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In situ atomic-scale observation of monolayer graphene growth from SiC

Nano Research 2018年第5期11卷 2809-2820页

作者： Kaihao Yu Wen Zhao Xing Wu jianing Zhuang Xiaohui Hu Qiubo Zhang Jun Sun Tao Xu Yang Chai feng Ding Litao Sun SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of Education School of Electronic Science and Engineering Southeast University Nanjing 210096 China Center for Multidimensional Carbon Materials Institute for Basic Science Ulsan 689-798 Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology Ulsan 689-798 Republic of Korea Institute of Textiles and Clothing The Hong Kong Polytechnic University Hong Kong 999077 China Shanghai Key Laboratory of Multidimensional Information Processing Department of Electrical Engineering East China Normal University Shanghai 200241 China College of Materials Science and Engineering Nanjing Tech University Nanjing 210009 China Center for Advanced Carbon Materials Southeast University and Jiangnan Graphene Research Institute Changzhou 213100 China Center for Advanced Materials and Manufacture Joint Research Institute of Southeast University and Monash University Suzhou 215123 China Department of Applied Physics The Hang Kong Polytechnic University Hang Kong 999077 China

Because of its high compatibility with conventional microfabrication processing technology, epitaxial graphene （EG） grown on SiC shows exceptional promise for graphene-based electronics. However, to date, a detailed understanding of the transformation from three-layer SiC to monolayer graphene is still lacking. Here, we demonstrate the direct atomic-scale observation of EG growth on a SiC （11^-00） surface at 1,000℃ by in situ transmission electron microscopy in combination with ab initio molecular dynamics （AIMD） simulations. Our detailed analysis of the growth dynamics of monolayer graphene reveals that three SiC （11^-00） layers decompose successively to form one graphene layer. Sublimation of the first layer causes the formation of carbon clusters containing short chains and hexagonal rings, which can be considered as the nuclei for graphene growth. Decomposition of the second layer results in the appearance of new chains connecting to the as-formed clusters and the formation of a network with large pores. Finally, the carbon atoms released from the third layer lead to the disappearance of the chains and large pores in the network, resulting in a whole graphene layer. Our study presents a clear picture of the epitaxial growth of the monolayer graphene from SiC and provides valuable information for future developments in SiC-derived EG technology.

关键词： graphene epitaxial growth in situ transmissionelectron microscopy

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Roles of FERONIA-like receptor genes in regulating grain size and quality in rice

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Science China(Life Sciences) 2021年第2期64卷 294-310页

作者： Long Wang Dandan Wang Zhuhong Yang Shun Jiang jianing Qu Wei He Zhenming Liu Junjie Xing Youchu Ma Qinlu Lin feng Yu State Key Laboratory of Chemo/Biosensing and Chemometrics and Hunan Province Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of BiologyHunan UniversityChangsha 410082China National Engineering Laboratory for Rice and By-product Deep Processing Central South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterChangsha 410125China

Grain yield and quality are critical factors that determine the value of grain *** this study,we analyzed the functions of 12 FERONIA-like receptor(FLR)family members in rice and investigated their effects on grain size and *** found that FLR1,FLR2 and FLR8 negatively regulated grain size,and FLR15 positively regulated grain ***1 mutants had a higher cell number and an accelerated rate of grain filling compared to wild-type plants,which led to grains with greater widths.A mechanism underlying the regulation of grain size by FLR1 is that FLR1 is associated with OsRac1 Rho-like GTPase,a positive regulator of grain *** grain quality,the flr1 mutant had a higher percentage of chalkiness compared with wild-type plants,and seeds carrying mutations in flr3 and flr14 had endosperms with white floury *** elucidate the possible mechanism underlying this phenomenon,we found that FLR1 was constitutively expressed during endosperm ***-seq analysis identified 2,367 genes that were differentially expressed in the flr1 mutant,including genes involved in starch and sucrose metabolism and carbon *** this study,we identified the roles played by several FLR genes in regulating grain size and quality in rice and provided insights into the molecular mechanism governing the FLR1-mediated regulation of grain size.

关键词： FLR chalkiness seed size grain quality OsRac1

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Design of the FPGA-based gigabit serial link for PandaX-III prototype TPC

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Radiation Detection Technology and Methods 2017年第2期1卷 113-116页

作者： Cheng Li Changqing feng jianing Dong Danyang Zhu Shubin Liu Qi An State Key Laboratory of Particle Detection and Electronics Hefei 230026China University of Science and Technology of China Hefei 230026China

Background:PandaX-III is aimed to search for neutrinoless double beta decay of 136Xe at China Jinping Underground *** test various design features of PandaX-III detector,a prototype TPC with 20 kg Xe containing inside is ***:Front-end boards installed inside the waterproof vessel integrate charge of Micromegas signal,digitize signal waveform and send data packet to back-end *** boards receive synchronous information(global clock,global trigger,etc.),as well as command messages from back-end *** order to satisfy the requirement of high data throughput and multiple types of synchronous data transmission,we propose an optical fiber link to communicate between front-end board and back-end ***:Communication of serial transmission is performed using FPGA-based gigabit transceiver with a 1 Gbit/s point-to-point speed.A dedicated user-defined protocol is implemented for various kinds of data ***:To validate the performance of this link,bit error rate and eye diagram were *** joint test with detector was conducted in *** test results showed sufficient data bandwidth and stable ***:To satisfy the requirement for data transmission between front-end board and back-end board in PandaX-III TPC detector readout,an FPGA-based gigabit serial link is designed and *** design shows good performance and will be applied to the R&D of PandaX-III TPC.

关键词： Gigabit transceiver TPC Micromegas PandaX-III

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Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice

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Neuroscience Bulletin 2020年第10期36卷 1158-1170页

作者： Xun Wu Wenxing Cui Wei Guo Haixiao Liu jianing Luo Lei Zhao Hao Guo Longlong Zheng Hao Bai Dayun feng Yan Qu Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China

Clinical advances in the treatment of intracranial hemorrhage(ICH)are restricted by the incomplete understanding of the molecular mechanisms contributing to secondary brain *** is a highly active unsaturated aldehyde which has been implicated in many nervous system *** results indicated a significant increase in the level of acrolein after ICH in mouse *** primary neurons,acrolein induced an increase in mitochondrial fragmentation,loss of mitochondrial membrane potential,generation of reactive oxidative species,and release of mitochondrial cytochrome ***,acrolein facilitated the translocation of dynaminrelated protein 1(Drpl)from the cytoplasm onto the mitochondrial membrane and led to excessive mitochondrial *** studies found that treatment with hydralazine(an acrolein scavenger)significantly reversed Drpl translocation and the morphological damage of mitochondria after *** parallel,the neural apoptosis,brain edema,and neurological functional deficits induced by ICH were also remarkably *** conclusion,our results identify acrolein as an important contributor to the secondary brain injury following ***,we uncovered a novel mechanism by which Drpl-mediated mitochondrial oxidative damage is involved in acroleininduced brain injury.

关键词： Intracerebral hemorrhage Secondary brain injury Acrolein Drp1 Mitochondrial oxidative damage

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Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury

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Neuroscience Bulletin 2021年第8期37卷 1160-1175页

作者： Wenxing Cui Xun Wu Dayun feng jianing Luo Yingwu Shi Wei Guo Haixiao Liu Qiang Wang Liang Wang Shunnan Ge Yan Qu Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi’an710038China

Traumatic brain injury(TBI)-induced coagulopathy has increasingly been recognized as a significant risk factor for poor outcomes,but the pathogenesis remains poorly *** this study,we aimed to investigate the causal role of acrolein,a typical lipid peroxidation product,in TBI-induced coagulopathy,and further explore the underlying molecular *** found that the level of plasma acrolein in TBI patients suffering from coagulopathy was higher than that in those without *** a controlled cortical impact mouse model,we demonstrated that the acrolein scavenger phenelzine prevented TBI-induced coagulopathy and recombinant ADAMTS-13 prevented acrolein-induced coagulopathy by cleaving von Willebrand factor(VWF).Our results showed that acrolein may contribute to an early hypercoagulable state after TBI by regulating VWF *** sequencing(mRNA-seq)and transcriptome analysis indicated that acrolein over-activated autophagy,and subsequent experiments revealed that acrolein activated autophagy partly by regulating the Akt/mTOR *** addition,we demonstrated that acrolein was produced in the perilesional cortex,affected endothelial cell integrity,and disrupted the blood-brain *** conclusion,in this study we uncovered a novel pro-coagulant effect of acrolein that may contribute to TBI-induced coagulopathy and vascular leakage,providing an alternative therapeutic target.

关键词： Traumatic brain injury Coagulopathy Autophagy Acrolein Von Willebrand factor

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基于临床CT数字体相关和有限元分析的股骨内部变形场研究

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北京生物医学工程 2024年第1期43卷 9-14,42页

作者：王家宁符绩智冯文天宋霏杨海胜北京工业大学环境与生命学部北京100124

目的验证基于临床CT的数字体相关(digital volume correlation,DVC)方法在测量股骨内部变形场时的准确性,并通过DVC进一步测量股骨在跌倒情况下的内部变形,验证基于临床CT的有限元分析方法(finite element analysis,FEA)在计算股骨内部... 详细信息

目的验证基于临床CT的数字体相关(digital volume correlation,DVC)方法在测量股骨内部变形场时的准确性,并通过DVC进一步测量股骨在跌倒情况下的内部变形,验证基于临床CT的有限元分析方法(finite element analysis,FEA)在计算股骨内部变形场的准确性。方法使用猪股骨,模拟侧向跌倒姿态,进行分步力学加载实验,同步进行多次CT成像。通过重复扫描和虚拟位移验证DVC方法的准确性。DVC以子体积作为配准两组图像的研究对象,分别设置8、12、16和20 mm的子体积进行测试。量化误差指标包括位移系统误差-平均值(mean)、位移随机误差-标准差(standard deviation,SD)、应变准确度-平均绝对误差(mean absolute error,MAER)和应变精确度-标准差误差(standard deviation of the error,SDER)。基于CT图像建立股骨有限元模型,模拟实验条件,计算股骨内部位移,与DVC测量的内部变形场对比验证。结果基于临床CT的DVC方法重复扫描位移偏差小于0.013 mm,MAER和SDER均小于200με;虚拟位移偏差小于0.098 mm,MAER为1093~1687με,SDER为604~1267με,远小于骨组织屈服应变。FEA计算的位移和DVC测量的位移之间具有较强的相关性(R^(2)≥0.76,P<0.05)。结论基于临床CT的DVC方法可以准确测量股骨内部变形场,并且基于临床CT的有限元模型可以准确计算股骨内部变形场。

关键词： CT图像有限元分析数字体相关骨质疏松股骨骨折

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认知融合联合12针系统经会阴前列腺穿刺活检在日间手术模式中的应用

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临床泌尿外科杂志 2024年第2期39卷 111-114,119页

作者：杨睿孙佳宁蒋晓舻欧阳奎张峰赵红伟潍坊医学院临床医学院山东潍坊261053 青岛大学附属烟台毓璜顶医院泌尿外科滨州医学院

目的:探讨认知融合联合12针系统经会阴前列腺穿刺活检在日间手术模式下开展的安全性和有效性。方法:回顾性收集2019年6月—2022年8月于青岛大学附属烟台毓璜顶医院在日间手术模式下行经会阴前列腺认知融合穿刺活检的489例患者的临床病... 详细信息

目的:探讨认知融合联合12针系统经会阴前列腺穿刺活检在日间手术模式下开展的安全性和有效性。方法:回顾性收集2019年6月—2022年8月于青岛大学附属烟台毓璜顶医院在日间手术模式下行经会阴前列腺认知融合穿刺活检的489例患者的临床病理特征,观察前列腺癌(prostate cancer,PCa)检出率、手术时间、疼痛耐受度、并发症等情况。结果:共检出PCa261(53.37%)例,有临床意义前列腺癌(clinically significant prostate cancer,csPCa)占78.93%(206/261)。系统穿刺与认知融合穿刺的PCa总检出率差异无统计学意义(47.03%vs 44.17%,230例vs216例,P=0.135),认知融合穿刺较系统穿刺检出更多csPCa(36.61%vs32.92%,179例vs 161例,P<0.001)。平均手术时间(8.92±0.98)min;视觉模拟评分(visual analogue scale,VAS)平均(2.50±1.16)分;术后并发症发生率为10.02%,其中急性尿潴留5例,血尿35例,发热9例,无脓毒症发生,经对症处理后均好转。结论:认知融合联合12针系统经会阴前列腺穿刺活检在日间手术模式下开展是安全有效的。

关键词：经会阴前列腺活检日间手术认知融合

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基于纵向数据的谷氨酰转肽酶水平与代谢综合征的关联性分析

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郑州大学学报（医学版） 2022年第2期57卷 186-190页

作者：刘玉洁王喆毛倩管佩霞朱高培王晓璇冯佳宁王素珍石福艳李志强吴东妮杨文艳潍坊医学院公共卫生学院山东潍坊261053 锦州医科大学公共卫生学院辽宁锦州121000 锦州医科大学基础医学院辽宁锦州121000 锦州医科大学附属第三医院护理部辽宁锦州121000

目的:基于纵向体检数据,探讨代谢综合征(MS)与γ-谷氨酰转肽酶(GGT)的关联性。方法:收集2016年至2019年连续在辽宁省疾病预防控制中心体检人员的体检资料。以随访期内是否发生MS将研究对象分组,未发生者为非MS组,随访1 a确诊MS者为MS1组... 详细信息

目的:基于纵向体检数据,探讨代谢综合征(MS)与γ-谷氨酰转肽酶(GGT)的关联性。方法:收集2016年至2019年连续在辽宁省疾病预防控制中心体检人员的体检资料。以随访期内是否发生MS将研究对象分组,未发生者为非MS组,随访1 a确诊MS者为MS1组,随访2年确诊者为MS2组;MS确诊后终止观察,不再随访。比较随访期内不同基线年龄非MS组与MS组的血清GGT水平;以lgGGT为因变量,纳入MS发病状态(发病为1,未发病为0)、性别(男为1,女为0)、基线年龄、GGT测定时间(2016、2017、2018、2019年分别取值1、2、3、4)及其与MS发病状态的交互项,构建多水平随机效应模型,分析血清GGT水平与MS的关联性。结果:多水平随机效应模型结果显示,随访时间(β=0.009,P=0.036)、MS发病状态(β=0.279,P<0.001)、基线年龄(β=-0.002,P<0.001)及其与MS发病状态的交互效应(β=-0.006,P<0.001)、性别(β=0.214,P<0.001)及其与MS的交互效应(β=-0.169,P=0.001)有统计学意义,随访时间与MS交互效应无统计学意义(β=0.016,P=0.287);MS组男性lgGGT低于女性。结论:即使血清GGT水平在正常范围内,但当其纵向升高时,提示机体可能已存在代谢紊乱;通过血清GGT水平纵向变化趋势可以预判机体代谢功能状态,提早发现MS。

关键词： γ-谷氨酰转肽酶代谢综合征随机效应模型

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Impurity-induced formation of bilayered graphene on copper by chemical vapor deposition

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Nano Research 2016年第9期9卷 2803-2810页

作者： Jun Li jianing Zhuang Chengmin Shen Yuan Tian Yande Que Ruisong Ma Jinbo Pan Yanfang Zhang Yeliang Wang Shixuan Du feng Ding Hong-Jun Gao Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Textiles and Clothing Hong Kong Polytechnic UniversityKowloonHong KongChina Beijing Key Laboratory for Nanomaterials and Nanodevices Beijing 100190China

High-quality single-layered and bilayered graphene (SLG and BLG) was synthesized on copper foil surfaces by controllable chemical vapor deposition (CVD). Impurity nanoparticles formed on the copper foil surface by hightemperature annealing were found to play a crucial role in the growth of BLG. Analysis of energy-dispersive spectrometry (EDS) data indicated that these nanoparticles consisted of silicon and aluminum. According to the inverted wedding cake model, these nanoparticles served as nucleation centers for BLG growth and the free space between a nanoparticle and graphene served as the center of C injection for the continuous growth of the adlayer beneath the top layer. By combining phase-field theory simulations, we confirmed the mechanism of BLG growth and revealed more details about it in comparison with SLG growth. For the first time, this study led to a complete understanding of the BLG growth mechanism from nucleation to continuous growth in the CVD process, and it has opened a door to the thickness-controllable synthesis of graphene. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

关键词： graphene chemical vapor deposition (CVD) bilayer growth mechanism

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Dynamic features of near-inertial oscillations in the Northwestern Pacific derived from mooring observations from^2015 to 2018

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Journal of Oceanology and Limnology 2020年第4期38卷 1092-1107页

作者： HU Shijian LIU Lingling GUAN Cong ZHANG Linlin WANG jianing WANG Qingye MA Jie WANG Fujun JIA Fan feng Junqiao LU Xi WANG Fan HU Dunxin CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China College of Marine Science University of Chinese Academy of SciencesQingdao 266071China

Near-inertial oscillation is an important physical process transferring surface wind energy into deep *** investigated the near-inertial kinetic energy(NIKE)variability using acoustic Doppler current profiler measurements from a mooring array deployed in the tropical western Pacific Ocean along 130°E at 8.5°N,11°N,12.6°N,15°N,and 17.5°N from September 2015 to January *** features,decay timescales,and significant seasonal variability of the observed NIKE were *** the mooring sites of 17.5°N,15°N,and 12.6°N,the NIKE peaks occurred in boreal autumn and the NIKE troughs were observed in boreal *** contrast,the NIKE at 11°N and 8.5°N showed peaks in winter and troughs in *** cyclones and strong wind events played an important role in the emergence of high-NIKE events and explained the seasonality and latitudinal characteristics of the observed NIKE.

关键词： near-inertial kinetic energy western Pacific Ocean tropical cyclones mooring array seasonal variability

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