检索结果-南通市图书馆

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li jianhua huang Di Zhao Lemei Zhu Zheyu Zhang Min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical simulation of micro-particle deposition in a realistic human upper respiratory tract model during transient breathing cycle

引用

Particuology 2011年第4期9卷 424-431页

作者： jianhua huang Lianzhong Zhang Jiangsu Xuzhou Construction Machinery Research Institute XCMG Co. Ltd. Xuzhou 221004 China School of Physics Nankai University Tianjin 300071 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi' an 710075 China

An more reliable human upper respiratory tract model that consisted of an oropharynx and four generations of asymmetric tracheo-bronchial （TB） airways has been constructed to investigate the micro-particle deposition pattern and mass distribution in five lobes under steady inspiratory condition in former work by huang and Zhang （2011 ）. In the present work, transient airflow patterns and particle deposition during both inspiratory and expiratory processes were numerically simulated in the realistic human upper respiratory tract model with 14 cartilaginous rings （CRs） in the tracheal tube. The present model was validated under steady inspiratory flow rates by comparing current results with the theoretical models and pub- lished experimental data. The transient deposition fraction was found to strongly depend on breathing flow rate and particle diameter but slightly on turbulence intensity. Particles were mainly distributed in the high axial speed zones and traveled basically following the secondary flow. ＂Hot spots＂ of deposition were found in the lower portion of mouth cavity and posterior wall of pharynx/larynx during inspiration, but transferred to upper portion of mouth and interior wall of pharynx/larynx during expiration. The deposition fraction in the trachea during expiration was found to be much higher than that during inspiration because of the stronger secondary flow.

关键词： Human upper respiratory tract Transient breathing cycle Airflow pattern Micro-particle deposition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modeling micro-particle deposition in human upper respiratory tract under steady inhalation

引用

Particuology 2011年第1期9卷 39-43页

作者： jianhua huang Lianzhong Zhang Suyuan Yu School of Physics Nankai University Tianjin 300071 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Institute of Nuclear Energy and New Energy Technology Tsinghua University Beijing 100084 China

A representative human upper respiratory tract （URT） with idealized oral region and asymmetric tracheo- bronchial （TB） airway has been modeled, and laminar-to-turbulent airflow for typical inhalation modes as well as micro-particle transport and deposition has been simulated using CFX10.0 software from Ansys Inc. on a personal computer. The asymmetric TB airway could not be replaced by an extended straight tube as outlet of the oral region while investigating the tracheal airflow field and particle deposition. Compared to an idealized oral airway with an extended straight tube, several differences could be noted：（i） The laryngeal jet extends further down the trachea and inclines towards the anterior wall; （ii） the turbulence level in trachea is less and decays more quickly; （iii） three recirculation zones are visible with intense adverse current after the glottis; （iv） deposition of small particles in trachea is reduced due to lower turbulence. Refined unstructured mesh with densified boundary layer mesh could be a proper substitute for the structured mesh in the human URT model with asymmetric TB airway. Based on the refined unstructured mesh, the physiological structure of uvula in the soft palate is properly simulated in the present human URT model.

关键词： Human upper airway model Asymmetric tracheobronchial (TB) airway Particle deposition Computational fluid-particle dynamic simulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Cauchy problem for the stochastic generalized Benjamin-Ono equation

引用

Science China Mathematics 2021年第2期64卷 331-350页

作者： Wei Yan jianhua huang Boling Guo College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007China College of Liberal Arts and Sciences National University of Defense TechnologyChangsha 410073China Institute of Applied Physics and Computational Mathematics Beijing 100088China

The current paper is devoted to the Cauchy problem for the stochastic generalized Benjamin-Ono *** establishing the bilinear and trilinear estimates in some Bourgain spaces,we prove that the Cauchy problem for the stochastic generalized Benjamin-Ono equation is locally well-posed for the initial data u0(x,w)∈L^(2)(Ω;H^(s)(R))which is F0-measurable with s≥1/2-α/4 andΦ∈L20,*** particular,whenα=1,we prove that it is globally well-posed for the initial data u0(x,w)∈L2(Ω;H1(R))which is F0-measurable andΦ∈L20,*** key ingredients that we use in this paper are trilinear estimates,the Ito formula and the Burkholder-Davis-Gundy(BDG)inequality as well as the stopping time technique.

关键词： Cauchy problem stochastic generalized Benjamin-Ono equation bilinear estimate trilinear estimate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Optimal Stability Matching Algorithm for DAG Blockchain Based on Matching Theory

引用

Chinese Journal of Electronics 2021年第2期30卷 367-377页

作者： XIA Xu huang jianhua ZHENG Hong TANG Ruicong East China University of Science and Technology

IOTA is a typical blockchain designed for IoT applications. The Markov chain monte carlo algorithm(MCMC) used in IOTA may lead to a large number of unverified blocks, which increases transaction delay to a certain extent. We propose a Stable matching algorithm(SMA) based on matching theory to stimulate nodes to verify blocks, thereby reducing the number of unverified blocks and the consensus delay. The structure of our Io T blockchain uses the Directed acyc1 ic graph(DAG)to improve the transaction processing capability. The nodes in the network are abstracted as transaction issuers and transaction verifiers. A verification service scheduling system is used to assign transactions to the verifiers and achieve the optimal matching. We designed a trust evaluation mechanism which offers verifiers references and awards to check transactions. The simulation results show that SMA can significantly reduce the number of orphan blocks and improve the transaction throughput, which helps to improve the reliability of the Io T blockchain.

关键词： stable matching algorithm directed acyclic graph verification service scheduling system blockchains SMA Markov processes transaction throughput IoT applications transaction verifiers transaction processing consensus delay Markov chain Monte Carlo algorithm Monte Carlo methods DAG blockchain optimal stability matching algorithm Internet of Things directed graphs scheduling computer network security transaction processing capability transaction issuers IoT blockchain IOTA orphan blocks

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Micro-particle deposition and lobar distribution of mass flow in human upper respiratory tract model

引用

Chinese Science Bulletin 2011年第4期56卷 380-385页

作者： huang jianhua ZHANG LianZhong School of Physics Nankai University Tianjin 300071 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China

A representative human upper respiratory tract model consisting of oropharyngeal and asymmetric tracheobronchial(TB) airways from the trachea(G0) to the main lobar bronchi(G2) was constructed. Laminar-to-turbulent airflow for typical inhalation modes as well as micro-particle transportation,wall deposition and mass flow to lobes was simulated using the CFX10.0 software from Ansys Inc. The numerical particle deposition efficiency of the oropharynx region and two generations(G1 and G2) of TB airways shows great agreement with the experimental data obtained from realistic casts. The particle deposition pattern indicates that inertial impaction is the primary mechanism in the human upper airway,and turbulence dispersion performs crescent influence especially for small particles. The initial positions of particles with different fates are confined to specifically concentrated zones. The particle mass distributions of five lobes are close to airflow distributions. The upper lobes receive fewer particles than lower lobes and the right middle lobe receives the least.

关键词：微观粒子呼吸道模型沉积效率质量流量 ANSYS公司人类肺航空公司

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ergodicity of stochastic Boussinesq equations driven by Lvy processes

引用

Science China Mathematics 2013年第6期56卷 1195-1212页

作者： ZHENG Yan huang jianhua Department of Mathematics National University of Defense Technology

We consider a class of stochastic Boussinesq equations driven by L6vy processes and establish the uniqueness of its invariant measure. The proof is based on the progressive stopping time technique.

关键词： Boussinesq equations Levy process invariant measure ergodicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Existence and asymptotic behavior of invasion wave solutions in temporally discrete diffusion systems with delays

引用

International Journal of Biomathematics 2018年第2期11卷 1-25页

作者： Hui Xue jianhua huang Zhixian Yu College of Science National University of Defense Technology Changsha Hunan 410073 P. R. China College of Science University of Shanghai for Science and Technology Shanghai 200093 P. R. China

This paper is concerned with the existence and asymptotic behavior of invasion wave solutions for a time-discrete delayed diffusion competitive system with non-quasimonotone conditions. The existence of invasion wave solution is investigated by applying upper lower solutions method and Schauder＇s fixed point theorem. Further, with the help of Ikeharas＇ theorem, we establish the exponential decay asymptotic behavior of traveling wave solutions at the minus/plus infinity.

关键词： Invasion wave solutions non-quasi-monotonicity diffusive competition sys-tems asymptotic behavior.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sm-Nd isotope study and dating on Honguleleng ophiolite in Xinjiang, China

引用

Chinese Science Bulletin 1999年第20期44卷 1914-1917页

作者： Zhangdong Jin jianhua huang Fuchun Li Nanjing Univ State Key Lab Res Mineral Deposits Nanjing 210093 Peoples R China

A study of the Sm-Nd isotope composition of Honguleleng ophiolite in Xinjiang, China, isochron age ((626±25)Ma),εNd(t) = 8.40,and its model age (TNdDM) in the range of 1 180-1 208 Ma, indicates that the ophiolite was formed in the late stage of the Upper Sinian. In combination with its facies association, petrochemistry, REE patterns, trace elements

关键词： ophiolite Sm-Nd isochron age Honguleleng Xinjiang.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Luminescence properties of phosphate phosphors Ba3Gd1-x(PO4)3：xSm^3＋

引用

Journal of Rare Earths 2018年第5期36卷 456-460页

作者： Honghui Li Xinghong Gong Yujin Chen jianhua huang Yanfu Lin Zundu Luo Yidong huang Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 China Fujian Normal University Fuzhou 350007 China

A series of reddish orange phosphors Ba3Gd1-x（PO4）3：xSm^3＋（x = 0.02, 0.04 0.12） were prepared by the high-temperature solid-state reaction. X-ray powder diffraction （XRD） and diffuse reflectance and photoluminescence spectra were utilized to characterize the structure and spectral properties of the phosphors. The phosphors have strong absorption in the near-UV region. CIE chromaticity coordinates of the phosphors are located in the reddish orange region since the strongest emission band is around 598 nm and related to the 4G5/2 - 6H7/2 transition of Sm^3＋. Optimal concentration of Sm^3＋ in the phosphors is about 6.0 at%. The quantum yield of the Ba3Gdo.94（PO4）3：0.06Sm^3＋ under excitation at 403 nm is about 52.07%. Temperature dependent photoluminescence spectra of the Ba3Gdo.94（PO4）3：0.06Sm^3＋ were measured and the phosphor exhibits high thermal stability of emission. All the results show that the Ba3Gd（PO4）3：Sm^3＋ phosphor may be a potential red phosphor for near-UV based white LEDs.

关键词： Ba3Gd(PO4)3 Sm^3+ phosphor Photoluminescence Reddish orange Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：