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The mechanism and therapy of aortic aneurysms

Signal Transduction and Targeted Therapy 2023年第3期8卷 963-982页

作者： jianing gao Huanhuan Cao gaofei Hu Yufei Wu Yangkai Xu Hongtu Cui Hong S.Lu Lemin Zheng The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular Science of Ministry of EducationNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking University100191 BeijingChina Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchResearch Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular DiseasesChinese Academy of Medical Sciences100191 BeijingChina Department of Physiology Saha Cardiovascular Research CenterUniversity of KentuckySouth LimestoneLexingtonKY 40536-0298USA

Aortic aneurysm is a chronic aortic disease affected by many factors.Although it is generally asymptomatic,it poses a significant threat to human life due to a high risk of rupture.Because of its strong concealment,it is difficult to diagnose the disease in the early stage.At present,there are no effective drugs for the treatment of aneurysms.Surgical intervention and endovascular treatment are the only therapies.Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm,the specific mechanisms remain unclear.Researchers are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and treatment.To better understand aortic aneurysm,this review elaborates on the discovery history of aortic aneurysm,main classification and clinical manifestations,related molecular mechanisms,clinical cohort studies and animal models,with the ultimate goal of providing insights into the treatment of this devastating disease.The underlying problem with aneurysm disease is weakening of the aortic wall,leading to progressive dilation.If not treated in time,the aortic aneurysm eventually ruptures.An aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic wall.The disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.

关键词： aortic diagnosis drugs treatment

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FertilityOnline:A Straightforward Pipeline for Functional Gene Annotation and Disease Mutation Discovery

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 455-465页

作者： jianing gao Huan Zhang Xiaohua Jiang Asim Ali Daren Zhao Jianqiang Bao Long Jiang Furhan Iqbal Qinghua Shi Yuanwei Zhang The First Affiliated Hospital of USTC Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Key Laboratory of Innate Immunity and Chronic DiseasesSchool of Life SciencesCAS Center for Excellence in Molecular Cell ScienceUniversity of Science and Technology of ChinaCollaborative Innovation Center of Genetics and DevelopmentHefei 230027China

Exploring the genetic basis of human infertility is currently under intensive investigation.However,only a handful of genes have been validated in animal models as disease-causing genes in infertile men.Thus,to better understand the genetic basis of human spermatogenesis and bridge the knowledge gap between humans and other animal species,we construct the FertilityOnline,a database integrating the literature-curated functional genes during spermatogenesis into an existing spermatogenic database,SpermatogenesisOnline 1.0.Additional features,including the functional annotation and genetic variants of human genes,are also incorporated into FertilityOnline.By searching this database,users can browse the functional genes involved in spermatogenesis and instantly narrow down the number of candidates of genetic mutations underlying male infertility in a user-friendly web interface.Clinical application of this database was exampled by the identification of novel causative mutations in synaptonemal complex central element protein 1(SYCE1)and stromal antigen 3(STAG3)in azoospermic men.In conclusion,FertilityOnline is not only an integrated resource for spermatogenic genes but also a useful tool facilitating the exploration of the genetic basis of male infertility.FertilityOnline can be freely accessed at http://***/bsc/spermgenes2.0/index.html.

关键词： FertilityOnline Infertility Database Functional gene Mutation

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FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population

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Frontiers of Medicine 2022年第2期16卷 295-305页

作者： Haoran Wei Mingming Zhao Man Huang Chenze Li jianing gao Ting Yu Qi Zhang Xiaoqing Shen Liang Ji Li Ni Chunxia Zhao Zeneng Wang Erdan Dong Lemin Zheng Dao Wen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science&Technology and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersWuhan 430030China Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China The Institute of Cardiovascular Sciences Peking UniversityKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing 100191China Department of Cardiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cellular and Molecular Medicine Lerner Research InstituteCleveland ClinicClevelandOH 44195USA

The association among plasma trimethylamine-N-oxide(TMAO),FMO3 polymorphisms,and chronic heart failure(CHF)remains to be elucidated.TMAO is a microbiota-dependent metabolite from dietary choline and carnitine.A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction,with the longest follow-up of 7 years.The concentrations of plasma TMAO and its precursors,namely,choline and carnitine,were determined by liquid chromatography-mass spectrometry,and the FMO3 E158K polymorphisms(rs2266782)were genotyped.The top tertile of plasma TMAO was associated with a significant increment in hazard ratio(HR)for the composite outcome of cardiovascular death or heart transplantation(HR=1.47,95%CI=1.13-1.91,P=0.004)compared with the lowest tertile.After adjustments of the potential confounders,higher TMAO could still be used to predict the risk of the primary endpoint(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).This result was also obtained after further adjustment for carnitine(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).The FM03 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort,and lower TMAO levels were found in the AA-genotype.Thus,higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders,and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels.

关键词： chronic heart failure trimethylamine-N-oxide flavin monooxygenase 3 single nucleotide polymorphism

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考虑日内温度变化的夏季温敏负荷模型及其时变参数的两阶段辨识方法

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电力自动化设备 2024年第6期44卷 210-216页

作者：康进刘晓峰周毅高佳宁吴浩鞠平浙江大学电气工程学院浙江杭州310027 国家电网有限公司华东分部上海200002

现有关于电力负荷温敏特性的研究大多仅关注长时间尺度上最高温度与最大负荷之间的关系,而未分析日内不同温度下的温敏特性。建立能反映日内温度变化的温敏负荷模型,并引入2个假设以解决模型可辨识性的问题;提出适用于参数辨识的数据筛... 详细信息

现有关于电力负荷温敏特性的研究大多仅关注长时间尺度上最高温度与最大负荷之间的关系,而未分析日内不同温度下的温敏特性。建立能反映日内温度变化的温敏负荷模型,并引入2个假设以解决模型可辨识性的问题;提出适用于参数辨识的数据筛选方法和温敏负荷模型时变参数的两阶段辨识方法。算例结果表明,所提方法可以准确且鲁棒地辨识温敏负荷模型的时变参数,并得到日内温敏负荷曲线及温敏负荷占比。

关键词：温敏负荷时变参数两阶段辨识日内温度变化

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中川208烟草内生细菌微生物群落结构及其多样性

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中国烟草学报 2024年第1期30卷 63-71页

作者：高嘉宁张丹杨军伟乐山师范学院旅游与地理科学学院四川乐山614000 中国科学院、水利部成都山地灾害与环境研究所四川成都610041 四川省烟草公司攀枝花市公司四川攀枝花617061

【目的】分析中川208四个器官(根、茎、叶、花)的细菌群落多样性与物种组成,为利用中川208内生细菌资源提供科学依据。【方法】以中川208的根、茎、叶、花为研究对象,采用高通量测序与生物信息学分析方法,解析中川208不同器官内生细菌... 详细信息

【目的】分析中川208四个器官(根、茎、叶、花)的细菌群落多样性与物种组成,为利用中川208内生细菌资源提供科学依据。【方法】以中川208的根、茎、叶、花为研究对象,采用高通量测序与生物信息学分析方法,解析中川208不同器官内生细菌的群落结构与物种组成,探讨植物养分特征对优势细菌菌群的调控作用。【结果】(1)从中川208四种样品中共获得5460条特征序列(amplicon sequence variants:ASVs),归属于19门、72纲、161目、285科和389属。(2)各样本的细菌群落多样性为根>茎≥花>叶。Beta多样性和聚类分析表明,中川208的根和叶内生细菌群落组成较相似,与花和茎有明显区别。(3)物种组成上,根、茎、叶内以变形菌门和放线菌门相对丰度最高,花中以厚壁菌门和拟杆菌门的相对丰度最高。LEfSe分析结果表明,中川208不同器官中的细菌群落构成在属水平上存在显著差异性,特别是细菌属不动杆菌、短波单胞菌、异根瘤菌、芽孢杆菌、金黄杆菌、肠杆菌、另枝菌、毛螺菌、普拉梭菌、瘤胃球菌和Rosenbergiella的相对丰度在茎、叶、花内差异显著。(4)冗余分析表明,烟株总N(R2=0.730, P <0.001)、总糖(R2=0.883, P <0.001)和Mg(R2=0.907, P <0.01)含量与各器官中的优势细菌群落分布密切相关。【结论】中川208内生细菌群落多样性自根依次向花、茎、叶呈递减趋势,且不同器官中的内生细菌群落在物种组成上具有明显差异性。中川208植物器官中存在多种显著富集的细菌菌群,值得进一步研究与开发利用。

关键词：中川208 植物内生细菌群落结构多样性植物区室分化

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基于特许经营模式的城市停车楼项目投资管理决策分析

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工程造价管理 2024年第3期35卷 34-38页

作者：赵家发高佳宁天津市政工程设计研究总院有限公司天津300051 中国市政工程华北设计研究总院有限公司天津300074

为了解决日益凸显的城市停车问题,保障停车楼特许经营项目的合理收益,针对停车楼项目具有建设投资较大、收益率较低、投资回收困难等特点,文章结合具体案例,系统梳理了自走式、机械式停车楼建设运营全生命周期的成本收益,首先从停车楼... 详细信息

为了解决日益凸显的城市停车问题,保障停车楼特许经营项目的合理收益,针对停车楼项目具有建设投资较大、收益率较低、投资回收困难等特点,文章结合具体案例,系统梳理了自走式、机械式停车楼建设运营全生命周期的成本收益,首先从停车楼成本角度,建立基于建设期投资、运营维修费用等因素的分析体系,其次从停车楼收益角度,建立基于停车收费、其他收入等因素的分析体系。通过分析可知,对于自走式停车楼,各因素对收益水平影响程度排序依次为建设期投资、停车收费、其他收入以及运营维修费用。对于机械式停车楼,各因素对收益水平影响程度排序依次为建设期投资、停车收费、运营维修费用以及其他收入。通过研究各影响因素对两种类型停车楼投资收益水平的影响,进而为投资者投资决策分析提供相关建议。

关键词：停车楼特许经营成本效益投资决策

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基于LEAP模型的天津市城市客运交通节能减排情景预测

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交通节能与环保 2024年第1期20卷 66-70页

作者：陈永昊朱晓东孟维伟高佳宁中国市政工程华北设计研究总院有限公司天津300074

本文以天津市为研究对象,基于低排放分析平台(Low Emissions Analysis Platform,LEAP)构建城市客运交通碳排放测算模型,并采用情景分析法,对2030年低碳交通发展目标和发展路径进行探索。结果表明,四种发展情景下的天津市能源消耗及碳排... 详细信息

本文以天津市为研究对象,基于低排放分析平台(Low Emissions Analysis Platform,LEAP)构建城市客运交通碳排放测算模型,并采用情景分析法,对2030年低碳交通发展目标和发展路径进行探索。结果表明,四种发展情景下的天津市能源消耗及碳排放较基准情景均有减少,其中综合情景效果最佳,可实现节能81.90%、碳减排77.0%。因此,应大力促进公共交通,并积极探索清洁能源新技术以推动实现“双碳”目标。

关键词：城市客运交通碳排放 LEAP 情景分析

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Nutritional and lipid profile status of children with spinal muscular atrophy in China: A retrospective case-control study

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中华医学杂志(英文版) 2024年第10期137卷 1243-1245页

作者： Feng Yijie Wei Jia Yao Mei Jin jianing Cui Yiqin Long Qi Chen Fei Hong Yi Zhou Dongming Hu Jingjing Chen Xiao gao Feng Yuan Changzheng Mao Shanshan Department of Neurology Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China Department of Infection Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China Department of Nutrition Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China School of Public Health Zhejiang University School of Medicine Hangzhou Zhejiang China Children’s Hospital School of Public Health Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China

5q spinal muscular atrophy (5qSMA) is an autosomal recessive neuromuscular disorder caused by the lack of the survival motor neuron (SMN) protein encoded by the SMN1 gene, located at 5q11.2-q13.3.[1] The incidence is 1/10,000-1/6000 live births, and the mutation carrier rate in China is 1/42.[1] Spinal muscular atrophy (SMA) is mainly divided into four subtypes: SMA type I, II, III, and IV, based on the motor milestones ever achieved. Types I-III occur in children,[1] which often result in progressive muscular atrophy and weakness as well as multi-system dysfunction, including nutritional and metabolic issues.[2] Children with SMA may have hidden nutritional and lipid imbalances, despite normal body appearance and anthropometric measurements, making it difficult to detect early and intervene. Fewer studies have elucidated both the nutritional status and lipid metabolism in SMA patients,[2] especially in Asia, which may have some of the highest numbers of SMA patients in the world. To inform the development of targeted nutritional management strategies, this study aimed to investigate the nutritional status and serum lipid profile characteristics in children with SMA, based on a hospital-based case-control study in China. This study was approved by the Ethics Committee of Children's Hospital of Zhejiang University School of Medicine (No. 2019-IRB-171). Written informed consent was obtained from all the patients and their legal guardians.

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Clustering-based temporal deep neural network denoising method for event-based sensors

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Optoelectronics Letters 2024年

作者： LI jianing XU Jiangtao gao Jiandong Tianjin Key Laboratory of Imaging and Sensing Microelectronics Technology School of Microelectronics Tianjin University

To enhance the denoising performance of event-based sensors， we introduce a clustering-based temporal deep neural network denoising method (CBTDNN). Firstly， to cluster the sensor output data and obtain the respective cluster centers， a combination of density-based spatial clustering of applications with noise (DBSCAN) and Kmeans++ is utilized. Subsequently， long short-term memory (LSTM) is employed to fit and yield optimized cluster centers with temporal information. Lastly， based on the new cluster centers and denoising ratio， a radius threshold is set， and noise points beyond this threshold are removed. The comprehensive denoising metrics F1＿score of CBTDNN have achieved 0.8931， 0.7735， and 0.9215 on the Traffic Sequences Dataset， Pedestrian Detection Dataset， and Turntable Dataset， respectively. And these metrics demonstrate improvements of 49.90%， 33.07%， 19.31%， and 22.97% compared to four contrastive algorithms， namely nearest neighbor (NNb)， nearest neighbor with polarity (NNp)， Autoencoder， and multilayer perceptron denoising filter (MLPF). These results demonstrate that the proposed method enhances the denoising performance of event-based sensors.

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Optimizing support acidity of NiMo catalysts for increasing the yield of benzene, toluene and xylene in tetralin hydrocracking

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 71-84页

作者： Feng Chen jianing Huo Liang Zhao Jinsen gao Chunming Xu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China

To enhance the yields of benzene,toluene,and xylene in tetralin hydrocracking,the effect of the support acid properties of NiMo catalysts on hydrocracking performance of tetralin were investigated in this study.NaY zeolites were modified by hydrothermal treatment to form USY zeolites at different temperatures and adjust the type and amount of acid.In addition,H-Beta was loaded into the USY to further adjust the acidic properties of the catalysts.The result shows that when the total B acid content of the catalyst is maintained between 150 and 200μmol·g^(-1),the total acid amount is maintained between 1.7 and 1.9 mmol·g^(-1),and the L/B(L and B acids)ratio is maintained between 1.5 and 2,the catalysts have favorable performances on tetralin hydrocracking.Under this condition,the catalysts have a yield of benzene,toluene,and xylene higher than 30 wt%and a selectivity for benzene,toluene,and xylene higher than 35%.The tetralin conversion is greater than 85 wt%.The AB6 catalyst obtains the best hydrocracking effect with the conversion of tetralin reaching 90.24 wt%,the yields of benzene,toluene,and xylene reaching 33.58 wt%,and the selectivity of benzene,toluene,and xylene reaching 37.21%,respectively.

关键词： hydrocracking tetralin benzene toluene and xylene acid properties reaction pathways

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