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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu Wen Sun jianjun du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

Effects of different nozzle materials on atomization results via CFD simulation

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Chinese Journal of Chemical Engineering 2020年第2期28卷 362-368页

作者： Xiangyu Li jianjun du Licheng Wang Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology2 Linggong RoadDalian 116024China Research Institute of Dalian University of Technology in Shenzhen Gaoxin South fourth RoadNanshan DistrictShenzhen 518057China Dalian FISTA Specialized Chemistry Co.Ltd. 131 Guangxian RoadDalian 116023China

Spray drying,as a crucial operation in industrial production,converts solution to fine *** spray moiety directly affects the final particle morphology,size and *** with the experimental method,computational fluid dynamics(CFD)modeling is a powerful and convenient tool for simulating the spray *** on the verified CFD model,different materials of atomizer were simulated to investigate the effect on droplet size and distribution in this *** modeling result proved that the droplet size and distribution were influenced by the resistance coefficient of materials,wherein the Reynolds number could change the effect of roughness along with the change of mass flow rate on spray *** results in this work have implication for controlling droplet size through developing new spray nozzle with different materials or surface coating.

关键词： CFD modeling Spray process Atomizer materials Droplet size Size distribution

Late Quaternary Activity of the Huashan Piedmont Fault and Associated Hazards in the Southeastern Weihe Graben,Central China

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Acta Geologica Sinica(English Edition) 2017年第1期91卷 76-92页

作者： du jianjun LI dunpeng WANG Yufang MA Yinsheng Institute of Geomechanics Chinese Academy of Geological Sciences Beijing 100081 China Key Laboratory of Neotectonic Movement and Geohazard Ministry of Land and Resources Beijing 100081 China College of Zijin Mining Fuzhou University Fuzhou 350108 China Center of Oil and Gas Resources Survey China Geological Survey Beijing 100029 China

The Weihe Graben is not only an important Cenozoic fault basin in China but also a significant active seismic zone. The Huashan piedmont fault is an important active fault on the southeast side of the Weihe Graben and has been highly active since the Cenozoic. The well–known Great Huaxian County Earthquake of 1556 occurred on the Huashan piedmont fault. This earthquake, which claimed the lives of approximately 830000 people, is one of the few large earthquakes known to have occurred on a high–angle normal fault. The Huashan piedmont fault is a typical active normal fault that can be used to study tectonic activity and the associated hazards. In this study, the types and characteristics of late Quaternary deformation along this fault are discussed from geological investigations, historical research and comprehensive analysis. On the basis of its characteristics and activity, the fault can be divided into three sections, namely eastern, central and western. The eastern and western sections display normal slip. Intense deformation has occurred along the two sections during the Quaternary; however, no deformation has occurred during the Holocene. The central section has experienced significant high–angle normal fault activity during the Quaternary, including the Holocene. Holocene alluvial fans and loess cut by the fault have been identified at the mouths of many stream valleys of the Huashan Mountains along the central section of the Huashan piedmont fault zone. Of the three sections of the Huashan piedmont fault, the central section is the most active and was very active during the late Quaternary. The rate of normal dip–slip was 1.67–2.71±0.11 mm/a in the Holocene and 0.61±0.15 mm/a during the Mid–Late Pleistocene. As is typical of normal faults, the late Quaternary activity of the Huashan piedmont fault has produced a set of disasters, which include frequent earthquakes, collapses, landslides, mudslides and ground fissures. Ground fissures mainly occur on the hangin

关键词： Weihe Graben Huashan piedmont fault late Quaternary fault–related hazards normal fault

Detection and Identification of Tassel States at Different Maize Tasseling Stages Using UAV Imagery and Deep Learning

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Plant Phenomics 2024年第3期6卷 563-578页

作者： jianjun du Jinrui Li Jiangchuan Fan Shenghao Gu Xinyu Guo Chunjiang Zhao Information Technology Research Center Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China Beijing Key Lab of Digital Plants National Engineering Research Center for Information Technology in AgricultureBeijing 100097China College of Information Engineering Northwest A&F UniversityYanglingShanxi 712100 China

The tassel state in maize hybridization fields not only reflects the growth stage of the maize but also reflects the performance of the detasseling *** tassel detection models are primarily used to identify mature tassels with obvious features,making it difficult to accurately identify small tassels or detasseled *** study presents a novel approach that utilizes unmanned aerial vehicles(UAVs)and deep learning techniques to accurately identify and assess tassel states,before and after manually detasseling in maize hybridization *** proposed method suggests that a specific tassel annotation and data augmentation strategy is valuable for substantial enhancing the quality of the tassel training *** study also evaluates mainstream object detection models and proposes a series of highly accurate tassel detection models based on tassel categories with strong data *** addition,a strategy for blocking large UAV images,as well as improving tassel detection accuracy,is proposed to balance UAV image acquisition and computational *** experimental results demonstrate that the proposed method can accurately identify and classify tassels at various stages of *** tassel detection model optimized with the enhanced data achieves an average precision of 94.5%across all *** optimal model combination that uses blocking strategies for different development stages can improve the tassel detection accuracy to 98%.This could be useful in addressing the issue of missed tassel detections in maize hybridization *** data annotation strategy and image blocking strategy may also have broad applications in object detection and recognition in other agricultural scenarios.

关键词： identification different learning imagery detection deep maize stages states tasseling

NIR photosensitizers activated byγ-glutamyl transpeptidase for precise tumor fluorescence imaging and photodynamic therapy

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Science China Chemistry 2021年第5期64卷 808-816页

作者： Yingchao Chen Xueze Zhao Tao Xiong jianjun du Wen Sun Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China

Photodynamic therapy(PDT),a light triggered therapeutic mode,has been recognized as an attractive treatment for *** phototoxicity to normal tissues during treatment limited the development of PDT owing to the always“on”properties of *** photosensitizers are of great importance for improving the selectivity of ***,we regarded the overexpressed GGT(γ-Glutamyl transpeptidase)enzyme in tumor cells as a biomarker and developed an activatable photosensitizer Cy-GGT by decorating a specific recognition moiety of GGT,L-glutamic acid,to a hemicyanine dye based on photosensitizer Cy-NH_(2).Cy-GGT was in the“off”state with negligible fluorescence and suppressed singlet oxygen generation,but it could be specifically hydrolyzed to Cy-NH_(2) in the presence of GGT,accompanied with significant fluorescence recovery and singlet oxygen generation increase under light *** in vitro and in vivo studies indicated that Cy-GGT was suitable for precise tumor imaging and could work as an efficient photosensitizer for inhibiting tumor growth.

关键词： photodynamic therapy γ-glutamyl transpeptidase activatable fluorescence imaging

A ɑ-KA fluorescent probe for discrimination of blood cancer serum

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Chinese Chemical Letters 2017年第10期28卷 1991-1993页

作者： Yao Kang Jiangli Fan Qiang Jin Chenhui Shi jianjun du Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University

a-Ketoglutaric acid（a-KA） is an important metabolic intermediate in tricarboxylic acid circle in our *** mutations of isocitrate dehydrogenase-1（IDH1） and isocitrate dehydrogenase-2（IDH2）, however,will lead to the transformation of a-KA into 2-hydroxyglutarate（2-HG）, which is confirmed to closely related to actue myeloid leukemia（AML）. Therefore it is of great significance to detect a-KA level changes in serum. In this paper, a fluorescent ＂off-on＂ probe CH for a-KA was designed based on naphthalimide fluorophore by introducing a hydrazine group for a-KA recognition and a long alkyl amino chain to enhance PET efficiency and water solubility. Cetyltrimethyl ammonium bromide（CTAB） was added toform self-assembly micelles for accelerating the recognition process. CH shows a 28-fold fluorescence enhancement（（I - I_0）/I_0 at 550 nm） over other biological species by optimizing the chemical recognition process of CH with a-KA. Significantly, CH was successfully applied for thefluorescence discrimination of all kinds of blood cancer serum samples. This work would provide a potential method that is quick and convenient for sensing a-KA and may promote fluorescence detection in clinical diagnosis.

关键词： Biomarker Fluorescent probe a-Ketoglutaricacid Actue myeloid leukemia(AML) Serum detection

Reexamining the Seismological Implications of the Present-day Stress State of the Yingxiu-Beichuan Fault after the Wenchuan Earthquake

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Acta Geologica Sinica(English Edition) 2016年第2期90卷 567-577页

作者： QIN Xianghui CHEN Qunce FENG Chengjun du jianjun WU Manlu MENG Wen SUN Dongsheng Institute of Geomechanics Chinese Academy of Geological Sciences Key Laboratory of Neotectonic Movement and Geohazard Ministry of Land and Resources

The present-day stress state of the Yingxiu-Beichuan fault after the Wenchuan earthquake was re-estimated using measured in-situ stress data obtained after the Wenchuan earthquake. The results reveal that the gradient coefficients of principal stresses versus depth decrease from south to north along the Yingxiu-Beichuan fault, revealing that the stress level decreases from south to north. The consistency between the present-day stress levels and surface ruptures generated during the earthquake indicates that the accumulated tectonic stress beneath the Yingxiu-Beichuan fault before the Wenchuan earthquake was relieved in form of surface ruptures. This resulted in the stress remaining high in the southern section of the Yingxiu-Beichuan fault but relatively low in the northern section. Abnormal high pore pressure conditions and an extremely low frictional coefficient play important role in the interpretation of the stress field adjustment and seismic events observed after the Wenchuan earthquake along this fault, according to the estimation results using the Coulomb frictional-failure theory incorporating frictional coefficients ranging from 0.4 to 1.0. To accurately estimate the seismological hazard of the Yingxiu-Beichuan fault by analyzing fault instability using the Coulomb frictional-failure theory, much attention should be focused on the pore pressure conditions and the evolution state of the frictional coefficient under the present-day stress state.

关键词： stress state fault activity seismological hazard Coulomb frictional-failure theory Yingxiu-Beichuan fault

Protein nanoparticles containing Cu(Ⅱ)and DOX for efficient chemodynamic therapy via self-generation of H_(2)O_(2)

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Chinese Chemical Letters 2020年第12期31卷 3127-3130页

作者： Rui Cao Wen Sun Zheng Zhang Xiaojing Li jianjun du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

Chemodynamic therapy(CDT)refers to generating hydroxyl radical(OH)in tumor sites via hydrogen peroxide(H_(2)O_(2))catalyzed by transition metal ions in cancer cells under acidic ***,H_(2)O_(2) content is not enough for effective CDT,although H2O2 content in cancer cells is higher than that of normal ***,we synthesized DOX@BSA-Cu NPs(nanoparticles)for effective CDT by providing enhanced content of H2O2 in cancer *** results proved Cu^2+ in NPs could be reduced to Cu+by glutathione(GSH)and effectively converted H_(2)O_(2) to ***,the loaded low-dose doxorubicin(DOX)in the NPs could improve the content of H2O2 and resulted in more efficient generation of OH in cancer *** DOX@BSA-Cu NPs exhibited higher cytotoxicity to cancer *** research may provide new ideas for the further studies on more effective Cu(Ⅱ)-based CDT nanoagents.

关键词： Chemodyamic therapy Doxorubicin Hydrogen peroxide Fenton-like reaction Hydroxyl radical

Hydrogen peroxide-activatable iodoBodipy-phthalhydrazid conjugate nanoparticles for cancer therapy

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Nano Research 2023年第10期16卷 12294-12303页

作者： Haijun Ning Yuxin Yang Chengyuan Lv Danhong Zhou Saran Long Wen Sun jianjun du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China

The dependence on outer light source strongly hinders clinical applications of photodynamic therapy(PDT)to the deep-seated ***,the majority of documented PDT systems that function without the external light source rely on either the chemiluminescence resonance energy transfer(CRET)or fluorescence resonance energy transfer(FRET)mechanism,which decreases the energy transfer efficiency and reproducibility of ***,we developed a novel single-molecule triplet photosensitizer(iodoBodipy(IBDP)-L)that can be chemiexcited to triplet excited state to generate reactive oxygen species instead of outer light *** direct bonding of phthalhydrazid moiety to iodoBodipy fluorophore evoked valid intramolecular energy transfer(IET),and once phthalhydrazid part is activated by hydrogen peroxide,the released reaction energy could excite the iodoBodipy-phthalhydrazid conjugate as a *** product IBDP-L-COOH showed high triplet state quantum yield(ΦT=65%)and large spin-orbit coupling.A large amount of reactive oxygen species(ROS)was produced in MCF-7 cells,thus inhibiting the cell growth both in vitro and in vivo after IBDP-L was formulated into nanoparticles(NPs)via *** believe that the synthesized IodoBodipy-phthalhydrazid conjugate based on the IET mechanism will open a new door in the molecular design of efficient triplet photosensitizers for treating deeply seated tumors in the future.

关键词： luminol chemiexcited triplet photosensitizer cancer therapy intramolecular energy transfer(IET)mechanism

A deep learning-integrated phenotyping pipeline for vascular bundle phenotypes and its application in evaluating sap flow in the maize stem

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The Crop Journal 2022年第5期10卷 1424-1434页

作者： jianjun du Ying Zhang Xianju Lu Minggang Zhang Jinglu Wang Shengjin Liao Xinyu Guo Chunjiang Zhao Beijing Key Lab of Digital Plant Research Center of Information TechnologyBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Plant vascular bundles are responsible for water and material transportation, and their quantitative and functional evaluation is desirable in plant research. At the single-plant level, the number, size, and distribution of vascular bundles vary widely, posing a challenge to automatically and accurately identifying and quantifying them. In this study, a deep learning-integrated phenotyping pipeline was developed to robustly and accurately detect vascular bundles in Computed Tomography(CT) images of stem internodes. Two semantic indicators were used to evaluate and identify a suitable feature extraction network for semantic segmentation models. The epidermis thickness of maize stem was evaluated for the first time and adjacent vascular bundles were improved using an adaptive watershed-based approach. The counting accuracy(R^(2)) of vascular bundles was 0.997 for all types of stem internodes, and the measured accuracy of size traits was over 0.98. Combining sap flow experiments, multiscale traits of vascular bundles were evaluated at the single-plant level, which provided an insight into the water use efficiency of the maize plant.

关键词： Deep learning Maize stem Phenotyping Semantic segmentation Vascular bundle