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Clinical biomarkers of perioperative neurocognitive disorder:initiation and recommendation

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Science China Life Sciences 2025年

作者： jianhui liu Cheng Li Junyan Yao Lei Zhang Xuan Zhao Xin Lv Zhiqiang liu Changhong Miao Yingwei Wang Hong Jiang Weifeng Yu Tianlong Wang Dongxin Wang E Wang Xiaoping Gu Hailong Dong Junli Cao Yuan Shen Weihong Song Shengdi Chen Yanjiang Wang Guanghui liu Zhongcong Xie Lize Xiong Jialin C.Zheng Department of Anesthesiology Shanghai Ninth People’s Hospital School of Medicine Shanghai Jiao Tong University Department of Anesthesiology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine Department of Anesthesiology Xuanwu Hospital Capital Medical University Department of Anesthesiology and Critical Care Medicine Peking University First Hospital Department of Anesthesiology Xiangya Hospital of Central South University Department of Anesthesiology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Department of Anesthesiology Xijing Hospital Fourth Military Medical University Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical University Shanghai Mental Health Center of Shanghai Jiao Tong University Department of Anesthesiology Tongji Hospital School of Medicine Tongji University Anesthesia and Brain Research Institute Tongji University Oujiang Laboratory Key Laboratory of Alzheimer’s Disease of Zhejiang Province Zhejiang Provincial Clinical Research Center for Mental Disorders Institute of Aging School of Mental Health Affiliated Kangning Hospital The Second Affiliated Hospital Yuying Children’s Hospital Wenzhou Medical University Department of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Neurology Daping Hospital Third Military Medical University State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Geriatric Anesthesia Research Unit Department of Anesthesia Critical Care and Pain Medicine Massachusetts General Hospital Harvard Medical School Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Clinical Research Center for Anesthesiology and Perioperative Medicine Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital School of Medicine Tongji University Center for Tr

Perioperative neurocognitive disorder(PND) is a significant neurological complication in aging perioperative patients that impacts postoperative cognition. PND is currently diagnosed through cognitive function testing, which is limited by its subjectivity and time requirements. Thus, the identification of biomarkers to assess PND onset is a priority to identify at-risk individuals and enable interventions and treatments to patient outcomes. This article synthesizes expert perspectives on brain aging and PND, presents the latest clinical evidence on PND biomarkers(imaging, electroencephalography, and molecular biomarkers), and delves into the relationship between PND and other age-related cognitive disorders. Thorough review of PND research identified several biomarkers with high sensitivity and specificity,offering a solid scientific foundation to predict and diagnose PND. These biomarkers not only enhance diagnostic accuracy for clinicians but also provide opportunities for earlier intervention and more effective treatment, potentially enhancing patient outcomes and quality of life.

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Chaotic time series multi-step direct prediction with partial least squares regression

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Journal of Systems Engineering and Electronics 2007年第3期18卷 611-615页

作者： liu Zunxiong liu jianhui School of Information Engineering Huadong Jiaotong Univ Nachang 330013 P.R. China

Considering chaotic time series multi-step prediction, multi-step direct prediction model based on partial least squares （PLS） is proposed in this article, where PLS, the method for predicting a set of dependent variables forming a large set of predictors, is used to model the dynamic evolution between the space points and the corresponding future points. The model can eliminate error accumulation with the common single-step local model algorithm~ and refrain from the high multi-collinearity problem in the reconstructed state space with the increase of embedding dimension. Simulation predictions are done on the Mackey-Glass chaotic time series with the model. The satisfying prediction accuracy is obtained and the model efficiency verified. In the experiments, the number of extracted components in PLS is set with cross-validation procedure.

关键词： chaotic series prediction multi-step, local model partial least squares.

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混凝土抗冻融破坏性能研究进展

硅酸盐学报 2025年第1期53卷 190-211页

作者：刘剑辉王猛生杨玉柱刘琪陈正史才军广西大学土木建筑工程学院南宁530004 湖南大学土木工程学院长沙410082

在严寒或寒冷地区,混凝土的抗冻融破坏耐久性是决定混凝土结构使用寿命的重要因素。本文总结了近年来国内外关于混凝土冻融破坏理论的进展,基于不同作用机理分析了孔结构、含气量、饱水率对混凝土抗冻融破坏性能的直接影响以及混凝土内... 详细信息

在严寒或寒冷地区,混凝土的抗冻融破坏耐久性是决定混凝土结构使用寿命的重要因素。本文总结了近年来国内外关于混凝土冻融破坏理论的进展,基于不同作用机理分析了孔结构、含气量、饱水率对混凝土抗冻融破坏性能的直接影响以及混凝土内部的组成成分、外界因素、养护条件以及多种组合作用对混凝土抗冻融破坏性能的间接影响,概述了近几年混凝土冻融损伤模型,最后提出提升混凝土抗冻融破坏性能的方法。现有研究表明冻融循环过程中的水相转变是混凝土冻融破坏的主要原因;孔结构直接影响混凝土抗冻融破坏性,其中气泡间距系数与混凝土抗冻融破坏显著相关,是影响混凝土抗冻融破坏性能的决定性因素;混凝土所中使用的骨料、矿物掺合料、化学外加剂、纳米材料、纤维、水灰比及表面涂层都会影响混凝土的抗冻融破坏性能;养护条件、冻融温度和速率等实验方案和盐冻等组合作用也会对抗冻融破坏性能产生影响。

关键词：混凝土冻融破坏微观结构冻融损伤模型矿物掺合料外加剂

华北克拉通胶-辽-吉古元古代构造带的形成及动力学演化

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地质学报 2025年第1期99卷 23-43页

作者：刘建辉李圆硕徐玮男丁正江中国地质科学院地质研究所北京100037 山东省地质矿产勘查开发局第六地质大队山东威海264209

胶-辽-吉古元古代构造带的构造属性及动力学演化长期存在争议。本文通过总结该带构造-岩浆-变质作用及变质火山-沉积岩系的已有研究成果,发现造山前2.2~2.0 Ga花岗质岩石主要为形成于高温低压伸展构造环境的A型花岗岩,部分为源自下地壳... 详细信息

胶-辽-吉古元古代构造带的构造属性及动力学演化长期存在争议。本文通过总结该带构造-岩浆-变质作用及变质火山-沉积岩系的已有研究成果,发现造山前2.2~2.0 Ga花岗质岩石主要为形成于高温低压伸展构造环境的A型花岗岩,部分为源自下地壳基性岩部分熔融形成的I型花岗岩,它们与变质基性侵入岩及变质流纹岩-英安岩和变质玄武岩构成了造山前大陆伸展背景下的双峰式岩浆作用。它们“弧岩浆”属性的地球化学性质主要继承自源区太古宙TTG岩石或基性岩浆上升过程受大陆岩石圈地幔和地壳的同化混染作用。整个胶-辽-吉古元古代构造带没有发现真正意义上类似于现代板块洋-陆俯冲作用有关的岩石-构造组合(如残留洋壳、俯冲增生杂岩(楔)、弧背构造、大型走滑断裂、双变质带及岩浆作用的时空变化等)。龙岗地块和狼林地块具有统一的太古宙克拉通基底及演化历史。“南带”和“北带”的不同变质沉积地层具有类似的物源,沉积环境为稳定的被动陆缘,沉积时代为2.20~1.95 Ga,并经历了1.95~1.80 Ga顺时针变质P-T演化轨迹的中压—高压麻粒岩相和高温—超高温变质作用。综合已有的地质及地球物理证据,构建了胶-辽-吉古元古代构造带的起源及动力学演化模式:①华北克拉通东部陆块新太古代末巨量TTG岩石形成的同时,在下地壳形成巨量高密度的麻粒岩相—榴辉岩相残留物质,新太古代末已形成的稳定克拉通岩石圈地幔使这些高密度的麻粒岩相—榴辉岩相残留物质能够稳定保留。②在2.2~2.0 Ga,热的、相对低密度的软流圈热点上涌,东部陆块沿胶-辽-吉构造带发生陆内伸展变形,破裂形成北部的龙岗地块和南部的狼林地块。③在1.95~1.85 Ga,高密度的榴辉岩化下地壳连同岩石圈地幔,受重力(负浮力)作用驱动,俯冲(下沉)进入热的、低密度的软流圈地幔,带动龙岗地块和狼林地块沿胶-辽-吉带发生汇聚造山作用。④在1.85~1.80 Ga,造山带去根,软流圈上涌,造山带垮塌及造山后伸展。

关键词：华北克拉通胶-辽-吉古元古代构造带重力驱动的板块汇聚造山大陆伸展胶北地体

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Method for Predicting the Fatigue Life of Geometrically Discontinuous Structures Under Combined Bending and Torsion

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Acta Mechanica Solida Sinica 2019年第3期32卷 367-377页

作者： jianhui liu Xuemei Pan Yaobing Wei Youliang Wang School of Mechanical and Electronical Engineering Lanzhou University of Technology Lanzhou 730050 China

The fatigue damage model based on theory of damage mechanics is capable of predicting the fatigue life under multiaxial loading. Meanwhile, the application of critical plane method in the prediction of multiaxial fatigue life has made certain progress. According to the law of thermodynamics, a new damage evolution equation is developed in the present study to predict the fatigue life of geometrically discontinuous structure under tension-torsion loading based on damage mechanics and the critical plane method. The essence of this approach is tha t the st rain parame ter of the uniaxial nonlinear fatigue damage model is replaced with the equivalent strain, which consists of the releva nt parame ters of the critical plane. However, it is difficult to calculate the stress-strain status and the critical plane position of geometrically dis? continuous structure by theoretical methods because of the existence of stress concentration and the multiaxial nonproportional characteristics. Therefore, a new numerical simulation method is proposed to determine the critical plane of geometrically discontinuous structure under multiaxial loading by means of the finite element method and MATLAB software. The fatigue life of notched specimens subjected to combined bending and torsion is predicted using the proposed met hod, and the result is compared with t hose from the experimen ts and the Manson-Cfiffin law. The comparisons show that the proposed method is superior to the Manson-Coffin law and is capable of reproducing the experimental results reasonably when the geometry of the structure is complex. It completely meets the needs of engineering practice.

关键词： Damage mechanics Critical plane method Geometrically discontinuous structure Finite element method

A Two-point Method for Multiaxial Fatigue Life Prediction

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Acta Mechanica Solida Sinica 2022年第2期35卷 316-327页

作者： jianhui liu Xuemei Pan Youtang Li Xiaochuang Chen School of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou 730050China Lanzhou Jinchuan Advanced Materials Technology Co. Ltd.Lanzhou 730101China

Fatigue fracture is one of the most common failure modes of engineering compo-nents,and the combined action of geometrie discontinuity and multiaxial loading is more likely to cause severe fatigue damage of *** work focuses on the fatigue behavior of U-notched Q345 steel specimens with differen t notch sizes under proportional cyclic ***,based on the concept of strain energy,the calculation method of critical plane is given and the equivalent stress of the specified path on the critical plane is extracted to char-acterize the equivalent stress distribution state and the stress gradient ***,based on the high stress volume method and theory of critical distance,a simple method for determining the critical distance is given considering the contribution of stress at the dangerous point and the critical *** addition,based on the idea of stress-distance normalization,a new stress gradient impact factor is defined and a new method for predicting the multiaxial fatigue life of notched specimens is *** prediction results of the proposed model,the local stress-strain method and the point method of theory of critical distance are compared with the experimental *** comparisons show that the prediction results of the proposed model are closer to experimentai life,and the calculation accuracy is higher.

关键词： Multiaxial fatigue Stress gradient Life prediction Critical distance method Local stress-strain method

Electrostatic self-assembly of 2D/2D CoWO_(4)/g-C_(3)N_(4)p-n heterojunction for improved photocatalytic hydrogen evolution:Built-in electric field modulated charge separation and mechanism unveiling

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Nano Research 2022年第8期15卷 6987-6998页

作者： Haiyang Wang Ranran Niu jianhui liu Sheng Guo Yongpeng Yang Zhongyi liu Jun Li Henan Institute of Advanced Technology College of ChemistryZhengzhou UniversityZhengzhou 450052China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China

Two-dimensional(2D)semiconductor heterojunctions are considered as an effective strategy to achieve fast separation of photoinduced ***,a novel CoWO_(4)/g-C_(3)N_(4)(CWO/CN)p–n junction was synthesized using an electrostatic selfassembly *** constructed 2D/2D p–n heterostructure had a rich hetero-interface,increased charge density,and fast separation efficiency of photoinduced *** in-situ Kelvin probe force microscopy confirmed that the separation pathway of photoinduced carriers through the interface obeyed an II-scheme charge transfer *** results and density functional theory calculations indicated the differences of work function between CWO and CN induced the generation of built-in electric field,ensuring an efficient separation and transfer process of photoinduced *** the optimized conditions,the CWO/CN heterojunction displayed enhanced photocatalytic H_(2)generation activity under full spectrum and visible lights irradiation,*** study provides a novel approach to design 2D/2D hetero-structured photocatalysts based on p–n type semiconductor for photocatalytic H_(2)generation.

关键词： p-n junction interfacial charge transfer two-dimensional/two-dimensional photocatalytic H_(2)generation CoWO_(4)/g-C_(3)N_(4)heterojunction

Probabilistic Fatigue Life Framework of Notched Specimens Based on the Weibull Distribution Under Multiaxial Loading

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Acta Mechanica Solida Sinica 2024年第5期37卷 673-684页

作者： Jie Wang jianhui liu Jumei Lu Yingbao He Xuemei Pan Ziyang Zhang School of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou730050China

In engineering applications,the notch effect and size effect significantly influence the evaluation of fatigue performance in components,necessitating special attention in life *** study proposes a new probabilistic model,based on the theory of critical distance(TCD),to predict fatigue life,with the aim of quantitatively assessing the impact of notch effect and size *** stress distribution on the critical plane is first characterized using a sixth-order multinomial function,and the relative stress gradient function is utilized to calculate the value of the critical ***,the effect of the ratio of shear strain to normal strain on fatigue life under multiaxial loading is ***,the integration of the Weibull distribution into the TCD is employed for conducting probabilistic modeling of fatigue ***,fatigue experiments are conducted on notched specimens of Q355D steel,demonstrating that the life prediction results under 50%survival probability are superior to the traditional TCD method.

关键词： Theory of critical distance(TCD) Notch effect Size effect Strain ratio Weibull distribution

Effect of fence opening configurations on dune development

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Acta Oceanologica Sinica 2023年第7期42卷 185-193页

作者： Qingqian Ning Bailiang Li Changmao Zhou Yanyu He jianhui liu West Anhui University Lu’an 237000China Xi’an Jiaotong-Liverpool University Suzhou 215123China Transportation Portand Waterway Bureau of Yangpu Economic Development ZoneHaikou 570203China Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China

Fences have been widely used in coastal protection engineering for their low cost,simple deployment,and easy integration with *** effects of fence porosity and height on dune development have been investigated while not much attention has been paid to the effects of fence opening configurations,such as opening size and geometry,and porosity *** this study,we deployed eight fences with same height and similar porosity,but different opening configurations on a sandy beach in Pingtan,Fujian *** indicate that there is a similar two-dune-one-trough pattern for all fences at the beginning of dune development,and opening size,orientation,and geometry,and porosity distribution control the leeward dune peak *** with small openings and non-uniform porosity have high trapping efficiency,and upper denser porosity may be the optimal design as these fences have the highest trapping efficiency and *** conclusions from this study can provide guidance on practical fence design.

关键词： fence porosity dune development fence opening size fence opening geometry