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Bioinspired laminated bioceramics with high toughness for bone tissue engineering

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Regenerative Biomaterials 2022年第1期9卷 739-749页

作者： Jinzhou Huang Dong Zhai jianmin xue Tian Li Dudi Ren Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050P.R.China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049P.R.China

For the research of biomaterials in bone tissue engineering,it is still a challenge to fabricate bioceramics that overcome brittleness whilemaintaining the great biological ***,inspired by the toughness of naturalmaterials with hierarchical laminated structure,we presented a directional assembly-sintering approach to fabricate laminated MXene/calcium silicate-based(L-M/CS)*** from the orderly laminated structure,the LM/CS bioceramics exhibited significantly enhanced toughness(2.23MPa·m^(1/2))and high flexural strength(145MPa),which were close to the mechanical properties of cortical ***,the L-M/CS bioceramics possessed more suitable degradability than traditional CaSiO_(3)bioceramics due to the newly formed CaTiSiO_(5)after ***,the L-M/CS bioceramics showed good biocompatibility and could stimulate the expression of osteogenesisrelated *** mechanism of promoting osteogenic differentiation had been shown to be related to theWnt signaling *** work not only fabricated calciumsilicate-based bioceramics with excellentmechanical and biological properties for bone tissue engineering but also provided a strategy for the combination of bionics and bioceramics.

关键词： laminated bioceramics MXene bioinspired structure high toughness bone tissue engineering

Bioprinting of inorganic-biomaterial/neural-stem-cell constructs for multiple tissue regeneration and functional recovery

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National Science Review 2024年第4期11卷 228-244页

作者： Hongjian Zhang Chen Qin Zhe Shi jianmin xue Jianxin Hao Jinzhou Huang Lin Du Hongxu Lu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Tissue regeneration is a complicated process that relies on the coordinated effort of the nervous, vascular and immune systems. While the nervous system plays a crucial role in tissue regeneration, current tissue engineering approaches mainly focus on restoring the function of injury-related cells, neglecting the guidance provided by nerves. This has led to unsatisfactory therapeutic outcomes. Herein, we propose a new generation of engineered neural constructs from the perspective of neural induction, which offers a versatile platform for promoting multiple tissue regeneration. Specifically, neural constructs consist of inorganic biomaterials and neural stem cells(NSCs), where the inorganic biomaterials endows NSCs with enhanced biological activities including proliferation and neural differentiation. Through animal experiments, we show the effectiveness of neural constructs in repairing central nervous system injuries with function recovery. More importantly, neural constructs also stimulate osteogenesis, angiogenesis and neuromuscular junction formation, thus promoting the regeneration of bone and skeletal muscle, exhibiting its versatile therapeutic performance. These findings suggest that the inorganic-biomaterial/NSC-based neural platform represents a promising avenue for inducing the regeneration and function recovery of varying tissues and organs.

关键词： 3D bioprinting neural stem cells inorganic biomaterials neural constructs multiple tissue regeneration

Effects of Intrinsic Nitric Oxide on the Expression of Interleukin-4 and IFN-γ mRNA in the Bronchial and Lung Tissues of Sensitized Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2000年第1期20卷 29-31页

作者：薛建敏徐永健张珍祥 Department of Respiratory Medicine Tongji Hospital Tongji Medical University Wuhan

Summary: To investigate the effects of intrinsic nitric oxide (NO) on the expression of interleukin-4 (IL-4) mRNA and interferon-γ (IFN-γ) mRNA in the airway inflammation of asthma, the rat models of asthmatic inflammation were established by sensitizing and then challenging the animals with ovalbumin. The 24 animals were randomly divided into control group, sensitized group, sensitized and L-Arg-treated group as well as L-NAME-treated group equally. By using in situ hybridization combined with compute physiological quantitative imaging analysis techniques, the influence of intrinsic NO on the expression of IL-4 mRNA and IFN-Y mRNA in the airway inflammatory cells was observed. In situ hybridization study demonstrated that IL-4 mRNA expres- sion was obviously increased as compared with that in the control group, mainly distributed in the inflammatory cells in the submucous of airways in the sensitized group. The increase of intensity of IL-4 mRNA expression was positively correlated with the numbers of eosinophil (Eos) and lymphocyte (both with P<0. 05) in the sensitized group. There was no statistically difference IFN- γ expression between the control group and the sensitized group. Imaging analysis showed that L- NAME could inhibit the expression of IL-4 mRNA (P<0. 05) and increase the expression of IFNY mRNA (P<0. 05), while L-Arg could increase the expression of IL-4 mRNA in inflammatory cells (P<0. 05). It was indicated that a suitable levels of intrinsic NO can influence the expression of IL-4 mRNA of Th2 lymphocytes and the expression of IFN-γ mRNA of Th1 lymphocytes and in turn, promote the development of asthmatic airway inflammation.

关键词： asthma nitric oxide interleukin-4 interferon-γ in situ hybridization

含钼的硅酸盐生物陶瓷释放的化学离子对肌腱-骨相关的多细胞调控

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化学学报 2023年第10期81卷 1334-1340页

作者：杜琳薛健民郇志广吴成铁中国科学院上海硅酸盐研究所、高性能陶瓷和超微结构国家重点实验室上海200050 中国科学院大学北京100049

研究生物材料所产生的化学信号与细胞行为之间的作用关系,对于高性能组织工程材料的设计与制备具有重要的指导意义.本工作中,采用化学共沉淀法成功地合成了含钼(Mo)的硅酸盐(MS)生物活性陶瓷粉体,并探究其降解产生的活性离子化学信号对... 详细信息

研究生物材料所产生的化学信号与细胞行为之间的作用关系,对于高性能组织工程材料的设计与制备具有重要的指导意义.本工作中,采用化学共沉淀法成功地合成了含钼(Mo)的硅酸盐(MS)生物活性陶瓷粉体,并探究其降解产生的活性离子化学信号对肌腱-骨相关细胞(肌腱干/祖细胞(TSPCs)和骨髓间充质干细胞(BMSCs))的调控作用.所合成的MS生物陶瓷颗粒大小均一,其降解后的浸提液中含有Mo、钙(Ca)、硅(Si)三种生物活性离子.特定浓度范围的MS浸提液可以同时促进TSPCs和BMSCs的增殖和迁移活性.更重要的是,MS浸提液可以同时刺激TSPCs和BMSCs的特异性分化,说明MS生物陶瓷释放的化学离子所构建的微环境,能够同时协调TSPCs和BMSCs的细胞行为.因此,MS生物陶瓷有望作为一种有效的“生物活性因子”用于肌腱-骨损伤修复.

关键词：含钼的硅酸盐化学信号多细胞细胞行为

EFFECT OF PHYTOTOXIN ON ELECTRICAL RESISTANCE OF LEAF TISSUES FROM CULTIVARS DIFFERENT IN DISEASE RESISTANCE

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Chinese Science Bulletin 1987年第15期32卷 1055-1059页

作者：谢建敏薛应龙 Department of Biology Fudan University Shanghai Shanghai Instiute of Plant PhysiologyAcademia ainica. Department of Biology Fudan University Shanghai

The infection of pathogens to the host and the toxin produced by them can cause rapid and drastic changes in the permeability of plant *** the differences in the electrical resistance of plant tissues is a way to observe the changes in cell permeability,the degree of plant tissue damage and the resistance of plants. This method is more advantageous than the classical one of ion leakage measurement.

关键词： permeability advantageous drastic leakage wheat saturated crude sterile exogenous inbred

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浅论衡水的休闲渔业

河北渔业 2005年第6期 49-50页

作者：薛建民衡水市畜牧水产局河北衡水053000

休闲渔业包括游钓渔业、观赏鱼养殖业和水族观赏业,它是渔业经济新的增长点.随着人民生活水平的不断提高,物质文化需求也越来越多样化,钓鱼、养殖观赏鱼爱好者队伍在不断扩大,这为发展休闲渔业提供了广阔的市场.

关键词：休闲渔业水族观赏鱼游钓渔业渔业经济生活水平物质文化养殖业增长点多样化

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论地下浅层咸水的渔业利用

河北渔业 2006年第6期 3-5页

作者：薛建民衡水市畜牧水产局河北衡水053000

1概述,地下浅层咸水是指矿化度大于2g/L以上的地下水.又有微咸水和咸水之分.微咸水在河北的中东部平原,平面与浅层淡水相间分布,边界呈过渡状.水化学类型与浅层淡水近似,矿化度2～5g/L,咸水分布在中东部平原及滨海平原.咸水体顶板埋深0... 详细信息

1概述,地下浅层咸水是指矿化度大于2g/L以上的地下水.又有微咸水和咸水之分.微咸水在河北的中东部平原,平面与浅层淡水相间分布,边界呈过渡状.水化学类型与浅层淡水近似,矿化度2～5g/L,咸水分布在中东部平原及滨海平原.咸水体顶板埋深0～80m,厚度自西向东逐渐加大,由50～100m,最厚300m.水化学类型由西向东由硫酸盐型过渡为氯化物型,矿化度大于5g/L,最高达35g/L。

关键词：浅层咸水地下水渔业利用水化学类型东部平原矿化度相间分布滨海平原氯化物型硫酸盐型

Supercritical fluid extraction of polycyclic aromatic hydrocarbons in urban dust of Shanghai

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Supercritical fluid extraction of polycyclic aromatic hydroc...

Speciation of the elements and compositions on the surfaces of dust storm particles:The evidence for the coupling of iron with sulfur in aerosol during the long-range transport

第八届全国气溶胶会议暨第二届海峡两岸气溶胶科技研讨会

作者： Yu Ren Huaxin xue jianmin Chen Hongbo Wu Tiantao Cheng Center of Atmospheric Chemistry Studies, Department of Environmental Science & Engineering, Fudan University, Handan Road 220, Shanghai 200433

＜正＞EPA 16 priority polycyclic aromatic hydrocarbons （PAHs） were extracted by supercritical fluid extraction （SFE） in urban dust collected at twelve sites in Shanghai. Parameters affecting the collection efficiencies of PAHs were optimized. The characterization of the extracts was carried out by gas chromatography with mass detector in selective ion mode （GC-MS-SIM）. The limits of detection of the system for the quantification standards were in the range of 0.2-3.9 ng g-1. Ultrasonic extraction （USE） was used as a comparison with SFE. The results showed that SFE method has a better efficiency than USE for the extraction of PAHs in dust. With the method of SFE and GC-MS-SIM, the distribution of PAHs in dust samples in urban area of Shanghai was investigated. It can be concluded that the average concentrations of PAHs in traffic zone （14.21 μg g-1）, residential region （9.65 μg g-1） and industrial area （9.30 μg g-1） were much higher than those of outskirts （3.18 μg g-1） in Shanghai. Among the 16 PAHs analyzed in the dust samples, Chrysene was the most abundant compounds （2.12 μg g-1）, followed by Benzo[a]pyrene and Phenanthrene （both of 1.92 μg g-1）. PAHs with 3-ring, 4-ring and 5-ring were the main components in dust. This study is firstly applying SFE to investigate the PAHs distribution of dust of Shanghai, which would provide the basic information in understanding and controlling the pollution of PAHs at Shanghai.

关键词： Distribution Dust GC-MS-SIM PAHs SFE

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Chinese Science Bulletin 2005年第8期50卷 738-744页

作者： ZHANG Xingying1,2, ZHUANG Guoshun1,2,3, CHEN jianmin2 & xue Huaxin2 1. Center for Atmospheric Environment Study, Department of Chemistry, Beijing Normal University, Beijing 100875, China 2. Center for Atmospheric Chemistry Study, Department of Environ- mental Science and Engineering, Fudan University, Shanghai 200433, China 3. LAPC/NZC, Institute of Atmospheric Physics, NZC/LAPC, Chinese Academy of Sciences, Beijing 100029, China Center for Atmospheric Environment Study Department of Chemistry Beijing Normal University Beijing China Center for Atmospheric Chemistry Study Department of Environmental Science and Engineering Fudan University Shanghai China LAPC/NZC Institute of Atmospheric Physics NZC/LAPC Chinese Academy of Sciences Beijing China

The speciation of the elements on the surface of the particles collected during dust storm and non-dust storm in Beijing and Inner Mongolia was studied by XPS. The ma- jor species of iron on the surface were oxides, sulfate, silicate, FeOOH and minor part sorbed on SiO2/Al2O3. Sulfate is the dominant species of sulfur on the surface. SiO2 and Al2O3 are the main components of Si and Al on the surface respectively. One of the most important findings was that the Fe(II) (FeS and FeSO4) produced could account for up to 44.3% and 45.6% of the total Fe on the surface in the aerosol sample collected at that night and next day of the “peak” time of the dust storm occurring on March 20, 2002, while Fe2(SO4)3, one of the Fe(III) species on the surface decreased from 67.1% to 49.5% and 48.0% respectively. Both S and Fe en- riched on the surface of aerosol particles. Fe(II) accounted for 1.3%?5.3% of total Fe in bulk aerosol samples during dust storm. These results provided strong evidence to sup- port the hypothesis of the coupling between iron and sulfur in aerosols during the long-range transport, which would have important impact on the global biogeochemical cycle.

关键词：物种形成原理 XPS 大气悬浮物 Fe-S结合粒子集合