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早产及未足月胎膜早破与妊娠期生殖道感染的关系研究

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中国医药 2024年第7期19卷 1052-1055页

作者：王春静孟文颖翟建军北京市通州区妇幼保健院产科北京101101 首都医科大学附属北京同仁医院妇产科北京100005

目的明确早产及未足月胎膜早破(PPROM)与妊娠期生殖道感染(RTI)的相关性。方法选择2021年1月至2022年12月在北京市通州区妇幼保健院规律产前检查及分娩的早产或PPROM孕妇416例作为研究对象进行回顾性分析。根据分娩期间(分娩当次入院)... 详细信息

目的明确早产及未足月胎膜早破(PPROM)与妊娠期生殖道感染(RTI)的相关性。方法选择2021年1月至2022年12月在北京市通州区妇幼保健院规律产前检查及分娩的早产或PPROM孕妇416例作为研究对象进行回顾性分析。根据分娩期间(分娩当次入院)检查有无明确的RTI病原学证据分为观察组(171例,有证据)和对照组(245例,无证据)。对孕妇相关资料进行分析,比较2组孕早期患阴道炎症情况、PPROM发生率、分娩孕周、分娩方式、胎儿宫内窘迫发生情况及不同年龄孕妇妊娠结局、相同孕周分娩新生儿出生体重。结果观察组171例孕妇阴道分泌物常规检查前3位病原菌为解脲支原体感染14例(8.2%)、细菌性阴道病13例(7.6%)、霉菌性阴道炎10例(5.8%);细菌学培养RTI的常见病原体为无乳链球菌9例(5.3%)、白色念珠菌8例(4.7%)、大肠埃希菌6例(3.5%)。观察组孕早期患阴道炎症比例高于对照组[18.7%(32/171)比11.4%(28/245)],差异有统计学意义(P=0.042)。观察组与对照组PPROM发生率、分娩孕周、分娩方式、胎儿宫内窘迫发生率比较差异均有统计学意义(均P0.05)。观察组和对照组相同孕周分娩新生儿出生体重比较差异均无统计学意义(均P>0.05)。结论解脲支原体、无乳链球菌、白色念珠菌是RTI的主要致病菌;妊娠期RTI有增加早产或PPROM发病风险的可能,同时妊娠期RTI增加妊娠期母儿的不良结局。

关键词：早产未足月胎膜早破生殖道感染

基于微信平台的整合医学教学模式在国际留学生妇产科临床实习中的应用

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中国临床医生杂志 2024年第6期52卷 749-752页

作者：王文文刘浩宇陈敏秀翟建军首都医科大学附属北京同仁医院北京100176 首都医科大学第四临床医学院北京100176

目的探讨基于微信平台的整合医学教学模式在国际留学生妇产科临床实习中的应用效果。方法选取2020年1月至2023年12月于首都医科大学附属北京同仁医院妇产科临床实习的79名国际留学生为研究对象。入组者均须按要求完成4周的妇产科实习。... 详细信息

目的探讨基于微信平台的整合医学教学模式在国际留学生妇产科临床实习中的应用效果。方法选取2020年1月至2023年12月于首都医科大学附属北京同仁医院妇产科临床实习的79名国际留学生为研究对象。入组者均须按要求完成4周的妇产科实习。将研究对象按照随机数表法分为微信平台实习组(39名)及传统实习组(40名),其中传统实习组学生以带教老师的口头讲述以及教材学习为主,微信平台实习组在传统实习组基础上,增加微信平台的学习内容,主要包括基础理论、临床实践及以案例和问题为导向的学习模块,相关内容均以英文呈现,由妇产科教学干事或带教老师通过微信平台发送给学生。主要观察指标是两组学生的理论考核成绩和实践考核成绩,次要观察指标是两组同学在学习兴趣、自学能力、交流能力、对临床问题的理解深度、团队合作能力等五个方面的改善情况。结果微信平台实习组学生的理论考核成绩和实践考核成绩均高于传统实习组学生,差异有统计学意义(P<0.05)。微信平台实习组学生在学习兴趣、自学能力对临床问题的理解深度等三个方面的改善情况均明显优于传统实习组,差异有统计学意义(P<0.05)。结论基于微信平台的整合医学教学模式在国际留学生妇产科临床实习中取得了良好效果,有助于国际留学生的培养,值得进一步推广使用。

关键词：整合医学微信平台国际留学生妇产科临床实习

Clinical Observation of rhIL-2 Combined with Zhenqi Fuzheng and BaofuKang Suppository in the Treatment of Cervical Intraepithelial Neoplasia II with HPV Infection

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Open Journal of Obstetrics and Gynecology 2020年第8期10卷 1045-1055页

作者： Yu Cai jianjun zhai Jinping Xun Xiaojin He Department of Gynecology and Obstetrics BeiJing TongRen Hospital Capital Medical University Beijing China Department of Pathology BeiJing TongRen Hospital Capital Medical University Beijing China

Objective: To investigate the clinical effects of recombinant human interleukin-2 (rhIL-2) combined with Zhenqi Fuzheng and Baofukang on cervical intraepithelial neoplasia II (CINII) combined with human papilloma virus infection. Methods: There were 593 patients diagnosed with CINII with HPV infection, including 296 in the control group and 297 in the experimental group. The control group was given only Zhenqi Fuzheng oral and Baofukang suppository vaginal medicine. The experimental group was treated with rhIL-2 injection in addition to Zhenqi Fuzheng oral and Baofukang suppository vaginal medicine which is treated for 3 months. After 3 months, Thinprep cytologic test (TCT), human papilloma virus (HPV) quantitative examination and colposcopy biopsy were reviewed. Results: After 3 months of treatment, the negative conversion rate and total effective rate of HPV in the control group were 58.11% and 70.95% respectively, and the negative conversion rate and total effective rate of the experimental group were 79.46% and 90.57% respectively. There was significant difference between the two groups (p = 0.000). The curative rate of cervical lesions was significantly higher in the test group than in the control group, 89.56%, 68.91%, respectively. The statistical difference between the two groups is significant (p = 0.000). Conclusion: It has an essential clinical value that HPV infection patients and cervical intraepithelial neoplasia II associated with

关键词： Cervical Intraepithelial Neoplasia II Human Papilloma Virus Recombinant Human Interleukin-2 Zhenqi Fuzheng Baofukang

Clinical Observation of Misoprostol before and after Painless Induced Abortion

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Pharmacology & Pharmacy 2021年第5期12卷 91-99页

作者： Yu Cai Huilian Huang jianjun zhai Bibo Feng Department of Obstetrics and Gynecology Capital Medical University Affiliated Beijing Tongren Hospital Beijing China Ultrasonography Department Capital Medical University Affiliated Beijing Tongren Hospital Beijing China

Background: Though painless abortion is a safe, effective and excellent method of artificial abortion, intravenous anesthesia cannot effectively expand the cervix. Hard and tight cervix often affects the operation and easily inducesabortion complications. Misoprostol can induce uterine contraction and soften the cervix. Objective: To investigate the clinical effect of misoprostol on abortion before and after painless induced abortion. Methods: 600 case pregnant women were divided into three groups: A, B and C, 200 case in each group. All patients were anesthetized. In group A, misoprostol 0.2 ug was placed in the posterior fornix of vagina 2 hours before the operation of induced abortion;in group B, misoprostol 0.2 ug was not only placed in the posterior fornix of vagina 2 hours before the operation of induced abortion but also taken orally 2 hours and 6 hours after the operation;in group C, misoprostol was not used before and after the operation. The operation time, intraoperative bleeding volume, postoperative bleeding, the percentage of cervical relaxation and the rate of incomplete abortion among the three groups were compared. Results: Compared with group A and group B, the operation time of group C was longer and the amount of bleeding was more (P 0.05). The duration of bleeding in group B was less than that in group A (P Conclusion: The use of misoprostol before and after painless induced abortion can not only shorten the time of operation, reduce intraoperative and postoperative vaginal bleeding, but also has not incurred incomplete abortion(primary outcome).

关键词： Painless Induced Abortion Misoprostol Incomplete Induced Abortion

The lactylation index predicts the immune microenvironment and prognosis of pan-cancer patients

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BIOCELL 2024年第8期48卷 1223-1239页

作者： XUEJIA zhai JIE LIU JINWEI XIAO TAO ZHANG JUN WANG jianjun LI SHICANG YU Department of Oncology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China Department of Stem Cell and Regenerative Medicine Institute of Pathology and Southwest Cancer CenterSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China Key Laboratory of Cancer Immunopathology Ministry of EducationChongqing400038China International Joint Research Center for Precision Biotherapy Ministry of Science and TechnologyChongqing400038China Jin-feng Laboratory Chongqing401329China

Background:Protein lactylation is a new way for the“metabolic waste”lactic acid to perform novel ***,our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains *** construction of a scoring system for lactylation to predict the prognosis of pancancer patients and to evaluate the tumor immune microenvironment(TIME)would improve our understanding of the clinical significance of ***:Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma(PAAD)***,a scoring system was developed using the least absolute shrinkage and selection operator(LASSO)*** validation and external validation were both conducted to assess and confirm the predictive accuracy of the scoring ***,leucine rich repeat containing 1(LRRC1),a newly discovered lactylation-related gene,was analyzed in PAAD in ***:Utilizing the profiles of 332 lactylation-related genes,a total of 177 patients with PAAD were segregated into two distinct ***^(high) patients had a poorer prognosis than LacCluster^(low) *** the differential analysis between the LacCluster^(high) and LacCluster^(low) groups,we identified additional genes associated with *** genes were then integrated to construct the LacCluster-enhanced system,which enabled more accurate prognosis prediction for patients with ***,a lactylation index containing three genes(LacI-3)was constructed using LASSO *** was done to enhance the usability of the LacCluster-enhanced system in the *** to those in the LacI-3^(high) subgroup,patients in the LacI-3^(low) subgroup exhibited increased expression of immune checkpoint-related genes,more immune cell infiltration,lower tumor mutation burdens,and better prognoses,indicating a“hot tumor”***,knocking down the expression of LRRC1,

关键词： Pancreatic adenocarcinoma Pan-cancer Lactylation Prognosis Tumor immune microenvironment LRRC1

Effects of Aspirin on Pregnancy Outcome and Serum Endothelin-1 and Thrombomodulin Levels in Pregnancy Patients with Chronic Hypertension

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Open Journal of Obstetrics and Gynecology 2021年第8期11卷 1073-1080页

作者： Yu Cai jianjun zhai Bibo Feng Rui Chen Xingyue Tian Department of Gynecology and Obstetrics Beijing Tongren Hospital Affiliated to Capital Medical University Beijing China Department of Laboratory Medicine Beijing Tongren Hospital Affiliated to Capital Medical University Beijing China

Objective: To investigate the effect of aspirin on pregnancy outcome and serum levels of endothelin-1 (ET-1) and thrombomodulin (TM) in pregnancy patients with chronic hypertension. Methods: Selected patients with chronic hypertension (mild to moderate) during pregnancy, who were enrolled and delivered in the Beijing Tongren Hospital Department of Obstetrics and Gynecology between January 1, 2019 and December 30, 2020. The patients were randomly divided into control group (60) and experimental group (60). The control group was treated with labetalol and the test group was treated with labetalol and aspirin. The therapeutic effect and pregnancy outcome of the two groups were compared. The serum levels of ET-1 and TM were measured before treatment and one week after treatment. Results: Systolic blood pressure (SBP) decreased significantly one week after treatment in the two groups (P Conclusion: Besides routine treatment, aspirin can improve the outcome of pregnant women with chronic hypertension, which may be related to the regulation of ET-1 and TM by aspirin.

关键词： Pregnancy with Chronic Hypertension Aspirin Maternal and Fetal Outcomes ET-1 TM

The Role of IL-2, IL-4, IL-10 and IFN-γ Cytokines Expression in the Microenvironment of Cervical Intraepithelial Neoplasia

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Advances in Reproductive Sciences 2022年第4期10卷 106-114页

作者： Yu Cai jianjun zhai Yumei Wu Rui Chen Xingyue Tian Department of Gynecology and Obstetrics Beijing Tongren Hospital Capital Medical University Beijing China Department of Gynecology and Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China Department of Laboratory Medicine Beijing Tongren Hospital Capital Medical University Beijing China

Objective: To investigate the role of IL-2, IL-4, IL-10 and IFN-γ cytokines in the microenvironment of cervical intraepithelial neoplasia. Methods: 180 patients participating were enrolled in this trial, where 50 cases are in control group, 50 cases are in low-grade squamous intraepithelial lesion (LSIL) group, 50 cases are in high-grade squamous intraepithelial lesion (HSIL) group, and 30 cases have cervical carcinoma. ELISA methods are used to detect the expression of IL-2, IL-4, IL-10 and IFN-γ in the lavage fluid, and all data is analyzed using one-way analysis of variance. Results: The expression of IL-2 and IFN-γ in cervical lavage fluid gradually decreases with the aggravation of the lesion. The expression of IL-4 and IL-10 increases by the aggravation of pathological changes. There were statistically significant differences in IL-2 level among the four groups. IFN-γ levels are significantly different between the cervical cancer group and the other groups, also between HSIL and LSIL group, and between HSIL and the control group, but no statistically significant difference was observed in IFN-γ e between LSIL and the control group. The expressions of IL-4 and IL-10 between the cervical cancer group and the other groups were significantly different, and also between HSIL and the control group. But there was no statistically significant difference between LSIL and the control group, HSIL and LSIL. Conclusion: The cytokines of IL-2, IL-4, IL-10 and IFN-γ in the microenvironment of the cervix play an important role in the occurrence and development of cervical intraepithelial neoplasia. This study may provide the evidence for diagnosis and treatment of cervical intraepithelial neoplasia.

关键词： Cervical Intraepithelial Neoplasia IL-2 Il-4 IL-10 IFN-γ Vaginal Lavage Fluid

A sulfur isotope study of fine disseminated gold deposits in the Yunnan-Guizhou-Guangxi triangle area

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Chinese Science Bulletin 1999年第S2期44卷 180-182页

作者： LU jianjun, zhai Jianping, CHEN Xiaoming and GAO Jianfeng State Key Laboratory of Mineral Deposit Research, Nanjing University, Nanjing 210093, China State Key Laboratory of Mineral Deposit Research Nanjing University Nanjing 210093 China

THE fine disseminated gold deposits in Yunnan-Guizhou-Guangxi triangle area in S. China occur in thesedimentary rocks and are not relative to magmatism in space and genesis. Many authors have studiedthese deposits and obtained different conclusions. This note makes the first systematic study on sulfur isotope compositions to further discuss possible sources of ore-forming materials. 1 Sulfur isotope composition Figure 1 shows variations of sulfur isotope compositions of 232 sulfide separats from various depositsand their host rocks. S S values of pyrite from Mid-Triassic Banna Formation strata in the Jinya ore district can be divided into two groups: -7.4‰ to -6.4‰ and 2.7‰ to 14.1‰. Pyrite from the Jinyadeposits has δ34S values of -7.2‰-1.9‰, stibnite -6.7‰- -4.9‰ and arsenopyrite -4.1‰-

关键词： sulfur isotope fine disseminated gold deposits Yunnan Guizhou Guangxi.

驱动蛋白家族成员2C参与卵巢癌化疗耐药的机制研究

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中华老年医学杂志 2023年第3期42卷 347-351页

作者：王文文翟建军首都医科大学附属北京同仁医院妇产科北京100176

目的探讨KIF2C在上皮性卵巢癌化疗耐药中的作用及其潜在的分子机制。方法检测驱动蛋白家族成员(KIF)2C在顺铂敏感细胞株A2780和顺铂耐药细胞株A2780DDP中的差异表达。在A2780细胞株中加入不同浓度、不同时间的顺铂,检测KIF2C的差异表... 详细信息

目的探讨KIF2C在上皮性卵巢癌化疗耐药中的作用及其潜在的分子机制。方法检测驱动蛋白家族成员(KIF)2C在顺铂敏感细胞株A2780和顺铂耐药细胞株A2780DDP中的差异表达。在A2780细胞株中加入不同浓度、不同时间的顺铂,检测KIF2C的差异表达。用慢病毒感染A2780DDP细胞株,构建KIF2C稳定过表达的卵巢癌细胞株(KIF2C-OV)。将相同浓度的顺铂添加到KIF2C-OV及其对照组(Ctrl-OV)细胞系中。用CCK-8检测KIF2C过表达对耐药细胞株A2780DDP细胞增殖的影响。最后,对KIF2C在卵巢癌细胞系中发挥耐药作用的分子机制进行初步探索。结果 KIF2C在A2780DDP细胞株中显著低表达。在A2780细胞株中加入顺铂后,KIF2C的表达随着顺铂浓度和作用时间的增加而降低。用慢病毒感染A2780DDP细胞株,构建KIF2C-OV。加入顺铂后,KIF2C-OV细胞株的增殖能力明显低于Ctrl-OV细胞系。p-Erk在A2780DDP细胞株中表达升高。在A2780细胞株中加入不同浓度梯度及不同时间梯度的顺铂,p-Erk的表达随顺铂浓度的升高而升高,随顺铂作用的时间延长而升高。A2780DDP卵巢癌细胞系过表达KIF2C后,p-Erk表达水平下降。结论 KIF2C是卵巢癌化疗耐药的潜在靶基因,它可能通过MAPK/ERK通路发挥其耐药作用。

关键词：化疗耐药 KIF2C 卵巢癌机制