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Genome-wide identification of NAC gene family and expression analysis under abiotic stresses in Salvia miltiorrhiza

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BIOCELL 2022年第8期46卷 1947-1958页

作者： XIN LI jianmin pan FAISAL ISLAM JUANJUAN LI ZHUONI HOU ZONGQI YANG LING XU Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China Institute of Crop Science Ministry of Agriculture and Rural Affairs Laboratory of Spectroscopy SensingZhejiang UniversityHangzhou310058China

NAC(NAM,ATAF,CUC)is a class of transcription factors involved in plant growth regulation,abiotic stress responses,morphogenesis and *** miltiorrhiza is an important Chinese medicinal herb,but the characterization of NAC genes in this species is *** this study,based on the Salvia miltiorrhiza genomic databases,82 NAC transcription factors were identified,which were divided into 14 ***,phylogenetic analysis,gene structure,chromosomal localization and potential role of SmNACs in abiotic stress conditions were also *** results revealed that some SmNACs had different structures than others,which advised that these genes may have multiple/distinct ***-time quantitative polymerase chain reaction(RT-qPCR)analysis showed that SmNACs exhibited differential expression patterns under salt and drought *** NaCl induced salinity treatments modulated the expression of several SmNAC genes more in roots compared with ***,under drought stress conditions,more genes were upregulated in leaves compared with *** results will be useful for the further study involved in the functional characteristics of SmNAC genes,especially in response to salt and drought stresses,thereby may facilitate genetic breeding in Salvia miltiorrhiza.

关键词： Salvia miltiorrhiza Arabidopsis thaliana NAC transcription factors Genome-wide analysis Abiotic stress

Genome-wide identification of U-box gene family and expression analysis under abiotic stresses in Salvia miltiorrhiza

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BIOCELL 2022年第7期46卷 1751-1762页

作者： jianmin pan XIN LI JUANJUAN LI HUI LIU ZHUONI HOU ZONGQI YANG LING XU Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China UWA School of Agriculture and Environment and The UWA Institute of Agriculture Faculty of ScienceThe University of Western AustraliaPerth6009Australia

Plant U-box(PUB)E3 ubiquitin ligases play important roles in hormone signaling pathways and in response to different abiotic stresses,but little is known about U-box genes in Danshen(root of Salvia miltiorrhiza Bunge).Here,we identified and characterized 70 SmPUB genes based on its genome *** analysis of U-box genes from *** and Arabidopsis suggested that they can be clustered into seven subgroups(I–VII).Typical U-box domains were found in all identified SmPUB genes through the analysis of conserved ***,qRT-PCR was applied to analyze the relative expression levels of U-box genes in *** roots and leaves under PEG-induced water deficit and salt *** revealed that the SmPUB genes exhibited stronger response to drought than to salt *** the best of our knowledge,this report is the first to perform genome-wide identification and analysis of the U-box gene family in ***,and the results provide valuable information for better understanding of the function of U-box in ***.

关键词： Salvia miltiorrhiza U-box E3 ubiquitin ligase Gene-family Abiotic stresses Expression pattern

A generalization of Esseen's inequality for NA random variables

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Chinese Science Bulletin 1998年第13期43卷 1076-1080页

作者： jianmin pan Chuanrong Lu Department of Mathematics Hangzhou University Hangzhou China

The generalization of Esseen’s inequality for NA random variables under the relatively general conditions is discussed. These results are about the same as those of the independent variables.

关键词： negatively associated random variables Esseen’s inequality convergence rate of central limit theorem.

Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease

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World Journal of Gastroenterology 2017年第27期23卷 4958-4967页

作者： Uri Netz Jane Victoria Carter Maurice Robert Eichenberger Gerald Wayne Dryden jianmin pan Shesh Nath Rai Susan Galandiuk Price Institute of Surgical Research the Hiram C.Polk Jr.MD Department of SurgeryUniversity of Louisville School of Medicine Department of Surgery A Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev Department of Medicine Division of GastroenterologyHepatology and Nutrition University of Louisville School of Medicine Louisville Department of Bioinformatics and Biostatistics University of Louisville School of Public Health and Information Sciences

AIM To investigate genetic factors that might help define which Crohn's disease(CD) patients are likely to benefit from anti-tumor necrosis factor(TNF) therapy. METHODS This was a prospective cohort study. Patients wererecruited from a university digestive disease practice database. We included CD patients who received antiTNF therapy,had available medical records(with information on treatment duration and efficacy) and who consented to participation. Patients with allergic reactions were excluded. Patients were grouped as ever-responders or non-responders. Genomic DNA was extracted from peripheral blood,and 7 single nucleotide polymorphisms(SNPs) were assessed. The main outcome measure(following exposure to the drug) was response to therapy. The patient genotypes were assessed as the predictors of outcome. Possible confounders and effect modifiers included age,gender,race,and socioeconomic status disease,as well as disease characteristics(such as Montreal criteria). RESULTS121 patients were included. Twenty-one were nonresponders,and 100 were ever-responders. Fas ligand SNP(rs763110) genotype frequencies,TNF gene-308 SNP(rs1800629) genotype frequencies,and their combination,were significantly different between groups on multivariable analysis controlling for Montreal disease behavior and perianal disease. The odds of a patient with a Fas ligand CC genotype being a non-responder were four-fold higher as compared to a TC or TT genotype(P = 0.009,OR = 4.30,95%CI: 1.45-12.80). The presence of the A(minor) TNF gene-308 allele correlated with three-fold higher odds of being a non-responder(P = 0.049,OR = 2.88,95%CI: 1.01-8.22). Patients with the combination of the Fas ligand CC genotype and the TNF-308 A allele had nearly five-fold higher odds of being a non-responder(P = 0.015,OR = 4.76,95%CI: 1.35-16.77). No difference was seen for the remaining *** The Fas-ligand SNP and TNF gene-308 SNP are associated with anti-TNF treatment response in CD and may help se

关键词：反肿瘤坏死因素船边交货 ligand 抗体反应 Crohns 疾病挑选核苷酸多型性遗传型肿瘤坏死因素基因

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能耗管理系统的设计与实现

集成电路应用 2022年第5期39卷 55-57页

作者：潘建民上海浩臣机电科技有限公司上海201199

阐述能耗管理平台系统中的数据中心、通信层、设备配置、系统软件设计,实现数据采集、基于GIS的能耗总揽、能耗分类统计分析、事件与告警信息管理、实时数据的存储、历史数据记录、监管平台安全的功能。

关键词：能耗管理数据中心能耗分类统计事件与告警

Microbiome data analysis with applications to pre-clinical studies using QIIME2: Statistical considerations

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Genes & Diseases 2021年第2期8卷 215-223页

作者： Shesh N.Rai Chen Qian jianmin pan Jayesh P.Rai Ming Song Juhi Bagaitkar Michael Merchant Matthew Cave Nejat K.Egilmez Craig J.McClain Biostatistics and Bioinformatics Facility James Graham Brown Cancer CenterUniversity of LouisvilleLouisvilleKY40202USA Department of Biostatistics and Bioinformatics University of LouisvilleLouisvilleKY40202USA University of Louisville Alcohol Research Center University of LouisvilleLouisvilleKY40202USA University of Louisville Hepatobiology&Toxicology Center University of LouisvilleLouisvilleKY40202USA Department of Oral Immunology&Infectious Diseases University of LouisvilleLouisvilleKY40202USA Department of Medicine University of LouisvilleLouisvilleKY40202USA Robley Rex Louisville VAMC LouisvilleKY40206USA Department of Microbiology&Immunology University of LouisvilleLouisvilleKY40202USA

Diversity analysis and taxonomic profiles can be generated from marker-gene sequence data with the help of many available computational *** Quantitative Insights into Microbial Ecology Version 2(QIIME2)has been widely used for 16S rRNA data *** many articles have demonstrated the use of QIIME2 with suitable datasets,the application to preclinical data has rarely been talked *** issues involved in the pre-clinical data include the low-quality score and small sample size that should be addressed properly during *** addition,there are few articles that discuss the detailed statistical methods behind those alpha and beta diversity significance tests that researchers are eager to *** the program without knowing the logic behind it is extremely *** this article,we first provide a guideline for analyzing 16S rRNA data using *** we will talk about issues in pre-clinical data,and how they could impact the ***,we provide brief explanations of statistical methods such as group significance tests and sample size calculation.

关键词： 16S rRNA gene Alpha diversity ANOVA Beta diversity Bioinformatics Microbiome data QIIME Sample size calculation

Chinese expert consensus on the diagnosis and treatment of balanoposthitis

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Chinese Medical Journal 2024年第13期137卷 1519-1521页

作者： Li Zhang Amer A.A.Abdulrahman Hao Guo Jia’an Zhang Xinghua Gao Weihua pan Gang Wang Jinhua Xu Yuling Shi Liuqing Chen Hongxiang Chen Songmei Geng Yuping Ran Hongwei Wang Xiaoyong Man jianmin Chang Furen Zhang Litao Zhang Guangwen Yin Jianzhong Zhang Wei Lai Zhibin Niu Hongkun Jiang Haibo Liu Yaolong Chen Jianjian Wang Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Key Laboratory of Immunodermatology Ministry of Education and NHCNational Joint Engineering Research Center for Theranostics of Immunological Skin DiseasesShenyangLiaoning 110001China Department of Dermatology Chinese Academy of Medical Science and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200443China Department of Dermatology Wuhan No.1 HospitalWuhanHubei 430022China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518052China Department of Dermatology Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatovenereology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Huadong HospitalFudan UniversityShanghai 200040China Department of Dermatology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Dermatology Beijing HospitalBeijing 100730China Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250061China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Department of Dermatology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Dermatology Peking University People’s HospitalBeijing 100044 China Department of Dermatology Third Affi

Balanoposthitis(BP),a common male genitalia inflammation,is managed by clinicians from different specialties,including urology,pediatrics,dermatology,and *** to this diverse array of clinicians involved,there exists a lack of consistent,evidence-based recommendations for *** development of the consensus engaged 19 representative hospitals and it adhered to rigorous protocols,encompassing international registration(IPGRP-2021CN003)and the application of evidence grading criteria and recommendation standards[Appendix S1,Supplementary File,http://***/CM9/C42].Over the period from December 2020 to October 2022,consensus on 12 clinical issues was reached through comprehensive evidence searches and two iterations of Delphi surveys[Supplementary File,http://***/CM9/C42].

关键词： Delphi diagnosis rigorous

大型公立医院“学习型”后勤保障团队建设的实践与探索

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中国医院建筑与装备 2024年第2期25卷 20-25页

作者：潘正庞建民河北医科大学第一医院石家庄050000

近年来大型公立医院信息化建设提速,而后勤建设受诸多因素制约,往往落后于医院整体建设进程;支撑医院后勤运行的各种新技术、新设备、新系统也在不断更新,对后勤人员提出了更高的要求,亟须建设高素质的保障队伍来组织与实施。建设“学... 详细信息

近年来大型公立医院信息化建设提速,而后勤建设受诸多因素制约,往往落后于医院整体建设进程;支撑医院后勤运行的各种新技术、新设备、新系统也在不断更新,对后勤人员提出了更高的要求,亟须建设高素质的保障队伍来组织与实施。建设“学习型”后勤保障团队,打造团队学习力、提高竞争优势,是当下医院后勤建设的战略选择。在“学习型”后勤保障团队建设上,应以人才培养为基础,以学习建设为基本方法,以组织建设为抓手,强化思想和职业理念教育,积极构建新型保障管理体系,为一线医疗活动提供便捷高效的保障服务。

关键词：公立医院后勤保障团队团队建设后勤建设

THE DEVELOPMENT AND APPLICATION OF THE TECHNOLOGY OF THE FLUIDIZED PREHEAT CALCINATION AND THE GENERATION BY USING WASTE HEAT

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THE DEVELOPMENT AND APPLICATION OF THE TECHNOLOGY OF THE FLU...