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乳腺癌患者化疗药品不良反应影响因素研究

中华肿瘤防治杂志 2024年第6期31卷 376-382页

作者：刘建康范树豪李成尚杰山东省肿瘤防治研究院(山东省肿瘤医院)质量管理部山东第一医科大学(山东省医学科学院)山东济南250117 山东第一医科大学(山东省医学科学院) 山东济南250117

目的探究乳腺癌患者化疗药品不良反应(ADR)的发生率和影响因素,为其防治提供科学依据。方法回顾性分析2020-01-01-2022-12-31在山东第一医科大学附属肿瘤医院行化疗的乳腺癌患者临床资料。收集社会人口学特征、体格检查和健康状况等信... 详细信息

目的探究乳腺癌患者化疗药品不良反应(ADR)的发生率和影响因素,为其防治提供科学依据。方法回顾性分析2020-01-01-2022-12-31在山东第一医科大学附属肿瘤医院行化疗的乳腺癌患者临床资料。收集社会人口学特征、体格检查和健康状况等信息,共纳入5 431例患者。采用多因素非条件logistic回归分析乳腺癌患者化疗ADR的影响因素。结果在5 431例乳腺癌患者中,93例患者发生ADR,发生率为1.7%。多因素二分类logistic回归调整多种混杂因素后结果显示,患者过敏史(OR=2.36,95%CI:1.20~4.62)和疼痛程度(OR=1.06,95%CI:1.01~1.11)与ADR有关联,差异均有统计学意义,χ^(2)值分别为6.300和4.040,P值分别为0.012和0.041。分层分析结果显示,<60岁患者过敏史(OR=2.37,95%CI:1.12~5.03)和疼痛程度(OR=1.06,95%CI:1.01~1.11)与ADR发生风险有关联,差异有统计学意义,χ^(2)值分别为5.198和4.203,P值分别为0.024和0.043。在使用多西他赛和表柔比星的患者中,患者疼痛程度与ADR发生风险的OR值分别为1.80(95%CI:1.14~2.83)和5.54(95%CI:1.59~19.31),差异均有统计学意义,χ^(2)值分别为6.401和8.468,P值分别为0.011和0.007。结论乳腺癌化疗患者的过敏史和疼痛程度与ADR发生风险存在关联,临床医护人员需针对不同人群采取个性化的治疗措施。

关键词：乳腺癌化疗药物药品不良反应影响因素分析疼痛程度

Safety of high-carbohydrate fluid diet 2 h versus overnight fasting before non-emergency endoscopic retrograde cholangiopancreatography:A single-blind,multicenter,randomized controlled trial

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Chinese Medical Journal 2024年第12期137卷 1437-1446页

作者： Wenbo Meng Joseph W.Leung Zhenyu Wang Qiyong Li Leida Zhang Kai Zhang Xuefeng Wang Meng Wang Qi Wang Yingmei Shao Jijun Zhang Ping Yue Lei Zhang Kexiang Zhu Xiaoliang Zhu Hui Zhang Senlin Hou Kailin Cai Hao Sun Ping Xue Wei liu Haiping Wang Li Zhang Songming Ding Zhiqing Yang Ming Zhang Hao Weng QingyuanWu Bendong Chen Tiemin Jiang Yingkai Wang Lichao Zhang Ke Wu Xue Yang Zilong Wen Chun liu LongMiao Zhengfeng Wang Jiajia Li Xiaowen Yan Fangzhao Wang Lingen Zhang Mingzhen Bai Ningning Mi XianzhuoZhang Wence Zhou Jinqiu Yuan Azumi Suzuki Kiyohito Tanaka jiankang liu Ula Nur Elisabete Weiderpass Xun Li Department of General Surgery The First Hospital of Lanzhou UniversityLanzhouGansu 730000China Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province LanzhouGansu 730000China Division of Gastroenterology and Hepatology UC Davis Medical CenterSacramentoCA 95816USA Department of Minimally Invasive Surgery Tianjin Nankai HospitalTianjin 300100China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryShulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren UniversityHangzhouZhejiang 310000China Department of Hepatobiliary Surgery Southwest HospitalArmy Medical UniversityChongqing 400000China Hepatobiliary Surgery Department Shandong Provincial Third HospitalJinanShandong 250000China Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Biliary Tract Disease ResearchShanghai 200000China Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin UniversityChangchunJilin 130000China Department of Hepatobiliary Surgery The General Hospital of Ningxia Medical UniversityYinchuanNingxia 750000China Department of Hepatobiliary&Hydatid Digestive and Vascular Surgery CenterXinjiang Key Laboratory of Echinococcosis and Liver Surgery ResearchThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830000China Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030000China Department of General Surgery The Second Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of Biliopancreatic Endoscopic Surgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Gastrointestinal Surgery Department Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430000China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710000China Depart

Background:Although overnight fasting is recommended prior to endoscopic retrograde cholangiopancreatography(ERCP),the benefits and safety of high-carbohydrate fluid diet(CFD)intake 2 h before ERCP remain *** study aimed to analyze whether high-CFD intake 2 h before ERCP can be safe and accelerate patients’***:This prospective,multicenter,randomized controlled trial involved 15 tertiary ERCP centers.A total of 1330 patients were randomized into CFD group(n=665)and fasting group(n=665).The CFD group received 400 mL of maltodextrin orally 2 h before ERCP,while the control group abstained from food/water overnight(>6 h)before *** ERCP procedures were performed using deep sedation with intravenous *** investigators were blinded but not the *** primary outcomes included postoperative fatigue and abdominal pain score,and the secondary outcomes included complications and changes in metabolic *** outcomes were analyzed according to a modified intention-to-treat ***:The post-ERCP fatigue scores were significantly lower at 4 h(4.1±2.6 vs.4.8±2.8,t=4.23,P<0.001)and 20 h(2.4±2.1 vs.3.4±2.4,t=7.94,P<0.001)in the CFD group,with least-squares mean differences of 0.48(95%confidence interval[CI]:0.26-0.71,P<0.001)and 0.76(95%CI:0.57-0.95,P<0.001),*** 4-h pain scores(2.1±1.7 vs.2.2±1.7,t=2.60,P=0.009,with a least-squares mean difference of 0.21[95%CI:0.05-0.37])and positive urine ketone levels(7.7%[39/509]vs.15.4%[82/533],χ^(2)=15.13,P<0.001)were lower in the CFD *** CFD group had significantly less cholangitis(2.1%[13/634]vs.4.0%[26/658],χ^(2)=3.99,P=0.046)but not pancreatitis(5.5%[35/634]vs.6.5%[43/658],χ^(2)=0.59,P=0.444).Subgroup analysis revealed that CFD reduced the incidence of complications in patients with native papilla(odds ratio[OR]:0.61,95%CI:0.39-0.95,P=0.028)in the multivariable ***:Ingesting 400 mL of CFD 2 h before ERCP is safe,with a reduction in post-ERCP fatigue,

关键词： Endoscopic retrograde cholangiopancreatography ERCP Carbohydrate Fasting Safety Complications Enhanced recovery after surgery Randomized controlled trial

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湖南省自然灾害风险可接受程度研究

西北地质 2024年第1期57卷 55-63页

作者：刘健康刘丙秋匡文龙肖拥军林云志卢正新中化地质矿山总局湖南地质勘查院湖南长沙410018 湖南科技大学地球科学与空间信息工程学院湖南湘潭411201

自然灾害是湖南省面临的主要灾害之一,确定自然灾害风险可接受程度对该省的可持续发展意义重大。通过分析湖南省2010~2020年因灾死亡人数与经济损失、总人口、GDP等数据,参照国内外相关研究,开展自然灾害风险可接受水平研究。取意愿系数... 详细信息

自然灾害是湖南省面临的主要灾害之一,确定自然灾害风险可接受程度对该省的可持续发展意义重大。通过分析湖南省2010~2020年因灾死亡人数与经济损失、总人口、GDP等数据,参照国内外相关研究,开展自然灾害风险可接受水平研究。取意愿系数β=0.01,确定个人生命可接受风险标准;使用人均GDP这一指标,量化个人可接受经济风险;根据最低合理可行准则,分别构建社会生命与经济风险可接受准则模型。结果表明:个人可接受和可容忍生命风险分别为10^(-6)/a和10^(-5)/a;个人可接受经济风险指数为0.01,即个人经济风险的可接受风险范围不超过人均GDP的1%;因灾死亡100人的概率大于10^(-9)、经济损失10亿元的概率大于10^(-2)都属于不可接受风险。研究结果可用于辅助湖南省自然灾害风险的评估、决策与管理,也为其他地区相关研究提供参考。

关键词：自然灾害风险可接受程度 F-N曲线 F-D曲线湖南省

A regime-switching stochastic SIR epidemic model with a saturated incidence and limited medical resources

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生物数学学报:英文版 2023年第7期16卷 91-110页

作者： Wei Wei Wei Xu jiankang liu Department of Applied Mathematics Northwestern Polytechnical University Xi'an 710072 ShaanciP.R.China

The stochastic switching SIR epidemic model with saturated incidence and limited medical treatment is investigated in this *** using Lyapunov methods and Ito formula,we first prove that the system has a unique global positive solution with any positive initial *** combining inequality technique and the ergodic property of Markov switching,the suficient conditions for extinction and persistence in the mean of the disease are *** results demonstrate that increasing medical resources and improving supply efficiency can accelerate the transition from the persistent state to the extinct ***,the high incidence rate will slow down the extinction of the ***,the switching noise can induce the system to toggle between the extinct and persistent ***,some numerical simulations are carried out to confirm the analytical results.

关键词： Epidemic model extinction persistence Markov switching saturated incidence

藏东察雅县城地质灾害风险评价及源头管控对策建议

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中国地质灾害与防治学报 2024年第2期35卷 146-154页

作者：田尤陈龙黄海刘建康李元灵李洪梁中国地质科学院探矿工艺研究所四川成都611734 中国地质调查局地质灾害防治技术中心四川成都611734 西华大学应急学院四川成都610039

以藏东察雅县城为研究区,选取高程、坡度、坡形、坡向、斜坡结构、地层、距断层距离共7个评价指标,运用证据权重法,构建了地质灾害易发性评价模型。以4种降雨频率(10%、5%、2%、1%)下的年最大日降雨量作为动态诱发因子,建筑、人口和交... 详细信息

以藏东察雅县城为研究区,选取高程、坡度、坡形、坡向、斜坡结构、地层、距断层距离共7个评价指标,运用证据权重法,构建了地质灾害易发性评价模型。以4种降雨频率(10%、5%、2%、1%)下的年最大日降雨量作为动态诱发因子,建筑、人口和交通设施作为承灾体,评价地质灾害的动态风险性。结果表明,研究区斜坡以中、低风险为主,围绕县城场镇两侧的斜坡出现少量高风险和极高风险区。随着降雨频率的降低,区内高风险区、极高风险区面积最大增长5.34%和0.07%;低风险区、中风险区面积最大变化幅度分别为28.33%和23.32%。基于风险评价结果,提出考虑不同降雨频率的地质灾害风险源头管控方法,具体为:针对10%、5%、2%和1%不同降雨频率下的极高风险区,建议分别采取工程治理、工程治理/专业监测、专业监测、专业监测/群专结合的管控手段;针对1%降雨频率下的高风险与中风险区,建议采取群专结合与群测群防。该风险管控体系考虑了不同降雨频率下斜坡的动态风险,可提高山区城镇地质灾害风险的管控精细化水平。

关键词：易发性危险性风险评价源头管控察雅县城

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大豆玉米带状复合种植机械化技术发展

中国农机装备 2024年第4期 22-24页

作者：刘建康万奎军马俊岭河南省扶沟县农业农村局扶沟461300

确保国家粮油安全,将大豆玉米带状复合种植技术优势全面发挥出来,配套的带状复合种植机械化技术与装备是关键。本文以综述国内外大豆玉米种植机械化装备为基础,分析了大豆玉米带状复合种植机械化发展受阻的因素,最后提出了推动玉米大豆... 详细信息

确保国家粮油安全,将大豆玉米带状复合种植技术优势全面发挥出来,配套的带状复合种植机械化技术与装备是关键。本文以综述国内外大豆玉米种植机械化装备为基础,分析了大豆玉米带状复合种植机械化发展受阻的因素,最后提出了推动玉米大豆带状复合种植机械化发展的路径。

关键词：大豆玉米带状复合种植机械化发展

Efficient Preparation and Electrochemical Properties of BiOCl/Graphite by One-step Solvothermal Method

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 651-657页

作者：门丽娟 FEI Chi liu An 陈春钰 ZHOU jiankang JU Dianchun School of Metallurgy Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China

We used the surface-pretreated graphite paper(Gp)as a carrier and loaded BiOCl with high selectivity to Cl^(-)on its surface by solvothermal method to form BiOCl@Gp *** morphology,structure,and composition of the materials were characterized by scanning electron microscopy and nitrogen adsorption/desorption,and the results showed that the spherical BiOCl particles were uniformly dispersed on the surface of the Gp,forming a mesoporous BiOCl@Gp composite with a specific surface area of 22.82 m^(2)/g and a pore volume of 0.043 cm3/***,cyclic voltammetry and electrochemical impedance spectroscopy were used to test the electrochemical properties of the composites,and the stability of BiOCl and the high conductivity of Gp were synergistic,the BiOCl@Gp exhibited a specific capacitance of 30.2 F·g^(-1) at a current density of 0.5 A·g^(-1),and the selectivity of the BiOCl@Gp materials for Cl^(-)was significantly higher than that of SO_(4)^(2-),NO_(2)^(-),and HCO_(3)^(-).Therefore,BiOCl@Gp composite electrode materials can be used for the selective adsorption of Cl^(-)in wastewater,in order to achieve efficient wastewater recycling.

关键词： solvothermal method bismuth oxychloride electrochemistry electrode materials

A clean disposal method of carbide slag with carbon emission reduction:Used as a flux for iron ore sintering Author links open overlay panel

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Particuology 2024年第8期91卷 303-314页

作者： Hanxiao Meng jiankang Wang Xiang liu Kelang Jin Lei Zhang Hao Zhou State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou310027China

Limestone or quicklime is a necessary flux in the iron ore sintering *** production and application process will cause CO_(2) emissions and various environmental pollution,but this has not attracted enough *** slag(CS)is a calcium-rich solid waste produced in acetylene production,the harmless disposal of which is still incomplete,resulting in soil and groundwater *** study investigated the granulation characteristics and sintering performance of the sintering mixture with different proportions of *** results show that replacing limestone with an appropriate proportion of CS is promising and beneficial to the formation of high-quality bonding *** CS accounts for 75%of the total mass of CS and limestone,the tumbler index increases by 8.10%and the comprehensive index decreases only from 100 to 96.16,which is within the acceptable *** application of CS in iron ore sintering can achieve a clean disposal of it and a considerable carbon emission reduction,as the main component of which is Ca(OH)2.

关键词： Ironore sintering Carbide slag Flux Carbon emission Comprehensive index

Temperature stress analysis for bi-modulus beam placed on Winkler foundation

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Applied Mathematics and Mechanics(English Edition) 2017年第7期38卷 921-934页

作者： Jinling GAO Wenjuan YAO jiankang liu Department of Civil Engineering Shanghai University Shanghai Open Steel Structure Co. Ltd.

The materials with different moduli in tension and compression are called bi-modulus materials. Graphene is such a kind of materials with the highest strength and the thinnest thickness. In this paper, the mechanical response of the bi-modulus beam subjected to the temperature effect and placed on the Winkler foundation is studied. The differential equations about the neutral axis position and undetermined parameters of the normal strain of the bi-modulus foundation beam are established. Then, the analytical expressions of the normal stress, bending moment, and displacement of the foundation beam are derived. Simultaneously, a calculation procedure based on the finite element method （FEM） is developed to obtain the temperature stress of the bi-modulus struc- tures. It is shown that the obtained bi-modulus solutions can recover the classical modulus solution, and the results obtained by the analytical expressions, the present FEM proce- dure, and the traditional FEM software are consistent, which verifies the accuracy and reliability of the present analytical model and procedure. Finally, the difference between the bi-modulus results and the classical same modulus results is discussed, and several reasonable suggestions for calculating and optimizing the certain bi-modulus member in practical engineering are presented.

关键词： bi-modulus beam Winkler foundation temperature stress analytical so-lution secondary development of program