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重症监护室马尔尼菲篮状菌感染儿童的临床特征

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中国热带医学 2024年第7期24卷 761-766页

作者：李甜樊慧峰杨志勇卢秀兰武宇辉李木胜张剑珲黄莉广州医科大学附属妇女儿童医疗中心重症监护室广东广州510623 广州医科大学附属妇女儿童医疗中心呼吸科广东广州510623 广西医科大学附属第一医院儿科广西南宁530021 中南大学湘雅医学院附属儿童医院(湖南省儿童医院)重症监护室湖南长沙410007 深圳市儿童医院重症监护室广东深圳518038 广州医科大学附属妇女儿童医疗中心急诊科广东广州510623

目的探讨儿童重症监护室(pediatric intensive care unit,PICU)收治的马尔尼菲篮状菌(Talaromyces marneffei,TM)感染患儿的临床资料,以期提高儿童TM感染的诊疗水平。方法回顾性分析2013年1月—2022年12月中国南方4家医院PICU诊治的23... 详细信息

目的探讨儿童重症监护室(pediatric intensive care unit,PICU)收治的马尔尼菲篮状菌(Talaromyces marneffei,TM)感染患儿的临床资料,以期提高儿童TM感染的诊疗水平。方法回顾性分析2013年1月—2022年12月中国南方4家医院PICU诊治的23例TM感染患儿的临床资料,包括临床特征、实验室检查、治疗方案及转归。结果23例患儿中,男14例,女9例,中位年龄24个月,起病至入室时间15(10~30)d,1例存在免疫缺陷病。常见症状为发热(91.3%,21例)、咳嗽(78.3%,18例)和肝脾肿大(78.3%,18例)。严重临床并发症包括多器官功能障碍(69.6%,16例),脓毒性休克(65.2%,15例)及急性呼吸窘迫综合征(65.2%,15例)。所有患者C-反应蛋白(C-reactive protein,CRP)升高,69.2%(9/13)G试验阳性,53.3%(8/15)免疫球蛋白E升高,17.6%(3/17)CD4/CD8倒置,84.2%(16/19)自然杀伤细胞细胞减少。HIV检测均阴性。TM最常通过血液及骨髓培养检出。7例通过基因检测诊断免疫缺陷。采用两性霉素B或伏立康唑单药,或联合用药改口服续贯治疗,最终13例(56.5%)患儿死亡。结论HIV阴性儿童TM感染临床表现不典型,入住重症监护室者病情进展快,严重并发症多,死亡率高。多途径、多手段检测TM,结合免疫功能及基因检测,有助于早诊断。抗真菌治疗策略有待深入研究。

关键词：马尔尼菲篮状菌多器官功能障碍儿童重症监护呼吸系统

Physics-data coupling-driven method to predict the penetration depth into concrete targets

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 184-192页

作者： Shuai Qin Hao Liu jianhui Wang Qiang Zhao Lei zhang Institute of Defense Engineering AMSLuoyang 471000China Harbin Engineering University Harbin 150001China

The projectile penetration process into concrete target is a nonlinear complex *** the increase ofexperiment data,the data-driven paradigm has exhibited a new feasible method to solve such complex ***,due to poor quality of experimental data,the traditional machine learning(ML)methods,whichare driven only by experimental data,have poor generalization capabilities and limited prediction ***,this study intends to exhibit a ML method fusing the prior knowledge with experiment *** newML method can constrain the fitting to experimental data,improve the generalization ability and the predic-tion *** results show that integrating domain prior knowledge can effectively improve theperformance of the prediction model for penetration depth into concrete targets.

关键词： Penetration into concrete Artificial neural networks Prior knowledge fusion Prediction model

High-yield production of porous carbon spheres derived from enzymatic hydrolysis lignin for zinc ion hybrid capacitors

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 127-136页

作者： Tao Huang Xihong Zu jianhui Ma Wenbin Jian Xueqing Qiu Wenli zhang Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006China School of Advanced Manufacturing Guangdong University of TechnologyJieyang 522000China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

The widespread implementation of supercapacitors is hindered by the limited energy density and the pricey porous carbon electrode *** cost of porous carbon is a significant factor in the overall cost of supercapacitors,therefore a high carbon yield could effectively mitigate the production cost of porous *** study proposes a method to produce porous carbon spheres through a spray drying technique combined with a carbonization process,utilizing renewable enzymatic hydrolysis lignin as the carbon source and KOH as the activation *** purpose of this study is to examine the relationship between the quantity of activation agent and the development of morphology,pore structure,and specific surface area of the obtained porous carbon *** demonstrate that this approach significantly enhances the carbon yield of porous carbon,achieving a yield of 22%in contrast to the conventional carbonization-activation method(9%).The samples acquired through this method were found to contain a substantial amount of mesopores,with an average pore size of 1.59 to 1.85 nm and a mesopore ratio of 25.6%.Additionally,these samples showed high specific surface areas,ranging from 1051 to 1831 m2·g^(−1).Zinc ion hybrid capacitors with lignin-derived porous carbon cathode exhibited a high capacitance of 279 F·g^(−1) at 0.1 A·g^(−1) and an energy density of 99.1 Wh·kg^(−1) when the power density was 80 kW·kg^(−1).This research presents a novel approach for producing porous carbons with high yield through the utilization of a spray drying approach.

关键词： enzymatic hydrolysis lignin porous carbon spheres spray drying zinc ion hybrid capacitors

治疗药物监测在婴儿肺部烟曲霉菌感染药学监护应用实践

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儿科药学杂志 2024年第10期30卷 13-17页

作者：梁倩莹莫小兰吴玮哲吴艳兰张剑珲广州医科大学附属妇女儿童医疗中心广州515510

目的:总结并分享医师和药师联合治疗1例婴儿肺部烟曲霉菌感染的经验。方法:临床药师参与1例婴儿肺部烟曲霉菌感染的治疗过程,从药物选择、血药浓度监测及不良反应等方面优化给药方案,开展药学监护,实施个体化给药。结果:患儿通过药学监... 详细信息

目的:总结并分享医师和药师联合治疗1例婴儿肺部烟曲霉菌感染的经验。方法:临床药师参与1例婴儿肺部烟曲霉菌感染的治疗过程,从药物选择、血药浓度监测及不良反应等方面优化给药方案,开展药学监护,实施个体化给药。结果:患儿通过药学监护服务及时避免了不良事件并取得了良好的感染控制效果,病情好转出院。结论:治疗药物监测(TDM)是儿童使用药物后药效评估和不良反应监护的重要手段,临床药师利用专业优势参与制定个体化给药方案,可促进临床合理用药。

关键词：伏立康唑烟曲霉治疗药物监测婴儿药学监护

Synchronous deprotonation–protonation for mechanically robust chitin/aramid nanofibers conductive aerogel with excellent pressure sensing, thermal management, and electromagnetic interference shielding

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Nano Research 2024年第3期17卷 2038-2049页

作者： Xinxin zhang Kunpeng Qian jianhui Fang Sineenat Thaiboonrod Miao Miao Xin Feng Department of Chemistry College of SciencesShanghai UniversityShanghai 200444China Research Center of Nano Science and Technology College of SciencesShanghai UniversityShanghai 200444China School of Materials Sciences and Engineering Shanghai UniversityShanghai 200444China National Nanotechnology Center(NANOTEC) National Science and Technology Development Agency(NSTDA)Thailand Science ParkPathum Thani 12120Thailand

Aerogels with regularly porous structure and uniformly distributed conductive networks have received extensive attention in wearable electronic sensors,electromagnetic shielding,and so ***,the poor mechanical properties of the emerging nanofibers-based aerogels are limited in practical *** this work,we developed a synchronous deprotonation–protonation method in the KOH/dimethyl sulfoxide(DMSO)system at room temperature for achieving chitin cross-linked aramid nanofibers(CANFs)rather than chitin nanofibers(ChNFs)and aramid nanofibers(ANFs)separately by using chitin and aramid pulp as raw *** freeze-drying process,the cross-linked chitin/aramid nanofibers(CA)aerogel exhibited the synergetic properties of ChNF and ANF by the dual-nanofiber compensation *** mechanical stress of CA aerogel was 170 kPa at 80%compressive strain,increased by 750%compared with pure ChNF ***,the compressibility of CA aerogel was somewhat improved compared to ANF *** enhancement verified that the crosslinking reaction between ANF and ChNF during the synchronous deprotonation process was ***,the conductive aerogels with uniform porous structure(CA-M)were successfully obtained by vacuum impregnating CA aerogels in Ti_(3)C_(2)T_(x) MXene solution,displaying low thermal conductivity(0.01 W/(m·K)),high electromagnetic interference(EMI)shielding effectiveness(SE)(75 dB),flame retardant,and heat ***,the as-obtained CA-M aerogels were also applied as a pressure sensor with excellent compression cycle stability and superior human motion monitoring *** a result,the dual-nanofiber based conductive aerogels have great potentials in flexible/wearable electronics,EMI shielding,flame retardant,and heat insulation.

关键词： synchronous deprotonation–protonation electromagnetic interference(EMI)shielding flame retardant heat insulation pressure sensing

Fluid Pump Using a Bar-shaped Piezoelectric Transducer

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Chinese Journal of Mechanical Engineering 2011年第6期24卷 1130-1135页

作者： JIN Jiamei WANG Yin YANG Ying zhang jianhui State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

There are two kinds of piezoelectric pumps:check valve pumps and valve-less *** to use a check valve or not depends upon the application *** achieve large backpressure for higher flow rates,the pump with check valve is ***,adding check valves implies more complex structure and higher probability of valve blocking,*** order to solve the problem,effective driving and transport mechanics with compact construction and reliable service are being *** this paper,using the second-order longitudinal vibration mode of a bar-shaped piezoelectric vibrator for driving fluid,a piezoelectric pump is successfully *** proposed piezoelectric pump consists of coaxial cylindrical shells and a bar-shaped piezoelectric vibrator,which has a disk part and a cone *** lead zirconium titanate ceramic rings fixed in the vibrator are polarized along the thickness *** the second-order longitudinal vibration of the vibrator along its axis is excited,the disk part of the vibrator changes periodically the volume of the chamber and the cone part acts as a pin valve,driving the fluid from the inlet port to the outlet *** elements analysis on the proposed pump model is carried out to verify its operation principle and design by the commercial FEM software *** of the piezoelectric pump were manufactured,assembled,and tested for flow rate and backpressure to validate the concepts of the proposed pump and confirm the simulation results of modal and harmonic *** test results show that the performance of the proposed piezoelectric pump is about 910 mL/min in flow rate with a highest pressure level of 1.5 kPa under 400 V peak-to-peak voltage and 51.7 kHz operating *** is confirmed that this bar-shaped piezoelectric transducer can be effectively applied in fluid transferring mechanism of pump through this research.

关键词： piezoelectric pump check valve longitudinal vibration mode FEM simulation bar-shaped transducer

An Investigation of College English Autonomous Learning in Network Multimodal Context

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Intelligent Information Management 2023年第3期15卷 169-179页

作者： Chen Guan jianhui zhang College of Foreign Language Education and International Business Baoding University Baoding China

In the current society, based on the growing development of network information technology, the teaching in many colleges and universities has also introduced it to adapt to the situation. This trend can provide more useful conditions for students to learn, which requires students to master enough self-learning abilities to adapt to this model. The study in the paper shows that students are usually interested in autonomous learning in a multimodal environment, but the degree of strategy choice is relatively low, and the learning process is blind and passive with the lack of self-confidence. Facing the future, schools should actively integrate into network thinking, and teachers should change their roles and train and guide students’ learning strategies and learning motivations, so as to achieve better teaching results.

关键词： College English Autonomous Learning Ability Training Network Multimodal Context

Development of MoS_(2)-stainless steel catalyst by 3D printing for efficient destruction of organics via peroxymonosulfate activation

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Journal of Environmental Sciences 2024年第1期135卷 108-117页

作者： Yufeng Liu jianhui Xu Xin Fu Pengxu Wang Dan Li Yunfei zhang Shenggui Chen Chunhui zhang Peng Liu School of Environment and Civil Engineering Dongguan University of TechnologyDongguan 523808China School of Art and Design Guangzhou Panyu PolytechnicGuangzhou 511483China Dongguan Institute of Science and Technology Innovation Dongguan University of TechnologyDongguan 523808China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China

Herein,a novel MoS_(2)-stainless steel composite material was first synthetized via a 3D printing method(3DP MoS_(2)-SS)for peroxymonosulfate(PMS)activation and organics *** with MoS_(2)-SS powder/PMS system(0.37 g/(m^(2)/min)),4.3-fold higher k_(FLO)/S_(BET)value was obtained in 3DP MoS_(2)-SS/PMS system(1.60 g/(m^(2)/min),resulting from the superior utilization of active *** observed that 3DP MoS_(2)-SS significantly outperformed the 3DP SS due to the enhanced electron transfer rate and increased active ***,Mo^(4+)facilitated the Fe^(2+)/Fe^(3+)cycle,resulting in the rapid degradation of florfenicol(FLO).Quenching experiments and electron paramagnetic resonance spectra indicated that·OH,SO_(4)·^(-),O_(2)·^(-)and^(1)O_(2)were involved in the degradation of *** effect of influencing factors on the degradation of FLO were evaluated,and the optimized degradation efficiency of 98.69%was achieved at 1 mM PMS and pH of *** degradation products were detected by UPLC/MS analyses and several possible degradation pathways were proposed to be the cleavage of C-N bonds,dechlorination,hydrolysis,defluorination and *** addition,3DP MoS_(2)-SS/PMS system also demonstrated superior degradation performance for 2-chlorophenol,acetaminophen,ibuprofen and *** study provided deep insights into the MoS_(2)-SS catalyst prepared by 3DP technology for PMS activation and FLO-polluted water treatment.

关键词： 3D printing Stainless steel MoS_(2) Peroxymonosulfate activation Degradation mechanism

Organic solar cells with D18 or derivatives offer efficiency over 19%

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Journal of Semiconductors 2024年第5期45卷 1-4页

作者： Erming Feng Chujun zhang jianhui Chang Hengyue Li Liming Ding Junliang Yang Hunan Key Laboratory for Super-microstructure and Ultrafast Process School of PhysicsCentral South UniversityChangsha 410083China Center for Excellence in Nanoscience Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

In recent years,organic solar cells(OSCs)have garnered significant attention due to their distinctive attributes,such as flexibility,lightweight,and solution processing,which position them as alternatives for next-generation solar technologies[1−5].Thanks to breakthroughs in materials development,the power conversion efficiency(PCE)for single-junction OSCs has already surpassed 19%[6−13].The development of photoactive materials is pivotal in enhancing the PCEs,and several reviews have provided insights into materials design[14−18].Herein,we highlight single-junction OSCs based on D18 and its derivatives[19,20].

关键词： breakthrough insight derivatives