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Inhibition of central axon regeneration: perspective from chondroitin sulfate proteoglycans in lamprey spinal cord injury

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Neural Regeneration Research 2022年第9期17卷 1955-1956页

作者： jianli hu Li-Qing Jin Michael E.Selzer Shriners Hospitals Pediatric Research Center(Center for Neural Repair and Rehabilitation) Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA Department of Neurology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

Background:Failure of axon regeneration after spinal cord injury(SCI)underlies the paralysis that so profoundly affects patients’quality of *** factors are involved in the regeneration *** sulfate proteoglycans(CSPGs),normal constituents of the perineuronal nets in central nervous system(CNS),are secreted at the injury site and initially were thought to act as a purely physical *** the past decade,the receptor-like protein tyrosine phosphatases,protein tyrosine phosphatase sigma(PTPσ),and leukocyte common antigen-related phosphatase(LAR),have been identified as transmembrane receptors for *** two receptors for myelin-associated growth inhibitors,Nogo receptors 1 and 3(NgR1 and NgR3)also have been found to bind with CSPGs(Sharma et al.,2012).These findings suggest that CSPGs inhibit regeneration by interacting with these receptors,initiating downstream inhibitory signaling(Figure 1).

关键词： paralysis injury leukocyte

Heterogeneity in the regenerative abilities of central nervous system axons within species: why do some neurons regenerate better than others?

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Neural Regeneration Research 2020年第6期15卷 996-1005页

作者： William Rodemer jianli hu Michael E.Selzer Michael I.Shifman Shriners Hospitals Pediatric Research Center(Center for Neural Repair and Rehabilitation) the Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA Department of Neurology the Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

Some neurons,especially in mammalian peripheral nervous system or in lower vertebrate or in vertebrate central nervous system(CNS)regenerate after axotomy,while most mammalian CNS neurons fail to *** is an emerging consensus that neurons have different intrinsic regenerative capabilities,which theoretically could be manipulated therapeutically to improve ***-based comparisons between"good regenerating"and"bad regenerating"neurons in the CNS and peripheral nervous system of most vertebrates yield results that are inconclusive or difficult to *** least in part,this reflects the great diversity of cells in the mammalian *** mammalian nervous system imposes several methodical ***,the small sizes and large numbers of neurons in the CNS make it very difficult to distinguish regenerating neurons from non-regenerating ***,the lack of identifiable neurons makes it impossible to correlate biochemical changes in a neuron with axonal damage of the same neuron,and therefore,to dissect the molecular mechanisms of regeneration on the level of single *** review will survey the reported responses to axon injury and the determinants of axon regeneration,emphasizing non-mammalian model organisms,which are often under-utilized,but in which the data are especially easy to interpret.

关键词： axonal regeneration identifiable neurons intrinsic factors lamprey Mauthner cell Müller cell neuronal death non-mammalian model organisms spinal cord injury zebrafish

Impact of COVID-19 Interventions on Respiratory and Intestinal Infectious Disease Notifications-Jiangsu Province,China,2020–2023

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China CDC weekly 2024年第41期6卷 1059-1064,I0003页

作者： Ziying Chen Xin Liu Jinxing Guan Yingying Shi Wendong Liu Zhihang Peng jianli hu School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Acute Infectious Diseases Control and Prevention Jiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Jiangsu Province Engineering Research Center of Health Emergency Nanjing CityJiangsu ProvinceChina.

Introduction:Many measures implemented to control the coronavirus disease 2019(COVID-19)pandemic have reshaped the epidemic patterns of other infectious *** study estimated the impact of the COVID-19 pandemic on respiratory and intestinal infectious diseases and potential changes following ***:The optimal intervention and counterfactual models were selected from the seasonal autoregressive integrated moving average(SARIMA),neural network autoregression(NNAR),and hybrid models based on the minimum mean absolute percentage error(MAPE)in the test *** relative change rate between the actual notification rate and that predicted by the optimal model was calculated for the entire COVID-19 epidemic prevention period and the“reopening”***:Compared with the predicted notification rate based on the counterfactual model,the total relative change rates for the 9 infectious diseases were−44.24%,respiratory infections(−55.41%),and intestinal infections(−26.59%)during 2020–*** with the predicted notification rate based on the intervention model,the total relative change rates were+247.98%,respiratory infections(+389.59%),and intestinal infections(+50.46%)in *** them,the relative increases in influenza(+499.98%)and hand-foot-mouth disease(HFMD)(+70.97%)were ***:Measures taken in Jiangsu Province in response to COVID-19 effectively constrained the spread of respiratory and intestinal infectious *** and HFMD rebounded significantly after the lifting of COVID-19 intervention restrictions.

关键词： Impact lifting prevention

Gemcitabine Modulates the Microvessel Density and Apoptosis in Radiotherapy of Cervical Cancer

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The Chinese-German Journal of Clinical Oncology 2006年第4期5卷 282-284页

作者： hu jianli YU Shiying XIONG huihua YUAN Xianglin Center of Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430023 China Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective： To evaluate the effects of gemcitabine on the microvessel density （MVD） and apoptosis in radiotherapy of cervical cancer. Methods： Forty-seven patients with locally advanced cervical cancer （ⅡB, Ⅲ and IVA stage） were divided into two groups randomly： group A, 22 cases receiving radiotherapy combined with gemcitabine; group B, 25 cases receiving radiotherapy only. Tissue specimens were obtained from cervical tumor of all patients before and 24 h after radiotherapy with 10 Gy. MVD and apoptosis was detected by immunohistochemical staining and TUNEL assay respectively. Results： MVD （median） in group A was significantly reduced as compared with group B （P=0.001）. A-LI （median） in group A was significantly increased as compared with group B （P=0.034）. T0.5 in group A was significantly shorter than that in group B （P=0.018）. The reduction of MVD in group A was negatively correlated with T0.5 （r=-0.628）. There was no significant difference in gastrointestinal and haematological adverse effects between group A and group B. Conclusion： Gemcitabine, a novel potential radiosensitizer, can decrease the neoangiogenesis, increase the apoptosis in the early stage of radiotherapy of cervical cancer.

关键词： cervical cancer radiotherapy gemcitabine microvessel density apoptosis

Glypican-3 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta-analysis

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BIOCELL 2015年第2期39卷 25-31页

作者： Weiyu FU Hongyu LU Li LI Kefeng WU Yanping LI Yi LIU jianli hu Institute of Biochemistry and Molecular Biology Guangdong Medical UniversityZhanjiangGuangdongChina College of Food Science and Technology Guangdong Ocean UniversityZhanjiangGuangdongChina Guangdong Key Laboratory for Research and Development of Natural Drugs Guangdong Medical UniversityZhanjiangGuangdongChina Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Objective:To assess the diagnostic accuracy of serum GPC3 versus alpha-fetoprotein(AFP)for HCC by using the method of system ***:PubMed and EMBASE were searched from its inception to 20,April 2014 for studies that compared diagnostic accuracy of serum GPC3 with AFP for ***,specificity and other measures were pooled using random-effects *** receiver operating characteristic curve analysis was used to summarize the overall test ***:Fourteen studies were included in this *** estimates for serum GPC3 and AFP in diagnosing HCC were as follows:sensitivity,69%(95%confidence interval(CI),56-80%)vs.60%(95%CI,50-69%);specificity,91%(95%CI,76-97%)vs.92%(95%CI,84-98%);diagnostic odds ratio(DOR),22(95%CI,6-83)vs.18(95%CI,8-41);and area under sROC,0.85(95%CI,0.81-0.88)vs.0.80(95%CI,0.76-0.83).The pooled sensitivity and specificity for(GPC3+AFP)and AFP were:sensitivity 80%(95%CI,75-85%)vs.64%(95%CI,53-73%)and specificity 86%(95%CI,74-93%)vs.96%(95%CI,86-99%).A significant heterogeneity was found among the ten studies,and meta-regression and subgroup meta-analysis suggested that race and assay type were probably responsible for the ***:Serum GPC3 may be a promising diagnostic marker of HCC and it was helpful for early detection of primary hepatocellular carcinoma when combined with *** studies for specific race of patients,and using certain methods for detecting GPC3 are required to further confirm the diagnostic value of GPC3 for HCC.

关键词： Glypican-3 AFP Hepatocellular carcinoma diagnostic meta-analysis

Trends in disease burden of hepatitis B infection in Jiangsu Province,China,1990-2021

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Infectious Disease Modelling 2023年第3期8卷 832-841页

作者： Kang Fang Yingying Shi Zeyu zhao Yunkang Zhao Yichao Guo Buasivamu Abudunaibi huimin Qu Qiao Liu Guodong Kang Zhiguo Wang jianli hu Tianmu Chen State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen City361102Fujian ProvincePeople's Republic of China Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityPeople's Republic of China

Background:The incidence of hepatitis B virus(HBV)has decreased year by year in China after the expansion of vaccination,but there is still a high disease burden in Jiangsu Province of ***:The year-by-year incidence data of HBV in Jiangsu Province from 1990 to 2021 were *** incidence rates of males and females age groups were clustered by systematic clustering,and the incidence rates of each age group were analyzed and studied by using Joinpoint regression model and age-period-cohort effect model(APC).Results:Joinpoint regression model and APC model showed a general decrease in HBV prevalence in both males and *** addition,the results of the APC model showed that the age,period,and cohort effects of patients all affected the incidence of HBV,and the incidence was higher in males than in *** incidence is highest in the population between the ages of 15 and 30 years(mean:21.76/100,000),especially in males(mean:31.53/100,000)than in females(mean:11.67/100,000).Another high-risk group is those over 60 years of age(mean:21.40/100,000),especially males(mean:31.17/100,000)than females(mean:11.63/100,000).The period effect of the APC model suggests that HBV vaccination is effective in reducing the incidence of HBV in the ***:The incidence of HBV in Jiangsu Province showed a gradual downward trend,but the disease burden in males was higher than that in *** incidence is higher and increasing rapidly in the population between the ages of 15 and 30 years and people over 60 years of *** targeted prevention and control measures should be imple-mented for males and the elderly.

关键词： HBV Joinpoint regression model Age-period-cohort model Systematic clustering

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中国影视作品的海外传播策略与发展方向

中国文艺评论 2021年第12期 24-31页

作者：胡建礼《影视风向标》自媒体矩阵

当前,中国已是当之无愧的影视大国,不仅每年的电视剧和网剧产量高居世界第一,电影产量也名列前茅,但中国影视作品在海外的传播还不尽如人意。这主要有东西方文化差异、意识形态差异、影视作品质量尚需提高、中国在全球影视宣传发行渠道... 详细信息

当前,中国已是当之无愧的影视大国,不仅每年的电视剧和网剧产量高居世界第一,电影产量也名列前茅,但中国影视作品在海外的传播还不尽如人意。这主要有东西方文化差异、意识形态差异、影视作品质量尚需提高、中国在全球影视宣传发行渠道上的弱势地位等原因。中国影视作品海外传播的主要策略:一是“存异求同”讲好中国影视故事;二是做好海外宣传发行和销售工作。只有在内容和宣传发行上一起努力,中国才能真正从影视大国迈向影视强国。

关键词：电影电视剧海外传播走出去影视强国张艺谋贾樟柯

Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells

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Protein & Cell 2022年第7期13卷 532-539页

作者： Hezhen Shan Lingling Geng Xiaoyu Jiang Moshi Song Jianxun Wang Zunpeng Liu Xiao Zhuo Zeming Wu jianli hu Zhejun Ji Si Wang Piu Chan Jing Qu Weiqi Zhang Guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Advanced Innovation Center for human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Aging Translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Dear Editor,The interventions that slow aging or promote healthy aging may provide preventative measures for age-related diseases(Zhang et al.,2015).Therefore,it is crucial to identify drugs that target aging-related pathologies and improve health-span in geroscience *** model organisms such as *** and rodents,several small molecules capable of alleviating the onset or progression of aging,including rapamycin,nicotinamide mononucleotide,and metformin,have been discovered(Partridge et al.,2020).However,the safety and efficacy of these chemicals still need in-depth evaluation before clinical applications(Partridge et al.,2020).As a result,it is necessary to identify additional compounds with geroprotective effects for human cells to counteract the general trend of populational ***,transforming a promising compound into an approved drug requires enormous ***,repurposing previously approved drugs for new clinical applications offers a more efficient and less costly path toward drug ***,testing *** and Drug Administration(FDA)-approved drugs for geroprotective effects may dis-covernew therapeutics that have already been stringently tested in humans for safety.

关键词： drugs protective al.

温湿度独立控制技术在世博会瑞典王国馆暖通空调设计中的应用

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暖通空调 2010年第8期40卷 96-98页

作者：胡建丽中国建筑设计研究院

介绍了2010年上海世博会瑞典王国馆使用的定制型组合式湿度控制单元,并阐述了该产品的特点及适用条件。运行记录表明空调区域室内温湿度达到使用要求,效果比较满意。

关键词：温湿度独立控制转轮除湿机全热回收湿度控制单元