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Development of functional dye with redshifted absorption based on Knoevenagel condensation at 1-site in phenyl[b]-fused BODIPY

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Chinese Chemical Letters 2024年第6期35卷 349-352页

作者： Tianze Wang Junyi Ren Dongxiang Zhang Huan Wang jianjun du Xin-Dong Jiang Guiling Wang Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment Shenyang University of Chemical TechnologyShenyang 110142China Department of Cell Biology China Medical UniversityShenyang 110122China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

Integrating ring-fused modification withπ-conjugated extension is an effective approach for designing,synthesizing,and application for novel borondipyrromethene(BODIPY)*** this work,based on phenyl[b]-fused BODIPY,we made reasonable modification of the methyl group at 1-site to generate dye *** possessed near-infrared region(NIR)absorption and emission properties,and the intramolecular charge transfer(ICT)resulted in low ***,heat energy is evidently released in the presence of light,which can be exploited for intracellular photothermal therapy via the cell apoptosis process,reducing the inflammatory side-effects induced by *** research provides a crucial foundation for the novel molecule via BODIPY multi-directional alteration and its potential application in anti-tumor phototherapy.

关键词： NIR dyes [b]-Fused BODIPY Knoevenagel condensation Photothermal therapy Cell apoptosis

Geohazards Induced by the Lushan Ms7.0 Earthquake in Sichuan Province, Southwest China:Typical Examples, Types and Distributional Characteristics

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Acta Geologica Sinica(English Edition) 2013年第3期87卷 646-657页

作者： ZHANG Yongshuang DONG Shuwen HOU Chuntang GUO Changbao YAO Xin LI Bin du jianjun ZHANG Jiagui Institute of Geomechanics Chinese Academy of Geological Sciences Chinese Academy of Geological Sciences

Geohazards induced by the Lushan Ms 7.0 earthquake on April 20, 2013 mainly have four types： collapse, landslide, slope debris flow, and sand-soil liquefaction. These geohazards mainly occurred near the epicenter, on steep slopes or below cliffs in high mountain and deep valley areas, and at or near fault ends. They have no obvious relationships to active faults, but their relationships to the weathering degree and structures of rock and rock mass are obvious. Compared with the Wenchuan Ms 8.0 earthquake on May 12, 2008, the Lnshan earthquake is relatively little in the impact force and the throwing amount. All of these should be related to the magnitude of this earthquake, not very large but not very little. This character of the Lushan earthquake would make some processes uncompleted so as to bring about some concealed geohazards. Finally, in order to deal with challenges presented by such conceal geohazards, some brief recommendations are put forward.

关键词： Lushan earthquake geohazard collapse landslide slope debris flow sand-soil liquation

Engineering aggregates of julolidine-substituted aza-BODIPY nanoparticles for NIR-II photothermal therapy

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Chinese Chemical Letters 2024年第12期35卷 388-392页

作者： Lulu Cao Yikun Li Dongxiang Zhang Shuai Yue Rong Shang Xin-Dong Jiang jianjun du Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment Shenyang University of Chemical TechnologyShenyang 110142China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Department of Chemistry Graduate School of Advanced Science and EngineeringHiroshima UniversityHigashi-Hiroshima 7398526Japan

Near infrared-II(NIR-II)dyes have unique advantages in biomedical applications owing to the powerful ability in penetrating biological ***,NIR-II aza-BODIPY dye,QLD-BDP,was developed with julolidine at 1,7-sites and p-dimethylaminophenyl group at 3,*** to X-ray analysis,QLD-BDP exhibits significant distortion,and this molecule appears a bowl shaped *** photothermal conversion efficiency of the self-assembled QLD-BDP nanoparticles(QLD-BDP-NPs)can reach 50.5%,with maximum emission at 998 nm by the ***-BDP-NPs can cause the complete destruction of 4T1multicellular spheroids(MCSs),indicating a photothermal therapy(PTT)effect.

关键词： Aggregate NIR-II Julolidine Aza-BODIPY PTT

A Cyanine-based Liposomal Nanophotosensitizer for Enhanced Cancer Chemo-Photodynamic Therapy

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Chemical Research in Chinese Universities 2021年第4期37卷 925-933页

作者： LI Mengqi MA He SHI Chao ZHANG Han LONG Saran SUN Wen du jianjun FAN Jiangli PENG Xiaojun State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116024P.R.China State Key Laboratory of Fine Chemicals Shenzhen Research InstituteDalian University of TechnologyShenzhen518057P.R.China

Currently,chemotherapy is one of the most important treatment modalities for malignant tumors in the clinic,however,it exhibits some shortcomings,such as poor selectivity,limited efficacy and serious adverse ***,synergistic therapy and accurate drug delivery at tumor sites become a promising strategy for achieving tumor ***,a smart NIR fluorescence imaging-guided nanoliposome was fabricated by encapsulating a chemotherapeutic drug(doxorubicin,DOX),liposomes(L)and a near-infrared(NIR)photosensitizer(CY)to form L@CY@DOX,which could realize enhanced therapeutic efficacy of chemo-PDT in cancer therapy(PDT=photodynamic therapy).L@CY@DOX can induce mitochondrial apoptosis and produce severe toxicity at the cellular level,and L@CY@DOX can enrich in the tumor site,which significantly induces tumor *** vitro and in vivo studies demonstrated that L@CY@DOX exhibited great antitumor efficacy compared with each one of these monotherapies,indicating that the combination of chemotherapy and PDT possessed potential development prospects and is anticipated in clinical application.

关键词： Photodynamic therapy Liposome Photosensitizer Cyanine dye Doxorubicin Cancer

Heavy-atom-free orthogonal configurative dye 1,7-di-anthra-aza-BODIPY for singlet oxygen generation

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Chinese Chemical Letters 2024年第10期35卷 291-294页

作者： Yan Zhu Jia Liu Meiheng Lv Tingting Wang Dongxiang Zhang Rong Shang Xin-Dong Jiang jianjun du Guiling Wang Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment Shenyang University of Chemical TechnologyShenyang 110142China Department of Cell Biology China Medical UniversityShenyang 110122China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Department of Chemistry Graduate School of Advanced Science and EngineeringHiroshima UniversityHigashi-Hiroshima 7398526Japan

Spin-orbit,charge-transfer intersystem crossing(SOCT-ISC)can directly overcome the disadvantages of the traditional heavy-atom effect and improve the generation efficiency of reactive oxygen species(ROS).Since orthogonal molecular orbitals of donor-acceptor(D-A)pairs favor the SOCT-ISC transition,herein aza-borondipyrromethenes(aza-BODIPYs)with 1,7-di-anthracyl groups(An-azaBDP)was successfully prepared,owing to steric hindrance to produce a big dihedral angle between the two molecular orbital(MO)***,according to density functional theory(DFT)and time-dependent density functional theory(TDDFT),the energy difference between the S1-T1orbitals of An-aza BDP is small and more inclined towards ***-aza BDP can effectively generate singlet oxygen under light ***-aza BDP with light irradiation can induce apoptosis in SW620 cells,and can serve as a potential candidate for the treatment of cancer cells and tumors.

关键词： Orthogonal configuration Anthracene Heavy-atom-free Aza-BODIPY Singlet oxygen

Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy

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Chinese Journal of Chemical Engineering 2024年第8期72卷 19-25页

作者： Yao Pei Ran Wang Xiang Rong Xiang Xia Hexiang Wang Zongwei Zhang Tian Qiu Saran Long jianjun du Jiangli Fan Wen Sun Xiaojun Peng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China

The key factor in photothermal therapy lies in the selection of photothermal *** photothermal agents generally have problems such as poor photothermal stability and low photothermal conversion ***,we have designed and synthesized an isoindigo(IID)*** used isoindigo as the molecular center and introduced common triphenylamine and methoxy groups as *** order to improve the photothermal stability and tumor targeting ability,we encapsulated IID into *** a result,the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency(67%)upon 635 nm laser ***,the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges.

关键词： Photothermal therapy Isoindigo Nanoparticles Photoacoustic imaging

Se-sensitized NIR hot band absorption photosensitizer for anti-Stokes excitation deep photodynamic therapy

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Science China Chemistry 2022年第3期65卷 563-573页

作者： Dandan Ma Hui Bian Saran Long Panwang Zhou Ruisong Tian Yingnan Wu Haoying Ge Mingle Li jianjun du Jiangli Fan Yukui Zhang Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shenzhen Research Institute Dalian University of TechnologyShenzhen 518057China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea

Conventional anti-Stokes materials-involved deep photodynamic therapy(dPDT)requires much high-intensity irradiance due to low photosensitization ***,we proposed a"booster effector"approach to construct highly efficient hot band absorption phototherapeutics for low/biosafety power anti-Stokes light-triggered d ***,as"booster effector",was introduced into hot band absorption luminophores(HBAs),which not only significantly facilitated intersystem crossing,but also simultaneously enhanced hot band excitation efficiency atν808,as a result successfully enabling excellent photogenerated singlet oxygen capability of HBAs under ultra-low power anti-Stokes excitation(10 mW cm^(-2)in vitro).As far as we know,such low laser power-initiated photosensitization activity has never been reported in the existing anti-Stokes material ***,FUC-Se ME can self-assemble into uniform nanospheres in water,greatly boosting cellular uptake(>25-fold larger than FUC-Se),and achieve superior cancer-killing effect(808 nm,10 mW cm^(-2),5 min,the half-maximal inhibitory concentration IC50=1.36μM).After further PEGylation with folate-attached polymer,the resultant FUC-Se ME@FA can effectively enrich at the tumor(signal-to-background ratio,10).Under safety irradiation(330 mW cm^(-2)),FUC-Se ME@FA effectively inhibits deep-seated tumor progression(the tumor growth inhibition rate,84%).This work provides a successful paradigm,possibly being more clinically beneficial than conventional anti-Stokes materials.

关键词： anti-Stokes hot band absorption photodynamic therapy deep-seated tumor low power

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Effect of surface finish metallization on interfacial bonding behavior of sintered Ag joints

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China Welding 2022年第1期31卷 60-64页

作者： Yang Fan Wu Weizhen du jianjun Li Mingyu School of Mechanical Engineering and Automation Harbin Institute of Technology ShenzhenShenzhen 518055China Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology ShenzhenShenzhen 518055China

In this work,the sandwich joints were joined by low temperature pressureless sintering Ag *** morphology and thermal behavior of Ag nanoparticle paste was characterized and *** sintered Ag joints with different metallization were prepared and *** joints with Ag metallization exhibited superior shear strength and interface bonding ***,the joints with Cu metallization showed lowest shear strength and interface *** interfacial microstructures were observed and the diffusion kinetics between Ag and Au atoms were both *** excessive diffusion of Ag atoms towards the Au layer deteriorated the interface bonding ratio and shear *** work will help understand the bonding mechanism between sintered Ag and other metallization.

关键词： Sintered Ag interface Au metallization Cu oxidation

Co-seismic Faults and Geological Hazards and Incidence of Active Fault of Wenchuan Ms 8.0 Earthquake,Sichuan,China

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Acta Geologica Sinica(English Edition) 2009年第4期83卷 713-723页

作者： MA Yinsheng LONG Changxing TAN Chengxuan WANG Tao GONG Mingquan LIAO Chunting WU Manlu SHI Wei du jianjun PAN Feng Key Laboratory of Neotectonic Movement and Geohazard Ministry of Land and Resources Beijing 100081 Institute of Geomechanics Chinese Academy of Geological Sciences Beijing 100081 China University of Geosciences （Beijing） Beijing 100083

There are two co-seismic faults which developed when the Wenchuan earthquake happened. One occurred along the active fault zone in the central Longmen Mts. and the other in the front of Longmen Mts. The length of which is more than 270 kin and about 80 km respectively. The co-seismic fault shows a reverse flexure belt with strike of N45°-60°E in the ground, which caused uplift at its northwest side and subsidence at the southeast. The fault face dips to the northwest with a dip angle ranging from 50° to 60°. The vertical offset of the co-seismic fault ranges 2.5-3.0 m along the Yingxiu- Beichuan co-seismic fault, and 1.5-1.1 m along the Doujiangyan-Hanwang fault. Movement of the coseismic fault presents obvious segmented features along the active fault zone in central Longmen Mts. For instance, in the section from Yingxiu to Leigu town, thrust without evident slip occurred; while from Beichuan to Qingchuan, thrust and dextral strike-slip take place. Main movement along the front Longmen Mts. shows thrust without slip and segmented features. The area of earthquake intensity more than IX degree and the distribution of secondary geological hazards occurred along the hanging wall of co-seismic faults, and were consistent with the area of aftershock, and its width is less than 40km from co-seismic faults in the hanging wall. The secondary geological hazards, collapses, landslides, debris flows et al., concentrated in the hanging wall of co-seismic fault within 0-20 km from co-seismic fault.

关键词： Wenchuan earthquake co-seismic fault geological hazards