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中国卫生经济 2001年第6期20卷 14-17页

作者：侯建林雷海潮董竹敏刘金峰钟东波毛阿燕北京市肿瘤防治研究所 100034 北京市疾病预防与控制中心 100013 北京大学医学部 100083 国家卫生部医政司北京100044

重点分析美国营利性和非营利性医院在医疗服务市场中的作用及其各自的运行绩效,并对我国医疗机构分类管理改革提出了若干政策性建议。

关键词：营利性医院非营利性医院对比研究中国卫生改革美国

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新疆温泉县巴什干地区铀成矿地质特征及成矿条件

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现代矿业 2017年第9期33卷 34-38页

作者：曹建林张磊马传亮张虎军张雷核工业二一六大队

新疆温泉县巴什干地区地处博尔塔拉河、别珍套华力西褶皱带与博罗科努加里东褶皱谷接壤处两侧,属于古亚洲成矿域、天山铀成矿省、北天山西部铀成矿带、温泉铀成矿亚带,北天山西部主体属于哈萨克斯坦—准噶尔板块,由滨巴尔喀什泥盆、石... 详细信息

新疆温泉县巴什干地区地处博尔塔拉河、别珍套华力西褶皱带与博罗科努加里东褶皱谷接壤处两侧,属于古亚洲成矿域、天山铀成矿省、北天山西部铀成矿带、温泉铀成矿亚带,北天山西部主体属于哈萨克斯坦—准噶尔板块,由滨巴尔喀什泥盆、石炭纪残余洋盆、赛里木地块和博罗霍洛早古生代岛弧组成。该区地质演化历史漫长,过程复杂,尤其是华力西期构造岩浆活动最为强烈,铀成矿条件有利。结合该区地质工作成果,通过总结区内铀成矿地质特征、控矿因素、找矿标志,并对区内铀成矿条件进行了综合分析研究,认为该区具备有利的地质构造背景,具备铀富集有利的地层、岩体及构造条件以及有利于铀成矿的热液蚀变条件,并发现有多层较好的铀异常矿体。综合研究认为,该区具有较大的铀成矿潜力及较好的找矿前景,分析结果可为该地区铀成矿理论研究和进一步开展铀矿找矿勘探工作提供可靠依据。

关键词：铀矿地质特征控矿因素找矿标志铀成矿条件成矿潜力找矿前景

超短波对家兔膝关节骨性关节炎自由基代谢影响的实验研究

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陕西医学杂志 2010年第5期39卷 536-538,546页

作者：乔鸿飞雷建林杨峰西安交通大学第二医院骨二科西安710004

目的:探讨超短波对兔实验性膝关节骨性关节炎自由基代谢影响,为临床超短波的应用提供理论依据。方法:将45只日本大耳白兔随机分出10只为正常组、余35只行右后肢膝关节伸直位固定6周的方法造模。6周后随机抽取其中5只行造模结果检测。确... 详细信息

目的:探讨超短波对兔实验性膝关节骨性关节炎自由基代谢影响,为临床超短波的应用提供理论依据。方法:将45只日本大耳白兔随机分出10只为正常组、余35只行右后肢膝关节伸直位固定6周的方法造模。6周后随机抽取其中5只行造模结果检测。确定造模成功后,将余下30只动物随机分为空白对照组、布洛芬治疗组、超短波治疗组,每组10只。分别给予相应干预,在治疗给药30d后测定兔血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)的含量。结果:超短波治疗组同空白对照组、布洛芬治疗组比较血清中SOD显著升高,NO、MDA显著降低(P<0.01);布洛芬治疗组同空白对照组比较各数值无显著性差异。结论:超短波治疗通过提高血清SOD活性,降低NO、MDA含量,从而达到保护关节软骨,防治膝关节骨性关节炎的目的。

关键词：骨关节炎/治疗无线电波/治疗应用布洛芬/治疗应用动物,实验兔

炮制条件对附子总生物碱及酯型生物碱含量影响的动态研究

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陕西中医学院学报 2009年第2期32卷 61-63页

作者：王昌利雷建林张军武杨景亮陕西中医学院陕西咸阳712046

目的探索不同炮制条件对附子总生物碱及酯型生物碱含量的影响。方法采用蒸法和煮法,结合蒸煮时间,以分光光度法测定不同条件炮制品的附子总生物碱及酯型生物碱含量。结论蒸制10 h附子中总生物碱含量较高,酯型生物碱含量较低,故认为此工... 详细信息

目的探索不同炮制条件对附子总生物碱及酯型生物碱含量的影响。方法采用蒸法和煮法,结合蒸煮时间,以分光光度法测定不同条件炮制品的附子总生物碱及酯型生物碱含量。结论蒸制10 h附子中总生物碱含量较高,酯型生物碱含量较低,故认为此工艺为优选工艺。

关键词：附子总生物碱酯型生物碱

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附子炮制机理及制品药效毒理研究

现代中医药 2009年第1期29卷 53-54页

作者：王昌利杨景亮雷建林张军武陕西中医学院陕西咸阳712046

从附子的解毒机制、炮制方法、炮制机理、现代药理毒理学研究等方面,对附子的炮制方式进行了分析,为附子临床应用提供了依据。

关键词：附子解毒机制炮制机理

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang lei Xiao Zhiyong Kan Jing Guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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人源脂类外向转运蛋白ABCA1的结构

科学新闻 2018年第4期 39-39页

作者： Hongwu Qian Xin Zhao Pingping Cao jianlin lei 颜宁龚欣清华大学医学院

本研究首次解析了人源ABCA1全长蛋白的近原子分辨率冷冻电镜结构,其中整体结构为4.1埃,关键的胞外区结构域为3.9埃。ABCA1属于ABC超家族,这也是第一个ABCA亚家族的高分辨率结构,结构显示它具有非常特别的胞外区结构域。虽然ABCA1的核酸... 详细信息

本研究首次解析了人源ABCA1全长蛋白的近原子分辨率冷冻电镜结构,其中整体结构为4.1埃,关键的胞外区结构域为3.9埃。ABCA1属于ABC超家族,这也是第一个ABCA亚家族的高分辨率结构,结构显示它具有非常特别的胞外区结构域。虽然ABCA1的核酸结合结构域文章简介

关键词： ABCA1 转运蛋白结构域外向转运

Adaptive-basis decomposition-based low-rank network for efficient non-uniform motion deblurring

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Optoelectronics Letters 2025年第1期21卷 43-50页

作者： CHEN lei XIONG Qingbo ZHANG Wei LI Runde School of Software Henan University School of Applied Technology China University of Labor Relations

In this study, we present a unified sparsity-driven framework that significantly enhances motion deblurring performance by integrating two key components: a custom-designed dataset and a low-rank module(LRM). This framework leverages the inherent sparsity of per-pixel blur kernels to bolster both deblurring accuracy and model interpretability. Firstly, we propose an adaptive-basis decomposition-based deblurring(ADD) approach, which constructs a tailored training dataset to enhance the generalization capacity of the deblurring network. The ADD framework adaptively decomposes motion blur into sparse basis elements, effectively addressing the intricacies associated with non-uniform blurs. Secondly, an LRM is proposed to improve the interpretability of deblurring models as a plug-and-play module, primarily designed to identify and harness the intrinsic sparse features in sharp images. A series of ablation studies have been conducted to substantiate the synergistic advantages of combining the proposed ADD with the LRM for overall improvement in deblurring efficacy. Subsequently, we empirically demonstrate through rigorous experimentation that incorporating the LRM into an existing Uformer network leads to substantial enhancement in reconstruction performance. This integration yields a sparsity-guided low-rank network(SGLRN). Operating under the overarching principle of sparsity, SGLRN consistently outperforms state-of-the-art methods across multiple standard deblurring benchmarks. Comprehensive experimental results, assessed through quantitative metrics and qualitative visual evaluations, provide compelling evidence of its effectiveness. The overall deblurring results are available at Google Drive.

关键词： Image enhancement

Research on the Relationship between Molecular Activity of Additives and Lubricating Performance of Aluminum Rolling Oil

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China Petroleum Processing & Petrochemical Technology 2013年第3期15卷 13-18页

作者： Xia lei Sun jianlin Zeng Yingfeng Zhang Min Duan Qinghua School of Materials Science and Engineering University of Science and Technology Beijing Research Institute of Petroleum Processing Sinopec Corp.

In this paper,an ab initio,local density functional(LDF)method was used to explore the relationship between the molecular properties of additives and the lubricating performance of aluminum rolling *** structural properties of butyl stearate,dodecanol,docosanol,and methyl dodecanoate were studied according to the density functional *** calculated data showed that the atoms in or around the functional groups might be likely the reacting *** of the different functional groups and structure of ester and alcohol,two types of complex additives,dodecanol and butyl stearate,methyl dodecanoate and butyl stearate,respectively,were chosen for studying their tribological properties and performing aluminum cold rolling *** test results agreed with the calculated results very *** complex ester,*** dodecanoate and butyl stearate,had the best lubricating performance with a friction coefficient of 0.084 1 and a permissive-rolling thickness of 0.040 mm as compared with that of dodecanol-butyl stearate-base oil formulation.

关键词： aluminum rolling molecular properties lubricating performance DFT

Endogenous/exogenous dual stimulation“ROS engineering”amplification combined with autophagy-augmented for efficient ferroptosis therapy

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Nano Research 2025年第1期18卷 597-606页

作者： Pengye Du Pengpeng lei Yuan Liang Ran An Yi Wei Shuyu Liu Jianhao Zheng Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China

“Reactive oxygen species(ROS)engineering”is one of the most promising anti-tumor treatments developed in recent *** explosion of ROS will cause oxidative stress,thereby inducing tumor cell ***,ROS accumulation in tumor cells is eliminated by endogenous cellular self-regulation *** this work,a kind of endogenous/exogenous dual stimulation nanoagent noted as UMZC is *** reaction occurs between NH_(2)-MIL-88B(Fe)contained in UMZC and the overexpression of endogenous H_(2)O_(2)to generate ROS,amplified by endogenous H_(2)S of colon tumor *** addition,NH_(2)-MIL-88B(Fe)also functions to deplete glutathione(GSH)for stopping it from consuming *** nanoparticles at the core of UMZC convert near-infrared into visible light,which excites zinc phthalocyanine to initiate the photochemical reaction that generates more ROS,thus alleviating the lack of tissue penetration depth for visible *** agonist chitosan oligosaccharides induce enhancement of cellular autophagy for disrupting cellular metabolic stress and the resistance to oxidative stress of tumor cells,allowing“ROS engineering”to fully exert anti-tumor *** of ROS generation,GSH depletion,and induced cellular autophagy caused by nanoagents have promoting effects on the occurrence of ***,the nanoagents show the ability to effectively treat colon tumors.

关键词： reactive oxygen species(ROS)engineering upconversion nanoparticles cellular autophagy ferroptosis tumor therapy