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Efficient hydrogenolysis of fructose to 1,2-propanediol over bifunctional Ru-WO_(x)-MgO_(y) catalysts under mild reaction conditions via enhancing the chemoselective cleavage of C-C bonds

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Journal of Energy Chemistry 2024年第5期92卷 311-321页

作者： Shuang Luo Tie Shu Min Mao Haijie Yu Yuxin Zheng Daqian Ding Lingmei liu Kexin Yao jianjian Wang School of Chemistry and Chemical Engineering State Key Laboratory of Coal Mine Disaster Dynamics and ControlInstitute of Advanced Interdisciplinary StudiesMulti-scale Porous Materials CenterChongqing UniversityChongqing 401331China Key Laboratory for Efficient Conversion and Circular Economy of Coal Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina

Selective conversion of fructose to 1,2-propanediol(1,2-PDO)is considered as a sustainable and cost-effective alternative to petroleum-based processes,however,this approach still faces challenges associated with low efficiency and harsh reaction conditions.Here,we have successfully synthesized a novel bifunctional Ru-WO_(x)-MgO_(y) catalyst through a facile'one-pot'solvothermal method.Remarkably,this catalyst exhibits exceptional catalytic performances in the conversion of fructose to 1,2-PDO under mild reaction conditions.The yield of 1,2-PDO is up to 56.2%at 140°C for 4 h under an ultra-low hydrogen pressure of only 0.2 MPa,surpassing the reported results in recent literature(below 51%).Comprehensive characterizations and density functional theory(DFT)calculations reveal that the presence of oxygen vacancies in the Ru-WO_(x)-MgO_(y) catalyst,serving as active acidic sites,facilitates the chemoselective cleavage of C-C bonds in fructose,which leads to the generation of active intermediates and ultimately resulted in the high yield of 1,2-PDO.

关键词： Biomass Fructose 1,2-Propanediol Retroaldol condensation Heterogenous catalysis

Numerical Study of Heat Transfer Enhancement in the Electric Vehicle Battery via Vortex‑Induced Agitator

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Automotive Innovation 2023年第2期6卷 244-255页

作者： Yubo Lian Yinsheng Liao jianjian liu Zhiming Hu Haolun Xu BYD Auto Industry Company Limited 518118 ShenzhenChina

Convective heat transfer plays an important role in the development of a high-performance battery cell.Electric vehicles carry a large amount of the battery cells to reach a longer range of endurance mileage.Thermal diffusion around the battery cells can be considered as obstacles to improve the convective heat transfer coefficient.In this paper,a novel agitator taking advantage of strong vortices is designed to disrupt the thermal boundary layer around the battery cells,thereby improving the fluid mixing for enhanced convective heat transfer.A fluid–structure interaction algorithm is developed to simulate the convective heat transfer rate at various flapping motion.Under the comparison with clean channel,the vortex-induced vibra-tion by the agitated beam can increase the average Nusselt number by 119.59%.This research can be applied to optimize the thermal-structure design inside the electric vehicle battery.

关键词： Electric vehicle battery Thermal management Fluid–structure interaction Air cooling

Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 100-115页

作者： jianjian Chu Weicong Zhang Yan liu Baofeng Gong Wenbo Ji Tong Yin Chao Gao Danqi Liangwen Mengqi Hao Cuimin Chen Jianhua Zhuang Jie Gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease progression.Therefo re,there is an urgent need for new effective drugs.The underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease treatment.Inhibiting inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's disease.This review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's disease.The review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the brain.Lysosomes,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular homeostasis.Some studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s disease.Restoring the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s disease.Currently,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and targeting.Recently,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical properties.This review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s disease.This review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal function.In conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s disease.The application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023 edition)

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Chinese Herbal Medicines 2024年第1期16卷 3-12页

作者： Qing Zhao Tong Wang Hongbin Wang Peng Cao Chengyu Jiang Hongzhi Qiao Lihua Peng Xingdong Lin Yunyao Jiang Honglei Jin Huantian Zhang Shengpeng Wang Yang Wang Ying Wang Xi Chen Junbing Fan Bo Li Geng Li Bifeng liu Zhiyang Li Suhua Qi Mingzhen Zhang jianjian Zheng Jiuyao Zhou Lei Zheng Kewei Zhao Guangdong Engineering Research Center of Chinese Herbal Vesicles The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Institute of Life and Health Engineering the First Affiliated HospitalJinan UniversityGuangzhou 510630China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China College of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China Institute of Basic Medicine Chinese Academy of Medical SciencesBeijing 100005China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310030China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Department of Bone and Joint Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510630China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAomen 999078China Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233China School of Basic Medical Sciences Southern Medical UniversityGuangzhou 510515China School of Life Sciences Nanjing UniversityNanjing 210008China Nanfang Hospital Southern Medical UniversityGuangzhou 510515China Laboratory Animal Center Guangzhou University of Chinese MedicineGuangzhou 510405China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital Nanjing 210008China School of Medical and Technology Xuzhou Medical UniversityXuzhou 221004China School of Basic Medical Sciences Xi’an Jiaotong UniversityXi’an 710065China The First Affiliated Hospital of Wenzhou Medical University WenZhou 325035China

To promote the development of extracellular vesicles of herbal medicine especially the establishment of standardization,led by the National Expert Committee on Research and Application of Chinese Herbal Vesicles,research experts in the field of herbal medicine and extracellular vesicles were invited nationwide with the support of the Expert Committee on Research and Application of Chinese Herbal Vesicles,Professional Committee on Extracellular Vesicle Research and Application,Chinese Society of Research Hospitals and the Guangdong Engineering Research Center of Chinese Herbal Vesicles.Based on the collation of relevant literature,we have adopted the Delphi method,the consensus meeting method combined with the nominal group method to form a discussion draft of“Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023)”.The first draft was discussed in online and offline meetings on October 12,14,November 2,2022 and April and May 2023 on the current status of research,nomenclature,isolation methods,quality standards and research applications of extracellular vesicles of Chinese herbal medicines,and 13 consensus opinions were finally formed.At the Third Academic Conference on Research and Application of Chinese Herbal Vesicles,held on May 26,2023,Kewei Zhao,convenor of the consensus,presented and read the consensus to the experts of the Expert Committee on Research and Application of Chinese Herbal Vesicles.The consensus highlights the characteristics and advantages of Chinese medicine,inherits the essence,and keeps the righteousness and innovation,aiming to provide a reference for colleagues engaged in research and application of Chinese herbal vesicles at home and abroad,decode the mystery behind Chinese herbal vesicles together,establish a safe,effective and controllable accurate Chinese herbal vesicle prevention and treatment system,and build a bridge for Chinese medicine to the world.

关键词： Chinese herbal medicine extracellular vesicles research application consensus

锥头航行体高速斜入水的空泡流动特性数值研究

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中国造船 2024年第1期65卷 63-74页

作者：舒亮辛建建冯涛刘翔宇桂琴琴宁波大学船舶与海洋工程系宁波315211

数值研究弹体高速斜入水过程,考察空泡、流体动力特性和运动稳定性的变化规律。数值模型采用基于Realizable k-ε湍流模型的雷诺平均方法(RANS),并与模型试验结果进行对比,验证了该数值模型的精度。基于该方法模拟不同倾角下锥头弹体高... 详细信息

数值研究弹体高速斜入水过程,考察空泡、流体动力特性和运动稳定性的变化规律。数值模型采用基于Realizable k-ε湍流模型的雷诺平均方法(RANS),并与模型试验结果进行对比,验证了该数值模型的精度。基于该方法模拟不同倾角下锥头弹体高速斜入水过程,考察弹体入水从初始撞击、开空泡的形成与发展、颈缩、表面闭合和溃灭等多个阶段。研究表明:空泡表面闭合时间随倾角的增大而提前;在撞击水面瞬间,弹体表面承受巨大砰击载荷,在弹头形成局部高压,其峰值随倾角的增大而增大。随着入水倾角增大,弹体偏转角和横向位移减小,具有更好的弹道稳定性。

关键词：锥头弹体高速入水空泡流斜倾角数值模拟

免疫检查点抑制剂在合并自身免疫性疾病肿瘤患者中的应用进展

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肿瘤研究与临床 2024年第4期36卷 317-320页

作者：刘洋吕建建李绪彤康复大学青岛医院(青岛市市立医院)肿瘤科青岛266071

免疫检查点抑制剂在肿瘤治疗中发挥着越来越重要的作用, 不断改写肿瘤治疗指南。免疫检查点抑制合并自身免疫性疾病的特殊人群中的应用目前尚缺乏明确且统一的治疗建议。文章对免疫检查点抑制剂在合并自身免疫性疾病患者抗肿瘤治疗中的... 详细信息

免疫检查点抑制剂在肿瘤治疗中发挥着越来越重要的作用, 不断改写肿瘤治疗指南。免疫检查点抑制合并自身免疫性疾病的特殊人群中的应用目前尚缺乏明确且统一的治疗建议。文章对免疫检查点抑制剂在合并自身免疫性疾病患者抗肿瘤治疗中的安全性和有效性进行分析及总结, 为临床医生制定治疗决策提供参考。

关键词：肿瘤免疫检查点抑制剂免疫系统疾病药物相关的副作用和不良反应

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基于布里渊散射光时域分析的形状传感研究

光子学报 2024年第4期53卷 95-103页

作者：刘紫娟武佳琪张立欣李永倩王健健王宽华北电力大学(保定)电子与通信工程学院保定071003 华北电力大学(保定)电子与通信工程学院河北省电力物联网技术重点实验室保定071003 华北电力大学(保定)电子与通信工程学院保定市光纤传感与光通信技术重点实验室保定071003

搭建了基于布里渊散射光时域分析技术的应变测量系统,采用七芯光纤作为分布式形状传感器,通过测量七个纤芯在弯曲时的布里渊散射谱,验证了七芯光纤偏芯之间每两个对称芯所受应变值相等且互为相反数的特点。对比七芯光纤中间芯与偏芯的... 详细信息

搭建了基于布里渊散射光时域分析技术的应变测量系统,采用七芯光纤作为分布式形状传感器,通过测量七个纤芯在弯曲时的布里渊散射谱,验证了七芯光纤偏芯之间每两个对称芯所受应变值相等且互为相反数的特点。对比七芯光纤中间芯与偏芯的布里渊增益谱,测得偏芯在不同弯曲半径下的布里渊频移变化,得到偏芯在每个位置受到的应变值。利用并行传输标架形状重构算法对七芯光纤在曲率直径为0.112 m和0.052 m时的形状进行了重构,当曲率直径为0.112 m时,曲率重构误差为0.375%。

关键词：形状传感布里渊散射光时域分析七芯光纤并行传输标架

SCF泛素连接酶的体外泛素化体系构建与检测

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华中农业大学学报 2024年第2期43卷 273-279页

作者：胡健健梅文聪张文慧刘主作物遗传改良全国重点实验室/湖北洪山实验室/华中农业大学生命科学技术学院武汉430070

为研究蛋白质的体外泛素化过程,利用大肠杆菌表达系统异源表达和纯化APPBP1/UBA3(E1)、UBC12(E2)、Cullin1-Rbx1(E3)和Nedd8(neural precursor cell expressed developmentally down-regulated protein 8)蛋白,制备FITC-Cysteine绿色荧光素标记的泛素Ub(Ubiquitin),构建了SCF泛素连接酶的体外泛素化体系,同时实现快速检测SCF泛素连接酶中Cullin1蛋白的自泛素化修饰。结果表明,建立的体外SCF E3自泛素化活性反应体系具有较高的可操作性和便利性。

关键词： SCF泛素连接酶泛素化修饰 Cullin1蛋白荧光标记