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富血小板血浆来源的血小板细胞外囊泡分离技术与应用

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中国组织工程研究 2025年第1期29卷 156-163页

作者：李娇李晓丰李剑平辽宁省血液中心辽宁省输血医学研究所辽宁省沈阳市110044 中国医科大学药学院辽宁省沈阳市110122 哈尔滨市血液中心黑龙江省哈尔滨市150056 中国科学院苏州生物医学工程技术研究所江苏省苏州市215000

背景:血小板细胞外囊泡是循环中最丰富的囊泡,富含丰富的生物活性分子、遗传物质及蛋白质等信息分子,参与细胞通讯和物质交换,不仅具有良好的促凝活性,还具有促进组织修复和再生的巨大潜力,在再生医学具有广泛的应用前景。目的:从血小... 详细信息

背景:血小板细胞外囊泡是循环中最丰富的囊泡,富含丰富的生物活性分子、遗传物质及蛋白质等信息分子,参与细胞通讯和物质交换,不仅具有良好的促凝活性,还具有促进组织修复和再生的巨大潜力,在再生医学具有广泛的应用前景。目的:从血小板细胞外囊泡的分泌机制、在再生医学领域的应用及临床转化的限制因素进行阐述,为血小板细胞外囊泡的临床转化提供一些理论支撑。方法:应用计算机检索2005年1月至2023年8月PubMed数据库与血小板细胞外囊泡有关的文章,英文检索词为“platelet-derived,plateletrich plasma,extracellular vesicles,isolated,microvesicles exosomes,applications”,最后纳入符合主题标准的文献62篇进行综述分析。结果与结论:(1)活化的血小板细胞外囊泡可产生血小板微囊泡和血小板外泌体两种类型的囊泡,前者的分泌可能与肌动蛋白细胞骨架的不对称性相关,后者的分泌可能与H^(+)-ATP酶的调节相关。(2)血小板细胞外囊泡是血小板浓缩物和血小板本身的潜在效应物,可能通过促进血管生成、影响细胞行为、促凝与止血以及发挥炎症作用等几方面影响组织再生。(3)血小板细胞外囊泡在组织损伤、肌肉再生、软骨再生、骨关节炎等再生医学领域已有临床前报道,作为伤口愈合的潜在治疗方法已有临床试验数据,但血小板细胞外囊泡的分离方法、样本来源以及激活剂的种类等因素限制了血小板细胞外囊泡在再生医学领域的临床转化。(4)未来血小板细胞外囊泡可能成为再生医学中替代富血小板血浆的无细胞疗法,其临床转化还需要积极寻找鉴别血小板细胞外囊泡和血小板外泌体的特异性标志物,在激活剂刺激血小板细胞外囊泡产生的机制以及血小板细胞外囊泡的最佳收集方式、最佳储存方法、保质期限、临床应用的推荐剂量和最佳临床适应证还需要继续深入研究。

关键词：血小板来源富血小板血浆血小板裂解液细胞外囊泡微泡外泌体分离治疗组织损伤应用

Comparisons of Two Ensemble Mean Methods in Measuring the Average Error Growth and the Predictability

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Acta meteorologica Sinica 2011年第4期25卷 395-404页

作者： DING Ruiqiang li jianping State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029

In this paper, taking the Lorenz system as an example, we compare the influences of the arithmetic mean and the geometric mean on measuring the global and local average error growth. The results show that the geometric mean error （GME） has a smoother growth than the arithmetic mean error （AME） for the global average error growth, and the GME is directly related to the maximal Lyapunov exponent, but the AME is not, as already noted by Krishnamurthy in 1993. Besides these, the GME is shown to be more appropriate than the AME in measuring the mean error growth in terms of the probability distribution of errors. The physical meanings of the saturation levels of the AME and the GME are also shown to be different. However, there is no obvious difference between the local average error growth with the arithmetic mean and the geometric mean, indicating that the choices of the AME or the GME have no influence on the measure of local average predictability.

关键词： predictability arithmetic mean geometric mean Lorenz system

Vector mode based optical direct detection orthogonal frequency division multiplexing transmission in short-reach optical link

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Frontiers of Optoelectronics 2019年第1期12卷 41-51页

作者： jianping li Zhaohui li Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou 510632China State Key Laboratory of Optoelectronic Materials and Technologies and School of Electronics and Information Technology Sun Yat-sen UniversityGuangzhou 510275China

As one solution to implement the largecapacity space division multiplexing(SDM)transmission systems,the mode division multiplexing(MDM)has gained much attention *** vector mode(VM),which is the eigenmode of the optical fiber,has also been adopted to realize the optical communications including the transmission over free-space optical(FSO)and optical fiber *** the concerns on the short-reach optical interconnects,the low cost and high integration technologies should be *** detection(DD)with higher-order modulation formats in combination of MDM technologies could offer an available trade-off in system performance and *** review demonstrations of FSO and fiber high-speed data transmission based on the VM MDM(VMDM)*** special VMs,cylindrical vector beams(CVB),have been generated by the q-plate(QP)and characterized *** then they were used to implement the VMDM transmission with direct-detection orthogonal frequency division multiplexing(DD-OFDM).These demonstrations show the potential of VMDM-DD-OFDM technology in the large-capacity short-reach transmission links.

关键词： space division multiplexing (SDM) mode division multiplexing (MDM) few-mode fiber (FMF) vector mode (VM) cylindrical vector beam (CVB) orthogonal frequency division multiplexing (OFDM) direct detection (DD) optical interconnect

DNA replication licensing control and rereplication prevention

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Protein & Cell 2010年第3期1卷 227-236页

作者： Chonghua li jianping Jin Department of Biochemistry and Molecular Biology The University of Texas Medical School at HoustonHoustonTX 77030USA The Graduate School of Biomedical Sciences The University of Texas Health Science Center at HoustonHoustonTX 77030USA

Eukaryotic DNA replication is tightly restricted to onlyonce per cell cycle in order to maintain genome *** use multiple mechanisms to control the assemblyof the prereplication complex (pre-RC), a process knownas replication licensing. This review focuses on theregulation of replication licensing by posttranslationalmodifications of the licensing factors, including phosphorylation, ubiquitylation and acetylation. These modifications are critical in establishing the pre-RCcomplexes as well as preventing rereplication in each cellcycle. The relationship between rereplication and diseases, including cancer and virus infection, is discussedas well.

关键词： DNA replication licensing rereplication protein modification

Quantitative Comparison of Predictabilities of Warm and Cold Events Using the Backward Nonlinear Local Lyapunov Exponent Method

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Advances in Atmospheric Sciences 2020年第9期37卷 951-958页

作者： Xuan li Ruiqiang DING jianping li Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Key Laboratory of Physical Oceanography Institute for Advanced Ocean StudiesOcean University of China and Qingdao National Laboratory for Marine Science and TechnologyQingdao 266100China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Key Laboratory of Physical Oceanography/Institute for Advanced Ocean Studies Ocean University of China and Qingdao National Laboratory for Marine Science and TechnologyQingdao 266100China

The backward nonlinear local Lyapunov exponent method(BNLLE)is applied to quantify the predictability of warm and cold events in the Lorenz *** show that the maximum prediction lead times of warm and cold events present obvious layered structures in phase *** maximum prediction lead times of each warm(cold)event on individual circles concentric with the distribution of warm(cold)regime events are roughly the same,whereas the maximum prediction lead time of events on other circles are *** results show that warm events are more predictable than cold events.

关键词： backward nonlinear local Lyapunov exponent maximum prediction lead time layered structure statistical result

Revealing the correlation between structure evolution and electrochemical performance of high-voltage lithium cobalt oxide

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Journal of Energy Chemistry 2021年第3期30卷 786-794页

作者： Jiajia Wan jianping Zhu Yuxuan Xiang Guiming Zhong Xiangsi liu Yixiao li kelvin H.L.Zhang Chaoyu Hong Jianming Zheng Kai Wang Yong Yang Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory for Physical Chemistry of Solid SurfaceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021FujianChina Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina Ningde Amperex Technology Ltd Ningde 352100FujianChina School of Energy Xiamen UniversityXiamen 361005FujianChina

lithium cobalt oxide(LCO)is the dominating cathode materials for lithium-ion batteries(liBs)deployed in consumer electronic devices for its superior volumetric energy density and electrochemical *** constantly increasing demands of higher energy density urge to develop high-voltage LCO via a variety of ***,the corresponding modification mechanism,especially the influence of the long-and short-range structural transitions at high-voltage on electrochemical performance,is still not well understood and needs further *** on ss-NMR,in-situ X-ray diffraction,and electrochemical performance results,it is revealed that the H3 to H1-3 phase transition dictates the structural reversibility and stability of LCO,thereby determining the electrochemical *** introduction of La and Al ions could postpone the appearance of H1-3 phase and induce various types of local environments to alleviate the volume variation at the atomic level,leading to better reversibility of the H1-3 phase and smaller lattice strain,and significantly improved cycle *** a comprehensive long-range,local,and electronic structure characterization enables an in-depth understanding of the structural evolution of LCO,providing a guiding principle for developing high-voltage LCO for high energy density liBs.

关键词： lithium cobalt oxide High-voltage In-situ XRD Solid-state NMR Structure change

Determination of the Backward Predictability limit and Its Relationship with the Forward Predictability limit

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Advances in Atmospheric Sciences 2019年第6期36卷 669-677页

作者： Xuan li Ruiqiang DING jianping li State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences College of Earth Science University of Chinese Academy of Sciences Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and Technology College of Global Change and Earth System Sciences (GCESS) Beijing Normal University

In this work, two types of predictability are proposed—forward and backward predictability—and then applied in the nonlinear local Lyapunov exponent approach to the Lorenz63 and Lorenz96 models to quantitatively estimate the local forward and backward predictability limits of states in phase space. The forward predictability mainly focuses on the forward evolution of initial errors superposed on the initial state over time, while the backward predictability is mainly concerned with when the given state can be predicted before this state happens. From the results, there is a negative correlation between the local forward and backward predictability limits. That is, the forward predictability limits are higher when the backward predictability limits are lower, and vice versa. We also find that the sum of forward and backward predictability limits of each state tends to fluctuate around the average value of sums of the forward and backward predictability limits of sufficient ***, the average value is constant when the states are sufficient. For different chaotic systems, the average value is dependent on the chaotic systems and more complex chaotic systems get a lower average value. For a single chaotic system,the average value depends on the magnitude of initial perturbations. The average values decrease as the magnitudes of initial perturbations increase.

关键词： nonlinear local Lyapunov exponent forward and backward predictability limit negative correlation average value

Determining the Spectrum of the Nonlinear Local Lyapunov Exponents in a Multidimensional Chaotic System

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Advances in Atmospheric Sciences 2017年第9期34卷 1027-1034页

作者： Ruiqiang DING jianping li Baosheng li State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences Plateau Atmosphere and Environment Key Laboratory of Sichuan Province Chengdu University of Information Technology College of Global Change and Earth System Sciences Beijing Normal University University of Chinese Academy of Sciences

For an n-dimensional chaotic system, we extend the definition of the nonlinear local Lyapunov exponent （NLLE） from one- to n-dimensional spectra, and present a method for computing the NLLE spectrum. The method is tested on three chaotic systems with different complexity. The results indicate that the NLLE spectrum realistically characterizes the growth rates of initial error vectors along different directions from the linear to nonlinear phases of error growth. This represents an improvement over the traditional Lyapunov exponent spectrum, which only characterizes the error growth rates during the linear phase of error growth. In addition, because the NLLE spectrum can effectively separate the slowly and rapidly growing perturbations, it is shown to be more suitable for estimating the predictability of chaotic systems, as compared to the traditional Lyapunov exponent spectrum.

关键词： Lyapunov exponent nonlinear local Lyapunov exponent predictability

Investigation on low total temperature combustion characteristics of kerosene-fueled supersonic combustor

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Chinese Journal of Aeronautics 2022年第7期35卷 192-208页

作者： jianping li Kai WANG Guiqian JIAO Zilong liAO Jindong li School of Engine and Energy Northwestern Polytechnical UniversityXi’an 710072China

In this paper,the combustion characteristics of kerosene-fueled supersonic combustor under the conditions of Mach number 2.0,the total temperature at 700 K and the total pressure at 520 k Pa(simulated flight Mach number at 3.5)were studied by using the flame stabilizing method of cavity and strut from three aspects such as blockage ratios,kerosene equivalence ratios,location and quantity of injection *** results showed that:(A)The combustor with the strut realized the independent and stable combustion of *** combustion-induced back pressure in the block test with blockage ratio of 20%and 10%destroyed the inlet flow conditions;while the blockage ratio was 7.3%and 5%,the incoming flow conditions when kerosene was burned stably were not destroyed.(B)The kerosene Equivalence Ratio(ER)was more likely to be disturbed upstream than the induced back pressure when it rose,and an excessively high-ER would reduce the combustion efficiency;when the equivalence ratio was constant,the combustion efficiency of the blockage ratio of 7.3%was higher than the blockage ratio of 5%.The combustion efficiencies were 0.86(ER=0.13)and 0.78(ER=0.19)when the blockage ratio was 5%,respectively;the combustion efficiencies were 0.89(ER=0.16)and 0.82(ER=0.19)when the blockage ratio was 7.3%,respectively;the combustion efficiencies were 0.51(ER=0.25),0.81(ER=0.3),0.65(ER=0.34)and0.62(ER=0.42)when the blockage ratio was 20%,respectively.(C)The porous injection provided behind the strut was beneficial to the atomization of kerosene and improved the combustion efficiency of kerosene;the second injection after the cavity would reduce the combustion efficiency due to insufficient oxygen and combustion *** study expanded the working range of ramjet and provided a reference fuel injection scheme for Turbine-Based Combined Cycle(TBCC)engine.

关键词： Blockage ratio Combustion characteristics Combustion efficiency Kerosene equivalence ratio Low temperature