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Genes & Diseases 2024年第5期11卷 98-101页

作者： Xingchen Li Xin Xu jianliu wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Department of Obstetrics and Gynecology Beijing ChaoYang HospitalCapital Medical UniversityBeijing 100020China

Endometrial cancer(EC)is one of the most prominent malignancies in ***,despite these advancements in understanding EC pathogenesis,mortality rates have not *** force(TF)refers to endogenous mechanical forces exerted by cells.1 These forces act on the extracellular matrix and the extracellular tumor microenvironment through focal adhesions,thereby regulating cell proliferation and ***,the TF characteristics of endometrial cancer cells and their heterogeneity remain unclear.

关键词： endometrial metastasis endogenous

Biomechanics of pelvic organ prolapse

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Science China(Life Sciences) 2015年第2期58卷 218-220页

作者： REN Shuang XIE Bing wang jianliu RONG QiGuo College of Engineering Peking University Department of Obstetrics & Gynecology Peking University People's Hospital Peking University

Dear Editor,Pelvic organ prolapse （POP）, caused by damage of the sup- port system in the pelvic floor, is downward descent of fe- male pelvic organs, resulting in protrusion of the vagina, uterus, or both. It has been reported recently that POP has a prevalence of 3%-6% when defined by symptoms and up to 50% based on a vaginal examination [1]. POP is basically divided into anterior vaginal wall prolapse and posterior vaginal wall prolapse. The most common type of POP is anterior vaginal wall prolapse, clinically known as the cys- tocele [2].

关键词：生物力学器官盆腔阴道检查 POP 支持系统患病率盆底

Minimally invasive Fothergill-Manchester operation with connective tissue conservation

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Gynecology and Obstetrics Clinical Medicine 2022年第2期2卷 52-56页

作者： Xiuli Sun Ray Hodgson jianliu wang Peter Petros Gynecologic Department Peking University People's HospitalBeijingChina University of NSW SydneyAustralia University of Western Australia School of Engineering and Mathematical Sciences WA

Poor cure rates for prolapse repair reported by the PROSPECT TRIAL1 and total mesh bans after the Cumberlage Report,2 leave few options for vaginal surgery for urogynecologists *** remaining option,the Fothergill-Manchester Repair began as a modification of the Donald operation.3 Fothergill emphasized the role of cardinal ligament(CL)and uterosacral(USL)ligaments in uterine prolapse repair.4 The classical Manchester operation involves full thickness inverted V-shaped vaginal excisions(Fig.1).The cervix is dilated and if elongated,it is *** are severed and sutured to the anterior part of *** may also be *** sutures bring vaginal flaps into the cervical *** is *** operation can be traumatic,some even reported a large quantity blood loss as high as 850 ml,5 possibly related to severing of CLs which contains uterine artery branches and also,failure of Sturmdorf sutures to control bleeding from cervical amputation.

关键词： operation suture Manchester

Chinese expert consensus on fertility-preserving treatment for young women with early stage well differentiated endometrial cancer

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Gynecology and Obstetrics Clinical Medicine 2021年第1期1卷 49-53页

作者： Rong Zhou Qun Lu Guoli Liu Yiqin wang jianliu wang Peking University People's Hospital Expert Committee of Obstetrics and Gynecology of the Chinese Research Hospital AssociationChina

For young women with early stage well differentiated endometrial cancer who have fertility desire,it is import to give comprehensive assessment before initiation of conservative *** based therapy with regular assessment of treatment efficacy can achieve a promising *** complete remission patients are suggested with assisted reproductive technology or maintenance therapy depending on their immediate pregnancy *** is recommended for patients who have finished reproduction while re-treatment for recurrent cases should be carefully informed.

关键词： Fertility-preserving treatment Young women Endometrial cancer Progesterone

Pregnancy outcomes after fertility preservation in women with endometrial carcinoma and atypical endometrial hyperplasia:A systematic review and meta-analysis

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 190-196页

作者： Zerui Xiao Ziyi Song jianliu wang Huixin Liu Qun Lu Department of Obstetrics and Gynecology Peking University People’s HospitalChina Department of Clinical Epidemiology Peking University People's HospitalChina

Objective:The objective of the study was to compare the effects of assisted reproductive technology(ART)and spontaneous pregnancy on pregnancy outcomes in women with endometrial carcinoma(EC)and atypical endometrial hyperplasia(AEH)following fertility-sparing ***:Relevant studies published through July 2020 were identified from PubMed and Web of Science literature *** pregnancy outcomes of ART and spontaneous pregnancy were summarized and compared for women with complete remission of EC/AEH after fertility-sparing treatments.A subgroup analysis was performed based on whether patients had received in vitro fertilization and embryo transfer(IVF-ET)*** complete remission and recurrence rates of EC/AEH following fertility-sparing treatments were *** effect of pregnancy on recurrence rates of EC/AEH was also ***:Sixteen observational studies reporting pregnancy outcomes or recurrence with ART or spontaneous pregnancy for women with EC/AEH after fertility-sparing treatments were *** complete remission rate of EC/AEH was 81.5%(95%CI,78%–85%).Compared with spontaneous pregnancy,the pregnancy rate of ART was significantly higher(66.8%vs.43.7%,OR=2.64,95%CI 1.71–4.05,P<0.00001,I^(2)=14%).Subgroup analysis showed that the pregnancy rate of IVF-ET was significantly higher than that of spontaneous pregnancy(62.7%vs.35.1%,OR=2.85,95%CI 1.44-5.63,P=0.003,I^(2)=29%).The live birth rate of ART was significantly higher than that of spontaneous pregnancy(75.3%vs.47.8%,OR=3.96,95%CI1.76-8.77,P=0.0009,I^(2)=45%).The recurrence rate of EC/AEH was 31%(95%CI 24%–39%).Clinical pregnancy could reduce the recurrence rate of EC/AEH,but there was no significant evidence of an ***:ART,especially IVF-ET,could significantly improve pregnancy outcomes in women with EC/AEH receiving fertility-sparing *** complete remission,ART treatment might be a better option for women with EC/AEH than spontane

关键词： Endometrial carcinoma Atypical endometrial hyperplasia Fertility sparing treatment Assisted reproductive technology In vitro fertilization and embryo transfer

An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma

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Chinese Journal of Cancer Research 2019年第6期31卷 965-973页

作者： Xingchen Li Yuan Cheng Yangyang Dong Boqiang Shen Xiao Yang Jiaqi wang Jingyi Zhou jianliu wang Department of Obstetrics and Gynecology Peking University People's HospitalBeijing 100044China Beijing Key Laboratory of Female Pelvic Floor Disorders Diseases Beijing 100044China

Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December *** characteristics and preoperative serum calcium,albumin,carbohydrate antigen(CA)125,CA19-9,carcinoembryonic antigen(CEA)were extracted from patient records and evaluated according to postoperative peritoneal *** factors were assessed with Cox univariate and multivariate *** selected from multivariate analysis results were used to build a predictive ***:A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this *** analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology,tumor grade and lymph-vascular space invasion(LVSI).Moreover,peritoneal cytology was significantly associated with hypertension,tubal ligation,serum CA125,CA19-9,CEA and ionized calcium *** analysis revealed that albumin-adjusted calcium level,CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology(P<0.05).A combination of ionized calcium level with the other two indexes yielded significantly great area under the curve(AUC=0.824).Conclusions:This study enhanced the value of preoperative ionized calcium *** also identified several potential biomarkers to predict positive peritoneal cytology in EC patients before surgery.

关键词： Endometrial carcinoma serum calcium peritoneal cytology logistic regression predictive model

Enlarging ovarian cysts mimicking malignant or borderline tumors during pregnancy

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 228-232页

作者： Yibo Dai Guoli Liu Yan wang Jun Wei Zhiqi wang jianliu wang Department of Obstetrics and Gynecology Peking University People's HospitalBeijingChina

Background:Ovarian cysts are uncommon gestational *** of high-level progesterone,ovarian endometriomas may undergo decidualization during pregnancy,manifesting as enlarging cysts with papillae and rich blood *** cases can mimic malignant or borderline tumors,causing dilemmas in clinical ***,we present two cases of enlarging ovarian cysts during pregnancy with evidence suggesting decidualized *** diagnosis and treatment are further discussed,which add to our limited knowledge and might help future clinical *** summary:In the first case,a right ovarian cyst was detected by ultrasound in a 32-year-old pregnant *** cyst measured 4.2 cm in diameter at 7t6 weeks of gestation,and gradually increased to 9.6 cm7.6 cm5.6 cm at 37t5 weeks,with multiple solid papillae lining the inner *** cesarean section,an ovarian mass of approximately 9 cm in diameter was surgically removed,which was later identified by pathological review as an endometrioma with *** second case also presented as an enlarging ovarian mass during the first and second *** size of the cyst peaked at 24t5 weeks of gestation,measuring 6.9 cm5.6 cm4.1 *** in the third trimester,the tumor slightly *** follow-up was adopted after successful vaginal delivery,and the cyst was found to have undergone quick regression shortly after *** patients recovered well after delivery with no further ***:Endometriomas with decidualization during gestation may resemble borderline or malignant *** monitoring and proper management are essential for guiding clinical management.

关键词： Ovarian cyst Pregnancy Pregnancy complication Endometrioma Decidualization Case report

Embarking on a brand new journey with Gynecology and Obstetrics Clinical Medicine

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Gynecology and Obstetrics Clinical Medicine 2024年第1期4卷 1-2页

作者： wang jianliu Department of Obstetrics and Gynecology Peking University People's HospitalBeijingChina

The year 2024 is a milestone for Gynecology and Obstetrics Clinical Medicine(GOCM)as the journal has decided to transition and collaborate with BMJ Publishing *** GOCM,this signifies a newjourney,while we continue to ... 详细信息

关键词： journal journey finding

Urinary catheterization management after vaginal prolapse surgery:A national survey among Chinese urogynecologists and nurses

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Gynecology and Obstetrics Clinical Medicine 2022年第2期2卷 63-68页

作者： Yiqian Chen Yi Liang Xiaodan Li Xiuli Sun jianliu wang Peking University School of Nursing Xueyuan Rd 38#Haidian DistrictBeijing100191China Department of Obstetrics and Gynecology Peking University People's HospitalNo.11 Xizhimen South StreetBeijing100044China Department of Thoracic Surgery The First Affiliated Hospital of Guangxi Medical UniversityNo.6 Shuangyong RoadNanningGuangxi530021China

Background:Urinary catheterization after vaginal prolapse surgery can cause inconvenience for patients,elevate the risk of urinary tract infections,and potentially prolong the *** China,there is no consensus on the optimal time to remove the urinary catheter after vaginal prolapse ***,it will be valuable to gain insight into the nationwide catheterization management after the vaginal prolapse ***:From March to May 2020,an online questionnaire was shared and purposive non-probabilistic sampling was used to recruit the *** urogynecologists currently performing vaginal prolapse surgery and involved nurses were included in this ***:1363 urogynecologists and 436 nurses responded and 99.5%of them reported using transurethral indwelling catheters(TIC)for post-operative bladder drainage in their *** duration of initial catheterization after vaginal prolapse surgery was generally 1–7 days,with a median duration of 3 days for anterior colporrhaphy(AC)and anterior&posterior colporrhaphy(APC),and 2 days for other *** the same type of surgery,the median duration of catheterization varied by *** AC,it was shorter by 1 day in West China and South China(P<0.001);for PC,it was 2 days in most regions,while 1 day in East China(P<0.05);and for APC,it was 3 days in most regions,while 4 days in Northeast China(P<0.05).No statistically significant difference was found in duration of catheterization in hospital ***:The findings suggested that duration of catheterization after prolapse surgery varied greatly in China,potentially resulting in unnecessary prolonging of ***-designed studies are urgently needed to optimize catheterization management after vaginal prolapse surgery in China.

关键词： Pelvic organ prolapse Transurethral indwelling catheterization Urinary catheterization Vaginal surgery

Characteristics of molecular classification in 52 endometrial cancer and atypical hyperplasia patients receiving fertility-sparing treatment

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 38-43页

作者： Yiqin wang Nan Kang Liwei Li Zhiqi wang Rong Zhou Danhua Shen jianliu wang Department of Obstetrics and Gynecology Peking University People's HospitalBeijing100044China Department of Pathology Peking University People's HospitalBeijing100044China

Objective To investigate the molecular classification of endometrial cancer(EC)and atypical endometrial hyperplasia(AEH)patients treated with fertility-sparing treatment(FST),and its relationship with clinicopathological factors and treatment ***:A total of 52EC and AEH patients who received FST and molecular classification tested by next generation sequencing in Peking University People's Hospital from June 2020 to December 2022,were retrospectively *** analyzed the relationship between molecular classification and clinicopathological factors and treatment ***(1)Of the 52 patients,including 46EC and 6 AEH patients,42(80.8%)achieved complete remission(CR)after FST,with a median time to achieve CR of 9 *** cases(23.8%)had recurrence.(2)Patients were distributed into 4 molecular subgroups as 39 cases(75%)of copy number low(CNL),7 cases(13.5%)of microsatellite instability-high(MSI-H),4 cases(7.7%)of POLE mutations(POLEmut),and 2 cases(3.8%)of copy number high(CNH).Patients with MSI-H subgroup had more family history of tumor(6/7),more with loss of expression of mismatch repair(MMR)protein(7/7),and higher expression level of Ki-67(3/3).(3)Patients with MSI-H subgroup had the lowest CR rate at 6 months(0/7,P=0.014),and survival analysis showed that such patients were less likely to achieve CR than those with CNL(P=0.022).For CNL patients,median 6-month CR rate was 40.6%.In addition,CR was obtained in 3(3/4)POLEmut patients and 2(2/2)CNH patients,*** Molecular classification relates with the treatment response in patients with EC and AEH receiving *** with MSI-H subgroup have poor treatment efficacy,and patients with CNL need to be further divided to predict treatment *** are also a few successful cases in POLEmut and CNH subtgroups,which needs further research.

关键词： Endometrial cancer Fertility-sparing Progesterone Molecular classification Efficacy