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Excessive gestational weight gain in early pregnancy and insufficient gestational weight gain in middle pregnancy increased risk of gestational diabetes mellitus

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Chinese Medical Journal 2022年第9期135卷 1057-1063页

作者： Aiqi Yin Fuying Tian Xiaoxia Wu Yixuan Chen Kan Liu Jianing Tong Xiaonian Guan Huafan Zhang Linlin Wu jianmin niu Department of Obsetics Shenchen Matemity and Chid Helthare HoptalThe First School of Cinial MedicneSouthem Medcal UnierityShenzhenGuangdong 518028China

Background:Gestational weight gain(GWG)is associated with the risk of gestational diabetes mellitus(GDM).However,the effect of weight gain in different trimesters on the risk of GDM is unclear.This study aimed to evaluate the effect of GWG on GDM during different trimesters.Methods:A birth cohort study was conducted from 2017 to 2020 in Shenzhen,China.In total,51,205 participants were included comprising two models(early pregnancy model and middle pregnancy model).Gestational weight(kg)was measured at each prenatal clinical visit using a standardized weight scale.Logistic regression analysis was used to assess the risk of GDM.Interaction analysis and mediation effect analysis were performed in the middle pregnancy model.Results:In the early pregnancy model,the risk of GDM was 0.858 times lower(95%confidence interval[CI]:0.786,0.937)with insufficient GWG(iGWG)and 1.201 times higher(95%CI:1.097,1.316)with excessive GWG after adjustment.In the middle pregnancy model,the risk of GDM associated with iGWG increased 1.595 times(95%CI:1.418,1.794)after adjustment;for excessive GWG,no significant difference was found(P=0.223).Interaction analysis showed no interaction between GWG in early pregnancy(GWG-E)and GWG in middle pregnancy(GWG-M)(F=1.268;P=0.280).The mediation effect analysis indicated that GWG-M plays a partial mediating role,with an effect proportion of 14.9%.Conclusions:eGWG-E and iGWG-M are associated with an increased risk of GDM.Strict control of weight gain in early pregnancy is needed,and sufficient nutrition should be provided in middle pregnancy.

关键词： Gestational diabetes mellitus Gestational weight gain Early pregnancy Middle pregnancy

Improved Scatter Search Algorithm for Multi-skilled Personnel Scheduling of Ship Block Painting

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Journal of Harbin Institute of Technology(New series) 2023年

作者： Guanglei Jiao Zuhua Jiang jianmin niu Wenjuan Yu Department of Industrial Engineering and Management， Shanghai Jiao Tong University Shanghai Ship Technology Research Institute

This paper focuses on the optimization method for multi-skilled painting personnel scheduling. The budget working time analysis is carried out considering the influence of operating area， difficulty of spraying area， multi-skilled workers， and worker’s efficiency， then a mathematical model is established to minimize the completion time. The constraints of task priority， paint preparation， pump management， and neighbor avoidance in the ship block painting production are considered. Based on this model， an improved scatter search (ISS) algorithm is designed， and the hybrid approximate dynamic programming (ADP) algorithm is used to improve search efficiency. In addition， the two solution combination methods of path-relinking and task sequence combination are used to enhance the search breadth and depth. The numerical experimental results show that ISS has a significant advantage in solving efficiency compared with the solver in small scale instances; compared with the scatter search algorithm and genetic algorithm， ISS can stably improve the solution quality. Verified by the production example， ISS effectively shortens the total completion time of the production， which is suitable for scheduling problems in the actual painting production of the shipyard.

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妊娠早期心血管代谢风险与不良妊娠结局的深圳出生队列研究

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中华心血管病杂志 2024年第2期52卷 158-164页

作者：陈艺璇吴琳琳吴晓霞万艳梅黄旭娜牛建民南方医科大学第一临床医学院深圳市妇幼保健院产科深圳518028 中山大学附属第八医院产科(深圳福田) 深圳518033

目的探讨妊娠早期心血管代谢异常与不良妊娠结局(APO)的相关性。方法本研究为队列研究。入选2021年1月1日至2022年10月31日在南方医科大学附属深圳妇幼保健院招募的妊娠早期(妊娠6~13+6周)单胎孕妇。记录妊娠早期心血管代谢指标,包括体... 详细信息

目的探讨妊娠早期心血管代谢异常与不良妊娠结局(APO)的相关性。方法本研究为队列研究。入选2021年1月1日至2022年10月31日在南方医科大学附属深圳妇幼保健院招募的妊娠早期(妊娠6~13+6周)单胎孕妇。记录妊娠早期心血管代谢指标,包括体重指数(BMI)、血压、空腹血糖(FPG)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)。记录APO发生情况,包括妊娠高血压、子痫前期、妊娠期糖尿病、早产、胎儿生长受限、小于胎龄儿、胎盘早剥。妊娠早期以下指标满足1项及以上即定义为心血管代谢异常:BMI升高(BMI≥24 kg/m^(2))、TG升高(TG≥1.7 mmol/L)、HDL-C降低(HDL-C<1.0 mmol/L)、血压升高[收缩压≥130 mmHg(1 mmHg=0.133 kPa)和(或)舒张压≥85 mmHg]、FPG升高(FPG≥5.6 mmol/L)。将入组患者分为心血管代谢异常组和心血管代谢正常组。采用Poisson回归分析妊娠早期心血管代谢异常和APO的相关性。结果最终纳入14197名孕妇,年龄(32.0±4.1)岁。心血管代谢正常组8139名,心血管代谢异常组6058例。心血管代谢异常组孕妇分娩孕周小,且早产、妊娠高血压、子痫前期、妊娠期糖尿病发生率较高(P均<0.05)。多因素Poisson回归分析结果显示,BMI升高(RR=1.22,95%CI 1.15~1.29)、FPG升高(RR=1.59,95%CI 1.38~1.82)、TG升高(RR=1.22,95%CI 1.13~1.31)、血压升高(RR=1.50,95%CI 1.39~1.63)是APO的独立危险因素,而HDL-C降低(RR=0.93,95%CI 0.70~1.23)不是APO的独立危险因素。血压升高(RR=5.57,95%CI 4.58~6.78)、BMI升高(RR=1.71,95%CI 1.40~2.09)、TG升高(RR=1.38,95%CI 1.10~1.74)是子痫前期的独立危险因素;FPG升高(RR=1.70,95%CI 1.45~1.99)对妊娠期糖尿病发生风险影响最大。结论妊娠早期血压、BMI、TG和FPG升高与APO密切相关。

关键词：代谢妊娠并发症心血管妊娠结局队列研究

Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population

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Chinese Medical Journal 2015年第1期128卷 125-127页

作者： Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang jianmin niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Obstetrics and Gynecology First Affiliated Hospital of Medical ColLege of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Obstetrics and Gynecology Aviation General Hospital Beijing 100025 China Department of Obstetrics and Gynecology Tongzhou Maternal and Child Health Hospital of Beijing Beijing 101101 China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Taiyuan Taiyuan Shanxi 030012 China Department of Obstetrics and Gynecology West China Second University Hospital Chengdu Sichuan 610041 China Department of Obstetrics and Gynecology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Obstetrics and Gynecology Sun Yat-sen Memorial Hospital of Sun Yat-sen University Guangzhou Guangdong 510120 China Department of Obstetrics and Gynecology Guangdong Women and Children Hospital Guangzhou Guangdong 510623 China Department of Obstetrics and Gynecology Boai Hospital of Zhongshan Zhongshan Guangdong 528403 China Department of Obstetrics and Gynecology Shenzhen People's Hospital Shenzhen Guangdong 518020 China Department of Obstetrics and Gynecology Miyunxian Hospital Beijing 101500 China World Diabetes Foundation Gentofte Denmark

INTRODUCTION Gestational diabetes mellitus （GDM） was earlier defined as ＂hyperglycemia first recognized during pregnancy＂ and has more recently been described by American Diabetes Association （ADA）（2012） as diabetes diagnosed during pregnancy that is not clearly overt diabetes. The hyperglycemia and adverse pregnancy outcomes study （HAPO） demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.

关键词： Criteria Gestational Diabetes Mellitus Oral Glucose Tolerance Test

强化常温解吸技术修复氯代烃污染土壤的工程应用

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环境工程 2024年第5期42卷 107-113页

作者：牛建敏臧翀王政华周敏潘文洁李红艳深圳市综合交通与市政工程设计研究总院有限公司广东深圳518003 湖南科技大学湖南湘潭411201

为研究该技术对不同氯代烃的去除效果,选取珠三角某氯代烃污染场地,采用化学氧化强化修复的常温解吸技术进行了小试试验和现场修复中试。结果表明:经过常温解吸技术,土壤中氯乙烯、三氯乙烯、四氯乙烯污染物的平均去除率均高于80%,经过... 详细信息

为研究该技术对不同氯代烃的去除效果,选取珠三角某氯代烃污染场地,采用化学氧化强化修复的常温解吸技术进行了小试试验和现场修复中试。结果表明:经过常温解吸技术,土壤中氯乙烯、三氯乙烯、四氯乙烯污染物的平均去除率均高于80%,经过碱活化过硫酸钠化学氧化后,除了重度污染土壤中四氯乙烯外,土壤中污染物去除率均高于90%,不同污染程度土壤中氯乙烯、三氯乙烯、四氯乙烯均达到修复目标值。现场修复后土壤氯乙烯、三氯乙烯、四氯乙烯均达到修复目标值。污染物初始浓度对氯代烃的去除有较大影响,初始浓度越高,氯代烃解吸速率越高。工程实践表明,该强化常温解吸技术应用于氯代烃污染土壤修复是可行的。

关键词：土壤修复强化常温解吸技术化学氧化氯代烃有机污染场地

HPLC Fingerprint Combined with Chemometrics and Network Pharmacology for Q-Markers Prediction Analysis of Saposhnikovia divaricata

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Journal of Analysis and Testing 2024年第1期8卷 83-94页

作者： Renguo Zhang Xinjian Liu Tong Wang Jie Yu Mengyuan Wang jianmin Sun Xueling Yu Na niu Ligang Chen College of Chemistry Chemical Engineering and Resource UtilizationKey Laboratory of Forest Plant EcologyNortheast Forestry UniversityHarbin 150040China

Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacodynamic targets.In this experiment,14 batches of SD were identified and screened for Q-marker candidate components using a combination of HPLC fingerprint with similarity analysis,principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis.Then,network pharmacology was used to predict Q-markers and core targets.The results showed that 5-O-methylvisammioside,cimifugin,and prim-O-glucosylcimifugin could be used as Q-markers of SD;while,MAPK1,MAPK3,PIK3CA,JUN,and MAPK8 were the core targets of SD for drug efficacy.To further evaluate the bind-ing efficiency of Q-markers,molecular docking of the main active ingredients of SD to the core targets was performed.The results showed that the compounds bind well to their targets,and binding energies were all less than-5 kcal/mol.The Q-markers obtained from the screening were closely related to the core target genes,which could achieve therapeutic effects by modulating the relevant signaling pathways.This study offers a reference for the establishment of a set of quality control evaluation system for SD potential Q-markers prediction analysis,and lays the foundation for elucidating the mechanism of actionunderlying itspharmacodynamic substance.

关键词： Saposhnikovia divaricata Q-markers Fingerprint Chemometrics Network pharmacology Molecular docking

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一种平衡式环行器收发隔离电路的设计与实现

电子器件 2022年第5期45卷 1039-1044页

作者：牛建民周郭飞公安部第一研究所北京100048

对于收发天线一体、收发频率相近、收发信号同时存在的无线电通信应用场景,比如UHF RFID的读卡器,目前一般使用单独的环行器来进行收发隔离,但其隔离度有限,一般在20 dB左右。从理论上分析了由两个环行器组成的平衡式环行器隔离电路的... 详细信息

对于收发天线一体、收发频率相近、收发信号同时存在的无线电通信应用场景,比如UHF RFID的读卡器,目前一般使用单独的环行器来进行收发隔离,但其隔离度有限,一般在20 dB左右。从理论上分析了由两个环行器组成的平衡式环行器隔离电路的隔离原理,并提出了一种改进平衡式环行器收发隔离电路,同时制作了电路模块。网络分析仪测试表明,该改进平衡式环行器收发隔离电路的发射端到天线端的传输损耗和天线端到接收端的传输损耗都在1 dB以内,在连接驻波比为1.2∶1的板式天线情况下,其收发隔离度达到了50 dB以上;实测当射频输入功率处于0.1 W~8.0 W区间时,该电路的收发隔离度稳定在40 dB以上,较使用单独环行器时的隔离度至少提高了20 dB。

关键词：平衡式环行器收发隔离 UHF RFID 载波泄露 3 dB电桥

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宽带UHF RFID读卡器天线设计实现

信息技术与信息化 2023年第7期 180-183页

作者：牛建民公安部第一研究所北京100048

针对矩形贴片微带天线带宽窄的问题,提出了一种采用E形贴片微带天线展宽技术设计制作的UHF RFID读卡器天线。首先介绍了目前展宽矩形贴片微带天线工作带宽的三种基本方法,并从理论上分析了矩形贴片微带天线的计算过程,然后通过HFSS仿真... 详细信息

针对矩形贴片微带天线带宽窄的问题,提出了一种采用E形贴片微带天线展宽技术设计制作的UHF RFID读卡器天线。首先介绍了目前展宽矩形贴片微带天线工作带宽的三种基本方法,并从理论上分析了矩形贴片微带天线的计算过程,然后通过HFSS仿真工具,分别设计了工作于840~845 MHz频段的矩形贴片微带天线和E形贴片微带天线,最后用薄铜板手工制作了E形贴片微带天线实物并进行测试,实验结果表明其将微带天线的相对带宽从0.3%提高到11%,达到了宽带读卡器天线的要求,同时天线增益也提高了2.3 dB。

关键词：微带天线矩形贴片 E形贴片 UHF RFID 读卡器天线

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低相位噪声倍频式信号源设计

信息技术与信息化 2023年第2期 140-143页

作者：牛建民公安部第一研究所北京100048

低相位噪声的信号源对雷达、测试测量仪器和UHF RFID等产品的性能起着关键的作用,针对常用锁相环间接频率合成技术,相位噪声一般都达不到-120 dBc/Hz@100 kHz以下的情况,描述了一种采用振荡器加多级倍频器的直接频率合成技术设计的信号... 详细信息

低相位噪声的信号源对雷达、测试测量仪器和UHF RFID等产品的性能起着关键的作用,针对常用锁相环间接频率合成技术,相位噪声一般都达不到-120 dBc/Hz@100 kHz以下的情况,描述了一种采用振荡器加多级倍频器的直接频率合成技术设计的信号源。首先从理论上介绍了射频信号自身相位噪声、倍频器相位噪声以及放大器相位噪声的计算方法,然后给出了该信号源的具体设计方案和器件选型过程,最后实际加工制作了该射频信号源。实验结果表明该信号源在输出频率786.43 MHz、输出功率是7.5 dBm时,相位噪声达到了-148 dBc/Hz@100 kHz。

关键词：相位噪声倍频器信号源雷达 UHF RFID