检索结果-南通市图书馆

中国实用内科杂志 2000年第8期20卷 475-477页

作者：刘洪郝建华向前深圳市南山医院内科 518001 深圳市南山医院检验科 518001

目的　探讨血管紧张素Ⅱ受体拮抗剂Losartan(商品名科素亚 )对老年高血压病肾功能的影响。方法　采用前瞻性分析研究 ,5 2例老年高血压病患者随机分为 2组 :Losartan组 (2 6例 5 0mg每日 1次 ) ;贝那普利组(2 6例 10mg每日 1次 ) ,疗程... 详细信息

目的　探讨血管紧张素Ⅱ受体拮抗剂Losartan(商品名科素亚 )对老年高血压病肾功能的影响。方法　采用前瞻性分析研究 ,5 2例老年高血压病患者随机分为 2组 :Losartan组 (2 6例 5 0mg每日 1次 ) ;贝那普利组(2 6例 10mg每日 1次 ) ,疗程 12周。观察治疗前后肾功能指标及血压的变化。结果　Losartan能显著降低高血压 (P 0 0 5 )。结论　Losartan单独治疗老年原发性高血压患者在有效降低高血压同时 ,具有减少蛋白尿 ,保护肾功能作用。

关键词：原发性高血压肾功能药物治疗科素亚

在线全文

学校读者我要写书评

暂无评论

基于3种典型踏面的高速转向架稳定性研究

中国铁道科学 2010年第3期31卷 57-63页

作者：梁树林朴明伟郝剑华兆文忠长春轨道客车股份有限公司吉林长春130062 大连交通大学机械工程学院辽宁大连116028

在分析高速轮轨匹配特征的基础上,以350 km.h-1速度等级的CRH3动车组作为研究对象,应用线性稳定性分析方法绘制高速轮轨空间的稳定安全裕度3维图。线性稳定性计算表明:等效锥度越大,转向架蛇行振动固有频率越高,因而必须不断增强抗蛇行... 详细信息

在分析高速轮轨匹配特征的基础上,以350 km.h-1速度等级的CRH3动车组作为研究对象,应用线性稳定性分析方法绘制高速轮轨空间的稳定安全裕度3维图。线性稳定性计算表明:等效锥度越大,转向架蛇行振动固有频率越高,因而必须不断增强抗蛇行减振器的串联刚度。非线性稳定性仿真计算表明:抗蛇行减振器需要利用其动态液压刚度的非线性形成宽频带吸能特性,以满足衰减蛇行振动、控制蛇行振幅和权衡准静态曲线通过性能等要求。仿真计算得出的动车转向架横向加速度值与实际测试的加速度值相吻合。根据曲线踏面磨耗情况确定了CRH3动车组选用3个典型车轮踏面(XP55,S1002CN和LMA)可以达到的最高商业运营速度。

关键词：动车转向架轮轨关系高速列车轮轨匹配踏面磨耗抗蛇行减振器稳定性

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji jianhua Zhuang Yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Study on Sealing Characteristics of Sliding Seal Assembly of Aircraft Hydraulic Actuator

在线全文

学校读者我要写书评

暂无评论

Instrumentation 2024年第1期11卷 18-29页

作者： Weinan Li Saixin Shi Hongxia Tang Liang Chen Jiawei Zhang hao Tang jianhua Zhao Shijiazhuang Haishan Industrial Development Corporation Shijiazhuang 050200 China Heavy Machinery Fluid Power Transmission and Control Laboratory Yanshan UniversityQinhuangdao 066004China

The hydraulic actuator,known as the"muscle"of military aircraft,is responsible for flight attitude adjustment,trajectory control,braking turn,landing gear retracting and other actions,which directly affect its flight efficiency and ***,the sealing assembly often has the situation of over-aberrant aperture fit clearance or critical over-aberrant clearance,which increases the failure probability and degree of movable seal failure,and directly affects the flight efficiency and safety of military *** this paper,the simulation model of hydraulic actuator seal combination is established by ANSYS software,and the sealing principle is *** change curve of contact width and contact pressure of combination seal under the action of high-pressure fluid is *** effects of different oil pressure,fit clearance and other parameters on the sealing performance are ***,the accelerated life test of sliding seal components is carried out on the hydraulic actuator accelerated life test rig,and the surface morphology is compared and *** research shows that the O-ring is the main sealing element and the role of the check ring is to protect and support the O-ring to prevent damage caused by squeezing into the fit clearance,so the check ring bears a large load and is prone to shear *** fit clearance is the main factor affecting the damage of the check ring,and the damage parts are mainly concentrated at the edge of the sealing *** paper provides a theoretical basis for the design of hydraulic actuator and the improvement of sealing performance.

关键词： hydraulic actuator contact stress sealing characteristics maximum shear stress

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

DS/FH测控系统抗干扰性能分析与测试

空间科学学报 2013年第5期33卷 540-547页

作者：潘点飞程乃平郝建华装备学院北京101416

为全面、有效衡量用于应急测控的直扩/跳扩(DS/FH)系统的综合抗干扰性能,采用最低性能指标约束法,对系统抗干扰性能进行综合分析.以音调干扰、脉冲干扰以及高动态环境为例,探讨了不同干扰条件对系统最低性能指标的影响.为解决最低性能... 详细信息

为全面、有效衡量用于应急测控的直扩/跳扩(DS/FH)系统的综合抗干扰性能,采用最低性能指标约束法,对系统抗干扰性能进行综合分析.以音调干扰、脉冲干扰以及高动态环境为例,探讨了不同干扰条件对系统最低性能指标的影响.为解决最低性能指标约束下系统抗干扰性能测试步骤繁多、效率低、代价高的不足,采用蚁群算法,将指标测试次序建模为最佳路径选择问题.通过实例仿真验证了测试模型的正确性与有效性.该方法对DS/FH测试方案的选择具有指导意义.

关键词：直扩跳扩(DS FH) 最低性能指标约束蚁群算法干扰测试

菊科入侵植物三叶鬼针草的繁殖特征及其与入侵性的关系

在线全文

学校读者我要写书评

暂无评论

植物学报 2009年第6期44卷 656-665页

作者：郝建华刘倩倩强胜南京农业大学杂草研究室南京210095 常熟理工学院生物与食品工程学院常熟215500

三叶鬼针草(Bidens pilosa)是一种危害严重的菊科入侵植物。通过实验观察和人工控制套袋等方法,对其花序开花动态、花粉胚珠比(P/O)、自交亲和性、花粉活力、访花昆虫和种子(瘦果)的萌发率等与繁殖相关的特征进行了研究,探讨了这些繁殖... 详细信息

三叶鬼针草(Bidens pilosa)是一种危害严重的菊科入侵植物。通过实验观察和人工控制套袋等方法,对其花序开花动态、花粉胚珠比(P/O)、自交亲和性、花粉活力、访花昆虫和种子(瘦果)的萌发率等与繁殖相关的特征进行了研究,探讨了这些繁殖特征与入侵性的关系。三叶鬼针草在10-11月开花,单个花序的花期约为5-6天。每小花的花柱基部有圆筒状的蜜腺环绕。单个花序内可自交亲和,自交结实率和花粉活力均较高,其P/O值为1754.12±29.87。主要访花者为灰蝶科(Lycaenidae)、粉蝶科(Pieridae)和茧蜂科(Braconidae)昆虫。三叶鬼针草所具有的灵活交配机制是其入侵成功的重要因素。此外,三叶鬼针草结实量大、种子产生迅速且适于传播,以及种子萌发范围广和短期快速萌发等特性也增强了其入侵性。

关键词：菊科三叶鬼针草繁育系统入侵性繁殖特征

部分菊科入侵种种子(瘦果)的萌发能力和幼苗建群特性

在线全文

学校读者我要写书评

暂无评论

生态环境学报 2009年第5期18卷 1851-1856页

作者：郝建华吴海荣强胜南京农业大学杂草研究室江苏南京210095 常熟理工学院生物与食品工程学院江苏常熟215500

对入侵种种子生物学各方面的了解有助于更好地预测入侵趋势和评估可持续管理的策略。研究通过对部分菊科入侵种种子(瘦果)进行的室内萌发实验和土壤埋藏实验,通过与相关研究的对比和分析,对这些入侵种的萌发能力和幼苗建群特性进行了研... 详细信息

对入侵种种子生物学各方面的了解有助于更好地预测入侵趋势和评估可持续管理的策略。研究通过对部分菊科入侵种种子(瘦果)进行的室内萌发实验和土壤埋藏实验,通过与相关研究的对比和分析,对这些入侵种的萌发能力和幼苗建群特性进行了研究。10个入侵种种子室内萌发实验的结果表明,在25℃、12h光照的情况下,除钻形紫菀和一年蓬以外,被研究的其它8个种的终萌发率超过了50%,而且都显示出早期快速萌发的特点。用SPSS的曲线拟合工具对10个种的累积萌发趋势进行了曲线回归分析,对应的最佳模型均为三次曲线方程。不同土壤埋藏深度下幼苗出苗实验的结果表明,菊科8个入侵种的种子在表土的出苗率均最高,随着覆土厚度的增加,种子的出苗率逐渐降低,当覆土厚度超过3cm以上时,所有种子均不能出苗。种子在不同的埋藏深度的出苗情况与种子的大小有关,较大种子破土能力相对较强;种子在不同的埋藏深度的出苗情况与种子本身的萌发能力也相关。土壤埋藏期限的实验结果表明,随埋藏时期的增加,小蓬草、苏门白酒草和一年蓬3个入侵种种子的活力逐步降低,在土壤中埋藏12个月后,其活力分别为21.34%、18.15%和27.38%。这些入侵种较广的种子萌发温度适应范围和高萌发率为防除工作带来了困难。在生产上,可通过不同时期的翻耕、将种子深埋等措施减少这些入侵种的危害。

关键词：菊科埋藏实验萌发入侵种幼苗种子

基于改进PSO-RBFNN的海洋蛋白酶发酵过程软测量

在线全文

学校读者我要写书评

暂无评论

化工学报 2018年第3期69卷 1221-1227页

作者：朱湘临凌婧王博郝建华丁煜函江苏大学电气信息工程学院江苏镇江212013 中国水产科学研究院黄海水产研究所海洋酶与酶工程开放实验室山东青岛266071

针对海洋蛋白酶(marine protease,MP)发酵过程中某些关键参量难以在线检测,离线测量存在大滞后、易染菌的问题,提出了一种基于改进的粒子群-径向基神经网络(PSO-RBFNN)的MP发酵过程软测量建模方法。首先采用指数下降惯性权重(exponentia... 详细信息

针对海洋蛋白酶(marine protease,MP)发酵过程中某些关键参量难以在线检测,离线测量存在大滞后、易染菌的问题,提出了一种基于改进的粒子群-径向基神经网络(PSO-RBFNN)的MP发酵过程软测量建模方法。首先采用指数下降惯性权重(exponential decreasing inertia weight,EDIW)策略对粒子群算法进行改进,克服了固定惯性权重和自适应惯性权重的粒子群算法易于陷入局部极小,进化后期收敛速度慢以及全局搜索能力弱的缺点;然后,采用改进后的粒子群算法对径向基神经网络连接权值进行在线优化,确定RBFNN拓扑结构;最后,根据MP发酵过程的输入/输出向量构建RBFNN软测量模型。实验仿真结果表明,EDIW策略改进的PSO-RBFNN软测量模型训练时间缩短了40%左右,模型预测精度提高了3%以上。

关键词：海洋蛋白酶改进粒子群算法径向基神经网络软测量模型

Plasmonic enhancement and polarization dependence of nonlinear upconversion emissions from single gold nanorod@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2016年第1期5卷 224-234页

作者： Jijun He Wei Zheng Filip Ligmajer Chi-Fai Chan Zhiyong Bao Ka-Leung Wong Xueyuan Chen jianhua hao Jiyan Dai Siu-Fung Yu Dang Yuan Lei Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Central European Institute of Technology Brno University of TechnologyBrno 61669Czech Republic Department of Chemistry Hong Kong Baptist UniversityHong KongChina

Lanthanide-doped upconversion nanocrystals(UCNCs)have recently become an attractive nonlinear fluorescence material for use in bioimaging because of their tunable spectral characteristics and exceptional *** materials are often introduced into the vicinity of UCNCs to increase their emission intensity by means of enlarging the absorption cross-section and accelerating the radiative decay ***,plasmonic nanostructures(e.g.,gold nanorods,GNRs)can also influence the polarization state of the UC fluorescence—an effect that is of fundamental importance for fluorescence polarization-based imaging methods yet has not been discussed *** study this effect,we synthesized GNR@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures with precise control over the thickness of the SiO_(2) *** evaluated the shell thicknessdependent plasmonic enhancement of the emission intensity in ensemble and studied the plasmonic modulation of the emission polarization at the single-particle *** hybrid plasmonic UC nanostructures with an optimal shell thickness exhibit an improved bioimaging performance compared with bare UCNCs,and we observed a polarized nature of the light at both UC emission bands,which stems from the relationship between the excitation polarization and GNR *** used electrodynamic simulations combined with Förster resonance energy transfer theory to fully explain the observed *** results provide extensive insights into how the coherent interaction between the emission dipoles of UCNCs and the plasmonic dipoles of the GNR determines the emission polarization state in various situations and thus open the way to the accurate control of the UC emission anisotropy for a wide range of bioimaging and biosensing applications.

关键词： Förster resonance energy transfer gold nanorods lanthanide-doped upconversion nanocrystals plasmon-enhanced nonlinear fluorescence polarization modulation