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Magnetic Actuation Systems and Magnetic Robots for Gastrointestinal Examination and Treatment

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Chinese Journal of Electrical Engineering 2023年第1期9卷 3-28页

作者： Hongbo Sun Jianhua Liu Qiuliang Wang Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

Magnetic actuation technology(MAT)provides novel diagnostic tools for the early screening and treatment of digestive cancers,which have high morbidity and mortality rates worldwide.The application of magnetic actuation systems and magnetic robots in gastrointestinal(GI)diagnosis and treatment to provide a comprehensive reference manual for scholars in the field of MAT research are reviewed.It describes the basic principles of magnetic actuation and magnetic field safety,introduces the design,manufacturing,control,and performance parameters of magnetic actuation systems,as well as the applicability and limitations of each system for different parts of the GI tract.It analyzes the characteristics and advantages of different types and functions of magnetic robots,summarizes the challenges faced by MAT in clinical applications,and provides an outlook on the future prospects of the field.

关键词： Magnetic actuation medical robots capsule endoscope electromagnetic permanent magnets

Concept of radial slippage propagation triggering self-loosening and optimisation design of novel anti-loosening structures

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Friction 2023年第6期11卷 865-880页

作者： Hao GONG Jianhua Liu Huihua FENG Jiayu HUANG Beijing Institute of Technology School of Mechanical EngineeringBeijing100081China

Self-loosening of bolted joints can occur in a vibration environment,and it may induce bolt fatigue fracture with catastrophic consequences.It is essential to clarify the self-loosening mechanism,based on which novel anti-loosening thread structures can be developed.In this paper,we propose the concept of radial slippage propagation and provide new insights into the self-loosening process.The new theory states that the slippage along the radial direction of the thread surface induces more slippage areas(slippage propagation),and self-loosening occurs due to the dynamic evolution and propagation of contact states on the thread and bearing surfaces with an increase in the number of vibration cycles.Finite element analysis(FEA)was used to validate the propagation process of slippage areas on the thread surface.A novel bolted joint with step thread engagement was developed,which could prevent the occurrence of relative motion of the external and internal threads in the radial direction and thus block slippage propagation.A three-dimensional(3D)finite element model(FEM)of the novel thread structure was established,and a test specimen was manufactured using two special tools.FEA and experiments validated its superior anti-loosening and anti-fatigue performances,and the convenience of installation and removal.Experimental validation of the radial slippage propagation theory and the performance optimisation of the step-thread structure should be performed in the future.

关键词： bolted joint self-loosening slippage propagation step thread transversal vibration

Digital Twin-based Quality Management Method for the Assembly Process of Aerospace Products with the Grey-Markov Model and Apriori Algorithm

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Chinese Journal of Mechanical Engineering 2022年第5期35卷 66-86页

作者： Cunbo Zhuang Ziwen liu Jianhua Liu Hailong Ma Sikuan Zhai Ying Wu Laboratory of Digital Manufacturing School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314000China Shanghai Institute of Spacecraft Equipment Shanghai 200240China

The assembly process of aerospace products such as satellites and rockets has the characteristics of single-or small-batch production,a long development period,high reliability,and frequent disturbances.How to predict and avoid quality abnormalities,quickly locate their causes,and improve product assembly quality and efficiency are urgent engineering issues.As the core technology to realize the integration of virtual and physical space,digital twin(DT)technology can make full use of the low cost,high efficiency,and predictable advantages of digital space to provide a feasible solution to such problems.Hence,a quality management method for the assembly process of aerospace products based on DT is proposed.Given that traditional quality control methods for the assembly process of aerospace products are mostly post-inspection,the Grey-Markov model and T-K control chart are used with a small sample of assembly quality data to predict the value of quality data and the status of an assembly system.The Apriori algorithm is applied to mine the strong association rules related to quality data anomalies and uncontrolled assembly systems so as to solve the issue that the causes of abnormal quality are complicated and difficult to trace.The implementation of the proposed approach is described,taking the collected centroid data of an aerospace product’s cabin,one of the key quality data in the assembly process of aerospace products,as an example.A DT-based quality management system for the assembly process of aerospace products is developed,which can effectively improve the efficiency of quality management for the assembly process of aerospace products and reduce quality abnormalities.

关键词： Quality management Digital twin Assembly process Aerospace product Grey Markov model Apriori algorithm

Editorial for Special Issue on Bioelectromagnetics

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Chinese Journal of Electrical Engineering 2023年第1期9卷 1-2页

作者： Jianhua Liu Xin Zhang Vitalii Zablotskii Institute of Electrical Engineering Chinese Academy of SciencesChina High Magnetic Field Laboratory Chinese Academy of SciencesChina Czech Academy of Sciences Czechia

Bioelectromagnetic technology uses the principles and methods of electrical engineering to study the bioelectromagnetic phenomena,characteristics and laws generated by life activities,the effects and mechanisms of electromagnetic field on organisms,the application of bioelectromagnetics in medical and life science instruments,as well as their applications.It is an interdisciplinary discipline integrating electrical science,physics,biology,informatics and medicine.Research on bioelectromagnetic technology can promote the development of new biomedical imaging,new bioelectromagnetic regulation and intervention technologies and provide an inexhaustible driving force for the source innovation of life science instruments and medical equipment.

关键词： driving integrating instruments

Identification of MSA-2: An oral antitumor non-nucleotide STING agonist

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Signal Transduction and Targeted Therapy 2021年第2期6卷 197-198页

作者： Jianhua Liu Xu Huang Jianxun Ding Department of Urology The First Hospital of Jilin University71 Xinmin Street130021 ChangchunPeople's Republic of China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin Street130022 ChangchunPeopled Republic of China Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin University71 Xinmin Street130021 ChangchunPeople’s Republic of China

In a recent study in Science,Pan et al.1 identified an orally available non-nucleotide human stimulator of interferon genes(STING)agonist,MSA-2(benzothiophene oxobutanoic acid),with excellent safety tolerance in vivo.The noncovalently tethered dimers of MSA-2 could bind STING with nanomolar affinity,and the acidic tumor microenvironment would substantially increase the cell entry and retention of MSA-2 and its dimerized interaction with STING,thus leading to a superior antitumor potency of combined MSA-2 and anti-PD-1 treatments.This work has encouraged further design and discovery of clinical human STING agonists for systematic cancer therapy(Fig.1).

关键词： al. interferon stimulator

Methods and Practices for Institutional Benchmarking based on Research Impact and Competitiveness: A Case Study of ShanghaiTech University

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Journal of Data and Information Science 2019年第3期4卷 55-72页

作者： Jiang Chang Jianhua Liu Library and information services ShanghaiTech University Shanghai 201210 China Beijing Wanfang Data Ltd. Beijing 100038 China

Purpose: To develop and test a mission-oriented and multi-dimensional benchmarking method for a small scale university aiming for internationally first-class basic research.Design/methodology/approach: An individualized evidence-based assessment scheme was employed to benchmark ShanghaiTech University against selected top research institutions,focusing on research impact and competitiveness at the institutional and disciplinary levels.Topic maps opposing ShanghaiTech and corresponding top institutions were produced for the main research disciplines of ShanghaiTech. This provides opportunities for further exploration of strengths and weakness. Findings: This study establishes a preliminary framework for assessing the mission of the university. It further provides assessment principles, assessment questions, and indicators.Analytical methods and data sources were tested and proved to be applicable and efficient.Research limitations: To better fit the selective research focuses of this university, its schema of research disciplines needs to be re-organized and benchmarking targets should include disciplinary top institutions and not necessarily those universities leading overall rankings.Current reliance on research articles and certain databases may neglect important research output types.Practical implications: This study provides a working framework and practical methods for mission-oriented, individual, and multi-dimensional benchmarking that ShanghaiTech decided to use for periodical assessments. It also offers a working reference for other institutions to adapt. Further needs are identified so that ShanghaiTech can tackle them for future benchmarking.Originality/value: This is an effort to develop a mission-oriented, individually designed,systematically structured, and multi-dimensional assessment methodology which differs from often used composite indices.

关键词： Differentiating evaluation Mission-driven assessment Evidence-based assessment Benchmarking Research performance

Recent progress on imaging technology and performance testing of PET/MR

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Radiation Detection Technology and Methods 2023年第1期7卷 84-89页

作者： Jianing liu jianhua Geng Department of Nuclear Medicine National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China

Purpose Integrated positron emission tomography and magnetic resonance(PET/MR)is a multimodality imaging technology integrating PET and MR,which can reflect the anatomical structure and physiological function simultaneously.With the development of this technology,PET/MR plays an increasingly important role in clinical diagnosis and treatment.This review would demonstrate the current state of the latest advancement of PET/MR detection technology.Methods In this review,some studies of PET/MR detection technology in motion artifact correction,time of flight,noise reduction,performance testing methods,and phantoms were summarized.Results and conclusions PET/MR is advancing rapidly in imaging technology and has achieved phased achievements.The performance testing results of different models prove that the integration of PET and MR does not affect the respective performance,and the performance testing phantom for PET/MR needs further development.

关键词： Positron emission tomography Magnetic resonance imaging Motion correction Time of flight Performance test

Multi-Branch Cable Harness Layout Design Based on Genetic Algorithm with Probabilistic Roadmap Method

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Chinese Journal of Mechanical Engineering 2021年第2期34卷 68-78页

作者： Yingfeng Zhao Jianhua Liu Jiangtao Ma Linlin Wu School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

Current studies on cable harness layouts have mainly focused on cable harness route planning.However,the topological structure of a cable harness is also extremely complex,and the branch structure of the cable harness can affect the route of the cable harness layout.The topological structure design of the cable harness is a key to such a layout.In this paper,a novel multi-branch cable harness layout design method is presented,which unites the probabilistic roadmap method(PRM)and the genetic algorithm.First,the engineering constraints of the cable harness layout are presented.An obstacle-based PRM used to construct non-interference and near to the surface roadmap is then described.In addition,a new genetic algorithm is proposed,and the algorithm structure of which is redesigned.In addition,the operation probability formula related to fitness is proposed to promote the efficiency of the branch structure design of the cable harness.A prototype system of a cable harness layout design was developed based on the method described in this study,and the method is applied to two scenarios to verify that a quality cable harness layout can be efficiently obtained using the proposed method.In summary,the cable harness layout design method described in this study can be used to quickly design a reasonable topological structure of a cable harness and to search for the corresponding routes of such a harness.

关键词： Cable harness layout Probabilistic roadmap method Genetic algorithm Hybrid fuzzy control

Optimization of several surface treatment processes for alleviating fretting damage of a locking pin

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Friction 2022年第8期10卷 1217-1233页

作者： Jifan HE Zhenbing CAI Yanping REN Jinfang PENG Jianhua Liu Minhao ZHU School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China Traction Power State Key Laboratory Southwest Jiaotong UniversityChengdu 610031China School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

The operational safety and reliability of a variable gauge train are affected by the anti-fretting wear performance of the locking mechanism.The main purpose of this study is to optimize the surface treatment process for a locking pin material under actual service conditions to alleviate fretting damage.Based on the two basic principles of surface strengthening and friction reduction,a substrate(AISI 4135 steel)surface was treated by laser quenching(LQ),plasma nitriding(PN),and bonded MoS2 coating.Systematic fretting wear tests were conducted,and the wear behavior and damage mechanism of various treated surfaces were comprehensively investigated.The results indicate that the wear resistances of the LQ-and PN-treated surfaces were significantly improved,and their main wear mechanisms were abrasive wear,delamination,and oxidation wear.The MoS_(2) coating exhibits the lowest friction coefficient and energy dissipation due to its self-lubricating property,but it incurs the highest wear rate and failure in the form of plastic deformation.Furthermore,the rough compound layer with a high hardness on the PN-treated surface is conducive to the formation and maintenance of the third-body contact at the fretting interface,consequently resulting in a significant reduction in wear.An optimal surface treatment process for alleviating fretting damage of the locking pin is recommended via comprehensive evaluation,which provides a reference for the anti-fretting protection of related mechanical components.

关键词： locking pin fretting wear surface treatment dynamic response wear mechanism