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A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids

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Cancer Biology & Medicine 2023年第7期20卷 519-536页

作者： Ruixin Yang Yutong Du Wingyan Kwan Ranlin Yan Qimeng Shi Lu Zang Zhenggang Zhu jianming Zhang chen Li Yingyan Yu Department of General Surgery of Ruijin Hospital Shanghai Institute of Digestive SurgeryShanghai Key Laboratory for Gastric NeoplasmsShanghai Jiaotong University School of MedicineShanghai 200025China Institute of Translational Medicine Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 201210China

Objective:Organoids are a powerful tool with broad application prospects in biomedicine.Notably,they provide alternatives to animal models for testing potential drugs before clinical trials.However,the number of passages for which organoids maintain cellular vitality ex vivo remains unclear.Methods:Herein,we constructed 55 gastric organoids from 35 individuals,serially passaged the organoids,and captured microscopic images for phenotypic evaluation.Senescence-associatedβ-galactosidase(SA-β-Gal),cell diameter in suspension,and gene expression reflecting cell cycle regulation were examined.The YOLOv3 object detection algorithm integrated with a convolutional block attention module(CBAM)was used to evaluate organoid vitality.Results:SA-β-Gal staining intensity;single-cell diameter;and expression of p15,p16,p21,CCNA2,CCNE2,and LMNB1 reflected the progression of aging in organoids during passaging.The CBAM-YOLOv3 algorithm precisely evaluated aging organoids on the basis of organoid average diameter,organoid number,and number×diameter,and the findings positively correlated with SA-β-Gal staining and single-cell diameter.Organoids derived from normal gastric mucosa had limited passaging ability(passages 1–5),before aging,whereas tumor organoids showed unlimited passaging potential for more than 45 passages(511 days)without showing clear senescence.Conclusions:Given the lack of indicators for evaluating organoid growth status,we established a reliable approach for integrated analysis of phenotypic parameters that uses an artificial intelligence algorithm to indicate organoid vitality.This method enables precise evaluation of organoid status in biomedical studies and monitoring of living biobanks.

关键词： Gastric cancer organoids cellular senescence senescence-associatedβ-galactosidase artificial intelligence

基于概率潮流的含风电、光伏接入的电力系统静态安全稳定性研究

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武汉大学学报（工学版） 2024年第6期57卷 765-772页

作者：甘艳黄菁雯吴军吕华林陈佳邹建明蔡泓威何靖萱杜志叶国家电网华中分部湖北武汉430077 武汉大学电气与自动化学院湖北武汉430072 武汉大学电网环境保护全国重点实验室湖北武汉430072

受风电、光伏等新能源出力的不确定性因素影响,需重新对有接入新能源的新型电力系统进行概率潮流计算与静态安全稳定性分析,目前所采用的Monte-Carlo法存在计算耗时长的问题,难以运用于实际工程。为此,基于光照强度和风速概率分布特性,... 详细信息

受风电、光伏等新能源出力的不确定性因素影响,需重新对有接入新能源的新型电力系统进行概率潮流计算与静态安全稳定性分析,目前所采用的Monte-Carlo法存在计算耗时长的问题,难以运用于实际工程。为此,基于光照强度和风速概率分布特性,分别构建光伏阵列和风力发电机组的出力概率密度函数模型,采用基于Gram-Charlier级数展开的半不变量法进行概率潮流计算,实现了对含风电、光伏接入的新型电力系统的潮流计算和静态稳定分析。以IEEE(Institute of Electrical and Electronics Engineers)30标准测试模型为算例对所提算法进行验证,结果表明,所提算法在保持Monte-Carlo法高精度优点的同时还具有较高的计算速度;研究了风电和光伏渗透率对电力系统潮流和静态安全稳定性的影响,结果表明,随着渗透率的增加,潮流分布值域扩大且部分支路可能出现负值,存在功率反向传输问题,导致系统运行风险增大;探索了线路增容对降低有功功率和节点电压越限风险以及提高静态安全稳定性的效果。

关键词：概率潮流半不变量法级数展开新能源接入静态安全稳定性

Scalable synthesized high-performance TiO_(2)-Si-C hybrid anode for lithium batteries

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Journal of Energy Chemistry 2023年第2期77卷 348-358,I0009页

作者： Liao Shen chengjie Xu Jingguo Gao jianming Tao Qiaobao Zhang Yue chen Yingbin Lin Zhigao Huang Jiaxin Li College of Physics and Energy Fujian Provincial Solar Energy Conversion and Energy Storage Engineering Technology Research CenterFujian Normal UniversityFuzhou 350117FujianChina Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials Fuzhou 350117FujianChina Fujian Provincial Collaborative Innovation Center for Advanced High-Field Superconducting Materials and Engineering Fuzhou 350117FujianChina Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005FujianChina

At present,developing a simple strategy to effectively solve the shackles of volume expansion,poor conductivity and interface compatibility faced by Si-C anode in lithium batteries(LIBs)is the key to its commercialization.Here,low-cost nano-Si powders were prepared from Si-waste of solar-cells by sanding treatment,which can effectively reduce the commercialization cost for Si-C anode.Furthermore,micro-nano structured Gr@Si/C/TiO_(2) anode materials with graphite(Gr)as the inner core,TiO_(2)-doped and carbon-coated Si as the outer coating-layer,were synthesized at kilogram-scale per milling batch.Comprehensive characterization results indicate that TiO_(2)-doped carbon layer can improve the interface compatibility with the electrolyte,further promote the reduction of electrode polarization,and finally enhance the battery performance for the Gr@Si/C/TiO_(2) anodes.Accordingly,Gr@Si/C/TiO_(2) composites can output excellent LIB performance,especially with high initial coulombic efficiency(ICE)of 82.51%and large average reversible capacity of~810 mA h g^(-1) at 0.8 A g^(-1) after 1000 cycles.Moreover,Gr@Si/C/TiO_(2)‖NCM811 pouch full cells deliver impressive performance especially with high energy density of~489.3 W h kg^(-1) based on the total weight of active materials,suggesting its promising application in the high performance LIBs.

关键词： Lithium-ion batteries Si-C anodes Kilogram-scale preparation Interface compatibility Electrochemical mechanism

基于T-PLS-GRA的造纸干燥过程能耗非优原因追溯模型

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中国造纸学报 2024年第1期39卷 91-99页

作者：戴景波陈晓彬方子言郑启富张垚张敏董云渊廖建明浙江工业大学化工学院浙江杭州310014 衢州学院化学与材料工程学院浙江衢州324000

本研究建立了一种结合T-PLS(全潜结构投影)和GRA(灰色关联度分析)的造纸干燥过程能耗非优原因追溯模型。该模型首先基于机理知识和方差特性,去除造纸干燥过程生产数据中的非核心特征变量,并通过3σ原则和箱形图剔除异常值;然后使用施胶... 详细信息

本研究建立了一种结合T-PLS(全潜结构投影)和GRA(灰色关联度分析)的造纸干燥过程能耗非优原因追溯模型。该模型首先基于机理知识和方差特性,去除造纸干燥过程生产数据中的非核心特征变量,并通过3σ原则和箱形图剔除异常值;然后使用施胶前定量与卷取车速数据,结合K-Means聚类算法,实现不同生产状态的分类;最后针对不同的生产状态,对比T-PLS和PLS建立的经济指标计算模型,选用基于T-PLS-GRA算法,构建造纸干燥过程能效非优原因追溯模型。结合国内某造纸厂实时生产数据对该模型进行了验证。结果表明,该模型基于经济指标判断工业生产状态过程,对非优过程预测精准率为77.7%,可较好地跟踪造纸过程设备运行状态的变化过程;并且能追溯非优状态原因及整个工况下,非优生产状态中最大贡献变量出现频次,为企业改进工艺流程及节能优化提供了参考依据。

关键词：造纸干燥过程能效非优原因追溯机器学习

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碲锌镉心脏专用SPECT动态心肌灌注显像定量参数在INOCA和OCAD患者预后评估中的诊断价值

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国际放射医学核医学杂志 2024年第1期48卷 5-14页

作者：李琳琳庞泽堃陈越汪娇李剑明天津医科大学心血管病临床学院泰达国际心血管病医院核医学科天津300457

目的探究碲锌镉(CZT)心脏专用SPECT动态心肌灌注显像(D-MPI)定量参数在缺血伴非阻塞性冠状动脉疾病(INOCA)和阻塞性冠状动脉粥样硬化性心脏病(OCAD)患者预后评估中的诊断价值,并与心肌灌注显像(MPI)半定量参数进行比较。方法回顾性分析2... 详细信息

目的探究碲锌镉(CZT)心脏专用SPECT动态心肌灌注显像(D-MPI)定量参数在缺血伴非阻塞性冠状动脉疾病(INOCA)和阻塞性冠状动脉粥样硬化性心脏病(OCAD)患者预后评估中的诊断价值,并与心肌灌注显像(MPI)半定量参数进行比较。方法回顾性分析2020年3月至2021年7月于泰达国际心血管病医院行CZT心脏专用SPECT D-MPI、具备显像前后3个月内的冠状动脉造影(CAG)资料并最终完成随访的100例INOCA患者[其中,男性37例、女性63例,年龄62.0(55.3,66.0)岁]和同期诊断为OCAD的203例患者[其中,男性122例、女性81例,年龄63.0(57.0,69.0)岁]的临床资料,随访内容为主要不良心血管事件(MACE)的发生情况。根据随访结果将INOCA和OCAD患者分别分为无MACE组和有MACE组。比较无MACE组与有MACE组患者的D-MPI定量参数[心肌血流储备(MFR)、静息心肌血流量(r-MBF)和负荷心肌血流量(s-MBF)]及MPI半定量参数[负荷总积分(SSS)、静息总积分(SRS)、总积分差(SDS)、负荷总灌注缺损(s-TPD)和静息总灌注缺损(r-TPD)]间的差异。计量资料的组间比较采用两独立样本t检验或Mann-Whitney U检验,计数资料的组间比较采用Pearson卡方检验。采用受试者工作特征(ROC)曲线评估D-MPI定量参数和MPI半定量参数预测INOCA和OCAD患者发生MACE的诊断效能。采用Delong检验和净重新分类指数(NRI)进一步验证D-MPI定量参数和MPI半定量参数的诊断效能的差异。结果100例INOCA患者中,有MACE组的s-MBF和MFR均显著低于无MACE组[1.27(1.03,1.88)ml/(min·g)对2.25(1.59,3.13)ml/(min·g)、1.65(1.35,2.04)对2.52(1.75,3.39)],差异均有统计学意义(Z=-2.986、-2.859,均P<0.05)。ROC曲线分析结果显示,s-MBF和MFR对预测INOCA患者发生MACE具有较高的诊断效能[曲线下面积(AUC)=0.777、0.765,均P<0.001],当s-MBF临界值为1.57 ml/(min·g)时,预测INOCA患者MACE的灵敏度为72.7%、特异度为75.3%;当MFR临界值为2.04时,预测INOCA患者MACE的灵敏度为81.8%、特异度为66.3%。NRI结果显示,s-MBF≤1.57 ml/(min·g)、MFR≤2.04对于INOCA患者预后的正确分类比例较MPI半定量参数异常(SSS≥4分且SDS≥2分)分别提高了44.4%和44.5%。203例OCAD患者中,有MACE组的s-MBF和MFR均显著低于无MACE组[1.21(0.61,1.51)ml/(min·g)对1.76(1.14,2.56)ml/(min·g)、1.51(0.81,1.91)对2.02(1.50,2.86)],差异均有统计学意义(Z=-2.891、-2.984,均P<0.05)。ROC曲线分析结果显示,MFR和s-MBF对预测OCAD患者发生MACE具有较高的诊断效能(AUC=0.725、0.718,均P<0.001),当MFR临界值为1.71时,预测OCAD患者MACE的灵敏度为75.0%、特异度为63.6%;当s-MBF临界值为1.49 ml/(min·g)时,预测OCAD患者MACE的灵敏度为81.3%、特异度为61.5%。NRI结果显示,s-MBF≤1.49 ml/(min·g)、MFR≤1.71对于OCAD患者预后的正确分类比例较MPI半定量参数异常(SSS≥4分且SDS≥2分)分别提高了32.9%和28.7%。结论CZT心脏专用SPECT D-MPI获得的MFR和s-MBF均可以作为预测INOCA及OCAD患者发生MACE的诊断指标,并具有较好的预后诊断效能,与MPI半定量参数相比,能为临床提供更准确的预后评估。

关键词：心肌灌注显像碲锌镉血流储备分数,心肌冠状动脉疾病体层摄影术,发射型计算机,单光子预后

传统村落风貌韧性评价体系研究——以潮州凤山楼村为例

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城市建筑 2024年第9期21卷 96-100页

作者：金文灿陈佳琪何韶颖郭健铭广东工业大学建筑与城市规划学院

城镇化快速推进下的传统村落发展面临着脆弱性和不确定性持续增强的局面,而韧性理论为其风貌可持续发展研究提供了新的视角。从韧性评估视角切入,利用层次分析法构建了潮州传统村落风貌韧性评价指标体系及其评价函数,通过对潮州市凤山... 详细信息

城镇化快速推进下的传统村落发展面临着脆弱性和不确定性持续增强的局面,而韧性理论为其风貌可持续发展研究提供了新的视角。从韧性评估视角切入,利用层次分析法构建了潮州传统村落风貌韧性评价指标体系及其评价函数,通过对潮州市凤山楼村的风貌韧性评价,研究村落风貌演变过程中的扰动因素及作用机制,并提出村落风貌保护传承与适应性演进的策略建议。研究成果可为村落风貌保护与发展工作提供技术支持,更可为地方政府相关工作提供科学的决策依据,对实现村落文化振兴具有重要的社会价值。

关键词：传统村落风貌韧性评价指标体系

The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers

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Genes & Diseases 2023年第3期10卷 735-738页

作者： Chang-Zhou Feng Ning-Zhe Li Xi-Bo Hu Yin-Yin Xie Qiu-Hua Huang jianming Zhang Zhu chen Sai-Juan chen Fudi Wang Xiao-Jian Sun Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Life Sciences&Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China The First Affiliated Hospital School of Public HealthInstitute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiang 310058China The First Affiliated Hospital Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

Ferroptosis is a form of regulated cell death characterized by iron-dependent overaccumulation of lipid peroxides,which causes membrane damage and cell lysis.Ferroptosis can be prevented by cellular antioxidant mechanisms such as glutathione peroxidase 4(GPX4)-mediated elimination of the lipid peroxides at the cost of glutathione(GSH).As the rate-limiting step of GSH synthesis,the availability of intracellular cystine is controlled by the cell membrane-located cystine/glutamate antiporter system xc−.Indeed,the initially identified small molecule inducers of ferroptosis,RSL3 and erastin,turned out to be inhibitors of GPX4 and system xc−,respectively.

关键词： system initially limiting

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基于YOLOv5的肺炎CT检测

自动化应用 2024年第7期65卷 52-53,56页

作者：许广荣许建明彭亦飞陈奕明邵阳学院信息科学与工程学院湖南邵阳422000

神经网络的发展让计算机模拟人类大脑神经元来解释图像,可以准确且迅速地识别图像内容,因此,通过计算机辅助医疗诊断的技术具有一定研究意义。将肺炎CT的检测作为目标检测的分类问题进行考虑,通过YOLOv5提取肺炎CT医学影像的特征,判断... 详细信息

神经网络的发展让计算机模拟人类大脑神经元来解释图像,可以准确且迅速地识别图像内容,因此,通过计算机辅助医疗诊断的技术具有一定研究意义。将肺炎CT的检测作为目标检测的分类问题进行考虑,通过YOLOv5提取肺炎CT医学影像的特征,判断患者是否患有肺炎,可以减少医护人员的工作量。最后得到的模型检测效果较好,可以在一定程度上辅助医生诊断。

关键词：目标检测肺炎检测 YOLOv5 深度学习

Methods for alleviation of impacts of axial diffusion on decomposition products monitoring in gas‐insulated transmission lines

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High Voltage 2022年第1期7卷 41-51页

作者： Rui Qiu Weijiang chen Wenjun Zhou Ming Liu jianming Zou Yu Zheng Han Li Shizhuo Hu Jianhui Yu School of Electrical Engineering and Automation Wuhan UniversityWuhanChina State Grid Corporation of China BeijingChina Central China Branch of State Grid Corporation of China WuhanChina

Considering the long length of gas‐insulated transmission lines(GILs),novel methods are required to alleviate the impacts of axial diffusion on decomposition products'moni-toring.The diffusion process of two typical decomposition products,SO2 and SO2F2,was studied.During the diffusion experiments,SO2 and SO2F2 were generated by partial discharges.Based on Fick’s law,an axial diffusion model of SO2 and SO2F2 was proposed.By combining the experiment and simulation results,it was found that the diffusion coefficient of SO2 was greater than that of SO2F2.In addition,the concentration variation at different positions would experience some delay and decay in axial direction.The delay and decay were inversely related to the diffusion coefficient and increased with prolongation of the distance.Based on the diffusion characteristics determined,methods for optimising the monitoring positions,correcting concentration,and using the concentration ratio and generation rate were proposed to alleviate the impacts of diffusion.The methods could allow the decomposition products to be monitored in 1 month and reduce the monitoring error to 10%or less.The diffusion model and the methods could be useful for monitoring decomposition products in GILs.

关键词： diffusion axial positions