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爱在记忆消失前:评影片《叫我郑先生》

当代电影 2022年第12期 20-23页

作者：陈箭箭深圳大学艺术学部戏剧影视学院

2022年的中国内地电影市场上映了两部与阿尔兹海默症有关的老年题材电影,它们分别是《妈妈!》以及《叫我郑先生》。前者豆瓣评分为7.5,两位主演分别获得第12届北京国际电影节最佳女主角(吴彦姝)以及第35届“金鸡奖”最佳女主角(奚美娟)... 详细信息

2022年的中国内地电影市场上映了两部与阿尔兹海默症有关的老年题材电影,它们分别是《妈妈!》以及《叫我郑先生》。前者豆瓣评分为7.5,两位主演分别获得第12届北京国际电影节最佳女主角(吴彦姝)以及第35届“金鸡奖”最佳女主角(奚美娟)殊荣。后者豆瓣评分为7.2,主演则是2021年末去世的演员图们。

关键词：最佳女主角北京国际电影节阿尔兹海默症老年题材电影内地电影郑先生奚美娟金鸡奖

Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 744-757页

作者： Lifan Lin Xinmiao Li Yifei Li Zhichao Lang Yeping Li jianjian Zheng Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Department of Urology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China

Liver fibrosis is primarily driven by the activation of hepatic stellate cells(HSCs),a process associated with *** Rb1(GRb1),a major active component extracted from Panax ginseng,inhibits HSC ***,the potential role of GRb1 in mediating HSC ferroptosis remains *** study examined the effect of GRb1 on liver fibrosis both in vivo and in vitro,using CCl4-induced liver fibrosis mouse model and primary HSCs,LX-2 *** findings revealed that GRb1 effectively inactivated HSCs in vitro,reducing alpha-smooth muscle actin(a-SMA)and type I collagen(Col1A1)***,GRb1 significantly alleviated CCl4-induced liver fibrosis in *** a mechanistic standpoint,the ferroptosis pathway appeared to be central to the antifibrotic effects of ***,GRb1 promoted HSC ferroptosis both in vivo and in vitro,characterized by increased glutathione depletion,malondialdehyde production,iron overload,and accumulation of reactive oxygen species(ROS).Intriguingly,GRb1 increased Beclin 1(BECN1)levels and decreased the System Xc-key subunit *** experiments showed that BECN1 silencing inhibited GRb1-induced effects on HSC ferroptosis and mitigated the reduction of SLC7A11 caused by ***,BECN1 could directly interact with SLC7A11,initiating HSC *** conclusion,the suppression of BECN1 counteracted the effects of GRb1 on HSC inactivation both in vivo and in ***,this study highlights the novel role of GRb1 in inducing HSC ferroptosis and promoting HSC inactivation,at least partly through its modulation of BECN1 and SLC7A11.

关键词： Ginsenoside Rb1 Ferroptosis Liver fibrosis Hepatic stellate cells

Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 100-115页

作者： jianjian Chu Weicong Zhang Yan Liu Baofeng Gong Wenbo Ji Tong Yin Chao Gao Danqi Liangwen Mengqi Hao Cuimin chen Jianhua Zhuang Jie Gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease *** re,there is an urgent need for new effective *** underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease *** inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's *** review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's *** review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

Efficient hydrogenolysis of fructose to 1,2-propanediol over bifunctional Ru-WO_(x)-MgO_(y) catalysts under mild reaction conditions via enhancing the chemoselective cleavage of C-C bonds

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Journal of Energy Chemistry 2024年第5期92卷 311-321页

作者： Shuang Luo Tie Shu Min Mao Haijie Yu Yuxin Zheng Daqian Ding Lingmei Liu Kexin Yao jianjian Wang School of Chemistry and Chemical Engineering State Key Laboratory of Coal Mine Disaster Dynamics and ControlInstitute of Advanced Interdisciplinary StudiesMulti-scale Porous Materials CenterChongqing UniversityChongqing 401331China Key Laboratory for Efficient Conversion and Circular Economy of Coal Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina

Selective conversion of fructose to 1,2-propanediol(1,2-PDO)is considered as a sustainable and cost-effective alternative to petroleum-based processes,however,this approach still faces challenges associated with low efficiency and harsh reaction ***,we have successfully synthesized a novel bifunctional Ru-WO_(x)-MgO_(y) catalyst through a facile'one-pot'solvothermal ***,this catalyst exhibits exceptional catalytic performances in the conversion of fructose to 1,2-PDO under mild reaction *** yield of 1,2-PDO is up to 56.2%at 140°C for 4 h under an ultra-low hydrogen pressure of only 0.2 MPa,surpassing the reported results in recent literature(below 51%).Comprehensive characterizations and density functional theory(DFT)calculations reveal that the presence of oxygen vacancies in the Ru-WO_(x)-MgO_(y) catalyst,serving as active acidic sites,facilitates the chemoselective cleavage of C-C bonds in fructose,which leads to the generation of active intermediates and ultimately resulted in the high yield of 1,2-PDO.

关键词： Biomass Fructose 1,2-Propanediol Retroaldol condensation Heterogenous catalysis

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学科育人价值:内涵剖析与实践审思

当代教育科学 2022年第9期 69-75页

作者：束婷婷陈建建湖北大学化学化工学院山东省教育招生考试院

对学科育人价值的理解是实现学生学科核心素养发展的基本前提。从价值结构的角度来看,学科育人价值是学科客体对于满足学生主体发展需要的价值。由于缺乏对学科育人价值的深度认识,我国基础教育学科育人实践表现出价值主体地位的缺失、... 详细信息

对学科育人价值的理解是实现学生学科核心素养发展的基本前提。从价值结构的角度来看,学科育人价值是学科客体对于满足学生主体发展需要的价值。由于缺乏对学科育人价值的深度认识,我国基础教育学科育人实践表现出价值主体地位的缺失、价值关系模糊、价值内容空泛等问题。鉴于此,促进学科育人价值的实现,应进行以下调整:澄清并确认学科与学生之间的价值关系;将价值目标转化为具体可操作的实践目标;开发能够有效促进学生发展的正价值、高价值及复合价值活动。

关键词：学科育人育人价值核心素养

Engineering Cu_(2)O/Cu/N-C interface to induce directional migration of charge for driving photocatalytic homo-coupling of terminal alkynes

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Nano Research 2024年第8期17卷 6895-6902页

作者： Xiaoqin Yan Tianyi Xu Wenwen Zhan Yang Yang Yang Yu jianjian Yi Xiaoxiao He Lei Yang Jianwei Zhao Liming Sun Xiguang Han Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Department of ChemistrySchool of Chemistry&Materials ScienceJiangsu Normal UniversityXuzhou 221116China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China College of Environmental Science and Engineering Yangzhou UniversityYangzhou 225009China Shenzhen HUASUAN Technology Co. LtdShenzhen 518055China

The efficient utilization of visible light catalysts for organic reactions necessitates not only the effective separation of photogenerated electrons and holes to participate in the reaction,but also their ability to form key intermediates with reactant *** present study successfully synthesized a crusiform-like mesoporous structure of nitrogen-doped carbon-coated Cu_(2)O/Cu(Cu_(2)O/Cu/N-C)with a Cu_(2)O/dual electron acceptor interface using etched HKUST-1 as the precursor.A series of theoretical and experimental studies have demonstrated that the Cu_(2)O/Cu/N-C interface in the photocatalytic homo-coupling of terminal alkynes not only effectively enhances the separation of photogenerated electron−hole pairs,but also facilitates the formation of the key intermediate[Cu_(2)O/Cu/N-C]-phenylacetylide and promotes the rearrangement of its internal *** a result,the homo-coupling reaction can be effectively *** primary reason for the functional role of Cu_(2)O/Cu/N-C interface lies in the downward bending of energy band from Cu_(2)O to N-doped C layers,induced by the different work functions of Cu_(2)O,Cu and N-doped C ***,Cu_(2)O/Cu/N-C photocatalysts demonstrate exceptional photocatalytic activity in the homo-coupling reaction of terminal alkynes under blue-light irradiation and air *** present study presents a novel research methodology for the development of highly efficient visible light catalysts to facilitate organic reactions in future applications.

关键词： photocatalysis homo-coupling of terminal alkynes directional migration of charges heterojunction interface Cu_(2)O carbon coated

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Research 2024年第3期6卷 51-69页

作者： Jianan Lu Huaming Li Guoqiang Zhangi Fan Yangi Xiaotao Zhangi An Pingi Zhouhan Xui Yichen Gui Rui Wangi Dan Yingi jianjian Liui Jianmin Zhangi Ligen Shi Department of Neurosurgery Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Clinical Research Center for Neurological Diseases of Zhejiang Province HangzhouChina.

Immunosenescence refers to the multifaceted and profound alterations in the immune system brought about by aging,exerting complex influences on the pathophysiological processes of diseases that manifest upon *** a combination of single-cell RNA sequencing,cytometry by time of flight,and various immunological assays,we investigated the characteristics of immunosenescence in the peripheral blood of aged mice and its impact on the cerebral immune environment after ischemic *** results revealed some features of *** observed an increase in neutrophil counts,concurrent with accelerated neutrophil aging,characterized by altered expression of aging-associated markers like CD62L and consequential changes in neutrophil-mediated immune ***/macrophages in aged mice exhibited enhanced antigen-presentation capabilities.T cell profiles shifted from naive to effector or memory states,with a specific rise in T helper 1 cells and T helper 17 cells subpopulations and increased regulatory T cell activation in CD4 T ***,regulatory CD8 T cells marked by Klra decreased with aging,while a subpopulation of exhausted-like CD8 T cells expanded,retaining potent immunostimulatory and proinflammatory ***,these inherent disparities not only persisted but were further amplified within the ischemic hemispheres following *** summary,our comprehensive insights into the key attributes of peripheral immunosenescence provide a vital theoretical foundation for understanding not only ischemic strokes but also other age-associated diseases.

关键词： alterations retaining Impact

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地面占压下长输油气管线力学性能分析

低温建筑技术 2018年第3期40卷 153-157页

作者：陈剑健中海福建天然气有限责任公司福建莆田351158

采用经典Boussinesq解积分计算地面占压堆载作用下埋地长输管线受到的土体附加应力,基于弹性地基梁理论将埋地管线简化为梁单元进行研究分析并建立力学平衡方程,然后采用有限差分法对该力学平衡方程进行数值求解。综合考虑管线运行内压... 详细信息

采用经典Boussinesq解积分计算地面占压堆载作用下埋地长输管线受到的土体附加应力,基于弹性地基梁理论将埋地管线简化为梁单元进行研究分析并建立力学平衡方程,然后采用有限差分法对该力学平衡方程进行数值求解。综合考虑管线运行内压,最终计算出地面占压堆载作用下埋地管线的力学特性和变形情况。同时选取典型长输油气管线占压场景进行风险评估,用ABAQUS有限元数值分析方法验证该方法的可行性和准确性。

关键词：地面占压长输油气管线附加应力有限元模拟

基于S-IFOWA算子的多属性决策方法及其应用

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南昌大学学报（理科版） 2015年第5期39卷 415-419页

作者：陈建建黄先玖南昌大学数学系江西南昌330031

基于直觉模糊有序加权平均算子的相关思想,提出一种新的集成算子—对称直觉模糊有序加权平均(S-IFOWA)算子.并研究此算子的相关性质及给出基于S-IFOWA算子的多属性决策方法,并用实例来说明该方法的可行性和有效性。

关键词：模糊 S-IFOWA算子多属性决策