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Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats

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Food Science and Human Wellness 2024年第5期13卷 2562-2572页

作者： Nan Shang Xiaoyu Bao Michael Doschak jianping Wu Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada College of Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthyChina Agricultural UniversityBeijing 100193China Faculty of Pharmacy&Pharmaceutical Sciences University of AlbertaEdmonton T6G 2H5Canada

Ovotransferrin,an iron-binding glycoprotein,accounting for approximately 12%of egg white protein,is a member of transferrin fam *** previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts,while inhibits osteoclastogenesis and resorption *** work aims to study the efficacy of orally administered ovotransferrin on the prevention of osteoporosis using ovariectomized(OVX)Sprague-Dawley *** administration of ovotransferrin showed no negative effect on body weight,food intake and organ *** 12-week treatment,feeding ovotransferrin at a dose of 1%(1 g ovotransferrin/100 g diet)prevented OVX-induced bone loss and maintained relatively high bone mineral density and integrated bone *** serum concentration of biomarkers indicating bone formation was increased in ovotransferrin administration groups,while the bone resorption biomarkers were *** feeding also decreased the production of serum cytokine TNF-αand IL-6,which are two stimulators for osteoclast *** addition to its direct regulatory role on bone turnover,ovotransferrin supplementation might benefit osteoporosis prevention by inhibiting adipogenesis,and regulating immune *** results suggested the potential application of ovotransferrin as a functional food ingredient on the prevention of osteoporosis.

关键词： Ovotransferrin Ovariectomized(OVX)rats Bone mineral density Bone microarchitecture Bone resorption Inflammation

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The synthesis of fluorescent nanoclusters based on the etching reaction

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Nano Research 2024年第5期17卷 4631-4638页

作者： Hongbin Lin Yitao Cao Qiaofeng Yao Tiankai Chen Huiting Shan jianping Xie Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)and Key Laboratory of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Key Laboratory of Integrated Organic CircuitsMinistry of EducationDepartment of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China

Thiolate-protected atomically precise nanoclusters(NCs)demonstrate a series of unique luminescent characteristics attributed to their various peculiar electronic ***,fluorescent NCs present extraordinary practical values in biosensing and bioimaging research ***,restricted by the types of fluorescent NCs,there are great difficulties in promoting the development of NCs in fluorescent research *** a result,it is of significant necessity for researchers to develop new synthetic pathways to produce high-quality fluorescent *** to the analysis about the structural characteristics of fluorescent NCs,some general features like longer motif and higher ligand-to-metal ratio can be found,consistent to some presented regularities in etching ***,in this work,we used Au_(25)(MHA)_(18)(MHA=6-mercaptohexanoic acid)as a model nanocluster and utilized the etching reaction to systematically explore etching products and their corresponding luminescent ***,we also identified three main reaction processes in the entire etching reaction process,which can generate new metal nanocluster species with various fluorescent ***,the etching reaction will provide a good platform to produce new luminescent metal NC species.

关键词： etching reaction metal nanoclusters fluorescent properties fluorescent conversion

Study on the Relationship between Structural Aspects and Aerodynamic Characteristics of Archimedes Spiral Wind Turbines

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1517-1537页

作者： Yuanjun Dai Zetao Deng Baohua Li Lei Zhong jianping Wang Mechanical and Electrical Engineering Institue Xinjiang Agricultural UniversityUrumqi830052China College of Mechanics Shanghai DianJi UniversityShanghai201306China School of Energy Engineering Xinjiang Institute of EngineeringUrumqi830023China

A combined experimental and numerical research study is conducted to investigate the complex relationship between the structure and the aerodynamic performances of an Archimedes spiral wind turbine(ASWT).Two ASWTs are considered,a prototypical version and an improved *** is shown that the latter achieves the best aerodynamic performance when the spread angles at the three sets of blades areα_(1)=30°,α_(2)=55°,α3=60°,respectively and the blade thickness is 4 *** a velocity V=10 m/s,a tip speed ratio(TSR)=1.58 and 2,the maximum CP values are 0.223 and 0.263 for the prototypical ASWT and improved ASWT,respectively,and the maximum C_(P) enhancement is 17.93%.For V=10 m/s and TSR=2,the CP values of the prototypical ASWT and improved ASWT are 0.225 and 0.263,respectively,with an aerodynamic performance enhancement of 16.88%.Through mutual verification of the test outcomes and numerical results,it is concluded that the proposed approach can effectively lead to aerodynamic performance improvement.

关键词： Archimedes spiral wind turbine aerodynamic performance numerical calculation

Selenium Regulates Antioxidant Capacities and Diterpenoid Biosynthesis in the Medicinal Plant Isodon rubescens

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1705-1716页

作者： Fenglan Zhao Shuwen Wu Xue Meng jianping Xue Yongbo Duan Anhui Provincial Engineering Laboratory for Efficient Utilization of Featured Resource Plants College of Life SciencesHuaibei Normal UniversityHuaibei235000China Huaibei Key Laboratory of Efficient Cultivation and Utilization of Resource Plants College of Life SciencesHuaibei Normal UniversityHuaibei235000China

Dōng líng căo,the dried aboveground parts of Isodon rubescens(hemls.)Hara.,is commonly consumed as a med-icinal decoction or tea *** beverages can be an important source of human dietary selenium(Se).However,how *** plants respond to exogenous Se remains *** this study,a pot cultivation experiment was employed to investigate the phenotypic and physiological responses of *** plants exposed to *** days after applying different concentrations of sodium selenate to the soil,the Se enrichment capa-city,growth indices,antioxidant capacities,and the content ofﬂavonoids and diterpenoids were measured in the ***,the oridonin content was quantiﬁed using the high-performance liquid chromatography method,and the expression levels of key diterpenoid synthesis genes were analyzed by quantitative real-time PCR(qRT-PCR).*** plants efﬁciently accumulated Se,with the Se content increasing proportionally to the applied dose,reaching levels of nearly 200 mg·kg^(-1) dry leaves as Se concentration *** of the three Se treat-ments signiﬁcantly altered the phenotypic indices,except a longer root length occurred in the 3μM·kg^(-1) Se *** three Se doses,6μM·kg^(-1) Se gave the highest accumulation ofﬂavonoids,diterpenoids,and oridonin,with the increase of 2.0-,1.8-,and 1.9-fold in aboveground parts,*** application boosted the activities of antioxidant enzymes and antioxidant capacities according to 2,2-Diphenyl-1-picrylhydrazyl(DPPH),ferric reducing/antioxidant power,and tea brewing color *** key synthase genes were upregulated signiﬁcantly by 6μM·kg^(-1) Se treatment,notably 1-deoxy-D-xylulose 5-phosphate reductoisomerase(IrDXR),with a 5-fold increase,and kaurene synthase-like 4(IrKSL4),with a 6-fold ***,Se application in *** cultivation may be a potential biofortiﬁcation method to supplement Se while increasingﬂavonoid and diterpenoid contents.

关键词： Flavonoids oridonin physiological indicators quantitative real-time PCR selenium

基于机器学习的薄板等离子弧搭接焊的熔深预测

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材料科学与工艺 2023年第4期31卷 51-59页

作者：贾琪何建萍李芳华学明上海工程技术大学材料科学与工程学院上海201620 上海市激光制造与材料改性重点实验室(上海交通大学) 上海200240

在等离子弧搭接焊中,搭接焊接头的焊缝熔深是评价焊接质量的关键指标之一,而焊接过程中的热输入信息和熔池图像信息都与焊缝熔深有密切关系。本文通过建立304L不锈钢薄板等离子弧搭接焊数据采集系统,利用LabVIEW实时检测电信息,采用视... 详细信息

在等离子弧搭接焊中,搭接焊接头的焊缝熔深是评价焊接质量的关键指标之一,而焊接过程中的热输入信息和熔池图像信息都与焊缝熔深有密切关系。本文通过建立304L不锈钢薄板等离子弧搭接焊数据采集系统,利用LabVIEW实时检测电信息,采用视觉传感技术实时获取薄板等离子弧搭接焊过程中的熔池图像,并通过图像处理方法获得熔池的几何参数信息,结合焊接工艺参数,选择峰值电流、峰值电压、焊接速度、离子气流量、保护气流量、熔池宽度和熔池后端长度作为输入量,焊缝熔深作为输出量,建立了基于支持向量机回归和BP神经网络的熔深预测模型。实验验证表明,采用径向基函数的支持向量机回归模型可以有效地对焊缝熔深进行预测,并具有很好的泛化能力,可为进一步实现在线优化焊接工艺参数提供依据。

关键词：等离子弧焊薄板 LabVIEW 视觉传感 SVR 熔深预测

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High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye he jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(he FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

Hybrid Content Distribution Framework for Large-Scale Vehicular Ad Hoc Networks

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ZTE Communications 2016年第3期14卷 22-28页

作者： he jianping CAI Lin Department of Electrical & Computer Engineering University of Victoria

Content distribution in large-scale vehicular ad hoc networks is difficult due to the scalability issue. A message may need to be carried by several vehicles till it reaches the destination. To select an appropriate next-hop carrier, the current carrier should ex- change control messages with a large number of vehicles encountered, and thus the pure ad hoc solution is not scalable. In this paper, we introduce a hybrid-network solution. We first divide the area into regions, and select a hot spot in each region to install a road-side unit （RSU）. RSUs can coordinate message exchanges between vehicles, and storage devices are used to temporarily hold a message waiting for the next-hop carrier. The RSUs and the vehicles traveling between them construct an overlay store-car- ry-and-forward content distribution network. Two types of vehicles exist, one with fixed mobility patterns such as buses, and the other with random patterns such as taxis. Considering one or both types of vehicles, utility-based optimization problems can be formulated to find the optimal routing solutions. Using the bus and taxi traces of Shanghai city, we demonstrate the effectiveness of the hybrid framework in terms of delivery delay, delivery ratio and overhead ratio.

关键词： content distribution VANETs utility-based routing store-carry-and-forward

维普期刊数据库

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西晋名士“约言”观之成因及其文学影响

四川大学学报（哲学社会科学版） 2022年第6期 66-75页

作者：何剑平刘学涛四川大学中国俗文化研究所成都610207

“约言”是西晋名士对于清谈语言的讲究,是理想谈论必备的条件之一,对两晋南北朝文学有至深影响。论辩推重“约言”较早反映在西晋东都洛阳的名士群中,以乐广、阮瞻等为代表,它的生成既有中土论辩强调“理足则止”“不务烦辞”的言语传... 详细信息

“约言”是西晋名士对于清谈语言的讲究,是理想谈论必备的条件之一,对两晋南北朝文学有至深影响。论辩推重“约言”较早反映在西晋东都洛阳的名士群中,以乐广、阮瞻等为代表,它的生成既有中土论辩强调“理足则止”“不务烦辞”的言语传统,也有西晋汉译佛典《般若经》《维摩诘经》等传播的背景因素。其中后者所倡超越名言概念,逐次遣言乃至废言(无言)的思辨观,直接影响到东晋南北朝文体论对“精约”与“繁缛”二体的评价标准。

关键词：西晋名士 “约言”观论辩传统佛典传译两晋南北朝文学

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Current therapies for osteoarthritis and prospects of CRISPR-based genome,epigenome,and RNA editing in osteoarthritis treatment

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Journal of Genetics and Genomics 2024年第2期51卷 159-183页

作者： Yuxi Chen Xiao Luo Rui Kang Kaixin Cui jianping Ou Xiya Zhang Puping Liang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center for Reproductive Medicine The Third Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhouGuangdong 510630China

Osteoarthritis(OA)is one of the most common degenerative joint diseases worldwide,causing pain,disability,and decreased quality of *** balance between regeneration and inflammation-induced degradation results in multiple etiologies and complex pathogenesis of ***,there is a lack of effective therapeutic strategies for OA *** the development of CRISPR-based genome,epigenome,and RNA editing tools,OA treatment has been improved by targeting genetic risk factors,activating chondrogenic elements,and modulating inflammatory *** by cell therapy and in vivo delivery vectors,genome,epigenome,and RNA editing tools may provide a promising approach for personalized OA *** review summarizes CRISPR-based genome,epigenome,and RNA editing tools that can be applied to the treatment of OA and provides insights into the development of CRISPR-based therapeutics for OA ***,in-depth evaluations of the efficacy and safety of these tools in human OA treatment are needed.

关键词： Osteoarthritis Genome editing Epigenone editing RNA editing