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Effcacy-oriented compatibility for Tianma(Rhizoma Gastrodiae),Yanlingcao(Trillium tschonoskii Maxim) and Bingpian(Borneolum Syntheticum) on improving cerebral ischemia stroke by network pharmacology and serum pharmacological methods

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Journal of Traditional Chinese Medicine 2022年第3期42卷 408-416页

作者： LI Zhiyong ZHU Na LI jianliang FENG Liang jiang Yanyan LI Caifeng LIN Ling HUANG Xiulan Postdoctoral mobile station of environmental biology Faculty of Life Science and TechnologyKunming University of Science and TechnologyKunmingYunnan 650500China Center for Analytical Chemistry of Chinese Materia Medica Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Pharmacological Department School of PharmacyMinzu University of ChinaBeijing100081China Aerosol preparation research center Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjingJiangsu 211198China Department of Chinese Materia Medica Chemistry School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China Academician work station Jiangxi University of Traditional Chinese MedicineNanchangJiangxi330004China

OBJECTIVE:To evaluate the compatibility of Tianma(Rhizoma Gastrodiae,TM),Yanlingcao(Trillium tschonoskii Maxim,YLC)and Bingpian(Borneolum Syntheticum,BP),and their efficacy in the treatment of cerebral ischemic ***:Network pharmacology was used to determine the compatibility of TM,YLC,and BP,and their potential *** middle cerebral artery occlusion(MCAO)rat model was used to evaluate the curative effect of the six combinations of TM,YLC,and BP(TZB1-TZB6)on cerebral ischemia,by using the weight matching method to *** potential component changes of TM and YLC in the blood and brains of rats were analyzed using ultra performance liquid chromatography-mass ***,molecular docking linked the results of animal experiments and network pharmacology,determining the potential component contributors of TM and YLC to treating ischemic ***:TZB reduced the cerebral infarct volume and protected the nerve cells in MCAO *** components of TM and YLC were also identified in the blood and brain homogenate,and BP can facilitate the entry of the components of TM and YLC into the blood and ***,pennogenin,and gastrodin induced effective binding activities with adenosine receptor ***:We investigate an approach that improves the means of folk prescription combined with multi technology that maybe promote the transformation of Chinese medicinal prescription into component-based Chinese medicine.

关键词： infarction,middle cerebral artery brain ischemia molecular docking simulation Adenosine receptor a1 network pharmacology

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高效液相色谱法测定双丙酮丙烯酰胺中3种阻聚剂

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化学分析计量 2024年第5期33卷 72-76页

作者：姜向柯郝建亮刘梅于桐程文娜烟台杰科检测服务有限公司山东烟台265231

建立高效液相色谱法测定双丙酮丙烯酰胺中吩噻嗪、对羟基苯甲醚和四甲基哌啶氮氧自由基亚磷酸三酯(阻聚剂705) 3种阻聚剂的含量。用乙醇溶解双丙酮丙烯酰胺及阻聚剂,振荡、超声助溶,样品溶液经过滤后采用高效液相色谱-二极管阵列检测器... 详细信息

建立高效液相色谱法测定双丙酮丙烯酰胺中吩噻嗪、对羟基苯甲醚和四甲基哌啶氮氧自由基亚磷酸三酯(阻聚剂705) 3种阻聚剂的含量。用乙醇溶解双丙酮丙烯酰胺及阻聚剂,振荡、超声助溶,样品溶液经过滤后采用高效液相色谱-二极管阵列检测器测定,以ZORBAX SB C_(18)色谱柱(250 mm×4.6 mm,5μm)分离,用标准曲线法定量。吩噻嗪、对羟基苯甲醚和四甲基哌啶氮氧自由基亚磷酸三酯的质量浓度分别在0.1~100、1~100、1~100 mg/L范围内与色谱峰面积线性关系良好,相关系数均大于0.999,方法检出限分别为0.25、2.5、2.5 mg/kg。样品加标平均回收率为95.2%~100.7%,测定结果的相对标准偏差为1.9%~2.9%(n=6)。该方法简便,能够满足双丙酮丙烯酰胺中吩噻嗪、对羟基苯甲醚和四甲基哌啶氮氧自由基亚磷酸三酯3种阻聚剂的测定要求。

关键词：高效液相色谱法双丙酮丙烯酰胺吩噻嗪对羟基苯甲醚四甲基哌啶氮氧自由基亚磷酸三酯阻聚剂

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Preparation of Modified Enteromorpha-Immobilized Microbial Agent and Research on Diesel Removal Performance

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China Petroleum Processing & Petrochemical Technology 2021年第3期23卷 151-160页

作者： Yang Yuping Li Nana Duan Weichao An Chenye Xue jianliang jiang Qing Cheng Dongle Shen Chanchan College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590 Qingdao Oasis Environmental&Safety Technology Co. Ltd.Qingdao 266555 Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneySydneyNWS 2007Australia College of City and Architecture Engineering Zaozhuang UniversityZaozhuang 277160

Offshore oil pollution has caused serious impacts on plants and aquatic organisms in the marine *** of oil pollution by immobilized bacteria has aroused wide attention due to the high degradation rate compared with free *** properties of the carrier for immobilization play an important role in the oil degradation *** our study,a marine oil degrading bacteria Sp8(Shewanella algae)was selected from sea water,and enteromorpha was used as carrier material for the immobilization of *** order to increase the hydrophobicity,sodium dodecylbenzene sulfonate(SDBS)was used as modifier to modify the surface of enteromorpha by the dipping *** alginate was used as the embedding carrier,and anhydrous calcium chloride was used as the cross-linking agent to prepare the SDBS-E immobilized microbial agent by the embedding *** with the degradation rate achieved by free bacteria(78.87±8.29%),the diesel removal rate accomplished by SDBS-E immobilized microbial agent increased to 90.39±1.24%.The analysis of diesel removal mechanism showed that the diesel removal pathway mainly included surface adsorption,internal uptake,and *** diesel removal efficiency relied on surface adsorption in the early stage,and then depended on biodegradation in the later *** removal of diesel by SDBS-E immobilized microbial agent conformed to the quasi-first-order degradation kinetic *** results of software-MOE suggested that enteromorpha-immobilized microbial agent adsorbed diesel mainly through hydrogen bonds formed with diesel *** study can provide a research basis and idea for the practical application of immobilization technology to remove petroleum from seawater in the future.

关键词： bioremediation immobilization diesel degradation enteromorpha modification

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Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP

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Cancer Biology & Medicine 2022年第6期19卷 893-909页

作者： Yan Qin Haizhu Chen Peng Liu Changgong Zhang jianliang Yang Lin Gui Xiaohui He Liqiang Zhou Shengyu Zhou Shiyu jiang Hongxin jiang Yuankai Shi Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Suzhou Municipal HospitalAffiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215001China

Objective:Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma(DLBCL)are *** study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients,and examine correlation of BCL2,TP53 and other genetic alterations with outcomes in patients treated with ***:Probe capture-based high-resolution sequencing was performed on 191 patients diagnosed with de novo ***,BCL2,and BCL6 protein expressions were detected by ***:The presence of BCL2 alterations significantly correlated with poor progression-free survival(PFS)(5-year PFS:13.7%vs.40.8%;P=0.003)and overall survival(OS)(5-year OS:34.0%vs.70.9%;P=0.036).Importantly,patients who harbored BCL2 gain/amplifications(BCL2GA/AMP)also had a remarkably inferior 5-year PFS(11.1%vs.38.3%;P<0.001)and OS(22.1%vs.69.6%;P=0.009).In contrast,neither BCL2 mutations nor BCL2 translocations were significantly prognostic for *** analyses showed that the presence of BCL2 alterations,especially BCL2GA/AMP,TP53 mutations,and International Prognostic Index(IPI)were significantly associated with inferior PFS and *** prognostic models for OS were constructed based on 3 risk factors,including BCL2 alterations(Model 1)or BCL2GA/AMP(Model 2),TP53 mutations,and IPI,to stratify patients into 4 risk groups with different survival ***:This study showed that DLBCL patients treated with R-CHOP,BCL2 alterations,especially BCL2GA/AMP and TP53 mutations were significantly associated with inferior outcomes,which were independent of the *** novel prognostic models we proposed predicted outcomes for DLBCL patients treated with R-CHOP,but further validation of the prognostic models is still warranted.

关键词： BCL2 TP53 genetic alterations diffuse large B-cell lymphoma prognosis

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Attenuation of Chlorinated Contamination in Three Different Depths of Aquifers at Remediation Site

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China Petroleum Processing & Petrochemical Technology 2023年第1期25卷 162-178页

作者： Sun Shaodong Li Weisi Huang Yongjun jiang Qing Bai Yu Wang Kunhua Xue jianliang Wang Bo Yan Dongdong Xu Conghai College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Shandong Provincial Eco-environment Monitoring Center Jinan 250102China Linyi Junhe Environmental Protection Technology Co. LtdLinyi Shandong 276000 Unicom Digital Technology Co. Ltd. College of Energy Storage Technology Shandong University of Science and TechnologyQingdaoShandong 266590China Shandong Juncheng Environment Examination Co. LtdLinyi Shandong 276000China

The cleanup of carbon tetrachloride(CCl4)in groundwater is challenging due to its high volatility and tendency to form a dense nonaqueous liquid *** the engineering applications perspective,the pump-and-treat(PAT)technology has substantial advantages owing to its large-scale implementation ability to solve groundwater ***,few studies focused on the variation in chloride contaminants in remediation sites after the contaminated groundwater was pumped and ***,we monitored the changes in chlorinated contamination in groundwater from 12 aquifers at the field level for 6 *** that the natural attenuation of chlorinated contamination is inseparable from the action of microorganisms,the major environmental factors influencing biodegradation were also evaluated.A redundancy analysis(RDA)showed that inorganic salts(DS,DN,and DF)were the most important factor(>60%)affecting the concentration of chloride contaminants,including the negative correlation between DN and the degradation of contaminants in shallow *** deep aquifers,DS,DF,and pH explained most of the degradation of chloride *** bedrock layers,DCl was positively relevant to the chloride contaminants in wells PTJ2 and *** addition,EC and DS accounted for 73.2%and 92.4%of the contaminant’s variance in wells PTJ4 and PTJ8,***,the concentrations of the corresponding contaminations and physicochemical variation in three different depths of aquifers were compared;the shallower aquifers showed a higher *** in situ monitoring and analysis of contaminated groundwater in remediation sites under PAT will promote practical wastewater treatment technologies in engineering applications.

关键词： groundwater chloride contaminants pump-and-treat biodegradation engineering application

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Fe_(2)O_(3)对高硅碱性球团固结性能的影响

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烧结球团 2024年第1期49卷 80-86页

作者：李绍春程福超王兴锋张建良刘征建王耀祖马黎明江回青鞍山钢铁集团有限公司大孤山球团厂辽宁鞍山114046 北京科技大学冶金与生态工程学院北京100083 北京科技大学智能科学与技术学院北京100083

深入研究Fe_(2)O_(3)对于高硅碱性球团生球以及成品球性能的影响,有助于促进基于我国铁矿资源特征的低碳炼铁技术发展。本文通过调整碱性球团用混合料中Fe_(2)O_(3)的含量,解析Fe_(2)O_(3)对高硅碱性球团生球、预热球和成品球性能的影... 详细信息

深入研究Fe_(2)O_(3)对于高硅碱性球团生球以及成品球性能的影响,有助于促进基于我国铁矿资源特征的低碳炼铁技术发展。本文通过调整碱性球团用混合料中Fe_(2)O_(3)的含量,解析Fe_(2)O_(3)对高硅碱性球团生球、预热球和成品球性能的影响规律,并采用扫描电镜以及图像识别处理系统表征高硅碱性球团的微观矿相结构。结果表明:随着混匀矿中赤铁矿配比的提高,高硅碱性球团生球、预热球和成品球的抗压强度均有所降低,随着Fe_(2)O_(3)配比的升高,成球性能劣化,生球的抗压强度降低至9.04 N/P。赤铁矿连晶固结性能变差,成品球的强度降低至3433 N/P。当两种矿粉的配比为50%时,球团孔隙率急剧增大为32.8%,A矿粉配比不宜超过40%。微观矿相结果表明,随着Fe_(2)O_(3)含量的增加,球团内部小颗粒尺寸晶粒变多,大颗粒尺寸晶粒减少,平均颗粒面积减少,晶粒间连晶性能变差,固结性能削弱,内部孔隙率提高。在制备高硅碱性球团时,含Fe_(2)O_(3)的精矿粉配加不宜太高,会对球团矿的固结性能产生不利影响。

关键词： Fe_(2)O_(3) 高硅碱性球团矿相结构抗压强度焙烧固结

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Analysis of the merged quasi-geoid of neighbouring areas

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Geodesy and Geodynamics 2018年第4期9卷 296-301页

作者： Chunxi Guo jianliang Nie Bin Wang Jie Tian Guangwei jiang Junying Chen Shijuan Zhang Geodetic Data Processing Centre National Administration of Surveying Mapping and Geoinformation of China

Employing the merged quasi-geoid, we analyses the causes of systematic errors in modelling of quasigeoid of neighbouring areas in the paper, and the efficient method is introduced to improve the accuracy of quasi-geoid. First, the systematic error is weakened with the moving window method applied to established quasi-geoids in two adjacent regions, and the accuracy of the merged quasi-geoid in the stitching region is checked using the measured GPS benchmark data; Second, the whole quasi-geoid is recomputed with data obtained from two adjacent regions if the accuracy of the quasi-geoid obtained from the first step in the stitching region is low; Finally, the quasi-geoids in two adjacent regions are recomputed respectively using GPS benchmark data of own region and adjacent region with the same solution if the accuracy of whole quasi-geoid obtained from the second step also is low. Actual data sets from Sichuan Province and Chongqing City are employed to test the moving window method. It is shown that the quasi-geoid models with high resolution and accuracy were obtained.

关键词： Merged quasi-geoid Moving window Systematic error

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CeO_(2)添加量对激光选区熔化TC4合金摩擦磨损性能的影响

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材料保护 2024年第7期57卷 66-72,135页

作者：李振华宋都都章煜尹博闫洪军蒋杨英唐建良浙江海洋大学海洋工程装备学院浙江舟山316022 舟山市7412工厂浙江舟山316022

钛合金具有广阔的应用前景,为提高钛合金的成形质量和耐磨性能,采用激光选区熔化(Selective Laser Melting,SLM)技术制备TC4合金,通过添加不同含量(0、0.10%、0.15%、0.20%、0.25%)的CeO_(2)对TC4合金进行改性。使用XRD、SEM、电子万能... 详细信息

钛合金具有广阔的应用前景,为提高钛合金的成形质量和耐磨性能,采用激光选区熔化(Selective Laser Melting,SLM)技术制备TC4合金,通过添加不同含量(0、0.10%、0.15%、0.20%、0.25%)的CeO_(2)对TC4合金进行改性。使用XRD、SEM、电子万能试验机、摩擦磨损试验机和三维光学轮廓仪探究了CeO_(2)含量对TC4合金的显微组织、相组成、力学性能及摩擦磨损性能的影响。结果表明:采用激光选区熔化技术制备添加适量CeO_(2)的TC4合金,相比TC4合金原样,其组织得到细化,力学性能提升,摩擦系数和磨损量明显下降,黏着磨损和磨粒磨损的作用效果减弱。当CeO_(2)的含量为0.15%时,试样的硬度达到356.8 HV,屈服强度和抗拉强度分别达到1027 MPa和1293 MPa,远超锻件水平,平均摩擦系数和磨损量达到最低值,分别为0.412和3.729×10^(-2)mm^(3),其磨损机制为轻微的黏着磨损和磨粒磨损。

关键词：激光选区熔化 TC4钛合金稀土改性摩擦学性能

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消肿止痛合剂调控PI3K/AKT信号通路对大鼠皮瓣IRI的影响

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甘肃医药 2024年第4期43卷 289-291,296页

作者：姚兴璋姚辉赵秋玥蒋振兴李兴勇李建亮张继伟安杰甘肃省中医院甘肃兰州730050 甘肃省人民医院甘肃兰州730000

目的:观察消肿止痛合剂通过PI3K/AKT信号通路对大鼠皮瓣缺血再灌注损伤的影响。方法:将60只SD大鼠随机分为四组,分别为假手术组、模型组、消肿止痛合剂组、消肿止痛合剂+PI3K抑制剂组。除正常组外,其他组建立大鼠随意皮瓣模型,四组大鼠... 详细信息

目的:观察消肿止痛合剂通过PI3K/AKT信号通路对大鼠皮瓣缺血再灌注损伤的影响。方法:将60只SD大鼠随机分为四组,分别为假手术组、模型组、消肿止痛合剂组、消肿止痛合剂+PI3K抑制剂组。除正常组外,其他组建立大鼠随意皮瓣模型,四组大鼠分别给予生理盐水、生理盐水、消肿止痛合剂、消肿止痛合剂+PI3K抑制剂。Western blot法检测大鼠皮瓣组织中磷酸化PI3K(pPI3K)、磷酸化Akt(p-Akt)蛋白的表达。结果:与假手术组、模型组相比,消肿止痛组p-PI3K、p-Akt蛋白表达量明显升高(P<0.05);消肿止痛合剂+PI3K抑制剂组p-PI3K、p-Akt蛋白表达量降低(P<0.05)。与消肿止痛合剂组相比,消肿止痛合剂+PI3K抑制剂组经加入PI3K抑制剂干预后,p-PI3K、p-Akt蛋白表达量降低(P<0.05)。结论:消肿止痛合剂可能通过作用于PI3K/AKT信号传导途径,对缓解皮瓣的IRI并提升其存活率具有积极效果。

关键词：消肿止痛合剂 PI3K/AKT信号通路缺血再灌注损伤

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Buckling of thin gel strip under swelling

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Theoretical & Applied Mechanics Letters 2017年第3期7卷 134-137页

作者： Ruiqi jiang jianliang xiao Jizhou Song Department of Engineering Mechanics Soft Matter Research Center and Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang University Hangzhou 310027 China Department of Mechanical Engineering University of Colorado Boulder CO 80309 USA

The buckling of thin gel film has attracted much attention due to its applications in the design of three- dimensional structure from two-dimensional template. We have established an analytical model to study the swelling-induced buckling of a thin gel strip with one edge clamped and the others free. The closed-form solutions for the amplitude and wavelength of the buckled shape are obtained by energy minimization of the total potential energy. The analytical results agree well with finite element analysis based on the inhomogeneous gel theory without any parameter fitting. The model provides a route to study complex postbuckling behaviors of thin gel films and guidelines to design the buckled configuration quantitatively by controlling the swelling ratio.

关键词： Thin gel film Swelling Buckling

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