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超长混凝土结构温度应力分析与设计措施

山西建筑 2024年第17期50卷 31-34,85页

作者：曹历曾建军四川国恒建筑设计有限公司四川成都610041

温度变化对超长混凝土结构的变形和内力存在较大影响。某工程位于成都市新津区,设计为1层地下室(局部2层地下室)。该地下室采用混凝土结构,平面尺寸达到600 m×53 m。出于保证使用功能考虑,要求整体地下室方案不设温度伸缩缝。为解决这... 详细信息

温度变化对超长混凝土结构的变形和内力存在较大影响。某工程位于成都市新津区,设计为1层地下室(局部2层地下室)。该地下室采用混凝土结构,平面尺寸达到600 m×53 m。出于保证使用功能考虑,要求整体地下室方案不设温度伸缩缝。为解决这一问题,设计人员提出了一些结构设计分析方法,并引入应力释放带,利用YJK结构设计软件对地下室顶板的温度应力进行评估,通过分析结果提出了控制地下室温度裂缝的措施,与现场修建完成后的实际情况对比,验证了该措施的有效性。

关键词：超长混凝土结构温度应力应力释放带

湛江安铺港海域海水及沉积物重金属污染分析与评价

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海洋技术学报 2024年第1期43卷 39-46页

作者：曾建军徐伟张露海域海岛环境科技研究院(天津)有限公司天津300110

为深入了解雷州半岛西北部海湾重金属污染状况,本文对湛江安铺港海域海水和沉积物中汞(Hg)、砷(As)、铜(Cu)、铅(Pb)、锌(Zn)、镉(Cd)、铬(Cr)等7种重金属元素的含量进行分析,并采用地累积指数法和潜在生态危害指数法对沉积物重金属污... 详细信息

为深入了解雷州半岛西北部海湾重金属污染状况,本文对湛江安铺港海域海水和沉积物中汞(Hg)、砷(As)、铜(Cu)、铅(Pb)、锌(Zn)、镉(Cd)、铬(Cr)等7种重金属元素的含量进行分析,并采用地累积指数法和潜在生态危害指数法对沉积物重金属污染进行评价。结果表明:安铺港海域海水Hg、As、Cu、Pb、Zn、Cd、Cr的平均含量分别为0.011μg/L、0.7μg/L、2.5μg/L、0.43μg/L、10.3μg/L、0.08μg/L、0.1μg/L,所有站位均符合第一类海水水质标准。表层沉积物Hg、As、Cu、Pb、Zn、Cd、Cr的平均含量分别为0.065×10^(-6)、11.7×10^(-6)、12.6×10^(-6)、21.6×10^(-6)、29.3×10^(-6)、0.12×10^(-6)、36.1×10^(-6),沉积物中总有机碳(Total Organic Carbon,TOC)的含量与重金属Hg、As、Cu、Pb、Zn、Cd含量均呈显著的正相关关系,说明表层沉积物中重金属的含量受到TOC的影响。地累积指数法评价结果显示,沉积物重金属Hg和Cu表现为轻度污染,而As、Pb、Zn、Cd、Cr表现为无污染。潜在生态危害指数法评价结果显示,安铺港海域各站位重金属潜在生态危害指数(Risk Index,RI)平均值为179.55,处于中等生态危害,重金属Hg具有较重的生态危害。

关键词：安铺港水质沉积物重金属污染评价

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广东省海域赤潮灾害的基本特征分析

海洋开发与管理 2024年第1期41卷 52-58页

作者：曾建军徐伟张露海域海岛环境科技研究院(天津)有限公司天津300110

文章通过收集《广东省海洋灾害公报》中2013—2022年的赤潮灾害数据,运用统计学方法对近10年广东省海域的赤潮灾害时空分布等基本特征进行综合分析,以期为赤潮灾害的预警、防治等工作提供参考依据。分析结果表明:时间分布上,近10年间广... 详细信息

文章通过收集《广东省海洋灾害公报》中2013—2022年的赤潮灾害数据,运用统计学方法对近10年广东省海域的赤潮灾害时空分布等基本特征进行综合分析,以期为赤潮灾害的预警、防治等工作提供参考依据。分析结果表明:时间分布上,近10年间广东省海域共发生赤潮95次,年平均9.5次,共发生面积3624.76km2,主要发生时间集中在1-4月,平均每次赤潮持续时间为8.8d;空间分布上,赤潮发生次数最多的主要位于珠三角海域,赤潮面积发生最大的则位于粤西海域。引发赤潮的生物共有26种,其中硅藻门13种、甲藻门10种、定鞭藻门、黄藻门和原生动物门各1种,引发赤潮次数最多的是夜光藻和红色赤潮藻,引发赤潮面积最大的是球形棕囊藻,近年来引发赤潮的生物种类呈现多样化的趋势。

关键词：赤潮基本特征广东省海域

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A H9N2 Human Case and Surveillance of Avian Influenza Viruses in Live Poultry Markets-Huizhou City,Guangdong Province,China,2021

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China CDC weekly 2022年第1期4卷 8-10页

作者： Guanting Zhang Liqin Xu Jian Zhang Qiaoyun Fang jianjun zeng Yan Liu Changwen Ke School of Public Health Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouGuangdongChina Huizhou Municipal Center for Disease Control and Prevention HuizhouGuangdongChina

Summary What is already known about this topic?An increasing number of human infected avian influenza A(H9N2)cases have been *** 2021,11 human infections with influenza A virus subtype H9N2(A/H9N2)have been reported in *** is added by this report?A new case of H9N2 that occurred in April 2021 in Huizhou City,Guangdong Province,China,was reported in this *** and laboratory information of the case and routine influenza surveillance data of avian influenza A were presented in this *** are the implications for public health practice?The emergence of a human infected with Avian Influenza Virus H9N2 demonstrates that there is an urgent need to strengthen the surveillance of influenza-like illness and live poultry market.

关键词： poultry Guangdong routine

Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

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Journal of Environmental Sciences 2024年第5期139卷 460-472页

作者： Sujie Sun Li Zhang Xue Li Lu Zang Ling Huang Junquan zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang Lu jianjun Chen Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and Vascular Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water ***,little is known regarding its toxic effects on cardiovascular ***,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L *** showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart ***,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart *** sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic ***-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular ***-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism ***-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting ***,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid Heart development Vascular development Hemopoiesis Zebrafish embryos

Comprehensive evaluation of an ionic liquid based deep purification process for NH_(3)-containing industrial gas

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Journal of Environmental Sciences 2024年第2期136卷 698-708页

作者： Guoxiong Zhan Fei Cao jianjun Chen Zhen Chen Yuanmeng Duan Fei Chang Shaojuan zeng Yinge Bai zengxi Li Xiangping Zhang Junhua Li State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China College of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China

Ammonia(NH_(3))emission has caused serious environment issues and aroused worldwide *** emerging ionic liquid(IL)provides a greener way to efficiently capture NH_(3).This paper provides rigorous process simulation,optimization and assessment for a novel NH_(3)deep purification process using *** process was designed and investigated by simulation and optimization using ionic liquid[C_(4)im][NTF_(2)]as *** objective functions,total purification cost(TPC),total process CO_(2)emission(TPCOE)and thermal efficiency(ηeff)were employed to optimize the absorption *** simulation and optimization results indicate that at same purification standard and recovery rate,the novel process can achieve lower cost and CO_(2)emission compared to benchmark *** process optimization,the optimal functions can achieve 0.02726$/Nm~3(TPC),311.27 kg CO_(2)/hr(TP-COE),and 52.21%(ηeff)for enhanced ***,compared with conventional process,novel process could decrease over$3 million of purification cost and 10000 tons of CO_(2)emission during the life *** results provide a novel strategy and guidance for deep purification of NH_(3)capture.

关键词： NH_(3) Capture Process Ionic Liquid Process Simulation Process Optimization Deep purification

Pollen and resource limitations to lifetime seed production in a wild population of the endangered plant Disanthus cercidifolius *** ***(Hamamelidaceae)

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Frontiers in Biology 2007年第4期2卷 437-442页

作者： XIAO Yian HE Ping zeng jianjun LI Xiaohong HU Wenhai College of Life Sciences Jinggangshan UniversityJi’an 343009China College of Life Sciences Southwest China Normal UniversityChongqing 400715China

Disanthus cercidifolius *** ***,a plant species that only occurs in a few counties in Hunan,Jiangxi and Zhejiang Provinces and with a relatively small number of individuals,is ranked as a second Class endangered species for conservation in *** have studied the effect of pollen and resources available to female reproduction,and the reproductive mechanism of“excess flowers with low fruit set”in Disanthus cercidifolius *** *** was *** are as follows:Pollen from different sources has significant effects on fruit set and seed set of Disanthus cercidifolius *** *** pollen source rather than pollen numbers significantly affected reproduction of this *** wild populations,producing one fruit needs about 54.8 flow-ers,and one satiation seed needs about 6.60 flowers or 83.19 *** fertilizing,which was propitious to flower develop-ment,the abortion rate of flower buds was decreasing,but the flowering rate was *** fruit set and seed set was also significantly increasing,while abortion rate of fruit was significantly *** the increasing percentages of cutting leaves,the fruit set decreased,but the abortion rate of fruit shows no significant differentiation among *** cutting branches that were puny,broken and insect-infested branches,the flower number seemed to be decreas-ing,but the fruit set and seed set all increased *** removing some flowers,the fruit set was calculated with respect to the number of flowers remaining after the treatment increased with increasing of percentages of flower removal,whereas fruit set calculated with respect to the initial number of flowers remained constant,and the mean weights of per fruit and per seed all decreased *** spatial or temporal heterogeneities in nutrient levels might allow limitation of seed set by resources and pollen in a natural population,while supplying resour

关键词： pollen limitation resource limitation hand-pollination seed set Disanthus cercidifolius Maxim.var.longipes H.T.Chang

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei zeng Meizhu Zhang Congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

共表达分子伴侣蛋白提高III型普鲁兰水解酶在短小芽孢杆菌中的分泌表达及发酵优化

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食品工业科技 2024年第10期45卷 149-157页

作者：曾静郭建军王通袁林江西省科学院微生物研究所江西南昌330096

本研究旨在通过共表达分子伴侣蛋白以及优化发酵条件来提高III型普鲁兰水解酶(TK-PUL)在短小芽孢杆菌中的分泌表达水平。通过构建共表达TK-PUL和分子伴侣蛋白的多种重组短小芽孢杆菌,并以胞外酶活为指标对其进行筛选,确定最有利于TK-PU... 详细信息

本研究旨在通过共表达分子伴侣蛋白以及优化发酵条件来提高III型普鲁兰水解酶(TK-PUL)在短小芽孢杆菌中的分泌表达水平。通过构建共表达TK-PUL和分子伴侣蛋白的多种重组短小芽孢杆菌,并以胞外酶活为指标对其进行筛选,确定最有利于TK-PUL分泌表达的分子伴侣蛋白及对应的重组短小芽孢杆菌。在此基础上采用单因素实验和响应面法优化重组短小芽孢杆菌的发酵条件。结果表明,共表达分子伴侣蛋白PrsA^(Ba)的重组短小芽孢杆菌的胞外酶活达到98.79 U/mL,提高了0.31倍。该重组短小芽孢杆菌的最佳培养基包括19.65 g/L葡萄糖、21.46 g/L酵母提取物、12.01 g/L MgCl_(2)·6H_(2)O、9.02 g/L脯氨酸、0.01 g/L FeSO4·7H_(2)O、0.01 g/L MnSO4·4H_(2)O、0.001 g/L ZnSO4·7H_(2)O。在发酵温度为35℃、起始发酵pH为7.0的条件下,该重组短小芽孢杆菌于最佳培养基中培养66 h时,其胞外酶活达到192.68 U/mL,提高了1.56倍。本研究通过共表达分子伴侣蛋白和发酵优化实现了TK-PUL在短小芽孢杆菌的高效分泌表达,为TK-PUL的应用提供了基础。

关键词： III型普鲁兰水解酶短小芽孢杆菌胞外分子伴侣蛋白发酵优化分泌表达

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