International Journal of Smart and Nano Materials 2023年第2期14卷 243-264页

作者： Hao Duan jianping gu Hao Zeng Akbar A.Khatibi Huiyu Sun State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjingChina Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of TechnologyNanjingChina School of Physical and Mathematical Sciences Nanjing Tech UniversityNanjingChina School of Engineering Royal Melbourne Institute of TechnologyMelbourneAustralia

This paper proposes a new thermoviscoelastic finite deformation model incorporating dual relaxation mechanisms to predict the complete thermo-mechanical response of amorphous shape memory *** model is underpinned by the detailed microscopic molecular mechanism and effectively reflects the current understanding of the glass transition *** evolution rules are obtained from the model to characterize the viscous flow,and a new theory named an internal stress model is introduced and combined with the dual relaxation mechanisms to capture the stress *** rationality of the constitutive model is verified as the theoretical results agree well with the experimental ***,the constitutive model is further simplified to facilitate engineering applications,and it can roughly capture the characteristics of shape memory polymers.

关键词： Shape memory polymers constitutive model dual relaxation mechanisms viscous flow rules internal stress model

Conventional versus drug-eluting bead transarterial chemoembolization:A better option for treatment of unresectable hepatocellular carcinoma

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Journal of Interventional Medicine 2021年第1期4卷 11-14页

作者： Murtuza Razi gu jianping He Xu Mohammed Jameeluddin Ahmed Department of Interventional Radiology Nanjing Medical University Third School of Clinical MedicineNanjing First HospitalNanjingJiangsu210006China

Transarterial chemoembolization(TACE) is a minimally invasive procedure involving intra-arterial catheter-based chemotherapy to selectively administer high doses of cytotoxic drugs to the tumor bed along with ischemic necrosis induced by arterial *** forms the essential core of management in patients with hepatocellular carcinoma(HCC) who are not suitable for curative therapies such as transplantation,resection,or percutaneous *** of hepatic cancer(s) has proven to be helpful in achieving local tumor control,and has supported the ability to prevent tumor progression,prolong patient life,and manage patient *** data have demonstrated that,in patients with single-nodule HCC ≤3 cm without vascular invasion,the 5-year overall survival with TACE was found to be comparable with hepatic resection and radiofrequency *** for several years,Lipiodol continues to play a vital role as a tumor-seeking and radiopaque drug delivery vector in interventional *** have been made to enhance the administration of chemotherapeutic agents to *** with conventional TACE,drug-eluting bead TACE is a fairly new drug delivery embolization technique that permits fixed dosing and has the ability to provide sustained release of anticancer agents over a period of *** present review discusses the basic procedure of TACE and its properties,and the effectiveness of conventional and drug-eluting bead chemoembolization systems currently available or presently undergoing clinical evaluation.

关键词： Transarterial chemoembolization Drug-eluting bead Hepatocellular carcinoma

Venous thromboembolism in patients with COVID-19.A prevalent and a preventable complication of the pandemic

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Journal of Interventional Medicine 2021年第2期4卷 62-65页

作者： Murtuza Razi jianping gu Xu He Jie Kong Mohammed Jameeluddin Ahmed Department of Interventional Radiology Nanjing Medical University Third School of Clinical MedicineNanjing First Hospital NanjingJiangsu210006China

Coronavirus disease 2019 or most commonly known as COVID-19 is a trending global infectious disease which a few months ago was affirmed as a global health emergency or a pandemic by the WHO Emergency *** common symptoms manifested in this pandemic disease are high grade fever,cough,fatigue,shortness of breath and flu like symptom which can evolve into severe respiratory disorders such as pneumonia,acute respiratory distress syndrome(ARDS)and/or end-organ *** that contribute to the severity or high mortality rate in COVID-19 include old age,comorbidities like hypertension,diabetes,hyperlipidaemia,neutrophilia,and organ and coagulation *** intravascular coagulation and other various coagulopathies including Venous thromboembolism have known to become a major contributing factor to high mortality *** thromboembolism is a disease which is a combination of deep vein thrombosis and pulmonary *** anticoagulation in patients prone to or with a pre-existing history of venous thromboembolism is associated with decreased mortality in severe COVID-19 *** review article focuses upon COVID-19 and increased incidence of venous thromboembolism in patients infected by COVID-19 along with the role it has in high mortality rate in COVID-19 patients.

关键词： Venous thromboembolism COVID-19 Coagulopathies Prophylactic anticoagulation Pandemic

Comparison of tumor response following conventional versus drug-eluting bead transarterial chemoembolization in early-and very early-stage hepatocellular carcinoma

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Journal of Interventional Medicine 2022年第1期5卷 10-14页

作者： Murtuza Razi Syed Safiullah jianping gu Xu He Mustafa Razi Jie Kong Department of Interventional Radiology Nanjing Medical University Third School of Clinical MedicineNanjing First HospitalNanjingJiangsu210006China Department of Diagnostic and Interventional Radiology Omega HospitalsRd no.12 Banjara HillsHyderabad500034TelanganaIndia Department of Vascular and Endovascular Surgery and Interventional Radiology Care Hospitals-Outpatient CenterRd no.12 Banjara HillsHyderabad500034TelanganaIndia

Objective:To compare the safety of conventional transarterial chemoembolization(cTACE)vs drug-eluting bead TACE(DEB-TACE)in very early-and early-stage hepatocellular carcinoma(HCC).Methods:Data of patients with early-and very early-stage HCC treated with cTACE or DEB-TACE were evaluated retrospectively in this study.A total of 40 patients were included,20 treated with cTACE and 20 with *** cTACE and DEB-TACE groups were comprised of 80%and 75%males,while there were 20%females in cTACE group and 25%in Deb-TACE group *** mean age of patients in cTACE group was 57.43+5.6 years,while it was 56.4+5.5 years in DEB-TACE *** patients had liver status of Child–Pugh Class A and a score≤7 in Child-Pugh class type B in very early-(stage 0)or early-phase(stage A)stages according to the Barcelona Clinic Liver Cancer(BCLC)***:The Child-Pugh class degradation in the cTACE group was slightly higher than that in the DEB-TACE *** complications like peritumoral parenchymal ischemia were observed in 4 patients in the cTACE group and 5 in the DEB-TACE *** bile duct dilation was seen in 2 patients in the cTACE group and 6 in the DEB-TACE *** significant variation in serious complications between the two groups was established in localized bile duct *** minor complications noted were liver failure,liver abscess,liver infarction,acute cholecystitis,biliary tree necrosis,and ***,no substantial variation in tumor response between the groups was reported immediately and 1-year post-procedural *** rate to other treatment modalities such as surgical resection,radiofrequency ablation(RFA),or swap between cTACE and DEB-TACE was substantially higher in the DEB-TACE group(40%)than in the cTACE group(10%)at the 1-year completion period of the ***:In terms of tumor response,the DEB-TACE group showed a better response,to some extent,as an initial therapy for HCC in the early stage

关键词： HCC TACE cTACE DEB-TACE

Study on the Relationship between Entrepreneur's Spiritual Capital and Employee Creativity

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Journal of Finance Research 2018年第2期2卷 45-47页

作者： Xue Chen jianping gu Evan David School of Business Nanjing Normal UniversityNanjingJiangsu210097China

Through this research about the relationship between entrepreneur'spiritual capitals and employee creativity,this paper explores the influence mechanism of entrepreneur's spiritual capital on employee creativity,and constructs a mediating *** research shows that entrepreneur's spiritual capital has positive predictive effect on employee creativity,and organizational innovation atmosphere plays a partial mediating role between them.

关键词： Entrepreneur's spiritual capital Employee creativity Organizational innovation atmosphere

Consensus among Chinese experts on standard interventional therapy for deep venous thrombosis of lower extremity(second edition)

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Journal of Interventional Medicine 2018年第3期1卷 125-136页

作者： jianping gu Ke Xu Gaojun Teng Nanjing First Hospital Nanjing Medical University The First Hospital of China Medical University Zhongda Hospital Southeast University

This is an update on the first edition of the expert consensus. This document discusses the indications and contraindications of interventional treatment methods for deep venous thrombosis such as anticoagulation, catheter-directed thrombolysis, percutaneous mechanical thrombectomy, percutaneous transluminal angioplasty and stent implantation. The operational procedures, considerations, preoperative management, and prevention of complications were also updated, supplemented, and revised. Emphasis is placed on the interventional treatment of acute and subacute deep venous thrombosis to effectively reduce the incidence of post-thrombosis syndrome.

关键词： deep venous thrombosis interventional therapy consensus