检索结果-南通市图书馆

Acute-on-Chronic Liver Failure Precipitated by Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a Patient with Hepatitis B Virus-Related Cirrhosis: A Case Report

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases & Immunity 2021年第3期1卷 169-173页

作者： Wanling Chen Qiran Zhang Shijun Li Ruiting Liang Haiqun Liang Yiqi Yu Chao Qiu jiannan lv Wenhong Zhang Department of Infectious Disease Beihai People’s HospitalGuangxi 536006China Department of Infectious Disease National Medical Center for Infectious DiseasesShanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China Key Laboratory of Medical Molecular Virology(MOE/MOH)Shanghai Medical College Fudan UniversityShanghai 200040China

We present a case of acute-on-chronic liver failure(ACLF)in a patient with hepatitis B virus(HBV)-related decompensated cirrhosis and coronavirus disease 2019(COVID-19).A 58-year-old woman with HBV-related and decompensated cirrhosis without any anti-viral treatment previously was admitted to the hospital due to a confirmed severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** admission,she was in stable *** computed tomography(CT)and laboratory findings showed no significant *** was initiated promptly for HBV,while antiviral therapy and supportive treatment were initiated for *** lung infection exacerbated after 10days of recurrent fever despite treatments,and there were signs of HBV *** and multiple organ dysfunction syndrome developed rapidly from day 10 to day *** patient’s clinical deterioration was also consistent with pneumonia progression and elevated interleukin 6 ***-CoV-2 likely precipitated ACLF in cirrhotic patients,either by inducing HBV flare or serving as an acute insult *** study discussed the underlying mechanisms of this process and management *** HBV status is necessary,and inflammatory parameters might be *** suppression should be initiated early,and variceal hemorrhage primary prevention might be beneficial in COVID-19 patients with cirrhosis.

关键词： Acute-on-chronic liver failure Decompensated cirrhosis SARS-CoV-2 infection

百万千瓦级超超临界火电机组锅炉给水泵转子动力学分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水泵技术 2021年第3期 9-14页

作者：吕建南张江涛成晓伟中国电建上海能源装备有限公司上海201316

锅炉给水泵是火电机组中的关键设备,本文针对某1000 MW级超超临界火电机组锅炉给水泵开展了干湿模态的转子动力学分析。湿模态转子动力学分析综合考虑了滑动轴承动力特性、各口环密封动力特性的影响,并研究了口环磨损对口环密封动力特... 详细信息

锅炉给水泵是火电机组中的关键设备,本文针对某1000 MW级超超临界火电机组锅炉给水泵开展了干湿模态的转子动力学分析。湿模态转子动力学分析综合考虑了滑动轴承动力特性、各口环密封动力特性的影响,并研究了口环磨损对口环密封动力特性及对给水泵转子动力学特性的影响。研究结果表明:在所有预定工况,转子系统临界转速及危险位置振动响应均满足要求,处于规定范围内,系统具有足够的安全裕度,符合API610对BB5型泵的要求。口环磨损导致的口环间隙增大会降低口环密封给系统提供的刚度,这会导致转子系统临界转速发生一定程度的减小。但该泵的临界转速和振动响应均有足够裕量,在口环可能发生的磨损范围内,泵的转子动力学特性均满足API610要求。

关键词：锅炉给水泵转子动力学分析口环密封临界转速

在线全文

学校读者我要写书评

暂无评论

灰铸铁热分析数学模型及选用范围的研究

上海金属 2008年第3期30卷 35-38页

作者：吕建南征灯科华勤上海大学材料科学与工程学院上海200072

由于炉料成分和熔炼条件的波动,使得热分析法在铸铁炉前成分检测精度上的不稳定是造成热分析法受限的主要原因。分别采用加碲和不加碲的样杯对灰铸铁进行热分析试验,通过二元线性回归建立热分析数学模型,比较成分检测的精度。研究结果表... 详细信息

由于炉料成分和熔炼条件的波动,使得热分析法在铸铁炉前成分检测精度上的不稳定是造成热分析法受限的主要原因。分别采用加碲和不加碲的样杯对灰铸铁进行热分析试验,通过二元线性回归建立热分析数学模型,比较成分检测的精度。研究结果表明:对于生产中炉料变化不大的情况,采用不加碲样杯进行热分析测试的精度会更高;如果不能严格控制炉料,用加碲样杯进行热分析,则能够保证比较稳定的精度。针对不同的炉料和熔炼条件,选用合适的热分析数学模型是铸铁炉前质量控制成功与否的关键。

关键词：灰铸铁热分析数学模型选用范围

2型糖尿病患者心外膜脂肪组织厚度与主动脉传播速度和颈动脉内-中膜厚度的相关性

在线全文

学校读者我要写书评

暂无评论

武警医学 2021年第8期32卷 645-649页

作者：张红丁琴宁宁吕剑楠吴小伟武警特色医学中心超声诊断科天津300162 武警特色医学中心内分泌与血液科天津300162

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者心外膜脂肪厚度(epicardial fat thickness,EFT)、主动脉传播速度(aortic velocity propagation,AVP)和颈动脉内-中膜厚度(carotid intima-media thickness,CIMT)之间的关联性。方法选取2019-11至2020-06武警特色医学中心内分泌与血液科住院的年龄>18岁未明确诊断冠心病的T2DM患者41例(T2DM组),同时选择37例非糖尿病患者(对照组),所有受试者均采用超声心动图测定EFT和AVP,用超声检查结果计算CIMT。结果T2DM组EFT[(8.41±1.62)mm]、CIMT[(0.93±0.21)mm]显著高于对照组[(6.32±2.19)mm、(0.53±0.11)mm],AVP[(28.21±16.03)mm)]显著低于对照组[(58.12±17.49)mm],差异均有统计学意义(P<0.05)。相关性分析显示,EFT和AVP呈显著负相关(r=-0.339,P=0.001),EFT与CIMT呈显著正相关(r=0.415,P<0.001),AVP与CIMT呈显著负相关(r=-0.629,P<0.001)。逐步线性回归分析显示,CIMT是EFT(β_(1)=3.255,95%CI:1.775~4.739,P=0.001)、AVP的独立预测因子(β_(2)=-30.868,95%CI:-45.805~-15.932,P<0.001)。ROC曲线分析显示,EFT 7.2 mm、CIMT 0.66 mm分别被确定为T2DM亚临床动脉粥样硬化的有效分界点,敏感性分别为75.8%和92.5%,特异性分别为71.1%和78.2%。结论T2DM患者EFT、CIMT升高,AVP降低,且EFT、AVP分别与CIMT显著相关,EFT、CIMT可以作为评估T2DM患者亚临床动脉粥样硬化的可靠指标。

关键词：超声心动图心外膜脂肪厚度主动脉传播速度颈动脉-内中膜厚度 2型糖尿病

乳腺癌原发肿瘤组织HES1、Her2、CXCR4及Survivin的表达及与术后复发、生存的关系

在线全文

学校读者我要写书评

暂无评论

中国煤炭工业医学杂志 2021年第5期24卷 530-535页

作者：宋天豹秦铁城张克钊王保信陈绍华吕建男河北中石油中心医院乳腺外科河北省廊坊市065000

目的探讨乳腺癌原发肿瘤组织发状分裂相关增强子1(HES1)、人类表皮生长因子受体2(Her2)、趋化因子受体4(CXCR4)及生存素(Survivin)的表达情况及与术后复发、生存的关系。方法选取河北中石油中心医院收治的原发性乳腺癌患者90例,均行乳... 详细信息

目的探讨乳腺癌原发肿瘤组织发状分裂相关增强子1(HES1)、人类表皮生长因子受体2(Her2)、趋化因子受体4(CXCR4)及生存素(Survivin)的表达情况及与术后复发、生存的关系。方法选取河北中石油中心医院收治的原发性乳腺癌患者90例,均行乳腺癌改良根治术,将术中所取原发肿瘤病理组织及癌旁组织送检,检测并比较肿瘤组织与癌旁组织HES1、Her2、CXCR4及Survivin表达水平。根据患者术后复发情况将其分为复发组和未复发组,比较二组HES1、Her2、CXCR4及Survivin表达情况,并分析上述指标与患者术后生存的关系。结果原发肿瘤组织HES1、Her2、CXCR4及Survivin表达阳性率分别为53.33%、56.67%、46.67%、51.11%,均显著高于癌旁组织的11.11%、14.44%、10.00%、13.33%(P3cm、腋窝淋巴结阳性、淋巴结转移个数>3个、临床分期为Ⅲ期的乳腺癌患者HES1、Her2、CXCR4及Survivin表达阳性率高于肿瘤≤2cm、腋窝淋巴结阴性、淋巴结转移个数≤3个、临床分期为Ⅰ~Ⅱ期的患者(P<0.05);复发组HES1、Her2、CXCR4及Survivin表达阳性率分别为73.17%、74.07%、63.41%、68.29%,均显著高于未复发组的36.73%、42.42%、32.65%、36.73%(P<0.05);HES1、Her2、CXCR4及Survivin阳性乳腺癌患者术后3年无瘤生存率较HES1、Her2、CXCR4及Survivin阴性患者呈明显下降趋势(P<0.05)。结论原发肿瘤病理组织中HES1、Her2、CXCR4及Survivin均呈高表达,且与患者肿瘤大小、腋窝淋巴结性质、淋巴结转移情况、临床分期及术后复发和无瘤生存存在相关性。

关键词：乳腺癌分裂相关增强子1 人类表皮生长因子受体2 趋化因子受体4 生存素

A Novel Human Antibody,HF,against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

在线全文

学校读者我要写书评

暂无评论

Engineering 2021年第11期7卷 1566-1576页

作者： Chunxia Qiao Ming lv Xinying Li Xiaoling Lang Shouqin lv Mian Long Yan Li Shusheng Geng Zhou Lin Beifen Shen jiannan Feng State Key Laboratory of Toxicology and Medical Countermeasures Institute of Pharmacology and ToxicologyBeijing 100850China Beijing Key Laboratory of Therapeutic Gene Engineering Antibody Beijing 100850China Institute of Military Cognitive and Brain Sciences Beijing 100850China Beijing Mabworks Biotech Co.Ltd. Beijing 100176China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China

Fully human antibodies have minimal immunogenicity and safety *** present,most potential antibody drugs in clinical trials are humanized or fully *** antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain ***,we describe a structure-based computer-aided de novo design technology for human antibody *** on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by ***,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than *** work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.

关键词： HER2/erb-B2 Human antibody Computer-aided design

609名军队飞行人员甲状腺疾病谱与危险因素分析

在线全文

学校读者我要写书评

暂无评论

空军医学杂志 2020年第2期36卷 117-119,152页

作者：申晓亮谢博多高俭张春媛吕建南马骁龙夏建军联勤保障部队北戴河康复疗养中心河北秦皇岛066100

目的分析飞行人员甲状腺疾病谱,为航空卫生保健提供依据。方法对某康复疗养中心的飞行人员年度大体检结果进行回顾性分析,采用描述性统计、χ2检验的统计学处理,明确不同机种飞行人员的甲状腺疾病谱,并对发病率前列的疾病率前列的危险... 详细信息

目的分析飞行人员甲状腺疾病谱,为航空卫生保健提供依据。方法对某康复疗养中心的飞行人员年度大体检结果进行回顾性分析,采用描述性统计、χ2检验的统计学处理,明确不同机种飞行人员的甲状腺疾病谱,并对发病率前列的疾病率前列的危险因素分析。结果甲状腺疾病患病率20.2%,甲状腺结节患病率最高,其次为甲状腺囊肿;甲状腺结节患病率与飞行时间、飞行人员年龄存在统计学意义,均表现为随着飞行时间和年龄增长先升高后降低,5 000~6 000 h甲状腺结节患病率最高,为44.4%;40~50岁飞行人员患病率最高为20.8%。不同机种甲状腺患病率无统计学意义。甲状腺囊肿患病率与飞行时间存在统计学意义,患病率随着飞行时间的增长先升高后降低,3 000~4 000 h甲状腺结节患病率最高,患病率7.4%。甲状腺囊肿患病率与年龄、飞行机种之间无统计学意义。结论积极从飞行时间和年龄方面开展甲状腺疾病防治工作,做到早发现、早诊断、早治疗。

关键词：飞行人员甲状腺疾病谱危险因素

Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第2期15卷 146-157页

作者： Longlong Luo Shi Wang Xiaoling Lang Tingting Zhou Jing Geng Xinying Li Chunxia Qiao jiannan Feng Beifen Shen Ming lv Yan Li Laboratory of Immunology Institute of Basic Medical SciencesBeijing100850China Laboratory of Cellular and Molecular Immunology Institute of ImmunologyHenan UniversityKaifeng475001China

Currently,display-based methods are well established and widely used in antibody engineering for affinity maturation and structural stability *** obtained a novel anti-human programmed death 1(PD-1)antibody using computer-aided design and a mammalian cell display technology *** used computer-aided modeling and distance geometry methods to predict and assign the key residues that contributed to the binding of human PD-L1 to ***,we analyzed the sequence of nivolumab(an anti-human PD-1 antibody,referred to as MIL75 in the article)to determine the template for antibody design and library *** identified a series of potential substitutions on the obtained template and constructed a virtual epitope-targeted antibody library based on the physicochemical properties and each possible location of the assigned key *** virtual antibody libraries were displayed on the surface of mammalian cells as the antigen-binding fragments of full-length immunoglobulin ***,we used flow cytometry and sequencing approaches to sort and screen the ***,we obtained a novel anti-human PD-1 antibody named ***78 competitively recognized the PD-1 epitopes that interacted with MIL75 and possessed an affinity comparable to *** results implied that FV78 possessed equivalent bioactivity in vitro and in vivo compared with MIL75,which highlighted the probability and prospect of FV78 becoming a new potential antibody therapy.

关键词： antibody computer-guided modeling distance geometry human PD-1 mammalian cell-displayed antibody library

Potent anti-angiogenesis and anti-tumor activity of a nove human anti-VEGF antibody, MIL60

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2014年第3期11卷 285-293页

作者： Jing Yang Qun Wang Chunxia Qiao Zhou Lin Xinying Li Yifei Huang Tingting Zhou Yan Li Beifen Shen Ming lv jiannan Feng Laboratory of Immunology Institute of Basic Medical Sciences Beijing China Department of Pathogens and Immunology Logistics College of Chinese People's Armed Police Forces Tianjin China Department of Ophthalmology General Hospital of People's Liberation Army Beijing China These authors contributed equally to this work

Angiogenesis is crucial for tumor development, growth and metastasis. Vascular endothelial growth factor （VEGF） has been implicated in promoting solid tumor growth and metastasis via stimulating tumor-associated angiogenesis, and blocking the activity of VEGF can starve tumors. Avastin, which is a humanized anti-VEGF antibody, has been successfully applied in clinics since 2004. However, the price of Avastin is extremely high for Chinese people. Here, we report a novel human anti-VEGF neutralizing antibody, MIL60, which shows an affinity comparable to that of Avastin （the KD value of MIL60 was 44.5 pM, while that of Avastin was 42.7 pM）. MIL60 displays favorable actions in inhibiting VEGF-triggered endothelial cell proliferation （the IC5o value of M IL60 was 31-6.4 ng/ml and that of Avastin was 47--.8.1 ng/ml）, migration （8 pg/ml or 0.8 pg/ml MIL60 versusthe control： P〈O.05） and tube formation （2 I^g/ml or 0.2 lzg/ml MIL60 versusthe control： P〈O.05） viathe VEGFR2 signaling pathway. Moreover, MIL60 was shown to inhibit tumor growth and angiogenesis in vivo in xenograft models of human colon carcinoma and ovarian cancer using immunotherapy and immunohistochemistry analysis （MIL60 versus N.S.： P=0.0007; Avastin versus N.S.： P=0.00046）. These data suggest that MIL60 is a potential therapeutic, anti-angiogenic agent. Our work provides a novel anti-VEGF antibody, which can be considered an anti-tumor antibody candidate and a new option for patients with various cancers.

关键词： angiogenesis anti-VEGF antibody cancer