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Associations of multiple metals exposure with immunoglobulin levels in pregnant women:Hangzhou Birth Cohort Study

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Journal of Environmental Sciences 2025年第5期151卷 560-572页

作者： Jiena Zhou Lanfei Jin Yexinyi Zhou Kunhong Zhong Kegui Huang Qi Zhang Jun Tang Xue Zhang Lihe Peng Shuai Li Na lv Dongdong Yu Qinheng Zhu Jing Guo Qiong Luo Guangdi Chen Department of Public Health and Key Laboratory of Reproductive Genetics(Ministry of Education)Women’s HospitalZhejiang University School of MedicineHangzhou 310058China Department of Clinical Laboratory Shaw HospitalZhejiang University School of MedicineHangzhou 310018China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China Jiashan County Center for Disease Control and Prevention JiashanZhejiang 314199China Department of Clinical Laboratory Women’s HospitalZhejiang University School of MedicineHangzhou 310020China Department of Obstetrics Women’s HospitalZhejiang University School of MedicineHangzhou 310020China

Metal may affect maternal immune function,but few epidemiological studies have reported the associations between multiple-metal exposure and maternal immunoglobulin(Ig)*** on the Hangzhou Birth Cohort Study,1059 participants were included,and eleven metals in whole blood samples and serum IgA,IgG,IgE and IgM levels were *** regression,quantile-based g-computation(QGC),and Bayesian kernel machine regression(BKMR)models were used to evaluate the *** with the first tertile of metal levels,arsenic(As)was negatively associated with IgE(β=-0.25,95%confidence interval(CI)=-0.48 to-0.02).Moreover,significant associations of manganese(Mn)with IgA,IgG and IgM were demonstrated(β=0.10,95%CI=0.04 to 0.18;β=0.07,95%CI=0.03 to 0.12;β=0.10,95%CI=0.03 to 0.18,respectively).Cadmium(Cd)were associated with higher levels of *** models showed the positive association of the metalmixtures with IgA and IgG,with Mn playing amajor *** and Cd had positive contributions to IgM,while As had negative contributions to *** the BKMR models,the latent continuous outcomes of IgA and IgG showed a significant increase when all the metals were at their 60th percentile or above compared to those at their 50th ***,exposure to metals was associated with maternal Igs,and mainly showed that Mn was associated with increased levels of IgA,IgG and IgM,and As was associated with low IgE levels.

关键词： Metals Immunoglobulin Pregnant woman Quantile-based g-computation (QGC) Bayesian kernel machine regression (BKMR)

Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway,as determined by network pharmacology

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 221-236页

作者： Zhuo-Cong Bao Ye Zhang Zhao-Dong Liu Hui-Jun Dai Fu Ren Ning Li Shang-Yu lv Yan Zhang Graduate School Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Clinical Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina International Education School International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a malignant disease with high incidence and mortality *** study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocurcumin(THC)on HCC and its mechanism of *** research hypothesis is that THC can inhibit the proliferation,migration,and invasion of HCC cells,and promote their apoptosis by regulating the TP53 target *** To explore the mechanism by which THC inhibits HCC cell proliferation via the TP53 signaling *** Potential targets of THC and HCC were identified from multiple *** core targets were subjected to analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,and visualization processing,using the online platform Metascape to identify the key molecules and signaling pathways involved in the action of THC against *** molecular mechanisms of action of THC against TP53 in the inhibition of HCC cells were verified using cell counting kit-8,Transwell,apoptosis,and western blotting *** Molecular docking results showed that THC had a high score for the TP53 target *** vitro experiments indicated that THC effectively inhibited the proliferation and migration of HCC cells,and affected the expression levels of TP53,MDM2,cyclin B,Bax,Bcl-2,caspase-9,and *** THC induces the apoptosis of HCC cells through the TP53 signaling pathway,thereby inhibiting their proliferation and migration.

关键词： Hepatocellular carcinoma cells Tetrahydrocurcumin TP53 Network pharmacology Molecular docking

NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

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Chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu Intensive Care Unit The Second Affiliated Hospital of Guangxi Medical University Department of Critical Care Medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences Institute Guangxi Medical University Department of Emergency The First Affiliated Hospital of Guangxi Medical University College & Hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging

Swensen模型在肺结节临床诊断中的应用研究(附115例报告)

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东南大学学报（医学版） 2019年第3期38卷 424-427页

作者：庞勃吕剑剑葛孝忠陈业庭朱青松陆小河马鞍山市人民医院胸心外科

目的:应用Swensen模型对肺结节进行良恶性分析。方法:回顾分析115例肺结节患者124个肺结节包括48个良性结节、76个恶性结节的资料,比较良恶性结节影像学征像的区别及Swensen系数在两者间的差异。结果:良性结节中形态不规则25例,分叶15例... 详细信息

目的:应用Swensen模型对肺结节进行良恶性分析。方法:回顾分析115例肺结节患者124个肺结节包括48个良性结节、76个恶性结节的资料,比较良恶性结节影像学征像的区别及Swensen系数在两者间的差异。结果:良性结节中形态不规则25例,分叶15例,有毛刺27例,胸膜牵拉征15例,血管集束征12例;恶性结节中形态不规则62例,分叶60例,有毛刺47例,胸膜牵拉征44例,血管集束征67例。在0~10、11~20、21~30mm的结节中,Swensen系数良性结节分别为0.0823±0.0622、0.2627±0.1733、0.6862±0.1881,恶性结节分别为0.1338±0.1288、0.3999±0.1629、0.5269±0.2269。结论:良恶性结节影像学表现在形态、分叶、胸膜牵拉征与血管集束征上都有明显的差异,但结节所在肺叶的位置及毛刺征表现无明显差异;Swensen系数在0.3~0.6区间时,良恶性结节的区分度较高。

关键词：肺结节 Swensen模型诊断

A Diffusion Model for Traffic Data Imputation

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IEEE/CAA Journal of Automatica Sinica 2025年第3期12卷 606-617页

作者： Bo Lu Qinghai Miao Yahui Liu Tariku Sinshaw Tamir Hongxia Zhao Xiqiao Zhang Yisheng lv Fei-Yue Wang the School of Artificial Intelligence University of Chinese Academy of Sciences Baidu Inc. IEEE the State Key Laboratory for Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences Meituan Guangdong University of Technology the Department of Transportation Engineering School of Transportation Science and Technology Harbin Institute of Technology

Imputation of missing data has long been an important topic and an essential application for intelligent transportation systems(ITS) in the real world. As a state-of-the-art generative model, the diffusion model has proven highly successful in image generation, speech generation, time series modelling *** now opens a new avenue for traffic data imputation. In this paper, we propose a conditional diffusion model, called the implicit-explicit diffusion model, for traffic data imputation. This model exploits both the implicit and explicit feature of the data simultaneously. More specifically, we design two types of feature extraction modules, one to capture the implicit dependencies hidden in the raw data at multiple time scales and the other to obtain the long-term temporal dependencies of the time series. This approach not only inherits the advantages of the diffusion model for estimating missing data, but also takes into account the multiscale correlation inherent in traffic data. To illustrate the performance of the model, extensive experiments are conducted on three real-world time series datasets using different missing *** experimental results demonstrate that the model improves imputation accuracy and generalization capability.

关键词： Data imputation diffusion model implicit feature time series traffic data

Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

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Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng Chen Yahui Wang Yi Liu Zhigang Li Xiangyin lv Liping Liu Yajing Chang Jiaming Shi Xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2C/C microspheres with controllable composition by coupling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2C/C microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2C/C microwave absorption hollow structure

Advances in purification technologies and applications of high-purity quartz resources

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Progress in Natural Science:Materials International 2025年第01期 51-64页

作者： Min Liu Guifang Wang Fanyue Zhao Wenfeng Li Gan Zhu Guangchuan Liang Wei Jian Libing Liao Guocheng lv School of Earth Sciences and Resources China University of Geosciences Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral Materials School of Materials Science and Technology China University of Geosciences School of Chemistry and Chemical Engineering Guangxi University

Quartz is a critical non-metallic mineral resource, with high-purity quartz sand playing a pivotal role in advanced industries such as semiconductors, solar energy, electric light sources, and special glass. In particular, 4N8-grade quartz sand(99.998 % purity and above) is indispensable for producing quartz crucibles, which are essential for semiconductors and solar energy applications. However, the global supply of high-quality quartz raw materials is limited, posing a challenge to meet the growing industrial demand. Furthermore, different industrial products utilize varying physicochemical properties of quartz, leading to distinct requirements for quartz raw materials and purification processes. Herein, this paper presents a comprehensive review of high-purity quartz, focusing on purification technologies and their applications. The principles, process flows, advantages and disadvantages of various purification methods are examined, with particular emphasis on chemical and physical purification techniques. The effectiveness of these methods in achieving higher purity levels and reducing impurities is critically analyzed. Furthermore, future trends in purification technologies and their potential impact on the highpurity quartz industry are discussed, offering insights for future research and applications in this field.

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混合式教学中学生线上学习满意度影响因素研究

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江苏高教 2025年第2期 78-85页

作者：高飞吕吉江苏省习近平新时代中国特色社会主义思想研究中心南京航空航天大学基地南京210016 南京特殊教育师范学院学生工作处南京210038 南京特殊教育师范学院教育科学学院南京210038

为了探讨混合式教学中学生线上学习满意度影响因素,研究构建了一个包含教师支持、互动交流、系统功能、内容特征以及自我效能感等多个维度的线上学习满意度模型,并采用结构方程模型进行假设检验。研究结果表明,教师支持和互动交流对线... 详细信息

为了探讨混合式教学中学生线上学习满意度影响因素,研究构建了一个包含教师支持、互动交流、系统功能、内容特征以及自我效能感等多个维度的线上学习满意度模型,并采用结构方程模型进行假设检验。研究结果表明,教师支持和互动交流对线上学习满意度有显著影响,而系统功能和内容特征的影响相对较小。此外,绩效期望和自我效能感对线上学习满意度也有重要影响。根据研究结果,提出了一些建议,包括提升学生的绩效期望、提高线上学习的自我效能感、加强师生互动与交流、提供激励和支持措施等,以提高混合式教学的线上学习效果。

关键词：混合式教学线上学习满意度影响因素教师支持互动交流

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走马楼三国吴简的书写生态及其书史意义

中国高校社会科学 2025年第1期 62-72,M0004页

作者：吕文明山东师范大学齐鲁文化研究院济南250014

走马楼吴简的书写者多是下层书吏,因为书写内容的特殊性,形成了以新隶体和早期楷书为主的书写形态。走马楼吴简代表了一个书写时代的结束,随着简牍官府文书簿籍逐渐被纸张书写取代,日常生活中对于纸张的使用成为一种趋势。走马楼吴简主... 详细信息

走马楼吴简的书写者多是下层书吏,因为书写内容的特殊性,形成了以新隶体和早期楷书为主的书写形态。走马楼吴简代表了一个书写时代的结束,随着简牍官府文书簿籍逐渐被纸张书写取代,日常生活中对于纸张的使用成为一种趋势。走马楼吴简主要字体是处于过渡状态的新隶体,一般先从民间兴起,文人士大夫受到影响后,开始在日常书写中使用并对其加以改造。经过改造的新字体得到上层社会认可之后,因为其使用的快捷、方便,迅速风行全国,继而对民间书写产生影响。走马楼吴简的书迹与传世书法作品相对照,可彰显三国时期文字发展演变的重要意义。

关键词：新隶体楷化谷朗碑黄朝名刺