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Building Simulation 2022年第9期15卷 1645-1660页

作者： jianlin ren Junjie He Xiangfei Kong Hongwan Li School of Energy and Environmental Engineering Hebei University of TechnologyTianjin300401China Department of Environmental Engineering Sciences University of FloridaUSA

Walking-induced fluctuations have a significant influence on indoor airflow and pollutant *** study developed a method to quantify the robustness of ventilation systems in the control of walking-induced fluctuation *** were conducted in a full-scale chamber with four different kinds of ventilation systems:ceiling supply and side return(CS),ceiling supply and ceiling return(CC),side supply and ceiling return(SC),and side supply and side return(SS).The measured temperature,flow and pollutant field data was(1)denoised by FFT filtering or wavelet transform;(2)fitted by a Gaussian function;(3)feature-extracted for the range and time scale disturbance;and then(4)used to calculate the range scale and time scale robustness for different ventilation systems with dimensionless equations developed in this *** selection processes for FFT filtering and wavelet transform,FFT filter cut-off frequency,wavelet function,and decomposition layers are also discussed,as well as the threshold for wavelet denoising,which can be adjusted accordingly if the walking frequency or sampling frequency differs from that in other *** results show that for the flow and pollutant fields,the use of a ventilation system can increase the range scale robustness by 19.7%-39.4% and 10.0%-38.8%,respectively;and the SS system was 7.0%-25.7% more robust than the other three ventilation ***,all four kinds of ventilation systems had a very limited effect in controlling the time scale disturbance.

关键词： FFT filtering wavelet denoising Gaussian fitting feature extraction robust

Help, hope and hype： ethical considerations of human microbiome research and applications

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Protein & Cell 2018年第5期9卷 404-415页

作者： Yonghui Ma Hua Chen Canhui Lan jianlin ren Centre for Bioethics Medical College Xiamen University Xiamen 361102 China Center for Bioethics School of Marxism Southern Medical University Guangzhou 510515 China Beijing Rexinchang Biotechnology Research Institute Co. Ltd Beijing China Institute for Human Microbiome Research Medical College Xiamen University Xiamen 361005 China Department of Digestive Diseases Zhongshan Hospital affiliated to Xiamen University Xiamen 361004 China

Recent years have witnessed an unprecedented explosion of scientific knowledge and advances in human microbiome research due to the emerging high-throughput molecular technologies. The term human microbiome refers to the population of microorganisms, including bacteria, viruses, fungi and protozoan, and their genetic material that live on and inside the human organisms （skin, mucous membranes, intestinal tract, etc.）（Honey, 2008）. A search of the literature at PubMed for the term ＂microbiome＂ in the title and abstract illustrates the fast progression of microbiome science. From 2006 to 2010 there were just 304 papers that used the word microbiome in their title and/or abstract, whereas the number has increased to 11,128 from 2011 to 2017.

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Differentiation of adipose-derived stem cells toward nucleus pulposuslike cells induced by hypoxia and a three-dimensional chitosan-alginate gel scaffold in vitro

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Chinese Medical Journal 2014年第2期127卷 314-321页

作者： Zhang Zhicheng Li Fang Tian Haiquan Guan Kai Zhao Guangmin Shan jianlin ren Dajiang People's Liberation Army Institute of Orthopedics Beijing Army General Hospital Beijing 100700 China

Background Injectable three-dimensional （3D） scaffolds have the advantages of fluidity and moldability to fill irregularshaped defects,simple incorporation of bioactive factors,and limited surgical ***-derived stem cells （ADSCs） are multipotent and can be differentiated toward nucleus pulposus （NP）-Iike cells.A hypoxic environment may be important for differentiation to NP-like cells because the intervertebral disc is an avascular ***,we investigated the induction effects of hypoxia and an injectable 3D chitosan-alginate （C/A） gel scaffold on *** The C/A gel scaffold consisted of medical-grade chitosan and *** porosity was calculated by liquid displacement *** microstructure was analyzed by light and scanning electron *** were isolated and cultured by conventional *** 2 BrdU-labeled ADSCs were co-cultured with the C/A *** were divided into three groups （control,normoxia-induced,and hypoxia-induced groups）.In the control group,cells were cultured in 10％ FBS/***-induced and normoxia-induced groups were induced by adding transforming growth factor-β1,dexamethasone,vitamin C,sodium pyruvate,proline,bone morphogenetic protein-7,and 1％ ITS-plus to the culture medium and maintaining in 2％ and 20％ O2,*** and morphological changes were observed by light and electron *** were characterized by flow *** viability was investigated by BrdU *** and type Ⅱ collagen were measured by safranin O staining and the Sicool method,*** expression of hypoxia-inducing factor-1α （HIF-1α）,aggrecan,and Type Ⅱ collagen was determined by reverse transcription-polymerase chain *** C/A gels had porous exterior surfaces with 80.57％ porosity and 50-200 μm pore *** cytometric analysis of passage 2 rabbit ADSCs showed high CD90 expression,while CD45 expression was very *** morphology of induced ADSCs resembl

关键词： intervertebral disc degeneration adipose-derived stem cells tissue engineering chitosan-alginate gel

Allosteric probe-modified liposome loading bufalin-fluorouracil complex for targeted colorectal cancer therapy

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Oncology and Translational Medicine 2022年第5期8卷 239-246页

作者： Fajiang Mao Xingli Wu Chenyue Yuan Haiyan Huang Yanyan Qiu jianlin ren Peihao Yin Department of Oncology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China Interventional Cancer Institute of Chinese Integrative Medicine Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China

Objective Bufalin,the main active anti-tumor monomer of toad venom,is crucial in cancer ***,intrinsic issues,such as poor solubility and systematic toxicity,have considerably mitigated its anticancer functions and caused unwanted side *** is essential to develop innovative targeting systems to precisely and efficiently deliver anticancer drugs to achieve satisfying therapeutic *** This work established a novel and more efficient system for simultaneously detecting and killing colorectal cancer *** proposed method designed two allosteric probes,a report probe and a recognize *** method exhibited high sensitivity towards cell detection via the recognizing probe identifying target cancer cells and the report probe’s signal *** bufalin and fluorouracil endowed better tumor cell *** We observed significantly enhanced fluorescence dots surrounding the HCT-116 cell *** fluorescence increments in the other three cells were identified,indicating that the established liposome complex could specifically bind with target *** addition,the best ratio of bufalin to fluorouracil was 0.15 and 0.5,*** improved the anti-tumor effects and achieved more than 60%tumor cell *** This method will provide new opportunities for intracellular biomolecule detection and targeted cancer cell therapy.

关键词： bufalin fluorouracil colorectal cancer imaging therapy

EXPERIMENTAL STUDY OF INFLUENCE OF LIQUID NITROGEN PRESERVATION ON ANTIGENICITY OF HUMAN HOMOGRAFT AORTIC VALVE

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Journal of Pharmaceutical Analysis 1999年第2期13卷 157-161页

作者： Fan Zhaohui,Huang Qingheng,Zhao Jian, Geng Xigang,Liu jianlin,ren Huping Department of Cardiovascular Surgery, First Affiliated Hospital of Xi′an Medical University, Xi′an 710061 Department of Cardiovascular Surgery First Affiliated Hospital Xi'an Medical University Xi'an 710061 China

To illustrate the effect of liquid nitrogen preservation on antigenicity of human homograft aortic valve (HAV), human aortic valve tissue were cocultured together with peripheral blood mononuclear cells (PBMCs). Following detections were done to show the difference of antigenicity of HAV indirectly at different period after being preserved in liquid nitrogen: ① 3H TdR incorporation (cpm) was observed after tissue cell cocultured and stimulation index (SI) was calculated;② Density of IL 2 in medium was measured by MTT means. The results indicated that antigenicity of fresh HAV was the strongest; with the prolong of being preserved, antigenicity decreased gradually. It decreased significantly within first 48 h preserved at 4℃, then decreased significantly after preserved in liquid nitrogen for 24 h. 2 weeks later, antigenicity decreased to the lowest level.

关键词： liquid nitrogen homograft aortic valve (HAV) antigenicity stimulation index(SI)

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三叶因子家族在胃癌发生中的作用机制

胃肠病学 2008年第1期13卷 57-60页

作者：詹晓娟任建林福建医科大学临床医学系 350000 厦门大学附属中山医院消化内科厦门大学消化疾病研究所

三叶因子家族(trefoil factor family,TFF)是一群主要由胃肠道黏液细胞分泌的小分子多肽,在黏膜修复和重建以及肿瘤的发生、发展过程中发挥重要作用,对其结构功能、遗传学改变等分子机制的研究一直是近20余年的研究热点。TFF在肠型胃癌... 详细信息

三叶因子家族(trefoil factor family,TFF)是一群主要由胃肠道黏液细胞分泌的小分子多肽,在黏膜修复和重建以及肿瘤的发生、发展过程中发挥重要作用,对其结构功能、遗传学改变等分子机制的研究一直是近20余年的研究热点。TFF在肠型胃癌中表达降低甚至缺失,在弥漫型胃癌中高表达。其在胃癌发生、发展过程中的机制涉及肿瘤抑制、促进肿瘤侵袭浸润以及促癌与抑癌的双重机制。通过对TFF在胃癌发生、发展中机制的深入研究,有望在胃癌防治方面开辟新途径。

关键词：三叶因子家族胃肿瘤机制

The attenuated effects of Jianpi Qushi herbs on patients receiving FOLFOX4 after colorectal cancer surgery:a meta-analysis

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The attenuated effects of Jianpi Qushi herbs on patients rec...

2014中国医师协会中西医结合医师大会

作者： Qi Shi Wen Li Qiqi Le Wenting Chen jianlin ren Qi Li Fenggang Hou

Purpose;The purpose of this meta-analysis was to systematically review the attenuating effects of Jianpi Qushi herbs on post-operational colorectal cancer patients on FOLFOX4 ***:CNKI,Wanfang Data,VIP,PubMed,MEDLINE,EMBASE,and the Cochrane Library databases(up to May2014) were searched in English or Chinese,and clinical trials with specific inclusion criteria were *** were analyzed by using ***:The meta-analysis comprised 8 randomized clinical trial studies of 449 patients;238 cases were in the treatment group and 211 were in the control *** results showed that Jianpi Qushi herbs could improve the quality of life for post-operational colorectal cancer patients on FOLFOX4(WMD = 8.883,95%confidence interval[CI]= 5.548 to 12.217);alleviate the symptoms defined by traditional Chinese medicine(odds ratio[OR]= 5.741,95%CI = 3.683 to 8.947);and reduce the incidence rate of neutropenia(relative risk[RR]= 0.669,95%CI = 0.503 to 0.888),decreased hemoglobin(RR = 0.654,95%CI = 0.464 to 0.922),diarrhea(RR = 0.427,95%CI = 0.275 to 0.662),nausea and vomiting(RR = 0.502,95%CI = 0.390 to 0.648),and neurotoxic reactions(RR = 0.752,95%CI = 0.595 to 0.951);however,the results showed no significant difference in the incidence rate of thrombocytopenia or liver and kidney ***:Jianpi Qushi herbs can improve the quality of life for patients undergoing FOLFOX4 treatment after colorectal cancer surgery,relieve symptoms,and somewhat reduce the adverse effects of chemotherapy.

关键词： Jianpi Qushi FOLFOX4 colorectal cancer meta-analysis

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磺化硅胶催化合成苯甲酸异戊酯的研究

石油化工应用 2016年第9期35卷 121-124页

作者：任建林宁夏大学化学化工学院宁夏银川750021

磺化硅胶是一种以化学键键合而成,性能稳定的固体酸催化剂。以磺化硅胶为催化剂,苯甲酸和异戊醇为原料合成了苯甲酸异戊酯,并获得了最佳合成条件:n(苯甲酸):n(异戊醇)=1:1.5,催化剂用量为反应物总质量的0.6%,回流时间为60 min,反应酯化... 详细信息

磺化硅胶是一种以化学键键合而成,性能稳定的固体酸催化剂。以磺化硅胶为催化剂,苯甲酸和异戊醇为原料合成了苯甲酸异戊酯,并获得了最佳合成条件:n(苯甲酸):n(异戊醇)=1:1.5,催化剂用量为反应物总质量的0.6%,回流时间为60 min,反应酯化率可达97.6%,催化剂重复使用5次后的酯化率仍达73.5%以上。磺化硅胶对合成苯甲酸异戊酯具有良好的催化活性。

关键词：固体酸催化剂磺化硅胶催化苯甲酸异戊酯

超声引导下微波消融术与开放手术应用在甲状腺结节治疗中疗效差异分析

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中国医学文摘（耳鼻咽喉科学） 2024年第1期39卷 17-19,26页

作者：任建林广饶县人民医院山东东营257300

目的超声引导下微波消融术与开放手术应用在甲状腺结节治疗中疗效差异分析。方法本文中研究对象具体构成为:我院诊治的甲状腺结节患者,根据需要分组后,组别为:对照组、实验组,指导依据为:电脑随机法,且2组甲状腺结节患者总例数为84;其中... 详细信息

目的超声引导下微波消融术与开放手术应用在甲状腺结节治疗中疗效差异分析。方法本文中研究对象具体构成为:我院诊治的甲状腺结节患者,根据需要分组后,组别为:对照组、实验组,指导依据为:电脑随机法,且2组甲状腺结节患者总例数为84;其中,42例在对照组中收入,42例在实验组中收入,2组入院时间开始于2020年12月,结束于2022年8月,在治疗阶段,将开放手术为对照组提供,超声引导下微波消融术为实验组提供,就2组患者最终疗效展开比较。结果两组甲状腺结节患者开展不同手术治疗期间,实验组患者各项手术指标优于对照组,P<0.05。患者术后并发症发生率比较,实验组低于对照组,P<0.05。术后甲状腺素水平比较,术前各项甲状腺素水平没有显著差异,术后6个月,实验组患者甲状腺素水平稳定程度优于对照组,P<0.05。比较两组患者各项炎性因子水平,实验组均低于对照组,P<0.05。结论在甲状腺结节治疗中采取超声引导下微波消融术治疗效果要优于开放手术,可以优化手术治疗指标,确保手术治疗安全性,在临床值得推广实施超声引导下微波消融术治疗。

关键词：甲状腺结节超声引导下微波消融术开放手术疗效

煤沥青炭化双电层电容器电极用活性炭前驱体的制备与表征

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石油化工应用 2014年第4期33卷 102-106页

作者：任建林宁夏大学化学化工学院宁夏银川750021

选择廉价的煤沥青为原料,无水三氯化铝为催化剂,在不同的工艺条件下制备了双电层电容器电极用活性炭前驱体。分别考察了催化剂用量、炭化时间等工艺条件对活性炭孔结构的影响,并采用DSC、SEM、XRD对其进行表征。实验结果表明,催化剂用... 详细信息

选择廉价的煤沥青为原料,无水三氯化铝为催化剂,在不同的工艺条件下制备了双电层电容器电极用活性炭前驱体。分别考察了催化剂用量、炭化时间等工艺条件对活性炭孔结构的影响,并采用DSC、SEM、XRD对其进行表征。实验结果表明,催化剂用量为煤沥青质量的7.5%、反应时间为6 h时煤沥青的软化点最高;以煤沥青为原料,采用无水三氯化铝为催化剂,能够制备得到微晶结构良好的活性炭前驱体;在炭化温度为580℃、炭化时间为50 min的煤沥青是较好的活性炭前驱体。

关键词：双电层电容器煤沥青活性炭前驱体表征