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Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages

Regenerative Biomaterials 2022年第1期9卷 888-899页

作者： Xinhui Zheng Lan Chen Ji Tan jianhua miao Xuanyong Liu Tieyi Yang Zhihong Ding Department of Orthopedics Gongli Hospital of Shanghai Pudong New AreaShanghai 200135China Department of Orthopedics Zhengzhou Central Hospital Affiliated Zhengzhou UniversityZhengzhou 450007China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou UniversityZhengzhou 450001China

The immune response induced by surface topography crucially determines the implant ***,how the immune response is mediated by the size of surface topography remains ***,various biocompatible Mg-Al layered double hydroxides sheet-array films with different sizes(nano,micro and nano/micro mixture)were constructed on the biomedical titanium,and their osteo-immunomodulation effects on the macrophages were *** nano-sheet array structures significantly promoted the polarization of M2 macrophages by activating the PI3K-AKT-mTOR signaling pathway with high gene expressions of integrin b2 and *** the micro-sheet array structures enhanced osteogenic differentiation of mouse bone marrow mesenchymal stem cells(mBMSCs)via ROCK-YAP/TAZ-mediated ***,the nano-sheet array structures promoted the osteogenic differentiation of mBMSCs with a high proportion of M2 macrophages through a shared *** study gave further information concerning integrin-induced focal adhesions in cells of different sheet array structures and their role in macrophage polarization and osteogenic differentiation of mBMSCs,which might help to design biomaterial surfaces with optimal geometry for a desired immunemodulation.

关键词： micro-nano topography immunomodulation macrophages osteogenesis

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Maackiain inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by inhibiting the MAPK/Ras signaling pathway

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Chinese Journal of Natural Medicines 2023年第3期21卷 185-196页

作者： JIANG Xing YANG Xiaonan SHI Yanxia LONG Yan SU Wenqing HE Wendong WEI Kunhua miao jianhua College of Pharmacy Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement/Guangxi Engineering Research Center of TCM Resource Intelligent Creation Guangxi Botanical Garden of Medicinal PlantsNanning 530023China The Second Affiliated Hospital Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China College of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China Department of Pharmacy Guangxi Medical University Affiliated Tumor HospitalNanning 530021China

Nasopharyngeal carcinoma(NPC)is the third most common malignancy with a high recurrence and metastasis rate in South *** compounds extracted from traditional Chinese herbal medicines have been developed and utilized for the treatment of a variety of cancers with modest properties and slight side ***(MA)is a type of flavonoid that was first isolated from leguminous plants,and it has been reported to relieve various nervous system disorders and exert anti-allergic as well as antiinflammatory *** this study,we demonstrated that MA inhibited proliferation,arrested cell cycle and induced apoptosis in nasopharyngeal carcinoma CNE1 and CNE2 cells in vitro and in *** expression of the related proteins associated with these processes were consistent with the above ***,transcriptome sequencing and subsequent Western blot experiments revealed that inhibition of the MAPK/Ras pathway may be responsible to the anti-tumor effect of MA on NPC ***,the effects of MA and an activator of this pathway,tertiary butylhydroquinone(TBHQ),alone or combination,were *** results showed TBHQ neutralized the inhibitory effects of *** data suggest that MA exerts its anti-tumor effect by inhibiting the MAPK/Ras signaling pathway and it has the potential to become a treatment for patients with NPC.

关键词： Nasopharyngeal carcinoma Maackiain Proliferation Cell cycle Apoptosis Transcriptome sequencing MAPK/Ras signaling pathway

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Two Ways to Induce Gynostemma pentaphyllum Plantlets from Tissue Culture

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Agricultural Biotechnology 2022年第6期11卷 78-83页

作者： Baobao QIANG Ying LIANG Kunhua WEI jianhua miao Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement Guangxi Engineering Research Center of TCM Resource Intelligent CreationGuangxi Botanical Garden of Medicinal PlantsNanning 530023China

[Objectives]This study was conducted to investigate rapid propagation systems of Gynostemma pentaphyllum.[Methods]Ten different media were tested to select the optimal media for inducing callus proliferation,bud differentiation and rooting by using tissue culture technology,with *** stem segments and leaves as *** stem segments of *** were used as explants to directly induce rooting and germination,and appropriate media were selected.[Results]The optimum callus induction medium for *** stem segments was MS+6-BA 1.0 mg/L+NAA 0.4 mg/L;the optimum rooting medium for stem callus was MS+NAA 0.2 mg/L;and the optimum germination medium for stem segments was MS+6-BA 1.0 mg/*** optimum callus induction medium for *** leaves was MS+6-BA 0.5 mg/L+NAA 0.2 mg/L;and the optimum rooting medium for leaves was MS+NAA 0.4 mg/*** optimum rooting medium for *** stem segments was MS+IAA 1.0 mg/L,with which the rooting rate was 100%,the average root length was about 3 cm,and the average number of sprouts per explant was 1.48,so it is the optimal condition.[Conclusions]This study provides a new method for in-vitro cultivation of *** and has far-reaching significance for improving human health.

关键词： Tissue culture Gynostemma pentaphyllum Callus Rooting Germination

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古琴美学中的儒道佛思想

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音乐研究 2002年第2期 7-13页

作者：苗建华中央音乐学院

古琴是我国最具代表意义的传统乐器,已经有了至少三千年的历史.在长期的发展过程中,古琴不仅有众多的作品传世,更有丰富的琴论文献留存.从先秦时的、到明清时的、,它们勾勒出了传统古琴美学思想的发展脉络.纵览这些文献,可发现古琴美学... 详细信息

古琴是我国最具代表意义的传统乐器,已经有了至少三千年的历史.在长期的发展过程中,古琴不仅有众多的作品传世,更有丰富的琴论文献留存.从先秦时的、到明清时的、,它们勾勒出了传统古琴美学思想的发展脉络.纵览这些文献,可发现古琴美学思想与儒、道、佛思想有十分密切的关系.先秦时儒、道就各有古琴美学命题提出,魏晋后佛家思想也开始逐渐渗入到古琴领域.此后,儒、道、佛三家思想均对传统古琴美学思想的发展产生影响,并各有诸多美学命题提出,其中"琴者,禁也"、"琴者,心也"、"攻琴如参禅"等命题更为重要,分别集中体现了儒、道、佛的古琴美学思想.

关键词：古琴美学李贽徐上瀛《溪山琴况》古琴音乐民间音乐

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“非遗”音乐当下的保护与传承——以中央音乐学院为例

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中央音乐学院学报 2023年第3期 3-8,21页

作者：苗建华中央音乐学院党委

音乐类非物质文化遗产(简称“非遗”音乐)作为我国优秀传统音乐文化的重要组成部分,对中华民族现代文明建设的意义不言而喻。文章认为,20年来我国在“非遗”音乐的保护传承方面取得了突出成就,但在传承方式、机制完善、理论研究、高校... 详细信息

音乐类非物质文化遗产(简称“非遗”音乐)作为我国优秀传统音乐文化的重要组成部分,对中华民族现代文明建设的意义不言而喻。文章认为,20年来我国在“非遗”音乐的保护传承方面取得了突出成就,但在传承方式、机制完善、理论研究、高校作用发挥等方面尚存在不少较突出的问题。中央音乐学院作为中国专业音乐教育的最高学府,在当下非物质文化遗产的系统性保护与传承中,应以学校“非遗”中心为核心,发挥多学科的协同优势,探索构建“非遗”音乐高校教育传承模式,加强基础理论研究,加大传播交流力度,进一步发挥引领作用,推动中华优秀传统音乐文化创造性转化、创新性发展。

关键词： “非遗”音乐保护传承

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Comparative genomics reveals the diversification of triterpenoid biosynthesis and origin of ocotilloltype triterpenes in Panax

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Plant Communications 2023年第4期4卷 271-285页

作者： Zijiang Yang Xiaobo Li Ling Yang Sufang Peng Wanling Song Yuan Lin Guisheng Xiang Ying Li Shuang Ye Chunhua Ma jianhua miao Guanghui Zhang Wei Chen Shengchao Yang Yang Dong National&Local Joint Engineering Research Center on Germplasm Innovation&Utilization of Chinese Medicinal Materials in Southwest China Yunnan Agricultural UniversityKunmingChina The Key Laboratory of Medicinal Plant Biology of Yunnan Province Yunnan Agricultural UniversityKunmingChina College of Food Science and Technology Yunnan Agricultural UniversityKunmingChina Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement Guangxi Botanical Garden of Medicinal PlantsNanningChina Yunnan Plateau Characteristic Agriculture Industry Research Institute KunmingChina

Gene duplication is assumed to be the major force driving the evolution of metabolite biosynthesis in *** from functional burdens,duplicated genes can mutate toward novelties until fixed due to selective ***,the extent to which this mechanism has driven the diversification of metabolite biosynthesis remains to be *** we performed comparative genomics analysis and functional characterization to evaluate the impact of gene duplication on the evolution of triterpenoid biosynthesis using Panax species as *** that whole-genome duplications(WGDs)occurred independently in Araliaceae and Apiaceae *** genomics revealed the evolutionary trajectories of triterpenoid biosynthesis in plants,which was mainly promoted by WGDs and tandem *** synthase(LAS)was likely derived from a tandemduplicate of cycloartenol synthase that predated the emergence of *** episodic diversifying selection,the LAS gene duplicates produced by g whole-genome triplication have given rise to triterpene biosynthesis in core eudicots through ***,functional characterization revealed that oxidosqualene cyclases(OSCs)responsible for synthesizing dammarane-type triterpenes in Panax species were also capable of producing ocotilloltype *** and biochemical evidence suggested that Panax genes encoding the above OSCs originated from the specialization of one OSC gene duplicate produced from a recent WGD shared by Araliaceae(Pg-b).Our results reveal the crucial role of gene duplication in diversification of triterpenoid biosynthesis in plants and provide insight into the origin of ocotillol-type triterpenes in Panax species.

关键词： gene duplication Panax genomes whole-genome duplications triterpenoid biosynthesis ocotilloltype triterpenes specialization

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琴诗中的禅意

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中国音乐 2006年第1期 87-89页

作者：苗建华中央音乐学院现代远程音乐教育学院

佛教宗派中,禅宗对中国古代文人的影响最大,以禅论道、以禅评诗在传统文人生活中风行一时,留下了大量禅意盎然的诗作,“士无故不彻琴瑟”,古琴与文人的密切关系又使诗中有大量描写古琴的篇章。这些琴诗通过琴与禅、琴与声、音与意乃至... 详细信息

佛教宗派中,禅宗对中国古代文人的影响最大,以禅论道、以禅评诗在传统文人生活中风行一时,留下了大量禅意盎然的诗作,“士无故不彻琴瑟”,古琴与文人的密切关系又使诗中有大量描写古琴的篇章。这些琴诗通过琴与禅、琴与声、音与意乃至音乐的审美情趣与准则等内容,表现了佛教无我、性空、顿悟、明心见性等思想。它们是禅宗诸理念在古琴领域的体现,从一个侧面显示出佛教文化对传统音乐文化的影响。

关键词：古琴诗词禅宗

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Gemcitabine and oxaliplatin combination chemotherapy in 30 patients with advanced pancreatic carcinoma

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The Chinese-German Journal of Clinical Oncology 2007年第5期6卷 461-463页

作者： Fan Zhao jianhua miao Di Zhao Shubo Chen Department of Oncology Wuxi Second Hospital Affiliated to Nanjing Medical University Wuxi 214002 China Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective: To evaluate the activity and safety of combination chemotherapy with gemcitabine plus oxaliplatin (GEMOX regimen) in patients of advanced pancreatic carcinoma. Methods: 30 patients with advanced pancreatic cancer were enrolled into this study. All patients received gemcitabine 1000 mg/m2, given by 30-minute intravenous infusion, on days 1 and 8 of each 21-day cycle. Oxaliplatin 100 mg/m2 was administered as a 2 h infusion on day 1 of each 21 day. Clinical outcomes for patients treated with two cycles of chemotherapy were evaluated according to WHO criteria. Results: All 30 patients were eligible for effectiveness and safety analysis. Objective response rate was approximately 20.0%. Clinical benefit response (CBR) was a composite of assessment of pain, performance status and body weight. The pain relief rate, improve-ment rate of performance status and body weight were 53.3%, 46.7% and 36.7%, respectively. The main adverse effects were bone marrow depression, peripheral nerve toxicity and gastrointestinal reaction. There was no treatment-related death during the chemotherapy. Conclusion: The high response rate with low toxicity observed in this study suggests that GEMOX regimen may be an effective alternative curative treatment for patients with advanced pancreatic carcinoma and can be used more extensively in clinical practice.

关键词： gemcitabine oxaliplatin advanced pancreatic carcinoma combined chemotherapy

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Preliminary perspectives on 3GPP standardization of the propagation channel model for FR3 bands for NR

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Science China(Information Sciences) 2025年第03期68卷 391-392页

作者： Pan TANG jianhua ZHANG Huixin XU Haiyang miao Ximan LIU State Key Laboratory of Network and Switching Technology Beijing University of Posts and Telecommunications

Introduction of the study item on the channel model for FR3 bands for NR. According to the 3rd generation partnership project(3GPP) schedule, 3GPP work for the sixth generation(6G) typically starts in 2024 during Release 19. This release aims to establish the technical foundations for 6G and include preliminary work on new 6G capabilities.

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A Comprehensive Survey of Few-shot Information Networks

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Machine Intelligence Research 2025年第1期22卷 60-78页

作者： Xinxin Zheng Feihu Che jianhua Tao School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Institute of Automation Chinese Academy of SciencesBeijing100190China Department of Automation Tsinghua UniversityBeijing100084China

Information networks store rich information in the nodes and edges,which benefit many downstream tasks,such as recommender systems and knowledge graph *** networks contain homogeneous information,heterogeneous information and knowledge graphs.A significant number of surveys focus on one of the three parts and summarize the research works,but few surveys conclude and compare the three kinds of information *** addition,in real scenarios,lots of information networks lack sufficient labeled data,so the combination of meta-learning and information networks can bring in extended *** paper concentrates on few-shot information networks and systematically presents recent works to help analyze and follow related works.

关键词： Few-shot learning meta-learning homogeneous information networks heterogeneous information networks knowledge graphs

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