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New insight into the role of exosomes in idiopathic membrane nephropathy

BIOCELL 2024年第1期48卷 21-32页

作者： jianhong liu KAI HE HAN WANG XIAOHONG CHENG Department of Nephrology Shaanxi Provincial Hospital of Traditional Chinese MedicineXian710000China School of BasicMedical Sciences and State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengdu611137China Department of Pathophysiology West China College of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu610041China

Exosomes,nanoscale extracellular vesicles(EVs)derived from the invagination of the endosomal membrane,are secreted by a majority of cell types.As carriers of DNA,mRNA,proteins,and microRNAs,exosomes are implicated in regulating biological activities under physiological and pathological conditions.Kidney-derived exosomes,which vary in origin and function,may either contribute to the pathogenesis of disease or represent a potential therapeutic resource.Membranous nephropathy(MN),an autoimmune kidney disease characterized by glomerular damage,is a predominant cause of nephrotic syndrome.Notably,MN,especially idiopathic membranous nephropathy(IMN),often results in end-stage renal disease(ESRD),affecting approximately 30%of patients and posing a considerable economic challenge to healthcare systems.Despite substantial research,therapeutic options remain ineffective at halting IMN progression,underscoring the urgent need for innovative strategies.Emerging evidence has implicated exosomes in IMN’s pathophysiology;Providing a fresh perspective for the discovery of novel biomarkers and therapeutic strategies.This review aims to scrutinize recent developments in exosome-related mechanisms in IMN and evaluate their potential as promising therapeutic targets and diagnostic biomarkers,with the hope of catalyzing further investigations into the utility of exosomes in MN,particularly IMN,ultimately contributing to improved patient outcomes in these challenging disease settings.

关键词： Exosomes Biomarkers Membranous nephropathy Therapeutic targets

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Cost-effective natural graphite reengineering technology for lithium ion batteries

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Chinese Chemical Letters 2024年第1期35卷 547-551页

作者： Pei liu Hongbin Wang Tao Huang Liewu Li Wei Xiong Shaoluan Huang Xiangzhong Ren Xiaoping Ouyang Jiangtao Hu Qianling Zhang jianhong liu Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China Shenzhen Eigen-Equation Graphene Technology Co. Ltd.Shenzhen 518000China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Graphite tailings produced by natural graphite is usually regarded as garbage to be buried underground,which would result in a certain waste of resources.Here,in order to explore the utilization of natural graphite tailings(NGT),a liquid-polyacrylonitrile(LPAN)is used to modify the NGT fragments and aggregate them together to form secondary graphite particles with low surface area and high tap density.Moreover,the modified NGT show much better electrochemical performances than those of original one.When tested in full cells coupled with NMC532 cathode,the material achieves a high rate capability and cycle stability at the cutoff voltage of 4.25 V as well as 4.45 V,which maintains 84.32%capacity retention after 500 cycles at 1 C rate(4.25 V),higher than that of the pristine one(73.65%).The enhanced performances can be attributed to the use of LPAN to create a unique carbon layer upon graphite tailings to reconstruct surface and repair defects,and also to granulate an isotropic structure of secondary graphite particles,which can help to weaken the anisotropy of Li^(+)diffusion pathway and form a uniform,complete and stable solid-electrolyte-interface(SEI)on the surface of primary NGT fragments to promote a fast Li+diffusion and suppress lithium metal dendrites upon charge and discharge.

关键词： Natural graphite Reengineering technology Liquid-polyacrylonitrile Lithium ion batteries High performance

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Challenges and approaches of single-crystal Ni-rich layered cathodes in lithium batteries

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National Science Review 2023年第12期10卷 203-222页

作者： Jiangtao Hu Hongbin Wang Biwei Xiao Pei liu Tao Huang Yongliang Li Xiangzhong Ren Qianling Zhang jianhong liu Xiaoping Ouyang Xueliang Sun Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen University 2. GRINM(Guangdong) Institute for Advanced Materials and Technology School of Materials Science and Engineering Xiangtan University Department of Mechanical and Materials Engineering University of Western Ontario Eastern Institute for Advanced Study Eastern Institute of Technology

High energy density and high safety are incompatible with each other in a lithium battery, which challenges today’s energy storage and power applications. Ni-rich layered transition metal oxides(NMCs) have been identified as the primary cathode candidate for powering next-generation electric vehicles and have been extensively studied in the last two decades, leading to the fast growth of their market share, including both polycrystalline and single-crystal NMC cathodes. Single-crystal NMCs appear to be superior to polycrystalline NMCs, especially at low Ni content(≤60%). However, Ni-rich single-crystal NMC cathodes experience even faster capacity decay than polycrystalline NMC cathodes, rendering them unsuitable for practical application. Accordingly, this work will systematically review the attenuation mechanism of single-crystal NMCs and generate fresh insights into valuable research pathways. This perspective will provide a direction for the development of Ni-rich single-crystal NMC cathodes.

关键词： single-crystal NMC attenuation mechanism modification strategy developing route

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Prelithiation Enhances Cycling Life of Lithium-Ion Batteries:A Mini Review

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Energy & Environmental Materials 2023年第6期6卷 1-9页

作者： Xiaomei liu Ze Wu Leqiong Xie Li Sheng jianhong liu Li Wang Kai Wu Xiangming He Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Contemporary Amperex Technology Co. LimitedNinde 352100China

During the last decade,the rapid development of lithium-ion battery(LIB)energy storage systems has provided significant support for the efficient operation of renewable energy stations.In the coming years,the service life demand of energy storage systems will be further increased to 30 years from the current 20 years on the basis of the equivalent service life of renewable energy stations.However,the life of the present LIB is far from meeting such high demand.Therefore,research on the next-generation LIB with ultra-long service life is imminent.Prelithiation technology has been widely studied as an important means to compensate for the initial coulombic efficiency loss and improve the service life of LIBs.This review systematically summarized the different prelithiation methods from anode and cathode electrodes.Moreover,the large-scale industrialization challenge and the possibility of the existing prelithiation technology are analyzed,based on three key parameters:industry compatibility,prelithiation efficiency,and energy density.Finally,the future trends of improvement in LIB performance by other overlithiated cathode materials are presented,which gives a reference for subsequent research.

关键词： cycle life lithium compensation lithium-ion battery prelithiation

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Insight into the Electrochemical Behaviors of NCM811|SiO-Gr Pouch Battery through Thickness Variation

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Energy & Environmental Materials 2023年第5期6卷 211-218页

作者： Xingqin Wang Youzhi Song Hao Cui jianhong liu Hua Huo Li Wang Yunzhi Gao Xiangming He Key Laboratory of Materials for New Energy Conversion and Storage(Ministry of Industry and Information Technology) School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Risesun Mengguli new energy Science and Technology Co.LTD Beijing 102200China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China

LiNi0.8Co0.1Mn0.1O2(NCM811)|SiOx-graphite(SiO-Gr.)battery chemistry is of intensive attention because its achievable practical energy density is approaching impressively 300 Wh Kg^(-1).However,it still suffers rapid capacity fades during repeated cycles,both chemical,electrochemical and mechanical irreversibility contribute.A comprehensive understanding behind the fading behavior of the cell chemistry is required before fully realize the benefits of this chemistry.Herein,the in-situ thickness variation is introduced as a diagnostic technique and is performed on 5-55 Ah NCM811|SiO-Gr cells.With the help of Li reference electrode and in-situ X-ray diffraction device,the correspondence between thickness variation and the electrode potential is carefully investigated.Firstly,the NCM811|SiO-Gr cell is characterized with the maximum cell thickness at around 80%state-of-charge(SOC)in the discharge process,rather than at 100%SOC.Secondly,the electrochemical behaviors during rate charge/discharge are diagnosed,and a Li platting signal is resolved from thickness variation profile at 2C.This work confirms that the thickness monitoring is a nondestructive and informative complement to conventional diagnostic techniques for failure analysis of pouch cells.

关键词： diagnostic technique electrochemical behavior NCM811 cathode Si-containing anode thickness variation

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Pathway for high-energy density LiMnFePO4 cathodes

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Progress in Natural Science:Materials International 2023年第1期33卷 126-131页

作者： Shaoluan Huang Wenzhong Lin Liewu Li Pei liu Tao Huang Zhencheng Huang Jinli kong Wei Xiong Wenwei Yu Shenghua Ye Jiangtao Hu Qianling Zhang jianhong liu Graphene Composite Research Center College of Chemistry and Environmental Engineering Shenzhen University Shenzhen Eigen–Equation Graphene Technology Co.Ltd.

Polyanion cathodes are credited for its thermal stability and better safety, no matter in lithium ion batteries or sodium ion batteries. Polyanion oxides with phosphate groups came to the public’s attention in 1997, and the representative material is LiFePO4, which has been widely applied and plays a huge role in the field of powder batteries and energy storage system. However, owing to the low lithiation potentials and storage sites, the energy densities of polyanion cathodes have been restricted, resulting of low-endurance and limited application scenarios. Accordingly, here, we use cheap and environmental friendly raw materials as precursors to synthesis high energy density LiMn0.6Fe0.4PO4@C cathode by a simple spray-drying and high temperature calcination process.The self-designed liquid polyacrylonitrile(LPAN) is added for the intention of nanoparticle coating, conductive network construction and particle granulation. The low-cost and carbon-coated LiMn0.6Fe0.4PO4cathode exhibits excellent reversible capacity, low electrochemical polarization and excellent rate capacity, which maintains93.5% capacity retention after cycling 1000 times at 5C. The work introduces a new avenue to fabricate olivine structure cathodes with outstanding electrochemical performance for the high energy density lithium ion batteries.

关键词： Polyanion cathode Liquid polyacrylonitrile Cost effective High energy density High stability

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Nondestructive monitoring of annealing and chemical-mechanical planarization behavior using ellipsometry and deep learning

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Microsystems & Nanoengineering 2023年第2期9卷 345-354页

作者： Qimeng Sun Dekun Yang Tianjian liu jianhong liu Shizhao Wang Sizhou Hu Sheng liu Yi Song The Institute of Technological Sciences Wuhan UniversityWuhanChina School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhanChina Hongyi Honor College of Wuhan University WuhanChina school of Power and Mechanical Engineering Wuhan UniversityWuhanChina The School of Microelectronics Wuhan UniversityWuhanChina

The Cu-flling process in through-silicon via(TSV-Cu)is a key technology for chip stacking and three-dimensional vertical packaging.During this process,defects resulting from chemical-mechanical planarization(CMP)and annealing severely affect the reliability of the chips.Traditional methods of defect characterization are destructive and cumbersome.In this study,a new defect inspection method was developed using Mueller matrix spectroscopic ellipsometry.TSV-Cu with a 3-μm-diameter and 8-μm-deep Cu filling showed three typical types of characteristics:overdishing(defect-OD),protrusion(defect-P),and defect-free.The process dimension for each defect was 13 nm.First,the three typical defects caused by CMP and annealing were investigated.With single-channel deep learning and a Mueller matrix element(MME),the TSV-Cu defect types could be distinguished with an accuracy rate of 99.94%.Next,seven effective MMEs were used as independent channels in the artificial neural network to quantify the height variation in the Cu flling in the z-direction.The accuracy rate was 98.92%after training,and the recognition accuracy reached 1 nm.The proposed approach rapidly and nondestructively evaluates the annealing bonding performance of CMP processes,which can improve the reliability of high-density integration.

关键词： annealing defect chemical

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Metallo-aerogels derived from chitosan with encapsulated metal nanoparticles as robust,efficient and selective nanocatalysts towards reduction of nitroarenes

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Nano Research 2021年第1期14卷 59-65页

作者： Yajing Shen Qingshu Zheng jianhong liu Tao Tu Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of ChemistryFudan University2005 Songhu RoadShanghai 200438China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China College of Chemistry and Molecular Engineering Zhengzhou University100 Kexue avenueZhengzhou 450001China

A series of robust metallo-aerogels are readily fabricated by pyrolysis of xerogels derived from chitosan-metal(M=Fe,Co,Ni)hydrogels.Owing to the strong coordination between metal ions and the functional groups(NH2 and OH)of chitosan,metallo-aerogels consisting of encapsulated metal-nanoparticles(MNPs)by graphite shells were obtained,as supported by various characterizations including high-resolution transmission electron microscope(HR-TEM),X-ray diffraction(XRD),and Raman.The resulting metalloaerogels could be functioned as highly stable,efficient and selective nanocatalysts towards the hydrogenation of nitroarenes to amines at low catalyst loading(1.2 mol.%-2.4 mol.%).Remarkably,the metallo-aerogels could be reused for more than 30 runs without obvious loss of activity and selectivity.These distinguished performances were attributed to the graphitic shells formed during the pyrolysis,which hampered the possible aggregation of MNPs,prevented metal leaching and increased their stability.

关键词： metallo-aerogels nanocatalysts nitroarenes reduction pyrolysis

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Modulating the electronic spin state by constructing dual-metal atomic pairs for activating the dynamic site of oxygen reduction reaction

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Nano Research 2023年第2期16卷 1869-1877页

作者： Shenghua Ye Shuhua Xie Yaqi Lei Xiuyuan Yang Jing Hu Lirong Zheng Zhida Chen Yonghuan Fu Xiangzhong Ren Yongliang Li Xiaoping Ouyang Qianling Zhang jianhong liu Xueliang Sun College of Chemistry and Environmental Engineering Graphene Composite Research CenterShenzhen UniversityShenzhen 518060China Department of Mechanical and Materials Engineering University of Western OntarioLondonOntario N6A 5B9Canada Shenzhen Eigen-Equation Graphene Technology Co.Ltd. Shenzhen 518000China Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

In this study,dual-metal atomic pairs of manganese(Mn)-iron(Fe)binuclear sites(BNSs)with two conjoint MnN4 and FeN4 moieties(MnFeN8)anchored onto a graphite-like structure(GLS)(Mn-Fe BNSs/GLS)were constructed.The binuclear MnFeN8 structure was verified experimentally and theoretically.Magnetic measurements and Gaussian calculations reveal that this unique Mn-Fe BNSs exhibit strong short-range electronic interaction between Mn and Fe sites,which decouples two paired d electrons in Fe sites,thereby transforming Fe sites from an intermediate to a high spin state.The optimal electronic configuration of Fe sites and their binuclear structure facilitate an oxygen reduction reaction(ORR)thermodynamically and dynamically,respectively,endowing Mn-Fe BNSs with improved ORR performance.

关键词： manganese(Mn)-iron(Fe)binuclear sites synergistic effect spin state oxygen reduction reaction

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Mapping paddy rice in Jiangsu Province,China,based on phenological parameters and a decision tree model

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Frontiers of Earth Science 2019年第1期13卷 111-123页

作者： jianhong liu Le LI Xin HUANG Yongmei liu Tongsheng LI Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest UniversityXi'an 710127China College of Urban and Environmental Science Northwest UniversityXi'an 710127China Guangdong Research Center of Smart Homeland Engineering South China Normal UniversityGuangzhou 510631China

Timely and accurate mapping of rice planting areas is crucial under China's current cropping structure. This study proposes a new paddy rice mapping method by combining phenological parameters and a decision tree model.Six phenological parameters were developed to identify paddy rice areas based on the analysis of the Moderate Resolution Imaging Spectroradiometer (MODIS)Enhanced Vegetation Index (EVI)time series and the Land Surface Water Index (LSWI)time series.The six phenological parameters considered the performance of different land cover types during specific phenological phases (EVI1 and EVI2),one-half of or the entire rice growing cycle (LSWI1 and LSWI2),and the shape of the LSWI time series (KurtosisLSWI and SkewnessLSWI).A hierarchical decision tree model was designed to classify paddy rice areas according to the potential separability of different land cover types in paired phenological parameter spaces.Results showed that the decision tree model was more sensitive to LSWI1,LSWI2,and SkewnessLswi than the other phenological parameters.A paddy rice map of Jiangsu Province for 2015 was generated with an optimal threshold set of(0.4,0.42,9,19,1.5,-1.7,0.0)with a total accuracy of 93.9%.The MODIS-derived paddy rice map generally agreed with the paddy land fraction map from the National Land Cover Dataset project,but there were regional discrepancies because of their different definitions of land use and the inability of MODIS to map paddy rice at a fragmental level.The MODIS-derived paddy rice map showed high correlation (R^2=0.85)with county-level agricultural statistics.The results of this study indicate that the phenological parameter-based paddy rice mapping algorithm could be applied at larger spatial scales.

关键词： phenological parameter paddy rice MODIS EVI LSWI decision tree

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