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Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field

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Frontiers of Medicine 2021年第2期15卷 170-177页

作者： jianpeng liu Xinhua Chen Shusen Zheng Division of Hepatobiliary Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Key Laboratory of Combined Multi-organ Transplantation Ministry of Public HealthKey Laboratory of the Diagnosis and Treatment of Organ TransplantationCAMSKey Laboratory of Organ TransplantationHangzhou 310003China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003China

Nanosecond pulsed electric field(nsPEF)is a novel,nonthermal,and minimally invasive modality that can ablate solid tumors by inducing *** animal experiments show that nsPEF can induce the immunogenic cell death of hepatocellular carcinoma(HCC)and stimulate the host’s immune response to kill residual tumor cells and decrease distant metastatic ***-induced immunity is of great clinical importance because the nonthermal ablation may enhance the immune memory,which can prevent HCC recurrence and *** review summarized the most advanced research on the effect of *** possible mechanisms of how locoregional nsPEF ablation enhances the systemic anticancer immune responses were *** stimulates the host immune system to boost stimulation and prevail ***,nsPEF increases the dendritic cell loading and inhibits the regulatory responses,thereby improving immune stimulation and limiting immunosuppression in HCC-bearing ***,nsPEF has excellent potential for HCC treatment.

关键词： nanosecond pulsed electric fields(nsPEF) hepatocellular carcinoma(HCC) immune response recurrence metastasis

Alternating twisted multilayer graphene:generic partition rules,double flat bands,and orbital magnetoelectric effect

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npj Computational Materials 2022年第1期8卷 1037-1044页

作者： Bo Xie Ran Peng Shihao Zhang jianpeng liu School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai201210China

Recently the alternating twisted trilayer graphene is discovered to exhibit unconventional superconductivity,which motivates us to study the electronic structures and possible correlation effects for this class of alternating twisted multilayer graphene(ATMG)*** this work we consider generic ATMG systems with M-L-N stacking configurations,in which the M(L)graphene layers and the L(N)layers are twisted by an angleθ(−θ).Based on analysis from a simplified k⋅p model approach,we derive generic partition rules for the low-energy electronic structures,which exhibit various band dispersions including two pairs of flat bands and flat bands co-existing with various gapless Fermionic *** a mirror-symmetric ATMG system with doubled flat bands,we further find that Coulomb interactions may drive the system into a state with intertwined electric polarization and orbital magnetization orders,which can exhibit an interaction-driven orbital magnetoelectric effect.

关键词： twisted bands orbital

Uncertainty evaluation of the isotope shift factors for 2s2p^(3,1)P_1~o–2s^2 ~1S_0 transitions in B Ⅱ

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Chinese Physics B 2017年第2期26卷 147-151页

作者： jianpeng liu Jiguang Li Hongxin Zou Interdisciplinary Center of Quantum Information National University of Defense Technology Changsha 410073 China Data Center for High Energy Density Physics Institute of Applied Physics and Computational Mathematics Beijing 100088 China

Accurate isotope shift factors of the 2s2p^（3,1）P_1~o–2s^2 ~1S_0 transitions in B II, obtained with the multi-configuration Dirac–Hartree–Fock and the relativistic configuration interaction methods, are reported. We found a linear correlation relation between the mass shift factors and the energies for the transitions concerned, considering all-order electron correlations. This relation is important for estimating the uncertainty in the calculation of isotope shift factors. These atomic data can be used to extract the nuclear mean-square charge radii of the boron isotopes with halo structures or to resolve the high precise spectroscopy of B II in astronomical observation.

关键词： isotope shifts B Ⅱ halo state MCDHF method

High precision slope deformation monitoring model based on the GPS/Pseudolites technology in open-pit mine

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Mining Science and Technology 2010年第1期20卷 126-131,137页

作者： WANG jianpeng, GAO Jingxiang, liu Chao, WANG Jian School of Environment and Spatial Informatics, China University of Mining & Technology, Xuzhou 221008, China [a] School of Environment Spatial Informatics China University of Mining & Technology Xuzhou 221008 China

As the number and geometric intensity of visual satellites are susceptible to large slopes in open-pit mines, we propose integration of GPS/Pseudolites (PLs) positioning technology which can increase the number of visible satellites, strengthen the geometric intensity of satellites and provide a precision solution for slope deformation monitoring. However, the un-modeled systematic errors are still the main limiting factors for high precision baseline solution. In order to eliminate the un-modeled systematic error, the Empirical Mode Decomposition (EMD) theory is employed. The multi-scale decomposition and reconstruction architecture are defined here on the basis of the EMD theory and the systematic error mitigation model is demonstrated as well. A standard of the scale selection for the systematic error elimination is given in terms of the mean of the accumulated standardized modes. Thereafter, the scheme of the GPS/PLs baseline solution based on the EMD is suggested. The simulation and experiment results show that the precision factors (DOP) are reduced greatly when PLs is located suitably. The proposed scheme dramatically improves the reliability of ambiguity resolution and the precision of baseline vector after systematic error being eliminated, and provides an effective model for high precision slope deformation monitoring in open-pit mine.

关键词： open-pit mine slope deformation PLs EMD

Theory for Charge Density Wave and Orbital-Flux State in Antiferromagnetic Kagome Metal FeGe

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Chinese Physics Letters 2024年第4期41卷 90-104页

作者：马海洋殷嘉鑫 M.Zahid Hasan 刘健鹏 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area Shenzhen 518045China Laboratory for Topological Quantum Matter and Advanced Spectroscopy(B7) Department of PhysicsPrinceton UniversityPrincetonNew Jersey 08544USA Princeton Institute for Science and Technology of Materials Princeton UniversityPrincetonNew Jersey 08544USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Liaoning Academy of Materials Shenyang 110167China

We theoretically study the charge order and orbital magnetic properties of a new type of antiferromagnetic kagome metal *** on first-principles density functional theory calculations,we study the electronic structures,Fermi-surface quantum fluctuations,as well as phonon properties of the antiferromagnetic kagome metal *** is found that charge density wave emerges in such a system due to a subtle cooperation between electron-electron interactions and electron–phonon couplings,which gives rise to an unusual scenario of interaction-triggered phonon instabilities,and eventually yields a charge density wave(CDW)*** further show that,in the CDW phase,the ground-state current density distribution exhibits an intriguing star-of-David pattern,leading to flux density *** orbital fluxes(or current loops)in this system emerge as a result of the subtle interplay between magnetism,lattice geometries,charge order,and spin-orbit coupling(SOC),which can be described by a simple,yet universal,tight-binding theory including a Kane-Mele-type SOC term and a magnetic exchange *** further study the origin of the peculiar step-edge states in FeGe,which sheds light on the topological properties and correlation effects in this new type of kagome antiferromagnetic material.

关键词： interaction phonon orbital

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阿尔茨海默症患者话语的非名词性资源蚀失

当代语言学 2019年第4期21卷 602-617页

作者：刘建鹏浙江师范大学外国语学院

本文以DementiaBank病理语料库中阿尔茨海默症患者语料为目标组,以同龄健康人语料为参照组,对阿尔茨海默症患者话语的非名词性资源蚀失进行了多维度的对比性描写与研究。研究显示阿尔茨海默症患者的非名词性资源蚀失在功能词和实体词都... 详细信息

本文以DementiaBank病理语料库中阿尔茨海默症患者语料为目标组,以同龄健康人语料为参照组,对阿尔茨海默症患者话语的非名词性资源蚀失进行了多维度的对比性描写与研究。研究显示阿尔茨海默症患者的非名词性资源蚀失在功能词和实体词都存在典型特征。功能词表现为代词、动作性动词、动作性介词和副词使用过多,而表示时空、状态性介词和冠词使用频率偏低。实体词表现为患者组动作性的物质过程高于参照组,而心智过程、关系过程和存在过程这些表征事物及事物静态属性和关系的比例较低。心理语言学角度的统计分析和参数也进一步证实了患者组和参照组之间存在明显差异;同时,经重点词提取列表以及心理语言学上的语言流利度分析证实,AD患者的命名困难最为突出,并且这种命名困难伴随解释困难。

关键词：阿尔茨海默症非名词性资源蚀失

Orf in Goats in China： Prevalence and Risk Factors

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Journal of Agricultural Science and Technology(A) 2016年第2期6卷 116-123页

作者： Yang Gao Yanqing Zhao jianpeng liu Ming Zhou Heyuan liu Fang liu Wenyu Yang Dekun Chen College of Veterinary Medicine Northwest A &F University Yangling 712100 Shaanxi Province China Department of Parasitology College of Basic Medicine Hubei University of Medicine Shiyan 442000 Hubei Province China Animal Diseases Control & Prevention Centre of Yulin City Yulin 719000 Shaanxi Province China

Orf is an important viral disease that affects goats and sheep and results in large economic losses. The aim of this study was to investigate the prevalence of off and identify the potential risk factors of this disease in the main breeding areas of China. Among 1,241 blood samples collected from goats without clinical signs of off, 433 samples （34.89%） were positive for off virus infection, which was detected by polymerase chain reaction （PCR） targeting a partial B2L sequence of the viral genome. Moreover, a total of 874 buceal swab samples were collected, of which 64 samples （7.32%） were positive for the orf virus on the basis of PCR detection. According to logistic regression, all of the variables, including age, breed, location and farm management, had significant impacts on the prevalence of orf. Lambs under intensive management in Yunnan province were more susceptible to off virus infection than animals in other groups. Anglo-Nubian goats were at more risk of off positivity than other breeds, whereas Saanen dairy goats were at significantly less risk. In summary, as the first epidemiological study of off in China, this investigation suggested that off is a neglected disease that requires more attention in the future.

关键词： Orf prevalence risk factors goats China.

Emergence of Chern Insulating States in Non-Magic Angle Twisted Bilayer Graphene

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Chinese Physics Letters 2021年第4期38卷 96-102页

作者： Cheng Shen Jianghua Ying Le liu jianpeng liu Na Li Shuopei Wang Jian Tang Yanchong Zhao Yanbang Chu Kenji Watanabe Takashi Taniguchi Rong Yang Dongxia Shi Fanming Qu Li Lu Wei Yang Guangyu Zhang Beijing National Laboratory for Condensed Matter Physics Key Laboratory for Nanoscale Physics and DevicesInstitute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China School of Physical Sciences and Technology ShanghaiTech UniversityShanghai 200031China Shanghai Tech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 200031China Beijing Key Laboratory for Nanomaterials and Nanodevices Beijing 100190China Songshan-Lake Materials Laboratory Dongguan 523808China Research Center for Functional Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan

Twisting two layers into a magic angle(MA) of ~1.1°is found essential to create low energy flat bands and the resulting correlated insulating,superconducting,and magnetic phases in twisted bilayer graphene(TBG).While most of previous works focus on revealing these emergent states in MA-TBG,a study of the twist angle dependence,which helps to map an evolution of these phases,is yet less ***,we report a magnetotransport study on one non-magic angle TBG device,whose twist angle θ changes from 1.25° at one end to 1.43°at the *** θ=1.25° we observe an emergence of topological insulating states at hole side with a sequence of Chern number |C|=4-|v|,where v is the number of electrons(holes) in moire unite *** θ> 1.25°,the Chern insulator from flat band disappears and evolves into fractal Hofstadter butterfly quantum Hall insulator where magnetic flux in one moire unite cell *** observations will stimulate further theoretical and experimental investigations on the relationship between electron interactions and non-trivial band topology.

关键词： Angle moire twist

考虑时序特性和环境效益的多目标多类型分布式电源规划

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电力系统保护与控制 2016年第19期44卷 32-40页

作者：马麟刘建鹏中国能源建设集团天津电力设计院有限公司天津300400

通过分析多种类型分布式电源并网所带来的投资及收益情况,提出了一种多类型分布式电源的选址定容规划方法。该方法考虑了负荷与分布式电源出力的时序特性以及分布式电源的环境效益,在对日负荷序列和分布式电源日出力序列进行归类的基础... 详细信息

通过分析多种类型分布式电源并网所带来的投资及收益情况,提出了一种多类型分布式电源的选址定容规划方法。该方法考虑了负荷与分布式电源出力的时序特性以及分布式电源的环境效益,在对日负荷序列和分布式电源日出力序列进行归类的基础上求取了典型日负荷序列和单位容量分布式电源的典型日出力序列。以分布式电源的位置、容量和类型为优化变量建立了数学规划模型并采用改进自适应遗传算法对模型进行求解。实际算例验证了所提出的方法及模型的可行性和有效性。

关键词：时序特性环境效益多类型分布式电源选址定容典型日负荷序列典型日出力序列