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Utilization of 3D printing technology in hepatopancreatobiliary surgery

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 123-134页

作者： Wujiang SHI Jiangang WANG jianjun GAO Xinlei zou Qingfu DONG Ziyue HUANG Jialin SHENG Canghai GUAN Yi XU Yunfu CUI Xiangyu ZHONG Department of Hepatopancreatobiliary Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin150086China Department of General Surgery Tangdu HospitalAir Force Medical UniversityXi’an710032China Key Laboratory of Basic Pharmacology of Ministry of Education Zunyi Medical UniversityZunyi563006China Key Laboratory of Functional and Clinical Translational Medicine Fujian Province UniversityXiamen Medical CollegeXiamen361000China Department of Pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials Yancheng Teachers UniversityYancheng224007China Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang Province Hangzhou310053China Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou350122China Key Laboratory of Myocardial Ischemia Harbin Medical UniversityMinistry of EducationHarbin150086China

The technology of three-dimensional(3D)printing emerged in the late 1970s and has since undergone considerable development to find numerous applications in mechanical engineering,industrial design,and biomedicine.In biomedical science,several studies have initially found that 3D printing technology can play an important role in the treatment of diseases in hepatopancreatobiliary surgery.For example,3D printing technology has been applied to create detailed anatomical models of disease organs for preoperative personalized surgical strategies,surgical simulation,intraoperative navigation,medical training,and patient education.Moreover,cancer models have been created using 3D printing technology for the research and selection of chemotherapy drugs.With the aim to clarify the development and application of 3D printing technology in hepatopancreatobiliary surgery,we introduce seven common types of 3D printing technology and review the status of research and application of 3D printing technology in the field of hepatopancreatobiliary surgery.

关键词： 3D printing Hepatopancreatobiliary surgery Organ model Cancer model

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Selection of elite lines of BpGH3.5-transgenic Betula platyphylla using growth adaptability analysis

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Journal of Forestry Research 2022年第6期33卷 1891-1901页

作者： Chu Wang Yang Wang jianjun zou Rusheng Peng Qibin Yu Guifeng Liu Jing Jiang State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China Jilin Provincial Academy of Forestry Sciences Changchun 130000People’s Republic of China Liaoning Poplar Research Institute Gaizhou 115200People’s Republic of China University of Florida GainesvilleFLUSA

White birch(Betula platyphylla)is precious material for pulpwood and widely distributed in 14 provinces of China.Previous study indicated that inhibited expression of a gene encoding an auxin amide synthase,BpGH3.5,in transgenic plants reduced the level of IAA–amino acid conjugation,resulting in more free IAA,thereby better growth of birch.Utilizing transgenic-B pGH3.5 lines to increase wood production in a wide range of environments is the goal for breeders.In three field trials here,we measured tree height,diameter at breast height,and volume of 16 BpGH3.5-transgenic 7-year-old white birch lines(including 12 antisense strand lines and 4 overexpression lines)and a wild-type white birch line from three sites that varied greatly in their environmental conditions.To select elite BpGH3.5-transgenic lines for each target environment,we used an additive main effects and multiplicative interaction model to analyze genotype by environment interaction,growth adaptability and stability.The selection criteria for elite transgenic lines were set as the average volume plus 0.75 times the standard deviation for the tested lines at each test site.Results showed that the effect of line and site for height was highly significant(P<0.01),and the effect of line×site was significant(P<0.05);selected as the elite lines were FG12,FG13 and FG27 at the Maoershan Experimental Forest Farm,FG13 and FG32 at the Shidaohe Forest Farm,and FG3 and FG31 at the Ecological Experiment Forest Farm.These seven high-yield,stable lines can now be tested in production trials or adjacent trial areas with similar environmental conditions,while the high-yield,unstable lines should be tested in production trials in areas deemed suitable for their growth.These results provide guidance on which released transgenic elite lines will grow best in a wide range of conditions.

关键词： Betula platyphylla BpGH3.5 Afforestation test Growth adaptability

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Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1-and G6PC-mediated gluconeogenesis

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药学学报:英文版 2023年第9期13卷 3728-3743页

作者： Hanyu Yang Mengxiang Su Ming Liu Yun Sheng Liang Zhu Lu Yang Ruijing Mu jianjun zou Xiaodong Liu Li Liu State Key Laboratory of Natural Medicines Key Laboratory of Drug Metabolism and PharmacokineticsChinaPharmaceutical UniversityNanjing 210009China Department of Pharmacology School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Pharmaceutical Analysis School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China

Type 2 diabetes(T2D) is often accompanied with an induction of retinaldehyde dehydrogenase 1(RALDH1 or ALDH1A1) expression and a consequent decrease in hepatic retinaldehyde(Rald)levels. However, the role of hepatic Rald deficiency in T2D progression remains unclear. In this study, we demonstrated that reversing T2D-mediated hepatic Rald deficiency by Rald or citral treatments, or liverspecific Raldh1 silencing substantially lowered fasting glycemia levels, inhibited hepatic glucogenesis,and downregulated phosphoenolpyruvate carboxykinase 1(PCK1) and glucose-6-phosphatase(G6PC)expression in diabetic db/db mice. Fasting glycemia and Pck1/G6pc mRNA expression levels were strongly negatively correlated with hepatic Rald levels, indicating the involvement of hepatic Rald depletion in T2D deterioration. A similar result that liver-specific Raldh1 silencing improved glucose metabolism was also observed in high-fat diet-fed mice. In primary human hepatocytes and oleic acidtreated HepG2 cells, Rald or Rald + RALDH1 silencing resulted in decreased glucose production and downregulated PCK1/G6PC mRNA and protein expression. Mechanistically, Rald downregulated direct repeat 1-mediated PCK1 and G6PC expression by antagonizing retinoid X receptor a, as confirmed by luciferase reporter assays and molecular docking. These results highlight the link between hepatic Rald deficiency, glucose dyshomeostasis, and the progression of T2D, whilst also suggesting RALDH1 as a potential therapeutic target for T2D.

关键词： Type 2 diabetes Retinaldehyde Retinaldehyde dehydrogenase 1 Gluconeogenesis Retinoid X receptor Oleic acid Glucose-6-phosphatase Phosphoenolpyruvate carboxykinase 1

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郭沫若早期对外国诗人的评价失误及其内在原因

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中国文学研究 2024年第1期 184-190页

作者：邹茜邹建军武汉理工大学外国语学院湖北武汉430070 华中师范大学文学院湖北武汉430079

作为中国新诗的开创者与开拓者,郭沫若在早期的诗论中对外国诗人及其作品有过诸多公允的评价,对中国新诗的产生和发展发挥了重要的作用;然而,他早期在评价外国诗人及其作品的时候,也存在不少的问题。郭沫若早期对外国诗人及其作品的评... 详细信息

作为中国新诗的开创者与开拓者,郭沫若在早期的诗论中对外国诗人及其作品有过诸多公允的评价,对中国新诗的产生和发展发挥了重要的作用;然而,他早期在评价外国诗人及其作品的时候,也存在不少的问题。郭沫若早期对外国诗人及其作品的评价存在五个方面的失误,本文对此进行了具体的揭示与分析,并探讨了这些失误出现的内在原因以及一些重要的外在原因。

关键词：郭沫若早期诗论外国诗人与诗作评价失误内在原因

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PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2391-2405页

作者： Peihua Liu Ling Jiang Weimin Kong Qiushi Xie Ping Li Xiaonan Liu Jiayi Zhang Ming Liu Zhongjian Wang Liang Zhu Hanyu Yang Ying Zhou jianjun zou Xiaodong Liu Li Liu Center of Drug Metabolism and Pharmacokinetics School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China

Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor(PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nuclear factor 4-alpha(HNF4 a)-glucose transporter 2(GLUT2) pathway. The PXR agonists atorvastatin and rifampicin significantly downregulated GLUT2 and HNF4 a expression, and impaired glucose uptake and utilization in HepG2 cells. Overexpression of PXR downregulated GLUT2 and HNF4 a expression, while silencing PXR upregulated HNF4 a and GLUT2 expression.Silencing HNF4 a decreased GLUT2 expression, while overexpressing HNF4 a increased GLUT2 expression and glucose uptake. Silencing PXR or overexpressing HNF4 a reversed the atorvastatininduced decrease in GLUT2 expression and glucose uptake. In human primary hepatocytes, atorvastatin downregulated GLUT2 and HNF4 a mRNA expression, which could be attenuated by silencing PXR. Silencing HNF4 a downregulated GLUT2 mRNA expression. These findings were reproduced with mouse primary hepatocytes. Hnf4 a plasmid increased Slc2 a2 promoter activity. Hnf4 a silencing or pregnenolone-16 a-carbonitrile(PCN) suppressed the Slc2 a2 promoter activity by decreasing HNF4 a recruitment to the Slc2 a2 promoter. Liver-specific Hnf4 a deletion and PCN impaired glucose tolerance and hepatic glucose uptake, and decreased the expression of hepatic HNF4 a and GLUT2. In conclusion, PXR activation impaired hepatic glucose metabolism partly by inhibiting the HNF4 aGLUT2 pathway. These results highlight the molecular mechanisms by which PXR activators induce hyperglycemia/diabetes.

关键词： Pregnane X receptor Hepatocyte nuclear factor4-alpha Glucose transporter 2 Hepatic glucose uptake Diabetes Drug-induced hyperglycemia

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Variations of alkenone temperature in the Sea of Japan during the last 170 ka and its paleoceanographic implications

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Chinese Science Bulletin 2014年第33期59卷 4498-4509页

作者： Yanguang Liu Jiaojie Chen Jinxia Chen Lei Xing jianjun zou Zhengquan Yao Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of Oceanography State Oceanic Administration Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education/Qingdao Collaborative Innovation Center of Marine Science and Technology Ocean University of China

Two sediment cores, KCES1 and ODP797,which were recovered from the Sea of Japan(JS), were measured for alkenone-derived sea surface temperatures(UK037-SSTs). Our results revealed that the SSTs closely follow the glacial-interglacial cycles during the last 170 ka,except in the last glacial maximum(LGM), during which the SST was higher than in the Holocene. The anomalous high temperature in the LGM is considered as an effect of the intrusion of a low salinity water mass into the JS when the sea level was almost below 130 m. On the glacialinterglacial to orbital timescale, the UK037-SSTs record in the JS correlated well with the benthic foraminiferal d18 O record and solar insolation, which suggests the dominant control of solar insolation and its related sea ice development on the SST in the JS. On the sub-orbital/millennial timescale, reduced SST corresponds to an enhanced east asian winter monsoon(EAWM) during the last glacial period(MIS3 and MIS4), indicating the dominant control of sea ice expansion due to the enhanced EAWM on the SST in the JS. In contrast, during the last interglacial period(MIS5), the SST in the JS was controlled by variations in the east Asian summer monsoon. These results highlight the key role of solar insolation and associated glacialinterglacial conditions in the variations of the SST in the JS since the last 170 ka.

关键词：海表温度日本海古海洋学烯酮末次间冰期太阳辐射 SST 末次盛冰期

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从2005—2023年国家自然科学基金资助项目浅谈中药多糖的研究现状

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中草药 2024年第4期55卷 1053-1062页

作者：吴建军邹剑马致洁徐愿巩仔鹏刘学伟国家自然科学基金委员会医学科学部十处北京100085 浙江中医药大学药学院浙江杭州310053 暨南大学药学院广东广州511443 首都医科大学附属北京友谊医院药学部北京100050 中日友好医院中医风湿病科北京100029 贵州医科大学药学院贵州省药物制剂重点实验室省部共建药用植物功效与利用国家重点实验室民族药与中药开发应用教育部工程研究中心贵州贵阳550004

该文通过对2005—2023年国家自然科学基金中医药领域资助的中药多糖相关的项目进行回顾性分析,系统梳理和总结中药多糖的研究内容和热点。分析发现,中药多糖的主要研究内容集中于“活性及作用机制”“构效关系”和“吸收和代谢”等方面... 详细信息

该文通过对2005—2023年国家自然科学基金中医药领域资助的中药多糖相关的项目进行回顾性分析,系统梳理和总结中药多糖的研究内容和热点。分析发现,中药多糖的主要研究内容集中于“活性及作用机制”“构效关系”和“吸收和代谢”等方面,主要研究热点包括“黄芪多糖”“肠道菌群”“当归多糖”和“枸杞多糖”等。最后提出了我国中药多糖研究领域主要存在的3个潜在问题:多糖化学结构的表征技术无法满足实际需求;多糖吸收与代谢途径的有待明确;中药多糖与小分子的整体协同作用有待阐明。旨在为今后我国中药多糖的研究者提供参考,并为相关项目的申请者提供借鉴。

关键词：国家自然科学基金中药多糖活性及作用机制构效关系吸收和代谢黄芪多糖肠道菌群当归多糖枸杞多糖

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民法典背景下刑民交叉案件办理实证分析——以J省F市检察机关案件办理为视角

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江西警察学院学报 2024年第2期 93-99页

作者：衷建军邹梦伊抚州市人民检察院江西抚州344000

《民法典》作为中国历史上跨时代的里程碑,在其实施的司法大背景下,刑民交叉问题持续成为司法理论界与实务界热议的焦点。一个案件同时涉及刑法和民法且两者有交叉,没有一成不变的适用规则。司法实践中,刑事责任和民事责任并不非此即彼... 详细信息

《民法典》作为中国历史上跨时代的里程碑,在其实施的司法大背景下,刑民交叉问题持续成为司法理论界与实务界热议的焦点。一个案件同时涉及刑法和民法且两者有交叉,没有一成不变的适用规则。司法实践中,刑事责任和民事责任并不非此即彼,而是相互衔接又同时并存。本文立足J省F市检察机关近年来办理的刑民交叉案件,对司法实践中部分刑民交叉案件办理现状进行总结,就民法典背景下正当高效处理刑民交叉案件提出可行性建议:应严守罪刑法定原则,准确认定刑事责任;准确把握构成要件,避免刑法介入民事纠纷;坚守刑法谦抑精神,优先适用民法调整;重视社会关系的修复,惩罚犯罪与保障人权并重,旨在更好明确刑民法律关系责任的区分与承担,准确认定检察官司法责任,期望能对优化刑民交叉案件的办理实践有所裨益。

关键词：民法典检查机关刑民交叉相互流转司法责任

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Benthic foraminiferal δ^(13)C minimum events in the southeastern Okhotsk Sea over the last 180 ka

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Chinese Science Bulletin 2014年第24期59卷 3066-3074页

作者： Yonghua Wu Xuefa Shi jianjun zou Zhenbo Cheng Kunshan Wang Shulan Ge Fengdeng Shi State Key Laboratory of Marine Geology Tongji University Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of Oceanography State Oceanic Administration

A total of six d13C minimum events,i.e.,VI,V,IV,III,II,and I,were observed via a stable carbon and oxygen isotope analysis of infaunal benthic foraminifera Uvigerina spp.in gravity core OS03-1 in the southeastern Okhotsk Sea over the last 180 ka.These events occurred at112–109,102–90,85–76,57–54,44–40,and 17–10 ka BP.The largest negative excursions reached 2.5%in event V and were greater than 1%in the other events.We proposed that all d13C minimum events were caused by the increase in sea surface water productivity,the weakened formation of Okhotsk Sea intermediate water,and the enhancement of the oxygen minimum zone.The negative excursions were unaffected by methane hydrate destabilization and subsequent methane release based on the results obtained by using archaeal lipid markers.

关键词：鄂霍次克海底栖有孔虫东南部事件氧同位素分析甲烷水合物甲烷释放分解释放

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内外统一的文学地理学批评方法及其路径——邹建军教授访谈录

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世界文学评论（高教版） 2024年第1期 11-17页

作者：邹建军黎骄阳华中师范大学文学院

文学地理学批评是由中国学者提出和发展起来的一种新的文学批评方法,最近二十年来有了很大的发展,在文学研究中已经发挥了很大的作用。如何认识文学地理学批评的性质与特征?如何重新理解“文学”与“地理”这样的传统概念?如何把文学地... 详细信息

文学地理学批评是由中国学者提出和发展起来的一种新的文学批评方法,最近二十年来有了很大的发展,在文学研究中已经发挥了很大的作用。如何认识文学地理学批评的性质与特征?如何重新理解“文学”与“地理”这样的传统概念?如何把文学地理学的相关理论运用到具体的文学批评实践中?本文是一篇关于中国文学地理学批评理论的主要建构者邹建军教授的访谈录,他的解答有利于促进中国的文学批评理论的发展,也有利于提升中国的文学地理学学科建设的水平。

关键词：文学地理学文学地理学批评内外统一文学的本质

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