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Five-view three-dimensional reconstructionfor ultrafast dynamic imaging of pulsedradiation sources

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Matter and Radiation at Extremes 2024年第2期9卷 63-73页

作者： jianpeng Gao Liang sheng Xinyi Wang Yanhong Zhang Liang Li Baojun Duan Mei Zhang Yang Li Dongwei Hei Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024China

Multiaxial neutron/x-ray imaging and three-dimensional (3D) reconstruction techniques play a crucial role in gaining valuable insights intothe generation and evolution mechanisms of pulsed radiation sources. Owing to the short emission time (∼200 ns) and drastic changes of thepulsed radiation source, it is necessary to acquire projection data within a few nanoseconds in order to achieve clear computed tomography3D imaging. As a consequence, projection data that can be used for computed tomography image reconstruction at a certain moment are oftenavailable for only a few angles. Traditional algorithms employed in the process of reconstructing 3D images with extremely incomplete datamay introduce significant distortions and artifacts into the final image. In this paper, we propose an iterative image reconstruction methodusing cylindrical harmonic decomposition and a self-supervised denoising network algorithm based on the deep image prior method. Weaugment the prior information with a 2D total variation prior and a 3D deep image prior. Single-wire Z-pinch imaging experiments have beencarried out at Qin-1 facility in five views and four frames, with a time resolution of 3 ns for each frame and a time interval of 40 ns betweenadjacent frames. Both numerical simulations and experiments verify that our proposed algorithm can achieve high-quality reconstructionresults and obtain the 3D intensity distribution and evolution of extreme ultraviolet and soft x-ray emission from plasma.

关键词： frames image sources

Oxygen microcapsules improve immune checkpoint blockade by ameliorating hypoxia condition in pancreatic ductal adenocarcinoma

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Bioactive Materials 2023年第2期20卷 259-270页

作者： Jiangchao Wu Xun Wang Li Chen Jianing Wang Junlei Zhang Jianghui Tang Yongtao Ji Jinyuan Song Lin Wang Yaxing Zhao Hui Zhang Taohong Li jianpeng sheng Dong Chen Qi Zhang Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Zhejiang University Cancer Center Zhejiang UniversityHangzhou310003China Department of Medical Oncology The First Affiliated HospitalSchool of MedicineZhejiang University#79 Qingchun RoadHangzhouZhejiang Province310003China College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310027China

Rationale:Hypoxia in tumor microenvironment(TME)represents an obstacle to the efficacy of immunotherapy for pancreatic ductal adenocarcinoma(PDAC)through several aspects such as increasing the expression of immune checkpoints or promoting *** hypoxic TME is a potential strategy to improve the validity of immune checkpoint blockade(ICB).Methods:Here,we synthesized polydopamine-nanoparticle-stabilized oxygen microcapsules with excellent stabilization,bioavailability,and biocompatibility for direct oxygen delivery into tumor sites by interfacial ***:We observed oxygen microcapsules enhanced the oxygen concentration in the hypoxia environment and maintained the oxygen concentration for a long period both in vitro and in *** found that oxygen microcapsules could significantly improve the efficiency of ICB against PDAC in ***,combined treatments using oxygen microcapsules and ICB could reduce the infiltration of tumor-associated macrophages(TAMs)and polarized pro-tumor M2 macrophages into anti-tumor M1 *** addition,combined treatments could elevate the proportion of T helper subtype 1 cells(Th1 cells)and cytotoxic T lymphocytes cells(CTLs)to mediate anti-tumor immune response in ***:In summary,this pre-clinical study indicated that reversing hypoxia in TME by using oxygen microcapsules was an effective strategy to improve the performances of ICB on PDAC,which holds great potential for treating PDAC in the future.

关键词： Hypoxia PD-1 Tumor microenvironment Pancreatic ductal adenocarcinoma Oxygen microcapsules

Synergetic treatment of oxygen microcapsules and lenvatinib for enhanced therapy of HCC by alleviating hypoxia condition and activating anti-tumor immunity

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Chinese Chemical Letters 2023年第4期34卷 148-153页

作者： jianpeng sheng Jiangchao Wu Xianghong Yin Zhu Sun Xun Wang Junlei Zhang Jianghui Tang Yongtao Ji Jinyuan Song Xiaobao Wei Lin Wang Yaxing Zhao Hui Zhang Taohong Li Qi Zhang Xueli Bai Li Chen Dong Chen Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310002China Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310002China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310002China School of Basic Medical Sciences Institute of Hypoxia MedicineWenzhou Medical UniversityWenzhou 325035China College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Department of Medical Oncology the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Hypoxia is a typical characteristic of hepatocellular carcinoma(HCC), which causes tremendous obstacles to tumor treatments. Current first-line treatment may further deteriorate tumor hypoxia. For example,Lenvatinib, a receptor tyrosine kinase inhibitor(RTKI), suppresses tumor growth via blocking vascular endothelial growth factor(VEGF) signaling, and can also inhibit angiogenesis, thus limiting oxygen supply to tumor sites. Therefore, alleviating tumor microenvironment(TME) hypoxia holds great potential for enhancing the therapeutic effect of RTKI. Here, nanoparticle-stabilized oxygen microcapsules, a stable and biocompatible oxygen-loaded delivery system, are successfully prepared through interfacial polymerization of polydopamine nanoparticles. The microcapsules with a large loading capacity of oxygen in the core show excellent bioavailability and dispersity, which could effectively improve the hypoxic TME when they serve as oxygen delivery vehicles. Synergetic treatments of Lenvatinib and oxygen microcapsules could induce the transition of “cold tumor” in an immune-suppressed state to “hot tumor” in an immune-activated state by improving tumor hypoxic TME and reducing angiogenesis in HCC. It is revealed that combined treatments of oxygen microcapsules and Lenvatinib could polarize tumor-associated macrophages(TAMs) to anti-tumor M1 cells and activate T cell-mediated anti-tumor immune *** results suggest that synergetic therapy using oxygen microcapsules and Lenvatinib could alleviate the hypoxic TME and enhance the therapeutic performance of RTKI, demonstrating a promising anti-tumor strategy for enhanced therapy of HCC.

关键词： Hypoxia Oxygen microcapsules Lenvatinib Immune Hepatocellular carcinoma

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乳化液的破乳与可生化性研究

上海环境科学 1994年第10期13卷 20-23,32页

作者：张建鹏刘如玲盛兆琪华东理工大学上海200237

根据混凝破乳处理乳化废液的实验参数,考察了混凝出水的可生化性。结果表明,PBT混凝剂,具有良好的破乳效果,COD_(Cr)和油的平均去除率,分别达90％与99％以上,混凝出水BOD_5/COD_(Cr)可达0.42～0.46;间歇曝气实验及呼吸耗氧速率曲线表明,... 详细信息

根据混凝破乳处理乳化废液的实验参数,考察了混凝出水的可生化性。结果表明,PBT混凝剂,具有良好的破乳效果,COD_(Cr)和油的平均去除率,分别达90％与99％以上,混凝出水BOD_5/COD_(Cr)可达0.42～0.46;间歇曝气实验及呼吸耗氧速率曲线表明,PBT混凝出水,宜进行生化处理。

关键词：乳化液可生化性混凝破乳废水处理

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脉冲射线源三维中子成像重建算法研究

光子学报 2022年第3期51卷 76-87页

作者：盛亮张艳红高建鹏李阳段宝军黑东炜西北核技术研究所强脉冲辐射环境模拟与效应国家重点实验室西安710024 清华大学工程物理系北京100084

借鉴计算机层析成像方法,通过多角度成像的方式得到氘氚燃烧区三维分布信息。介绍了球谐函数分解、最大期望代数迭代两种具有代表性的极少角度三维图像重建算法,并提出将球谐函数分解重建结果作为最大期望代数迭代初始值的重建约束方法... 详细信息

借鉴计算机层析成像方法,通过多角度成像的方式得到氘氚燃烧区三维分布信息。介绍了球谐函数分解、最大期望代数迭代两种具有代表性的极少角度三维图像重建算法,并提出将球谐函数分解重建结果作为最大期望代数迭代初始值的重建约束方法。该方法利用了激光、Z箍缩聚变靶具有一定球对称性的物理先验,既改善了球谐函数在极少角度投影重建表示能力不足、残影较大的缺点,又利用了最大期望算法局部最优的特点,可以将重建结果限制在物理似然域中,从而在一定程度上克服了极少角度投影三维重建解空间过大的问题。利用峰值信噪比、均方根误差、KL偏差等三种指标对重建结果进行了量化评价,结果表明球谐函数初值约束的最大期望代数迭代算法效果最好。

关键词：三维图像重建球谐函数分解最大期望迭代算法快中子成像惯性约束聚变

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页岩气藏体积压裂有效改造体积计算方法

地球科学（中国地质大学学报） 2017年第8期42卷 1314-1323页

作者：苏玉亮盛广龙王文东贾建鹏吴春新中国石油大学石油工程学院山东青岛266580 中国石油长庆油田分公司苏里格气田研究中心陕西西安710018 中海石油有限公司天津分公司天津300452

页岩气藏矿场压裂实践表明,储层有效改造体积(effective stimulated reservoir volume,简称ESRV)是影响页岩气藏体积压裂水平井生产效果的关键因素,ESRV的准确计算对页岩气藏压裂方案评价与体积压裂水平井产量预测具有重要作用.基于页... 详细信息

页岩气藏矿场压裂实践表明,储层有效改造体积(effective stimulated reservoir volume,简称ESRV)是影响页岩气藏体积压裂水平井生产效果的关键因素,ESRV的准确计算对页岩气藏压裂方案评价与体积压裂水平井产量预测具有重要作用.基于页岩储层改造体积(stimulated reservoir volume,简称SRV)多尺度介质气体运移机制,建立了SRV区域正交离散裂缝耦合双重介质基质团块来表征单元体渗流模型(representation elementary volume,简称REV),并结合北美页岩储层实例研究了次生裂缝间距、宽度等缝网参数对页岩气藏气体运移规律的影响.在此基础上根据SRV区域次生裂缝分布特征,采用分形质量维数定量表征裂缝间距分布规律,结合页岩气藏次生裂缝间距对基质团块内流体动用程度的影响规律,得到了页岩气藏体积压裂ESRV计算方法.结果表明SRV区域次生裂缝间距对基质团块内吸附及自由气影响较大,次生裂缝间距小于0.20m时可以实现SRV区域基质团块内流体向各方向裂缝的"最短距离"渗流.选取北美典型页岩储层生产井体积压裂数据进行ESRV计算,页岩气藏目标井ESRV占体积压裂SRV的37.78%.因此ESRV受改造区域次裂缝分布规律及SRV有效裂缝间距界限的影响,是储层固有性质及人工压裂因素综合作用的结果.

关键词：页岩气藏体积压裂有效改造体积裂缝间距石油地质

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混凝土现浇板原位加载试验应用技术研究

工程质量 2022年第7期40卷 77-79,84页

作者：徐平荣绳钦柱张建鹏五莲县建筑工程管理服务中心山东日照262300 山东省建筑科学研究院有限公司山东济南250031 山东省建筑质量检验检测中心有限公司山东济南250031

以某6层框架结构为例,因4层某楼板负弯矩筋钢筋保护层超出允许偏差较大,为保证结构工程的安全使用,考虑荷载最不利因素,采用分级加载方式,在楼板原位进行了安全性静载检验,测量混凝土现浇板的荷载、挠度、残余应变等指标,与理论形成对比... 详细信息

以某6层框架结构为例,因4层某楼板负弯矩筋钢筋保护层超出允许偏差较大,为保证结构工程的安全使用,考虑荷载最不利因素,采用分级加载方式,在楼板原位进行了安全性静载检验,测量混凝土现浇板的荷载、挠度、残余应变等指标,与理论形成对比,并对试验结果与理论结果进行讨论和分析,为后续类似工程提供参考。

关键词：试验分级加载挠度荷载

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钻芯修正回弹法检测混凝土强度的分析研究

工程质量 2022年第8期40卷 79-83页

作者：徐平荣绳钦柱张建鹏冯谦五莲县建筑工程管理服务中心山东日照262300 山东省建筑科学研究院有限公司山东济南250031 山东省建筑质量检验检测中心有限公司山东济南250031 中国建筑科学研究院有限公司北京100013

通过对比介绍回弹法和钻芯法两种检测混凝土强度方法,并对其优缺点进行阐述,引出钻芯修正回弹法,对钻芯修正的几种方法进行了介绍,并对计算程序进行了阐述,最后通过工程实例,采用修正量法和修正系数法对同一批混凝土强度进行修正对比,... 详细信息

通过对比介绍回弹法和钻芯法两种检测混凝土强度方法,并对其优缺点进行阐述,引出钻芯修正回弹法,对钻芯修正的几种方法进行了介绍,并对计算程序进行了阐述,最后通过工程实例,采用修正量法和修正系数法对同一批混凝土强度进行修正对比,可以得出,钻芯修正回弹法结合了回弹法和钻芯法的优势,极大地提高了检测人员的检测效率和检测精度,为工程实际提供了参考。

关键词：回弹法钻芯法钻芯修正回弹法混凝土强度修正量法修正系数法

基于检索器-鉴别器架构的电力地址匹配模型研究

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电力大数据 2023年第1期26卷 35-43页

作者：赵坚鹏盛方徐川子陈奕罗庆陈聪国网杭州供电公司浙江杭州310000

为解决电力地址库与外部地址库地址的匹配问题,保证电力地址准确性,实现电力系统与外部系统间数据信息共享互通,本文提出一种基于检索器-鉴别器架构的地址匹配模型。首先介绍地址匹配模型的详细结构,包括用于缩小地址检索范围的地址检... 详细信息

为解决电力地址库与外部地址库地址的匹配问题,保证电力地址准确性,实现电力系统与外部系统间数据信息共享互通,本文提出一种基于检索器-鉴别器架构的地址匹配模型。首先介绍地址匹配模型的详细结构,包括用于缩小地址检索范围的地址检索器和最终分辨地址是否匹配正确的地址鉴别器,其中地址检索器基于词频-逆文档频率算法构建,地址鉴别器基于中文预训练语言模型NEZHA构建。还提出了一种负样本训练方法提升地址鉴别器辨别效果。详细介绍了实验分析所使用的两个数据集。实验结果表明基于检索器-鉴别器架构的电力地址匹配模型能够准确从外部地址库中找出与电力地址匹配的地址,其中,地址鉴别器能够非常准确地从多个候选地址中找出准确匹配地址,其F1分数达0.99以上。

关键词：地址匹配电力地址词频-逆文档频率中文预训练语言模型负样本